Table s2. Core-periphery structure analysis of a concept lattice for AGBM dataset with 100 clusters annotated by the pathway information (p < 0.05).

category Clusters, Significantly overrepresented terms
BC : BioCarta term, GM : GenMAPP term, KG : KEGG term, PG : PharmGKB term
core cluster 71, 73
BC_Angiotensin_II_mediated_activation_of_JNK_Pathway_via_Pyk2_dependent_signaling
BC_BCR_Signaling_Pathway
BC_Bioactive_Peptide_Induced_Signaling_Pathway
BC_CCR3_signaling_in_Eosinophils
BC_CXCR4_Signaling_Pathway
BC_Cadmium_induces_DNA_synthesis_and_proliferation_in_macrophages
BC_Calcium_Signaling_by_HBx_of_Hepatitis_B_virus
BC_EGF_Signaling_Pathway
BC_EPO_Signaling_Pathway
BC_Erk1_Erk2_Mapk_Signaling_pathway
BC_Erk_and_PI_3_Kinase_Are_Necessary_for_Collagen_Binding_in_Corneal_Epithelia
BC_Fc_Epsilon_Receptor_I_Signaling_in_Mast_Cells
BC_Growth_Hormone_Signaling_Pathway
BC_How_Progesterone_Initiates_the_Oocyte_Maturation
BC_IGF_1_Signaling_Pathway
BC_IL_2_Receptor_Beta_Chain_in_T_cell_Activation
BC_IL_2_signaling_pathway
BC_IL_3_signaling_pathway
BC_IL_6_signaling_pathway
BC_Influence_of_Ras_and_Rho_proteins_on_G1_to_S_Transition
BC_Inhibition_of_Cellular_Proliferation_by_Gleevec
BC_Inhibition_of_Matrix_Metalloproteinases
BC_Insulin_Signaling_Pathway
BC_Integrin_Signaling_Pathway
BC_Keratinocyte_Differentiation
BC_Links_between_Pyk2_and_Map_Kinases
BC_MAPKinase_Signaling_Pathway
BC_METS_affect_on_Macrophage_Differentiation
BC_Multiple_antiapoptotic_pathways_from_IGF_1R_signaling_lead_to_BAD_phosphorylation
BC_NFAT_and_Hypertrophy_of_the_heart_Transcription_in_the_broken_heart
BC_Nerve_growth_factor_pathway_NGF
BC_PDGF_Signaling_Pathway
BC_Ras_Signaling_Pathway
BC_Regulation_of_transcriptional_activity_by_PML
BC_Role_of_EGF_Receptor_Transactivation_by_GPCRs_in_Cardiac_Hypertrophy
BC_Role_of_ERBB2_in_Signal_Transduction_and_Oncology
BC_Role_of_Erk5_in_Neuronal_Survival
BC_Role_of_MAL_in_Rho_Mediated_Activation_of_SRF
BC_Roles_of_arrestin_dependent_Recruitment_of_Src_Kinases_in_GPCR_Signaling
BC_Signaling_Pathway_from_G_Protein_Families
BC_Signaling_of_Hepatocyte_Growth_Factor_Receptor
BC_Sprouty_regulation_of_tyrosine_kinase_signals
BC_TPO_Signaling_Pathway
BC_T_Cell_Receptor_Signaling_Pathway
BC_The_IGF_1_Receptor_and_Longevity
BC_Transcription_factor_CREB_and_its_extracellular_signals
BC_Trefoil_Factors_Initiate_Mucosal_Healing
BC_Trka_Receptor_Signaling_Pathway
BC_fMLP_induced_chemokine_gene_expression_in_HMC_1_cells
BC_mCalpain_and_friends_in_Cell_motility
BC_p38_MAPK_Signaling_Pathway
communicating cluster 4, 6, 12, 18, 20, 23, 29, 35, 38, 40, 42, 57, 64, 65, 66, 67, 69, 78, 82, 92, 94, 95, 99
BC_ATM_Signaling_Pathway
BC_Activation_of_PKC_through_G_protein_coupled_receptor
BC_Agrin_in_Postsynaptic_Differentiation
BC_Antigen_Dependent_B_Cell_Activation
BC_Apoptotic_Signaling_in_Response_to_DNA_Damage
