| category | Clusters, Significantly overrepresented terms |
| core |
cluster, 24, 46 DNA dependent DNA replication DNA metabolism DNA repair DNA replication DNA replication and chromosome cycle G1 phase of mitotic cell cycle cell cycle cell cycle checkpoint cell proliferation cellular physiological process negative regulation of metabolism negative regulation of nucleobase nucleoside nucleotide and nucleic acid metabolism nucleobase nucleoside nucleotide and nucleic acid metabolism regulation of DNA metabolism regulation of DNA replication regulation of cell cycle regulation of metabolism regulation of nucleobase nucleoside nucleotide and nucleic acid metabolism regulation of physiological process response to DNA damage stimulus response to endogenous stimulus response to stress |
| communicating |
cluster, 1, 3, 21, 22, 26, 28, 34, 43, 44, 50, 55, 60, 62, 74, 84, 94 DNA packaging DNA recombination DNA replication initiation DNA topological change MAPKKK cascade M phase M phase of mitotic cell cycle M phase specific microtubule process RNA metabolism acute phase response antimicrobial humoral response blood coagulation calcium ion homeostasis calcium ion transport cation transport cell communication cellular process circadian rhythm coagulation cytokinesis di tri valent inorganic cation transport double strand break repair establishment and/or maintenance of chromatin architecture frizzled signaling pathway hemostasis inflammatory response innate immune response ion transport lipid transport localization metal ion transport microtubule based process microtubule cytoskeleton organization and biogenesis mitosis mitotic cell cycle morphogenesis neurogenesis neurophysiological process nuclear division organogenesis phosphate metabolism phospholipid biosynthesis phosphorus metabolism positive regulation of I kappaB kinase/NF kappaB cascade positive regulation of cell proliferation positive regulation of signal transduction purine nucleoside monophosphate biosynthesis purine nucleoside monophosphate metabolism purine ribonucleoside monophosphate biosynthesis purine ribonucleoside monophosphate metabolism regulation of DNA recombination regulation of I kappaB kinase/NF kappaB cascade regulation of body fluids regulation of mitosis regulation of signal transduction regulation of transcription regulation of transcription DNA dependent response to bacteria response to external biotic stimulus response to pest pathogen or parasite response to wounding rhythmic behavior sodium ion transport transcription transcription DNA dependent transport viral genome replication viral infectious cycle viral life cycle |
| peripheral |
cluster, 9, 12, 13, 16, 19, 23, 25, 27, 32, 33, 36, 37, 41, 47, 54, 59, 61, 63, 64, 65, 68, 70, 73, 76, 77, 78, 79, 85, 86, 8 8, 90, 92, 96, 99 ATbiosynthesis ATmetabolism G protein signaling coupled to cAMnucleotide second messenger G protein signaling coupled to cyclic nucleotide second messenger N glycan processing N linked glycosylation RNA modification activation of JAK protein activation of MAPK activation of NF kappaB inducing kinase alcohol metabolism amine biosynthesis amino acid activation amino acid biosynthesis amino acid derivative biosynthesis anti apoptosis apoptosis arginine biosynthesis arginine metabolism aromatic compound metabolism biogenic amine biosynthesis biosynthesis bone remodeling cAMmediated signaling carbohydrate metabolism carboxylic acid biosynthesis carboxylic acid catabolism carboxylic acid metabolism carnitine biosynthesis carnitine metabolism cation homeostasis cell cell adhesion cell cell signaling cell death cell fate commitment cell fate determination cell motility cell surface receptor linked signal transduction chemotaxis cholesterol biosynthesis cholesterol metabolism coenzyme biosynthesis coenzyme metabolism cofactor biosynthesis cofactor metabolism complement activation alternative pathway cyclic nucleotide mediated signaling cytolysis death deoxyribonucleotide metabolism dephosphorylation detection of abiotic stimulus detection of mechanical stimulus development di tri valent inorganic cation homeostasis embryo implantation energy derivation by oxidation of organic compounds enzyme linked receptor protein signaling pathway excretion fatty acid biosynthesis galactose metabolism generation of precursor metabolites and energy glutamine family amino acid biosynthesis glutamine family amino acid metabolism glycine biosynthesis glycine metabolism glycolipid metabolism groutransfer coenzyme metabolism heterocycle metabolism hexose metabolism homophilic cell adhesion humoral immune response hydrogen transport induction of apoptosis induction of programmed cell death insulin receptor signaling pathway intracellular receptor mediated signaling pathway iron ion homeostasis isoprenoid biosynthesis isoprenoid metabolism lactation lipid biosynthesis macromolecule biosynthesis macromolecule metabolism main pathways of carbohydrate metabolism meiosis metabolism metal ion homeostasis monovalent inorganic cation transport muscle development negative regulation of apoptosis negative regulation of blood