ArrayXPath

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ArrayXPath has searched   #pathways #nodes (non-redundant) #nodes (redundant) GenMAPP 45 1391 1875 PharmGKB 9 134 180 KEGG 70 740 1788 BioCarta 346 1584 8969

ArrayXPath has identified 2565 (97.68%) out of 2626 input elements in the following pathways

Source # pathways # identified nodes # total nodes GenMAPP 45 775 803 PharmGKB 9 35 145 KEGG 69 503 1529 BioCarta 335 1098 5092

Set FDR cut off

Cluster 1 has 17 gene products

ArrayXPath has identified 5 out of 17 input elements in 5 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Complement_Activation_Classical      1/16 (16) 0.0563 0.0925 GenMAPP//Hs_S1P_Signaling      1/25 (25) 0.0868 0.0951 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      1/49 (57) 0.1644 0.1350 GenMAPP//Hs_Nucleotide_Metabolism      1/15 (15) 0.0528 0.1736 GenMapp//Hs_Cell_Cycle      1/87 (96) 0.2763 0.1816

Cluster 2 has 342 gene products

ArrayXPath has identified 156 out of 342 input elements in 35 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Nuclear_Receptors      9/37 (52) 0.0114 0.1777 GenMapp//Hs_Wnt_signaling      13/61 (61) 0.0083 0.2570 GenMAPP//Hs_Apoptosis      7/34 (34) 0.0575 0.2818 GenMapp//Hs_Cell_Cycle      14/87 (96) 0.0630 0.2818 GenMAPP//Hs_G_Protein_Signaling      13/77 (81) 0.0519 0.2818 GenMAPP//Hs_Glycogen_Metabolism      7/33 (34) 0.0499 0.2818 GenMAPP//Hs_Fatty_Acid_Synthesis      4/15 (15) 0.0634 0.2818 GenMAPP//Hs_Translation_Factors      7/49 (51) 0.2488 0.7037 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      7/49 (57) 0.2488 0.7037 GenMAPP//Hs_G13_Signaling_Pathway      5/31 (32) 0.2193 0.7037 GenMAPP//Hs_Calcium_Channels      4/26 (28) 0.2878 0.7462 GenMapp//Hs_Krebs-TCA_Cycle      5/31 (32) 0.2193 0.7582 GenMAPP//Hs_Blood_Clotting_Cascade      3/19 (22) 0.3212 0.7686 GenMapp//Hs_Inflammatory_Response_Pathway      4/29 (29) 0.3628 0.8061 GenMAPP//Hs_Matrix_Metalloproteinases      3/28 (30) 0.5770 0.8494 GenMapp//Hs_Proteasome_Degradation      4/35 (35) 0.5098 0.8494 GenMAPP//Hs_Ovarian_Infertility_Genes      3/29 (32) 0.6017 0.8494 GenMapp//Hs_Monoamine_GPCRs      4/33 (33) 0.4620 0.8494 GenMAPP//Hs_Electron_Transport_Chain      10/105 (105) 0.6825 0.8494 GenMAPP//Hs_Fatty_Acid_Degradation      3/26 (26) 0.5248 0.8494 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      4/42 (44) 0.6593 0.8494 GenMAPP//Hs_tRNA_Synthetases      2/21 (21) 0.6648 0.8494 GenMAPP//Hs_Eicosanoid_Synthesis      2/15 (19) 0.4780 0.8494 GenMAPP//Hs_Heme_Biosynthesis      1/9 (9) 0.6325 0.8494 GenMAPP//Hs_MAPK_Cascade      2/24 (25) 0.7361 0.8629 GenMapp//Hs_GPCRs_Class_C_Metabotropic_glutamate_pheromone      1/15 (18) 0.8122 0.8629 GenMAPP//Hs_Complement_Activation_Classical      1/16 (16) 0.8321 0.8629 GenMAPP//Hs_Cholesterol_Biosynthesis      1/14 (14) 0.7899 0.8629 GenMAPP//Hs_Nucleotide_Metabolism      1/15 (15) 0.8122 0.8713 GenMapp//Hs_Gap_Junction_Proteins_Connexins      2/15 (15) 0.4780 0.8748 GenMapp//Hs_Ribosomal_Proteins      5/83 (83) 0.9494 0.8889 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      10/238 (292) 1.0000 0.8889 GenMapp//Hs_GPCRs_Other      6/119 (171) 0.9911 0.8889 GenMAPP//Hs_S1P_Signaling      1/25 (25) 0.9391 0.8889 GenMapp//Hs_Peptide_GPCRs      1/69 (72) 0.9996 0.8889

