б ü ӻ м Ʒü ڷм

   R for Bioinformatics and Biomedicine

ӻ Ƿ ü պм ùٸ ߿伺 ƹ ص ġ ʽϴ. Ʈ R statistical package dz м ̺귯 ڷó ǻ α׷ ȯ ׷ ׸⸦ մϴ. Ǵ нǿ ̿а ǰ о߿ R Ȱ ǽ ߽ϴ. ǰ Ϳ ü м R Ȱ ʰ DZ⸦ մϴ.

-  2013 11 б ü ӻ м Ʒü


Ͻ


: 2013 12 27() ~ 28(), 9 ~ 5                   

: ǰ е 3 ǽ
: б ü ӻ м Ʒü
:  ý۹̿ , Ǵ н

α׷ (Day 1, 27)

9:00 ~ 9:10

 

9:10 ~ 9:30 Introduction to R
9:30 ~ 10:40 Starting with R
- R Installation, R packages, workspace

- Data type and structure
- Basic R functions: built in functions
- File read and write
,
10:50 ~ 12:20 Data manipulation with R
- Vector, matrix

- Index, splice, conditional statement
- Data management: sorting, merging, reshaping
- Apply functions
- User defined function
,
12:20 ~ 13:30    
13:30 ~ 14:40

Statistical Analysis with Biomedical Data I
- Distributions

- Parametric tests

- Non-Parametric stats

, ӿ
14:50 ~ 16:00

Statistical Analysis with Biomedical Data II
- Correlation
- Regression
- ANOVA

, ȼ
16:10 ~ 17:20

Advanced R graphics and ggplot2
- Plot, histogram, qqplot, boxplot
- Layout, axis, legend and text
- ggplot2: scatterplot, histogram, boxplot, barplot, density plot
- Error bar, line graph

, ֿ

α׷ (Day 2, 28)

9:10 ~ 9:30 Machine Learning Algorithms for Biomedical Informatics
9:30 ~ 10:40 Microarray Data Analysis I
-
Introduction to Microarray Data
- Normalization methods
̼,
10:50 ~ 12:00 Microarray Data Analysis II
- Identifying DEG: t-test, SAM

- Volcano plot
- FDR
̼,
12:00 ~ 13:10    
13:10 ~ 14:20

Classification using R
-
K-Nearest Neighbor
- Support Vector Machine

- Logistic regression
- Feature selection

,
14:30~ 15:40

Evaluation and Validation
- Cross validation
- Train/validation/test set split
- Empirical p-value, permutation test
- Multiple testing
- Mean squared error rate

,
15:50 ~ 17:00

Case study: association of BRCA1 and BRCA2 mutations with survival in ovarian cancer (JAMA 2011)
- DEG extraction from RNA-seq data using TRAPR
- Clustering (K-means, hierarchical)
- Correlation analysis between methylation and expression data
- Survival analysis

̰ȭ,

: ǰ е 3 ǽ
: ö 4ȣ ȭ 2 ⱸ ż dzʼž մϴ. (3 ⱸ )
: Ǹ ʴ ߱ ̿Ͻñ ٶϴ.