coagulation negative regulation of coagulation negative regulation of physiological process negative regulation of programmed cell death neurotransmitter secretion nitric oxide mediated signal transduction nitrogen compound metabolism nuclear import nuclear organization and biogenesis nucleobase biosynthesis nucleobase metabolism nucleoside phosphate metabolism nucleoside triphosphate biosynthesis nucleoside triphosphate metabolism organic acid biosynthesis organic acid catabolism organic acid metabolism organismal physiological process ossification oxidative phosphorylation perception of sound pigment biosynthesis positive regulation of apoptosis positive regulation of enzyme activity positive regulation of programmed cell death positive regulation of protein kinase activity programmed cell death protein amino acid dephosphorylation protein amino acid phosphorylation protein biosynthesis protein metabolism protein modification protein nucleus import protein nucleus import translocation protein ubiquitination proton transport purine nucleoside triphosphate biosynthesis purine nucleoside triphosphate metabolism purine nucleotide biosynthesis purine nucleotide metabolism purine ribonucleoside triphosphate biosynthesis purine ribonucleoside triphosphate metabolism purine ribonucleotide biosynthesis purine ribonucleotide metabolism pyrimidine base biosynthesis pyrimidine base metabolism pyrimidine deoxyribonucleotide metabolism receptor mediated endocytosis regulation of GTPase activity regulation of G protein coupled receptor protein signaling pathway regulation of actin filament length regulation of actin polymerization and/or depolymerization regulation of anti apoptosis regulation of apoptosis regulation of biological process regulation of biosynthesis regulation of blood coagulation regulation of cellular process regulation of coagulation regulation of enzyme activity regulation of muscle contraction regulation of programmed cell death regulation of protein biosynthesis regulation of translation regulation of translational initiation response to abiotic stimulus response to biotic stimulus response to chemical substance response to external stimulus response to pathogen response to pathogenic bacteria response to radiation response to stimulus response to virus ribonucleoside triphosphate biosynthesis ribonucleoside triphosphate metabolism ribonucleotide biosynthesis ribonucleotide metabolism sensory perception of mechanical stimulus serine family amino acid biosynthesis serine family amino acid metabolism steroid biosynthesis steroid hormone receptor signaling pathway steroid metabolism sterol biosynthesis sterol metabolism tRNA aminoacylation tRNA aminoacylation for protein translation tRNA metabolism tRNA modification taxis transition metal ion homeostasis translation translational initiation transmembrane receptor protein tyrosine kinase signaling pathway transmembrane receptor protein tyrosine phosphatase signaling pathway tricarboxylic acid cycle tricarboxylic acid cycle intermediate metabolism tyrosine phosphorylation of JAK2 protein tyrosyl tRNA aminoacylation ubiquitin cycle urea cycle urea cycle intermediate metabolism |
| independent |
cluster, 2, 5, 8, 10, 11, 17, 20, 30, 45, 49, 51, 52, 53, 66, 72, 80, 82, 89, 93, 95, 97, 98 JAK STAT cascade NADPH metabolism NADPH regeneration NAD biosynthesis NAD metabolism RNA processing Wnt receptor signaling pathway actin filament organization age dependent response to reactive oxygen species amino acid derivative catabolism behavior biogenic amine catabolism carbohydrate catabolism cell cycle arrest cellular defense response energy reserve metabolism epidermal growth factor receptor signaling pathway establishment and/or maintenance of cell polarity glucan metabolism glycogen metabolism growth inactivation of MAPK indolalkylamine catabolism indolalkylamine metabolism indole and derivative metabolism indole derivative catabolism indole derivative metabolism intracellular signaling cascade intracellular transport lipid metabolism mRNA metabolism mRNA processing macrophage cell differentiation monocyte cell differentiation myeloid blood cell differentiation negative regulation of adenylate cyclase activity negative regulation of cell proliferation negative regulation of enzyme activity negative regulation of protein kinase activity nitric oxide biosynthesis nitric oxide metabolism oxygen and reactive oxygen species metabolism pentose phosphate shunt phosphate transport phosphoinositide mediated signaling phospholipase C activation polysaccharide biosynthesis pregnancy protein folding protein kinase cascade pyridine nucleotide biosynthesis regulation of gene expression epigenetic reproductive physiological process response to oxidative stress response to oxygen radicals response to reactive oxygen species response to superoxide response to xenobiotic stimulus signal complex formation superoxide metabolism tryptophan catabolism tryptophan metabolism vesicle mediated transport vitamin biosynthesis vitamin metabolism water soluble vitamin biosynthesis water soluble vitamin metabolism |