Cluster 3 has 288 gene products

ArrayXPath has identified 117 out of 288 input elements in 37 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Eicosanoid_Synthesis      5/15 (19) 0.0041 0.1259 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      8/49 (57) 0.0313 0.3738 GenMapp//Hs_Nuclear_Receptors      6/37 (52) 0.0611 0.3738 GenMapp//Hs_Proteasome_Degradation      6/35 (35) 0.0484 0.3738 GenMAPP//Hs_Blood_Clotting_Cascade      4/19 (22) 0.0537 0.3738 GenMAPP//Hs_Cholesterol_Biosynthesis      3/14 (14) 0.0884 0.3809 GenMAPP//Hs_Apoptosis      5/34 (34) 0.1176 0.3809 GenMAPP//Hs_S1P_Signaling      4/25 (25) 0.1229 0.3809 GenMapp//Hs_Cell_Cycle      10/87 (96) 0.1298 0.3809 GenMAPP//Hs_Acetylcholine_Synthesis      2/7 (7) 0.0970 0.3809 GenMAPP//Hs_Fatty_Acid_Degradation      4/26 (26) 0.1370 0.3809 GenMAPP//Hs_G_Protein_Signaling      7/77 (81) 0.3895 0.7432 GenMAPP//Hs_Translation_Factors      5/49 (51) 0.3303 0.7432 GenMAPP//Hs_G13_Signaling_Pathway      3/31 (32) 0.4374 0.7432 GenMapp//Hs_Smal_ligand_GPCRs      2/16 (16) 0.3564 0.7432 GenMapp//Hs_Krebs-TCA_Cycle      3/31 (32) 0.4374 0.7432 GenMAPP//Hs_Ovarian_Infertility_Genes      3/29 (32) 0.3942 0.7432 GenMAPP//Hs_Complement_Activation_Classical      2/16 (16) 0.3564 0.7786 GenMAPP//Hs_Steroid_Biosynthesis      1/9 (33) 0.5179 0.7921 GenMAPP//Hs_tRNA_Synthetases      2/21 (21) 0.4944 0.7921 GenMapp//Hs_Nucleotide_GPCRs      1/10 (10) 0.5556 0.8092 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      2/42 (44) 0.8520 0.8265 GenMapp//Hs_Ribosomal_Proteins      5/83 (83) 0.7897 0.8265 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      7/238 (292) 0.9998 0.8265 GenMapp//Hs_Peptide_GPCRs      3/69 (72) 0.9167 0.8265 GenMapp//Hs_GPCRs_Other      2/119 (171) 0.9995 0.8265 GenMAPP//Hs_Electron_Transport_Chain      2/105 (105) 0.9985 0.8265 GenMAPP//Hs_Matrix_Metalloproteinases      1/28 (30) 0.8983 0.8265 GenMAPP//Hs_Glycogen_Metabolism      1/33 (34) 0.9328 0.8265 GenMAPP//Hs_MAPK_Cascade      1/24 (25) 0.8587 0.8265 GenMAPP//Hs_Calcium_Channels      1/26 (28) 0.8801 0.8265 GenMapp//Hs_Inflammatory_Response_Pathway      2/29 (29) 0.6728 0.8265 GenMapp//Hs_Wnt_signaling      2/61 (61) 0.9588 0.8265 GenMAPP//Hs_Fatty_Acid_Synthesis      1/15 (15) 0.7044 0.8265 GenMAPP//Hs_Nucleotide_Metabolism      1/15 (15) 0.7044 0.8618 GenMapp//Hs_Gap_Junction_Proteins_Connexins      1/15 (15) 0.7044 0.8618 GenMapp//Hs_Monoamine_GPCRs      1/33 (33) 0.9328 0.8646

Cluster 4 has 283 gene products

ArrayXPath has identified 106 out of 283 input elements in 37 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Apoptosis      10/34 (34) 0.0001 0.0026 GenMapp//Hs_Wnt_signaling      11/61 (61) 0.0036 0.0549 GenMAPP//Hs_Ovarian_Infertility_Genes      6/29 (32) 0.0159 0.0972 GenMAPP//Hs_tRNA_Synthetases      5/21 (21) 0.0152 0.0972 GenMapp//Hs_Inflammatory_Response_Pathway      6/29 (29) 0.0159 0.0972 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      8/49 (57) 0.0229 0.1013 GenMAPP//Hs_Heme_Biosynthesis      3/9 (9) 0.0232 0.1013 GenMAPP//Hs_MAPK_Cascade      5/24 (25) 0.0266 0.1015 GenMAPP//Hs_G13_Signaling_Pathway      5/31 (32) 0.0708 0.2402 GenMAPP//Hs_Matrix_Metalloproteinases      4/28 (30) 0.1438 0.4389 GenMapp//Hs_Smal_ligand_GPCRs      2/16 (16) 0.3302 0.6720 GenMapp//Hs_Cell_Cycle      8/87 (96) 0.3027 0.6720 GenMAPP//Hs_Fatty_Acid_Degradation      3/26 (26) 0.2965 0.6720 GenMAPP//Hs_Complement_Activation_Classical      2/16 (16) 0.3302 0.6720 GenMAPP//Hs_Nucleotide_Metabolism      2/15 (15) 0.3023 0.6720 GenMapp//Hs_Peptide_GPCRs      5/69 (72) 0.5815 0.7720 GenMAPP//Hs_Orphan_GPCRs      1/15 (16) 0.6828 0.7720 GenMAPP//Hs_S1P_Signaling      2/25 (25) 0.5584 0.7720 GenMAPP//Hs_GPCRs_Class_B_Secretin_like      2/23 (28) 0.5124 0.7720 GenMAPP//Hs_Electron_Transport_Chain      7/105 (105) 0.6658 0.7720 GenMapp//Hs_Gap_Junction_Proteins_Connexins      1/15 (15) 0.6828 0.7720 GenMAPP//Hs_Eicosanoid_Synthesis      1/15 (19) 0.6828 0.7720 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      3/42 (44) 0.6069 0.7720 GenMapp//Hs_Krebs-TCA_Cycle      2/31 (32) 0.6775 0.7720 GenMAPP//Hs_Fatty_Acid_Synthesis      1/15 (15) 0.6828 0.7720 GenMAPP//Hs_Blood_Clotting_Cascade      2/19 (22) 0.4118 0.7720 GenMAPP//Hs_Cholesterol_Biosynthesis      1/14 (14) 0.6575 0.7720 GenMAPP//Hs_Glycogen_Metabolism      2/33 (34) 0.7110 0.7752 GenMapp//Hs_Nuclear_Receptors      2/37 (52) 0.7694 0.7829 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like_2      1/18 (20) 0.7483 0.7829 GenMAPP//Hs_G_Protein_Signaling      4/77 (81) 0.8327 0.8199 GenMapp//Hs_GPCRs_Other      6/119 (171) 0.8871 0.8206 GenMAPP//Hs_Calcium_Channels      1/26 (28) 0.8645 0.8206 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      6/238 (292) 0.9999 0.8249 GenMAPP//Hs_Translation_Factors      1/49 (51) 0.9776 0.8249 GenMapp//Hs_Ribosomal_Proteins      1/83 (83) 0.9985 0.8249 GenMapp//Hs_Proteasome_Degradation      1/35 (35) 0.9328 0.8249

