Post-transcriptional sequence modification of transcripts through RNA editing is an important mechanism for regulating protein function and is correlated with human disease phenotypes. The identification of RNA-editing sites is a fundamental step in the study of RNA editing. Determining the location of condition-specific RNA-editing sites and elucidating their functional roles will help toward understanding various biological phenomena that are mediated by RNA editing. In the present study, it is proposed that RCARE (RNA-sequence comparison and annotation for RNA editing), which searches, annotates, and visualizes RNA-editing sites using thousands of previously known editing sites, can be used for comparative analyses between multiple samples

SY LEE, JG Joung, CH Park and JH Kim RCARE: RNA-seq Comparison and Annotation for RNA Editing
[PMID ]