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 내용
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15:00시, 장소 추후 공지
Title: Dynamical network biomarkers for early diagnosis of complex diseases
Abstract : There are abrupt state changes during many biological processes and disease progression of complex diseases, e.g., cell differentiation process, proliferation process, or even disease deterioration process. Such dynamics generally signal the emergence of critical transition phenomena, which result in drastic changes in system states or eventually qualitative changes in phenotypes. Hence, it is of great importance to detect such transitions and further reveal their molecular mechanism. We developed a new model-free method, i.e., dynamical network biomarkers (DNBs), which can identify not only early-warning signals of the critical transitions for complex diseases but also their leading networks, which drive the whole system to initiate such transitions. Examples for cancers are provided to detect pre-disease stages for which traditional methods failed, for demonstrating the effectiveness of this novel approach.
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