Cluster 5 has 231 gene products

ArrayXPath has identified 97 out of 231 input elements in 30 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Translation_Factors      12/49 (51) 0.0000 0.0010 GenMapp//Hs_Ribosomal_Proteins      15/83 (83) 0.0002 0.0023 GenMAPP//Hs_tRNA_Synthetases      4/21 (21) 0.0435 0.2941 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      7/49 (57) 0.0364 0.2941 GenMAPP//Hs_Acetylcholine_Synthesis      2/7 (7) 0.0717 0.3879 GenMapp//Hs_Cell_Cycle      9/87 (96) 0.1083 0.4885 GenMapp//Hs_Krebs-TCA_Cycle      4/31 (32) 0.1396 0.5397 GenMAPP//Hs_Catacholamine_Biosynthesis      1/4 (4) 0.2373 0.8028 GenMAPP//Hs_Matrix_Metalloproteinases      2/28 (30) 0.5572 0.8158 GenMapp//Hs_Wnt_signaling      4/61 (61) 0.5755 0.8158 GenMAPP//Hs_Electron_Transport_Chain      7/105 (105) 0.5401 0.8158 GenMAPP//Hs_G13_Signaling_Pathway      2/31 (32) 0.6138 0.8158 GenMAPP//Hs_Complement_Activation_Classical      1/16 (16) 0.6633 0.8158 GenMAPP//Hs_S1P_Signaling      2/25 (25) 0.4950 0.8158 GenMAPP//Hs_Fatty_Acid_Degradation      2/26 (26) 0.5163 0.8158 GenMAPP//Hs_Glycogen_Metabolism      3/33 (34) 0.3679 0.8158 GenMapp//Hs_Monoamine_GPCRs      2/33 (33) 0.6484 0.8158 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      4/42 (44) 0.2933 0.8158 GenMapp//Hs_Nucleotide_GPCRs      1/10 (10) 0.4928 0.8158 GenMapp//Hs_Pentose_Phosphate_Pathway      1/7 (8) 0.3779 0.8158 GenMAPP//Hs_Nucleotide_Metabolism      1/15 (15) 0.6395 0.8158 GenMapp//Hs_Nuclear_Receptors      2/37 (52) 0.7103 0.8357 GenMAPP//Hs_G_Protein_Signaling      4/77 (81) 0.7576 0.8541 GenMAPP//Hs_Fatty_Acid_Synthesis      1/15 (15) 0.6395 0.8652 GenMAPP//Hs_MAPK_Cascade      1/24 (25) 0.8056 0.8719 GenMAPP//Hs_Apoptosis      1/34 (34) 0.9026 0.8786 GenMapp//Hs_Inflammatory_Response_Pathway      1/29 (29) 0.8623 0.8786 GenMapp//Hs_Proteasome_Degradation      1/35 (35) 0.9091 0.8786 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      3/238 (292) 1.0000 0.9020 GenMapp//Hs_GPCRs_Other      1/119 (171) 0.9998 0.9020

Cluster 6 has 392 gene products

ArrayXPath has identified 156 out of 392 input elements in 41 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Glycogen_Metabolism      8/33 (34) 0.0135 0.2554 GenMapp//Hs_Inflammatory_Response_Pathway      7/29 (29) 0.0211 0.2652 GenMAPP//Hs_Blood_Clotting_Cascade      5/19 (22) 0.0350 0.2732 GenMapp//Hs_Wnt_signaling      11/61 (61) 0.0362 0.2732 GenMAPP//Hs_Matrix_Metalloproteinases      6/28 (30) 0.0546 0.3437 GenMAPP//Hs_Cholesterol_Biosynthesis      5/14 (14) 0.0091 0.3439 GenMapp//Hs_Nucleotide_GPCRs      3/10 (10) 0.0706 0.3811 GenMapp//Hs_Proteasome_Degradation      6/35 (35) 0.1319 0.6231 GenMAPP//Hs_Nuclear_Receptors      6/37 (52) 0.1605 0.6678 GenMAPP//Hs_Fatty_Acid_Synthesis      3/15 (15) 0.1857 0.6678 GenMAPP//Hs_GPCRs_Class_B_Secretin_like      4/23 (28) 0.1945 0.6678 GenMAPP//Hs_Heme_Biosynthesis      2/9 (9) 0.2271 0.7151 GenMapp//Hs_Peptide_GPCRs      8/69 (72) 0.3918 0.9051 GenMAPP//Hs_Catacholamine_Biosynthesis      1/4 (4) 0.3461 0.9051 GenMAPP//Hs_G13_Signaling_Pathway      4/31 (32) 0.3809 0.9051 GenMAPP//Hs_MAPK_Cascade      3/24 (25) 0.4408 0.9051 GenMAPP//Hs_Orphan_GPCRs      2/15 (16) 0.4552 0.9051 GenMapp//Hs_Gap_Junction_Proteins_Connexins      2/15 (15) 0.4552 0.9051 GenMAPP//Hs_Eicosanoid_Synthesis      2/15 (19) 0.4552 0.9051 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      17/238 (292) 0.9654 0.9203 GenMapp//Hs_GPCRs_Other      5/119 (171) 0.9957 0.9203 GenMapp//Hs_Monoamine_GPCRs      3/33 (33) 0.6619 0.9203 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      5/49 (57) 0.5591 0.9203 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like_2      1/18 (20) 0.8537 0.9203 GenMapp//Hs_Cell_Cycle      8/87 (96) 0.6653 0.9203 GenMAPP//Hs_S1P_Signaling      2/25 (25) 0.7349 0.9203 GenMAPP//Hs_G_Protein_Signaling      6/77 (81) 0.8070 0.9203 GenMAPP//Hs_tRNA_Synthetases      1/21 (21) 0.8940 0.9203 GenMAPP//Hs_Calcium_Channels      3/26 (28) 0.4952 0.9203 GenMAPP//Hs_Translation_Factors      2/49 (51) 0.9664 0.9203 GenMAPP//Hs_Apoptosis      2/34 (34) 0.8728 0.9203 GenMapp//Hs_Krebs-TCA_Cycle      3/31 (32) 0.6186 0.9203 GenMAPP//Hs_Electron_Transport_Chain      8/105 (105) 0.8509 0.9203 GenMAPP//Hs_Ovarian_Infertility_Genes      3/29 (32) 0.5717 0.9203 GenMAPP//Hs_Steroid_Biosynthesis      1/9 (33) 0.6162 0.9203 GenMapp//Hs_Pentose_Phosphate_Pathway      1/7 (8) 0.5249 0.9203 GenMapp//Hs_Ribosomal_Proteins      2/83 (83) 0.9988 0.9203 GenMAPP//Hs_Fatty_Acid_Degradation      2/26 (26) 0.7549 0.9203 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      2/42 (44) 0.9366 0.9203 GenMAPP//Hs_Complement_Activation_Classical      1/16 (16) 0.8186 0.9203 GenMapp//Hs_Smal_ligand_GPCRs      1/16 (16) 0.8186 0.9664

