Table s6. Core-periphery structure analysis of a concept lattice for HCDC dataset with 100 clusters annotated by the pathway information (p < 0.05).

category Clusters, Significantly overrepresented terms
BC : BioCarta term, GM : GenMAPP term, KG : KEGG term, PG : PharmGKB term
core cluster 22, 26, 43
BC_AKAP95_role_in_mitosis_and_chromosome_dynamics
BC_Activation_of_Src_by_Protein_tyrosine_phosphatase_alpha
BC_Apoptotic_DNA_fragmentation_and_tissue_homeostasis
BC_Cell_Cycle_G1_S_Check_Point
BC_Cell_Cycle_G2_M_Checkpoint
BC_Cyclins_and_Cell_Cycle_Regulation
BC_Estrogen_responsive_protein_Efp_controls_cell_cycle_and_breast_tumors_growth
BC_How_Progesterone_Initiates_the_Oocyte_Maturation
BC_Protein_Kinase_A_at_the_Centrosome
BC_RB_Tumor_Suppressor_Checkpoint_Signaling_in_response_to_DNA_damage
BC_Role_of_Ran_in_mitotic_spindle_regulation
BC_Sonic_Hedgehog_SHH_Receptor_Ptc1_Regulates_cell_cycle
BC_Sonic_Hedgehog_Shh_Pathway
BC_Stathmin_and_breast_cancer_resistance_to_antimicrotubule_agents
BC_cdc25_and_chk1_Regulatory_Pathway_in_response_to_DNA_damage
GM_Cell_Cycle
communicating cluster 24, 28, 46, 57, 60, 93, 96
BC_Activation_of_Csk_by_cAMP_dependent_Protein_Kinase_Inhibits_Signaling_through_the_T_Cell_Receptor
BC_Activation_of_cAMP_dependent_protein_kinase_PKA
BC_Attenuation_of_GPCR_Signaling
BC_CD40L_Signaling_Pathway
BC_CDK_Regulation_of_DNA_Replication
BC_ChREBP_regulation_by_carbohydrates_and_cAMP
BC_Cycling_of_Ran_in_nucleocytoplasmic_transport
BC_Cystic_fibrosis_transmembrane_conductance_regulator_and_beta_2_adrenergic_receptor_pathway
BC_Effects_of_calcineurin_in_Keratinocyte_Differentiation
BC_Hypoxia_and_p53_in_the_Cardiovascular_system
BC_IL12_and_Stat4_Dependent_Signaling_Pathway_in_Th1_Development
BC_Mechanism_of_Gene_Regulation_by_Peroxisome_Proliferators_via_PPARa_alpha_
BC_Mechanism_of_Protein_Import_into_the_Nucleus
BC_Neuropeptides_VIP_and_PACAP_inhibit_the_apoptosis_of_activated_T_cells
BC_Nitric_Oxide_Signaling_Pathway
BC_Overview_of_telomerase_protein_component_gene_hTert_Transcriptional_Regulation
BC_Phospholipase_C_epsilon_pathway
BC_Regulation_of_BAD_phosphorylation
BC_Regulation_of_ck1_cdk5_by_type_1_glutamate_receptors
BC_Repression_of_Pain_Sensation_by_the_Transcriptional_Regulator_DREAM
BC_Sumoylation_by_RanBP2_Regulates_Transcriptional_Repression
BC_TACI_and_BCMA_stimulation_of_B_cell_immune_responses
BC_TNFR2_Signaling_Pathway
BC_The_reactions_that_feed_amino_groups_into_the_urea_cycle
BC_Transcription_Regulation_by_Methyltransferase_of_CARM1
BC_Transcription_factor_CREB_and_its_extracellular_signals
GM_Fatty_Acid_Synthesis
GM_S1P_Signaling
KG_Alanine_and_aspartate_metabolism
KG_Arginine_and_proline_metabolism
KG_Glutamate_metabolism
