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Sneddon`s syndrome associates livedo reticularis and neurological signs. Some familial cases have been described. Livedo is permanent, cyanotic, with no infiltration, and affects the limbs, trunk and sometimes the face. It may develop as early as childhood. Neurological signs may appear several decades later. Polymorphous, transient and multifocal, they include cerebrovascular accidents, epilepsy, vertigo and more rarely a pseudobulbar syndrome, chorea, episodes of amnesia or transient amaurosis. Brain scanning and NMR images reveal the development of infarcts. Sneddon`s syndrome may be a particular expression of obliterating vasculitis or of an antiphospholipid antibodies syndrome. To date, there is no efficient treatment to prevent neurological disorders. |