Cluster 7 has 243 gene products

ArrayXPath has identified 99 out of 243 input elements in 37 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Glycogen_Metabolism      12/33 (34) 0.0000 0.0000 GenMAPP//Hs_Translation_Factors      11/49 (51) 0.0003 0.0049 GenMAPP//Hs_Fatty_Acid_Synthesis      4/15 (15) 0.0155 0.1829 GenMAPP//Hs_G_Protein_Signaling      9/77 (81) 0.0732 0.4305 GenMAPP//Hs_Cholesterol_Biosynthesis      3/14 (14) 0.0648 0.4305 GenMAPP//Hs_Glucocorticoid_Mineralocorticoid_Metabolism      2/6 (9) 0.0578 0.4305 GenMAPP//Hs_Steroid_Biosynthesis      2/9 (33) 0.1214 0.6122 GenMAPP//Hs_S1P_Signaling      3/25 (25) 0.2409 0.7549 GenMAPP//Hs_MAPK_Cascade      3/24 (25) 0.2223 0.7549 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      5/49 (57) 0.2390 0.7549 GenMAPP//Hs_Complement_Activation_Classical      2/16 (16) 0.2994 0.7549 GenMAPP//Hs_Fatty_Acid_Degradation      3/26 (26) 0.2598 0.7549 GenMapp//Hs_Smal_ligand_GPCRs      2/16 (16) 0.2994 0.7549 GenMapp//Hs_GPCRs_Class_C_Metabotropic_glutamate_pheromone      2/15 (18) 0.2733 0.7549 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      4/42 (44) 0.3214 0.7563 GenMAPP//Hs_tRNA_Synthetases      2/21 (21) 0.4261 0.8356 GenMapp//Hs_Wnt_signaling      5/61 (61) 0.4051 0.8356 GenMapp//Hs_Pentose_Phosphate_Pathway      1/7 (8) 0.3912 0.8356 GenMapp//Hs_Nuclear_Receptors      3/37 (52) 0.4695 0.8721 GenMapp//Hs_Nucleotide_GPCRs      1/10 (10) 0.5083 0.8969 GenMAPP//Hs_Electron_Transport_Chain      4/105 (105) 0.9406 0.9535 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      6/238 (292) 0.9996 0.9535 GenMapp//Hs_Ribosomal_Proteins      4/83 (83) 0.8348 0.9535 GenMapp//Hs_GPCRs_Other      2/119 (171) 0.9984 0.9535 GenMapp//Hs_Peptide_GPCRs      2/69 (72) 0.9577 0.9535 GenMapp//Hs_Proteasome_Degradation      1/35 (35) 0.9186 0.9535 GenMapp//Hs_Cell_Cycle      4/87 (96) 0.8614 0.9535 GenMapp//Hs_Monoamine_GPCRs      1/33 (33) 0.9058 0.9535 GenMAPP//Hs_G13_Signaling_Pathway      2/31 (32) 0.6380 0.9535 GenMAPP//Hs_Apoptosis      2/34 (34) 0.6885 0.9535 GenMAPP//Hs_GPCRs_Class_B_Secretin_like      1/23 (28) 0.8061 0.9535 GenMAPP//Hs_Matrix_Metalloproteinases      1/28 (30) 0.8648 0.9535 GenMAPP//Hs_Calcium_Channels      1/26 (28) 0.8438 0.9535 GenMapp//Hs_Inflammatory_Response_Pathway      1/29 (29) 0.8742 0.9535 GenMAPP//Hs_Eicosanoid_Synthesis      1/15 (19) 0.6559 0.9535 GenMAPP//Hs_Ovarian_Infertility_Genes      1/29 (32) 0.8742 0.9953 GenMAPP//Hs_Orphan_GPCRs      1/15 (16) 0.6559 1.0064