peripheral cluster 1, 11, 13, 18, 25, 27, 30, 37, 40, 41, 44, 50, 55, 58, 63, 69, 70, 71, 73, 74, 77, 80, 83, 84, 86, 90, 92, 94, 98, 99
BC_ATM_Signaling_Pathway
BC_Acetylation_and_Deacetylation_of_RelA_in_The_Nucleus
BC_Actions_of_Nitric_Oxide_in_the_Heart
BC_Acute_Myocardial_Infarction
BC_Angiotensin_II_mediated_activation_of_JNK_Pathway_via_Pyk2_dependent_signaling
BC_Angiotensin_converting_enzyme_2_regulates_heart_function
BC_Aspirin_Blocks_Signaling_Pathway_Involved_in_Platelet_Activation
BC_BCR_Signaling_Pathway
BC_BTG_family_proteins_and_cell_cycle_regulation
BC_B_Cell_Survival_Pathway
BC_Bioactive_Peptide_Induced_Signaling_Pathway
BC_Biosynthesis_of_isoleucine
BC_Biosynthesis_of_leucine
BC_Biosynthesis_of_valine
BC_CARM1_and_Regulation_of_the_Estrogen_Receptor
BC_CXCR4_Signaling_Pathway
BC_Caspase_Cascade_in_Apoptosis
BC_Ceramide_Signaling_Pathway
BC_Chaperones_modulate_interferon_Signaling_Pathway
BC_Corticosteroids_and_cardioprotection
BC_D4_GDI_Signaling_Pathway
BC_Dicer_Pathway
BC_Double_Stranded_RNA_Induced_Gene_Expression
BC_EGF_Signaling_Pathway
BC_EPO_Signaling_Pathway
BC_Eph_Kinases_and_ephrins_support_platelet_aggregation
BC_Erk1_Erk2_Mapk_Signaling_pathway
BC_Erk_and_PI_3_Kinase_Are_Necessary_for_Collagen_Binding_in_Corneal_Epithelia
BC_FAS_signaling_pathway_CD95
BC_Fc_Epsilon_Receptor_I_Signaling_in_Mast_Cells
BC_GATA3_participate_in_activating_the_Th2_cytokine_genes_expression
BC_HIV_1_defeats_host_mediated_resistance_by_CEM15
BC_HIV_I_Nef_negative_effector_of_Fas_and_TNF
BC_IFN_gamma_signaling_pathway
BC_IGF_1_Signaling_Pathway
BC_IL_2_signaling_pathway
BC_IL_7_Signal_Transduction
BC_Induction_of_apoptosis_through_DR3_and_DR4_5_Death_Receptors
BC_Influence_of_Ras_and_Rho_proteins_on_G1_to_S_Transition
BC_Inhibition_of_Cellular_Proliferation_by_Gleevec
BC_Insulin_Signaling_Pathway
BC_Integrin_Signaling_Pathway
BC_Intrinsic_Prothrombin_Activation_Pathway
BC_Keratinocyte_Differentiation
BC_Leloir_pathway_of_galactose_metabolism
BC_Links_between_Pyk2_and_Map_Kinases
BC_MAPKinase_Signaling_Pathway
BC_Metabolism_of_Anandamide_an_Endogenous_Cannabinoid
BC_NFAT_and_Hypertrophy_of_the_heart_Transcription_in_the_broken_heart_
BC_NF_kB_Signaling_Pathway
BC_Nerve_growth_factor_pathway_NGF_
BC_PDGF_Signaling_Pathway
BC_Pertussis_toxin_insensitive_CCR5_Signaling_in_Macrophage
BC_Phosphorylation_of_MEK1_by_cdk5_p35_down_regulates_the_MAP_kinase_pathway_
BC_Platelet_Amyloid_Precursor_Protein_Pathway
BC_Ras_Signaling_Pathway
BC_Regulators_of_Bone_Mineralization
BC_Role_of_BRCA1_BRCA2_and_ATR_in_Cancer_Susceptibility
BC_Role_of_EGF_Receptor_Transactivation_by_GPCRs_in_Cardiac_Hypertrophy
BC_Role_of_MAL_in_Rho_Mediated_Activation_of_SRF
BC_Role_of_Mitochondria_in_Apoptotic_Signaling
BC_SODD_TNFR1_Signaling_Pathway
BC_SREBP_control_of_lipid_synthesis