BC_Attenuation_of_GPCR_Signaling
BC_B_Lymphocyte_Cell_Surface_Molecules
BC_Cell_Cycle_G1_S_Check_Point
BC_Ceramide_Signaling_Pathway
BC_Classical_Complement_Pathway
BC_Complement_Pathway
BC_Control_of_skeletal_myogenesis_by_HDAC_calcium_calmodulin_dependent_kinase_CaMK
BC_Cyclins_and_Cell_Cycle_Regulation
BC_Estrogen_responsive_protein_Efp_controls_cell_cycle_and_breast_tumors_growth
BC_HIV_Induced_T_Cell_Apoptosis
BC_Human_Cytomegalovirus_and_Map_Kinase_Pathways
BC_IL12_and_Stat4_Dependent_Signaling_Pathway_in_Th1_Development
BC_IL_5_Signaling_Pathway
BC_Ion_Channel_and_Phorbal_Esters_Signaling_Pathway
BC_Lectin_Induced_Complement_Pathway
BC_Lissencephaly_gene_LIS1_in_neuronal_migration_and_development
BC_Map_Kinase_Inactivation_of_SMRT_Corepressor
BC_Monocyte_and_its_Surface_Molecules
BC_Neutrophil_and_Its_Surface_Molecules
BC_Nitric_Oxide_Signaling_Pathway
BC_PTEN_dependent_cell_cycle_arrest_and_apoptosis
BC_Pelp1_Modulation_of_Estrogen_Receptor_Activity
BC_Pertussis_toxin_insensitive_CCR5_Signaling_in_Macrophage
BC_Phosphoinositides_and_their_downstream_targets
BC_Phospholipase_C_Signaling_Pathway
BC_Phospholipase_C_d1_in_phospholipid_associated_cell_signaling
BC_RB_Tumor_Suppressor_Checkpoint_Signaling_in_response_to_DNA_damage
BC_Ras_Independent_pathway_in_NK_cell_mediated_cytotoxicity
BC_Reelin_Signaling_Pathway
BC_Regulation_of_Splicing_through_Sam68
BC_Regulation_of_ck1_cdk5_by_type_1_glutamate_receptors
BC_Regulation_of_eIF4e_and_p70_S6_Kinase
BC_Role_of_MEF2D_in_T_cell_Apoptosis
BC_Role_of_PI3K_subunit_p85_in_regulation_of_Actin_Organization_and_Cell_Migration
BC_Role_of_arrestins_in_the_activation_and_targeting_of_MAP_kinases
BC_Sonic_Hedgehog_SHH_Receptor_Ptc1_Regulates_cell_cycle
BC_Stat3_Signaling_Pathway
BC_Stress_Induction_of_HSP_Regulation
BC_TACI_and_BCMA_stimulation_of_B_cell_immune_responses
BC_TNFR2_Signaling_Pathway
BC_TNF_Stress_Related_Signaling
BC_T_Cytotoxic_Cell_Surface_Molecules
BC_T_Helper_Cell_Surface_Molecules
BC_The_4_1BB_dependent_immune_response
BC_The_Role_of_Eosinophils_in_the_Chemokine_Network_of_Allergy
BC_Thrombin_signaling_and_protease_activated_receptors
BC_Tumor_Suppressor_Arf_Inhibits_Ribosomal_Biogenesis
BC_WNT_Signaling_Pathway
BC_Y_branching_of_actin_filaments
BC_cdc25_and_chk1_Regulatory_Pathway_in_response_to_DNA_damage
BC_uCalpain_and_friends_in_Cell_spread
peripheral cluster 2, 10, 25, 27, 30, 32, 36, 43, 45, 47, 48, 49, 51, 58, 60, 68, 74, 76, 79, 81, 83, 84, 88, 89, 90, 91, 96, 97
BC_Activation_of_Src_by_Protein_tyrosine_phosphatase_alpha
BC_Angiotensin_converting_enzyme_2_regulates_heart_function
BC_BTG_family_proteins_and_cell_cycle_regulation
BC_Basic_mechanism_of_action_of_PPARa_PPARb_d_and_PPARg_and_effects_on_gene_expression
BC_CBL_mediated_ligand_induced_downregulation_of_EGF_receptors
BC_CDK_Regulation_of_DNA_Replication