Cluster 8 has 272 gene products

ArrayXPath has identified 116 out of 272 input elements in 37 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMapp//Hs_Cell_Cycle      17/87 (96) 0.0003 0.0079 GenMAPP//Hs_G13_Signaling_Pathway      3/31 (32) 0.4617 0.6244 GenMAPP//Hs_Ovarian_Infertility_Genes      4/29 (32) 0.2001 0.6244 GenMapp//Hs_Inflammatory_Response_Pathway      2/29 (29) 0.6928 0.6244 GenMapp//Hs_Ribosomal_Proteins      7/83 (83) 0.5095 0.6244 GenMapp//Hs_Nuclear_Receptors      3/37 (52) 0.5843 0.6244 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      5/42 (44) 0.2453 0.6244 GenMAPP//Hs_Fatty_Acid_Degradation      2/26 (26) 0.6331 0.6244 GenMAPP//Hs_G_Protein_Signaling      5/77 (81) 0.7600 0.6244 GenMAPP//Hs_MAPK_Cascade      3/24 (25) 0.3037 0.6244 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      5/49 (57) 0.3594 0.6244 GenMAPP//Hs_Electron_Transport_Chain      8/105 (105) 0.6238 0.6244 GenMapp//Hs_Proteasome_Degradation      4/35 (35) 0.3094 0.6244 GenMapp//Hs_Wnt_signaling      5/61 (61) 0.5542 0.6244 GenMAPP//Hs_GPCRs_Class_B_Secretin_like      2/23 (28) 0.5648 0.6244 GenMAPP//Hs_Glycogen_Metabolism      3/33 (34) 0.5044 0.6244 GenMAPP//Hs_Apoptosis      3/34 (34) 0.5251 0.6244 GenMAPP//Hs_S1P_Signaling      2/25 (25) 0.6113 0.6244 GenMAPP//Hs_Eicosanoid_Synthesis      2/15 (19) 0.3435 0.6244 GenMAPP//Hs_Matrix_Metalloproteinases      2/28 (30) 0.6739 0.6244 GenMAPP//Hs_tRNA_Synthetases      2/21 (21) 0.5145 0.6244 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like_2      1/18 (20) 0.7814 0.6244 GenMapp//Hs_Pentose_Phosphate_Pathway      1/7 (8) 0.4451 0.6244 GenMAPP//Hs_Heme_Biosynthesis      1/9 (9) 0.5313 0.6244 GenMAPP//Hs_Complement_Activation_Classical      1/16 (16) 0.7409 0.6244 GenMAPP//Hs_Orphan_GPCRs      1/15 (16) 0.7180 0.6244 GenMAPP//Hs_Blood_Clotting_Cascade      1/19 (22) 0.7993 0.6244 GenMAPP//Hs_Calcium_Channels      1/26 (28) 0.8896 0.6739 GenMapp//Hs_GPCRs_Other      3/119 (171) 0.9978 0.6754 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      8/238 (292) 0.9996 0.6754 GenMapp//Hs_Krebs-TCA_Cycle      1/31 (32) 0.9281 0.6754 GenMapp//Hs_Peptide_GPCRs      1/69 (72) 0.9974 0.6754 GenMAPP//Hs_Translation_Factors      5/49 (51) 0.3594 0.8168 GenMapp//Hs_Monoamine_GPCRs      3/33 (33) 0.5044 0.8407 GenMAPP//Hs_Nucleotide_Metabolism      2/15 (15) 0.3435 0.9541 GenMapp//Hs_GPCRs_Class_C_Metabotropic_glutamate_pheromone      2/15 (18) 0.3435 0.9541 GenMapp//Hs_Gap_Junction_Proteins_Connexins      2/15 (15) 0.3435 0.9541

Cluster 9 has 21 gene products

ArrayXPath has identified 11 out of 21 input elements in 2 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMapp//Hs_Cell_Cycle      9/87 (96) 0.0000 0.0000 GenMapp//Hs_Proteasome_Degradation      1/35 (35) 0.2256 0.1457

Cluster 10 has 163 gene products

ArrayXPath has identified 54 out of 163 input elements in 26 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMapp//Hs_Cell_Cycle      9/87 (96) 0.0033 0.0772 GenMAPP//Hs_G_Protein_Signaling      7/77 (81) 0.0195 0.1504 GenMapp//Hs_Inflammatory_Response_Pathway      4/29 (29) 0.0193 0.1504 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      5/49 (57) 0.0305 0.1766 GenMAPP//Hs_Calcium_Channels      3/26 (28) 0.0667 0.3088 GenMAPP//Hs_Complement_Activation_Classical      2/16 (16) 0.1141 0.4402 GenMAPP//Hs_Blood_Clotting_Cascade      2/19 (22) 0.1518 0.5021 GenMAPP//Hs_Ovarian_Infertility_Genes      2/29 (32) 0.2880 0.6233 GenMapp//Hs_Wnt_signaling      3/61 (61) 0.3894 0.6233 GenMapp//Hs_Nucleotide_GPCRs      1/10 (10) 0.3126 0.6233 GenMAPP//Hs_MAPK_Cascade      2/24 (25) 0.2188 0.6233 GenMAPP//Hs_Nucleotide_Metabolism      1/15 (15) 0.4306 0.6233 GenMAPP//Hs_Matrix_Metalloproteinases      2/28 (30) 0.2741 0.6233 GenMapp//Hs_GPCRs_Class_C_Metabotropic_glutamate_pheromone      1/15 (18) 0.4306 0.6233 GenMAPP//Hs_Fatty_Acid_Synthesis      1/15 (15) 0.4306 0.6233 GenMAPP//Hs_Eicosanoid_Synthesis      1/15 (19) 0.4306 0.6233 GenMAPP//Hs_tRNA_Synthetases      1/21 (21) 0.5463 0.7441 GenMAPP//Hs_Electron_Transport_Chain      3/105 (105) 0.7558 0.7956 GenMapp//Hs_Nuclear_Receptors      1/37 (52) 0.7536 0.7956 GenMAPP//Hs_G13_Signaling_Pathway      1/31 (32) 0.6899 0.7956 GenMapp//Hs_Peptide_GPCRs      2/69 (72) 0.7322 0.7956 GenMAPP//Hs_Apoptosis      1/34 (34) 0.7235 0.7956 GenMAPP//Hs_Translation_Factors      1/49 (51) 0.8448 0.8506 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      4/238 (292) 0.9841 0.8822 GenMapp//Hs_GPCRs_Other      1/119 (171) 0.9904 0.8822 GenMapp//Hs_Ribosomal_Proteins      1/83 (83) 0.9591 0.8822

