Disease name

특발저혈소판자색반병  (Immune thrombocytopenic purpura)

Study name

특발성혈소판감소증 치료제 후보물질 발굴

Institute

건국대학교

Director

강영선

Email

kangyo67@konkuk.ac.kr

Contact

010-3328-9957

References

The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen. Kang YS, Kim JY, Bruening SA, Pack M, Charalambous A, Pritsker A, Moran TM, Loeffler JM, Steinman RM, Park CG. Proc   PMID: 14694198

A dominant complement fixation pathway for pneumococcal polysaccharides initiated by SIGN-R1 interacting with C1q. Kang YS, Do Y, Lee HK, Park SH, Cheong C, Lynch RM, Loeffler JM, Steinman RM, Park CG. Cell. 2006 Apr 7;125(1):47-58.  PMID: 16615889

SIGN-R1, a C-type lectin, binds to Bip/GRP78 and this interaction mediates the regurgitation of T-cell-independent type 2 antigen dextran through the endoplasmic reticulum. Choi HJ, Choi WS, Park JY, Prabagar MG, Kang KH, Jeon SJ, Park SG, Shin CY, Kang Y  PMID: 20951467

Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG Fc. Anthony RM, Nimmerjahn F, Ashline DJ, Reinhold VN, Paulson JC, Ravetch JV. Science. 2008 Apr 18;320(5874):373-6.  PMID: 18420934

Identification of a receptor required for the anti-inflammatory activity of IVIG.Anthony RM, Wermeling F, Karlsson MC, Ravetch JV. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19571-8. Epub 2008 Nov 26.  PMID: 19036920

A novel role for the IgG Fc glycan: the anti-inflammatory activity of sialylated IgG Fcs. Anthony RM, Ravetch JV. J Clin Immunol. 2010 May;30 Suppl 1:S9-14. Review.  PMID: 20480216

The role of differential IgG glycosylation in the interaction of antibodies with FcγRs in vivo. Anthony RM, Nimmerjahn F. Curr Opin Organ Transplant. 2010 Dec 9. [Epub ahead of print].  PMID: 21150612

SIGN-R1, a novel C-type lectin expressed by marginal zone macrophages in spleen, mediates uptake of the polysaccharide dextran. Kang YS, Yamazaki S, Iyoda T, Pack M, Bruening SA, Kim JY, Takahara K, Inaba K, Steinman RM, Park CG.Int Immunol. 2003 Feb;15(2  PMID: 12578847