BC_CTCF_First_Multivalent_Nuclear_Factor
BC_CTL_mediated_immune_response_against_target_cells
BC_Ca2_Calmodulin_dependent_Protein_Kinase_Activation
BC_Caspase_Cascade_in_Apoptosis
BC_Catabolic_Pathways_for_Methionine_Isoleucine_Threonine_and_Valine
BC_Cell_Cycle_G2_M_Checkpoint
BC_Cytokine_Network
BC_Cytokines_and_Inflammatory_Response
BC_D4_GDI_Signaling_Pathway
BC_Deregulation_of_CDK5_in_Alzheimers_Disease
BC_Dicer_Pathway
BC_Downregulated_of_MTA_3_in_ER_negative_Breast_Tumors
BC_Effects_of_calcineurin_in_Keratinocyte_Differentiation
BC_Eicosanoid_Metabolism
BC_Endocytotic_role_of_NDK_Phosphins_and_Dynamin
BC_Erythrocyte_Differentiation_Pathway
BC_Extrinsic_Prothrombin_Activation_Pathway
BC_FAS_signaling_pathway_CD95
BC_Fibrinolysis_Pathway
BC_GATA3_participate_in_activating_the_Th2_cytokine_genes_expression
BC_Gamma_aminobutyric_Acid_Receptor_Life_Cycle
BC_HIV_I_Nef_negative_effector_of_Fas_and_TNF
BC_IFN_gamma_signaling_pathway
BC_IL_10_Anti_inflammatory_Signaling_Pathway
BC_IL_17_Signaling_Pathway
BC_Induction_of_apoptosis_through_DR3_and_DR4_5_Death_Receptors
BC_Intrinsic_Prothrombin_Activation_Pathway
BC_Malate_aspartate_shuttle
BC_Mitochondrial_Carnitine_Palmitoyltransferase_CPT_System
BC_Multi_Drug_Resistance_Factors
BC_NFkB_activation_by_Nontypeable_Hemophilus_influenzae
BC_Nuclear_Receptors_in_Lipid_Metabolism_and_Toxicity
BC_Oxidative_Stress_Induced_Gene_Expression_Via_Nrf2
BC_Phospholipids_as_signalling_intermediaries
BC_Phosphorylation_of_MEK1_by_cdk5_p35_down_regulates_the_MAP_kinase_pathway
BC_Platelet_Amyloid_Precursor_Protein_Pathway
BC_Presenilin_action_in_Notch_and_Wnt_signaling
BC_Proteolysis_and_Signaling_Pathway_of_Notch
BC_Rac_1_cell_motility_signaling_pathway
BC_Regulation_of_BAD_phosphorylation
BC_Regulation_of_PGC_1a
BC_Regulators_of_Bone_Mineralization
BC_Rho_cell_motility_signaling_pathway
BC_Role_of_PPAR_gamma_Coactivators_in_Obesity_and_Thermogenesis
BC_Role_of_Tob_in_T_cell_activation
BC_SODD_TNFR1_Signaling_Pathway
BC_SREBP_control_of_lipid_synthesis
BC_Selective_expression_of_chemokine_receptors_during_T_cell_polarization
BC_Shuttle_for_transfer_of_acetyl_groups_from_mitochondria_to_the_cytosol
BC_Sonic_Hedgehog_Shh_Pathway
BC_TGF_beta_signaling_pathway
BC_TNFR1_Signaling_Pathway
BC_Th1_Th2_Differentiation
BC_The_role_of_FYVE_finger_proteins_in_vesicle_transport
BC_Toll_Like_Receptor_Pathway
BC_Visceral_Fat_Deposits_and_the_Metabolic_Syndrome
BC_Vitamin_C_in_the_Brain
BC_beta_arrestins_in_GPCR_Desensitization
BC_g_Secretase_mediated_ErbB4_Signaling_Pathway
independent cluster 11, 17, 24, 44, 46, 54, 77
BC_Antisense_Pathway
BC_Circadian_Rhythms
BC_Internal_Ribosome_entry_pathway
BC_Proepithelin_Conversion_to_Epithelin_and_Wound_Repair_Control
BC_Reversal_of_Insulin_Resistance_by_Leptin
BC_Stathmin_and_breast_cancer_resistance_to_antimicrotubule_agents
BC_Wnt_LRP6_Signalling