Cluster NA has 374 gene products

ArrayXPath has identified 154 out of 374 input elements in 36 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Electron_Transport_Chain      26/105 (105) 0.0000 0.0003 GenMapp//Hs_Ribosomal_Proteins      20/83 (83) 0.0002 0.0025 GenMapp//Hs_Krebs-TCA_Cycle      8/31 (32) 0.0113 0.1110 GenMAPP//Hs_Nucleotide_Metabolism      5/15 (15) 0.0145 0.1110 GenMapp//Hs_Proteasome_Degradation      8/35 (35) 0.0234 0.1431 GenMAPP//Hs_G13_Signaling_Pathway      7/31 (32) 0.0355 0.1548 GenMAPP//Hs_MAPK_Cascade      6/24 (25) 0.0318 0.1548 GenMAPP//Hs_G_Protein_Signaling      11/77 (81) 0.1696 0.5751 GenMapp//Hs_Pentose_Phosphate_Pathway      2/7 (8) 0.1600 0.5751 GenMAPP//Hs_Fatty_Acid_Synthesis      3/15 (15) 0.1999 0.6101 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      7/49 (57) 0.2433 0.6751 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      6/42 (44) 0.2683 0.6826 GenMapp//Hs_Cell_Cycle      5/87 (96) 0.9605 0.8480 GenMapp//Hs_Wnt_signaling      7/61 (61) 0.4551 0.8480 GenMapp//Hs_GPCRs_Other      2/119 (171) 1.0000 0.8480 GenMAPP//Hs_tRNA_Synthetases      3/21 (21) 0.3772 0.8480 GenMAPP//Hs_Translation_Factors      6/49 (51) 0.4038 0.8480 GenMAPP//Hs_Cholesterol_Biosynthesis      1/14 (14) 0.7875 0.8480 GenMAPP//Hs_Steroid_Biosynthesis      1/9 (33) 0.6298 0.8480 GenMapp//Hs_Nuclear_Receptors      2/37 (52) 0.9126 0.8480 GenMAPP//Hs_S1P_Signaling      2/25 (25) 0.7533 0.8480 GenMAPP//Hs_Apoptosis      2/34 (34) 0.8856 0.8480 GenMAPP//Hs_Glycogen_Metabolism      4/33 (34) 0.4565 0.8480 GenMAPP//Hs_GPCRs_Class_B_Secretin_like      1/23 (28) 0.9222 0.8480 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      2/238 (292) 1.0000 0.8480 GenMAPP//Hs_Matrix_Metalloproteinases      1/28 (30) 0.9556 0.8480 GenMapp//Hs_Smal_ligand_GPCRs      1/16 (16) 0.8299 0.8480 GenMapp//Hs_Inflammatory_Response_Pathway      3/29 (29) 0.5968 0.8480 GenMAPP//Hs_Blood_Clotting_Cascade      2/19 (22) 0.6052 0.8480 GenMAPP//Hs_Calcium_Channels      1/26 (28) 0.9444 0.8480 GenMAPP//Hs_Acetylcholine_Synthesis      1/7 (7) 0.5381 0.8480 GenMAPP//Hs_Orphan_GPCRs      1/15 (16) 0.8099 0.8480 GenMAPP//Hs_Fatty_Acid_Degradation      1/26 (26) 0.9444 0.9009 GenMAPP//Hs_Heme_Biosynthesis      1/9 (9) 0.6298 0.9155 GenMapp//Hs_GPCRs_Class_C_Metabotropic_glutamate_pheromone      1/15 (18) 0.8099 0.9509 GenMAPP//Hs_Eicosanoid_Synthesis      1/15 (19) 0.8099 0.9509

Cluster 1 has 17 gene products but doesn't match to PharmGKB pathways

Cluster 2 has 342 gene products

ArrayXPath has identified 8 out of 342 input elements in 4 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway_PD      2/8 (9) 0.0565 0.2262 PharmGKB//hs_Antiarrhythmic_Drug_Pathways      3/57 (63) 0.6385 0.6448 PharmGKB//Hs_Statin_Pathway      1/18 (18) 0.6448 0.6448 PharmGKB//Hs_Irinotecan_pathway_liver_cell      1/13 (27) 0.5189 0.6448

Cluster 3 has 288 gene products

ArrayXPath has identified 5 out of 288 input elements in 4 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_ACE_Inhibitor_Pathway      1/9 (10) 0.2975 0.5950 PharmGKB//Hs_Statin_Pathway      1/18 (18) 0.5196 0.6928 PharmGKB//hs_Antiarrhythmic_Drug_Pathways      2/57 (63) 0.7098 0.7098 PharmGKB//Hs_Gemcitabine_Pathway      1/8 (9) 0.2685 1.0739

Cluster 4 has 283 gene products

ArrayXPath has identified 6 out of 283 input elements in 5 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway      1/8 (14) 0.3139 0.1207 PharmGKB//Hs_Irinotecan_pathway_cancer_cell      2/19 (25) 0.2018 0.1207 PharmGKB//Hs_Gemcitabine_Pathway      1/8 (9) 0.3139 0.1207 PharmGKB//Hs_Irinotecan_pathway_liver_cell      2/13 (27) 0.1045 0.1608 PharmGKB//hs_Antiarrhythmic_Drug_Pathways      1/57 (63) 0.9670 0.2975