BC_Selective_expression_of_chemokine_receptors_during_T_cell_polarization
BC_Signal_transduction_through_IL1R
BC_Signaling_Pathway_from_G_Protein_Families
BC_Signaling_of_Hepatocyte_Growth_Factor_Receptor
BC_Sprouty_regulation_of_tyrosine_kinase_signals
BC_TNFR1_Signaling_Pathway
BC_TNF_Stress_Related_Signaling
BC_TSP_1_Induced_Apoptosis_in_Microvascular_Endothelial_Cell
BC_T_Cell_Receptor_Signaling_Pathway
BC_Th1_Th2_Differentiation
BC_The_4_1BB_dependent_immune_response
BC_The_PRC2_Complex_sets_Long_term_gene_Silencing_The_Modification_of_Histone_Tails
BC_Toll_Like_Receptor_Pathway
BC_Trka_Receptor_Signaling_Pathway
BC_Vitamin_C_in_the_Brain
BC_West_Nile_Virus
BC_Wnt_LRP6_Signalling
BC_fMLP_induced_chemokine_gene_expression_in_HMC_1_cells
BC_mCalpain_and_friends_in_Cell_motility
BC_p38_MAPK_Signaling_Pathway
BC_p53_Signaling_Pathway
BC_uCalpain_and_friends_in_Cell_spread
GM_Apoptosis
GM_Blood_Clotting_Cascade
GM_Cholesterol_Biosynthesis
GM_Complement_Activation_Classical
GM_Fatty_Acid_Degradation
GM_G13_Signaling_Pathway
GM_GPCRs_Class_C_Metabotropic_glutamate_pheromone
GM_Glycogen_Metabolism
GM_Inflammatory_Response_Pathway
GM_MAPK_Cascade
GM_Nucleotide_Metabolism
GM_Ovarian_Infertility_Genes
GM_Translation_Factors
GM_tRNA_Synthetases
KG_Fatty_acid_biosynthesis_path_1
KG_Inositol_phosphate_metabolism
KG_Methane_metabolism
KG_Methionine_metabolism
KG_Nicotinate_and_nicotinamide_metabolism
KG_Nitrogen_metabolism
KG_Selenoamino_acid_metabolism
KG_Sphingoglycolipid_metabolism
KG_Sphingophospholipid_biosynthesis
KG_Terpenoid_biosynthesis
KG_Valine_leucine_and_isoleucine_degradation
PG_Glucocorticoid_and_Inflammatory_genes_Pathway_Gene_Regulation
PG_Glucocorticoid_and_Inflammatory_genes_Pathway_PD
independent cluster 5, 7, 10, 12, 15, 29, 31, 32, 36, 48, 53, 56, 59, 64, 66, 72, 75, 78, 81, 100
BC_Biosynthesis_of_Cysteine_in_mammals
BC_Biosynthesis_of_threonine_and_methionine
BC_Catabolic_Pathways_for_Methionine_Isoleucine_Threonine_and_Valine
BC_Control_of_Gene_Expression_by_Vitamin_D_Receptor
BC_Endocytotic_role_of_NDK_Phosphins_and_Dynamin
BC_Formation_of_Ketone_Bodies_from_acetyl_CoA
BC_Neuroregulin_receptor_degredation_protein_1_Controls_ErbB3_receptor_recycling
BC_Role_of_Parkin_in_the_Ubiquitin_Proteasomal_Pathway
BC_The_information_processing_pathway_at_the_IFN_beta_enhancer
BC_mTOR_Signaling_Pathway
GM_Eicosanoid_Synthesis
GM_Gap_Junction_Proteins_Connexins_
GM_Matrix_Metalloproteinases
GM_Nuclear_Receptors
GM_Proteasome_Degradation
GM_TGF_Beta_Signaling_Pathway
GM_Wnt_signaling
KG_Alkaloid_biosynthesis_II KG_Butanoate_metabolism
KG_Citrate_cycle_TCA_cycle
KG_One_carbon_pool_by_folate
KG_Phenylalanine_tyrosine_and_tryptophan_biosynthesis
KG_Reductive_carboxylate_cycle_CO2_fixation
KG_Riboflavin_metabolism
KG_Synthesis_and_degradation_of_ketone_bodies