Cluster 5 has 231 gene products

ArrayXPath has identified 1 out of 231 input elements in 1 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//hs_Antiarrhythmic_Drug_Pathways      1/57 (63) 0.4254 0.4254

Cluster 6 has 392 gene products

ArrayXPath has identified 11 out of 392 input elements in 6 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_ACE_Inhibitor_Pathway      3/9 (10) 0.0146 0.0874 PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway_PD      1/8 (9) 0.4355 0.8218 PharmGKB//Hs_Irinotecan_pathway_cancer_cell      1/19 (25) 0.7589 0.8218 PharmGKB//Hs_Irinotecan_pathway_liver_cell      1/13 (27) 0.6127 0.8218 PharmGKB//hs_Antiarrhythmic_Drug_Pathways      3/57 (63) 0.8218 0.8218 PharmGKB//Hs_Statin_Pathway      1/18 (18) 0.7387 0.8218

Cluster 7 has 243 gene products

ArrayXPath has identified 7 out of 243 input elements in 6 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway_PD      2/8 (9) 0.0565 0.2792 PharmGKB//Hs_Irinotecan_pathway_liver_cell      2/13 (27) 0.1383 0.3414 PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway_Gene_Regulation      1/5 (5) 0.2385 0.3926 PharmGKB//Hs_ACE_Inhibitor_Pathway      1/9 (10) 0.3925 0.4845 PharmGKB//Hs_Irinotecan_pathway_cancer_cell      1/19 (25) 0.6662 0.5483 PharmGKB//Hs_Statin_Pathway      1/18 (18) 0.6448 0.5483

Cluster 8 has 272 gene products

ArrayXPath has identified 4 out of 272 input elements in 4 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway_PD      2/8 (9) 0.0177 0.0470 PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway_Gene_Regulation      1/5 (5) 0.1426 0.1890 PharmGKB//Hs_ACE_Inhibitor_Pathway      1/9 (10) 0.2453 0.2166 PharmGKB//hs_Antiarrhythmic_Drug_Pathways      1/57 (63) 0.8946 0.5927

Cluster 9 has 21 gene products but doesn't match to PharmGKB pathways

Cluster 10 has 163 gene products

ArrayXPath has identified 3 out of 163 input elements in 2 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_ACE_Inhibitor_Pathway      1/9 (10) 0.1896 0.3098 PharmGKB//hs_Antiarrhythmic_Drug_Pathways      2/57 (63) 0.3881 0.3171

Cluster NA has 374 gene products

ArrayXPath has identified 4 out of 374 input elements in 3 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_Gemcitabine_Pathway      1/8 (9) 0.1698 0.2547 PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway_PD      1/8 (9) 0.1698 0.2547 PharmGKB//Hs_Statin_Pathway      1/18 (18) 0.3536 0.3536

Cluster 1 has 17 gene products

ArrayXPath has identified 3 out of 17 input elements in 4 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Alanine_and_aspartate_metabolism      2/21 (22) 0.0023 0.0050 KEGG//Hs_Glycine,_serine_and_threonine_metabolism      1/25 (26) 0.0981 0.0725 KEGG//Hs_Nitrogen_metabolism      1/21 (21) 0.0829 0.0725 KEGG//Hs_Arginine_and_proline_metabolism      1/43 (52) 0.1646 0.0913

Cluster 2 has 342 gene products

ArrayXPath has identified 79 out of 342 input elements in 50 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Sphingoglycolipid_metabolism      16/87 (95) 0.0076 0.0765 KEGG//Hs_Inositol_phosphate_metabolism      17/89 (93) 0.0038 0.0768 KEGG//Hs_Nicotinate_and_nicotinamide_metabolism      14/77 (78) 0.0143 0.0951 KEGG//Hs_Fatty_acid_biosynthesis_(path_1)      2/3 (34) 0.0277 0.1385 KEGG//Hs_Purine_metabolism      7/92 (121) 0.8425 0.3823 KEGG//Hs_Pyrimidine_metabolism      3/47 (56) 0.8701 0.3823 KEGG//Hs_Alanine_and_aspartate_metabolism      1/21 (22) 0.8940 0.3823 KEGG//Hs_Nitrogen_metabolism      3/21 (21) 0.3516 0.3823 KEGG//Hs_Androgen_and_estrogen_metabolism      3/27 (35) 0.5183 0.3823 KEGG//Hs_Propanoate_metabolism      2/23 (23) 0.6894 0.3823 KEGG//Hs_Pyruvate_metabolism      3/33 (34) 0.6601 0.3823 KEGG//Hs_Tyrosine_metabolism      3/37 (49) 0.7368 0.3823 KEGG//Hs_Valine,_leucine_and_isoleucine_degradation      2/31 (41) 0.8364 0.3823 KEGG//Hs_Fructose_and_mannose_metabolism      2/25 (26) 0.7339 0.3823 KEGG//Hs_Porphyrin_and_chlorophyll_metabolism      2/21 (22) 0.6392 0.3823 KEGG//Hs_Oxidative_phosphorylation      7/66 (66) 0.4979 0.3823 KEGG//Hs_Glutathione_metabolism      1/29 (29) 0.9558 0.3823 KEGG//Hs_Tryptophan_metabolism      4/55 (62) 0.8236 0.3823 KEGG//Hs_Arginine_and_proline_metabolism      2/43 (52) 0.9429 0.3823 KEGG//Hs_Pantothenate_and_CoA_biosynthesis      1/8 (8) 0.5714 0.3823 KEGG//Hs_Ubiquinone_biosynthesis      3/31 (32) 0.6163 0.3823 KEGG//Hs_Sulfur_metabolism      1/6 (6) 0.4698 0.3823 KEGG//Hs_Bile_acid_biosynthesis      2/26 (29) 0.7541 0.3823 KEGG//Hs_Taurine_and_hypotaurine_metabolism      1/5 (5) 0.4104 0.3823 KEGG//Hs_Aminosugars_metabolism      2/15 (17) 0.4524 0.3823 KEGG//Hs_Galactose_metabolism      2/22 (32) 0.6650 0.3823 KEGG//Hs_Glycolysis__Gluconeogenesis      3/52 (60) 0.9114 0.3823 KEGG//Hs_Fatty_acid_metabolism      6/57 (80) 0.5155 0.3823 KEGG//Hs_Carbon_fixation      2/16 (17) 0.4871 0.3823 KEGG//Hs_Citrate_cycle_(TCA_cycle)      3/18 (19) 0.2652 0.3823 KEGG//Hs_Glyoxylate_and_dicarboxylate_metabolism      2/11 (16) 0.3026 0.3823 KEGG//Hs_Reductive_carboxylate_cycle_(CO2_fixation)      2/7 (7) 0.1490 0.3823 KEGG//Hs_Aminoacyl-tRNA_biosynthesis      2/20 (21) 0.6118 0.3823 KEGG//Hs_Glycine,_serine_and_threonine_metabolism      1/25 (26) 0.9314 0.3823 KEGG//Hs_Urea_cycle_and_metabolism_of_amino_groups      1/18 (19) 0.8534 0.3823 KEGG//Hs_Pentose_phosphate_pathway      1/17 (19) 0.8367 0.3823 KEGG//Hs_Histidine_metabolism      2/27 (27) 0.7729 0.3823 KEGG//Hs_One_carbon_pool_by_folate      1/12 (20) 0.7204 0.3823 KEGG//Hs_Cysteine_metabolism      1/13 (13) 0.7488 0.3823 KEGG//Hs_Flavonoids,_stilbene_and_lignin_biosynthesis      1/7 (11) 0.5232 0.3823 KEGG//Hs_D-Glutamine_and_D-glutamate_metabolism      1/3 (3) 0.2713 0.3823 KEGG//Hs_Glutamate_metabolism      1/23 (24) 0.9147 0.3823 KEGG//Hs_Terpenoid_biosynthesis      1/4 (7) 0.3445 0.3823 KEGG//Hs_Phospholipid_degradation      1/10 (11) 0.6537 0.3823 KEGG//Hs_Prostaglandin_and_leukotriene_metabolism      1/22 (23) 0.9049 0.3823 KEGG//Hs_Pentose_and_glucuronate_interconversions      1/11 (12) 0.6888 0.3823 KEGG//Hs_Phenylalanine_metabolism      1/22 (24) 0.9049 0.4022 KEGG//Hs_Folate_biosynthesis      1/13 (22) 0.7488 0.4405 KEGG//Hs_Ascorbate_and_aldarate_metabolism      1/11 (11) 0.6888 0.4920 KEGG//Hs_Lipopolysaccharide_biosynthesis      1/5 (8) 0.4104 0.6840

Cluster 3 has 288 gene products

ArrayXPath has identified 80 out of 288 input elements in 50 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Bile_acid_biosynthesis      2/26 (29) 0.7744 0.3832 KEGG//Hs_Fatty_acid_metabolism      7/57 (80) 0.3806 0.3832 KEGG//Hs_Glycolysis__Gluconeogenesis      3/52 (60) 0.9251 0.3832 KEGG//Hs_Tyrosine_metabolism      3/37 (49) 0.7623 0.3832 KEGG//Hs_Prostaglandin_and_leukotriene_metabolism      5/22 (23) 0.0684 0.3832 KEGG//Hs_Carbon_fixation      3/16 (17) 0.2269 0.3832 KEGG//Hs_Valine,_leucine_and_isoleucine_degradation      4/31 (41) 0.4064 0.3832 KEGG//Hs_Inositol_phosphate_metabolism      12/89 (93) 0.2001 0.3832 KEGG//Hs_Nicotinate_and_nicotinamide_metabolism      12/77 (78) 0.0889 0.3832 KEGG//Hs_Sphingoglycolipid_metabolism      13/87 (95) 0.1021 0.3832 KEGG//Hs_Glycine,_serine_and_threonine_metabolism      4/25 (26) 0.2571 0.3832 KEGG//Hs_Androgen_and_estrogen_metabolism      3/27 (35) 0.5467 0.3832 KEGG//Hs_Porphyrin_and_chlorophyll_metabolism      1/21 (22) 0.9038 0.3832 KEGG//Hs_Butanoate_metabolism      2/29 (31) 0.8252 0.3832 KEGG//Hs_Synthesis_and_degradation_of_ketone_bodies      1/6 (6) 0.4840 0.3832 KEGG//Hs_Purine_metabolism      6/92 (121) 0.9387 0.3832 KEGG//Hs_Pyrimidine_metabolism      3/47 (56) 0.8877 0.3832 KEGG//Hs_Glutamate_metabolism      2/23 (24) 0.7113 0.3832 KEGG//Hs_Methionine_metabolism      2/10 (10) 0.2795 0.3832 KEGG//Hs_Selenoamino_acid_metabolism      3/11 (11) 0.0969 0.3832 KEGG//Hs_Folate_biosynthesis      2/13 (22) 0.3992 0.3832 KEGG//Hs_Histidine_metabolism      2/27 (27) 0.7926 0.3832 KEGG//Hs_Alanine_and_aspartate_metabolism      4/21 (22) 0.1659 0.3832 KEGG//Hs_Arginine_and_proline_metabolism      3/43 (52) 0.8468 0.3832 KEGG//Hs_Lipopolysaccharide_biosynthesis      1/5 (8) 0.4236 0.3832 KEGG//Hs_Tryptophan_metabolism      6/55 (62) 0.5198 0.3832 KEGG//Hs_Pyruvate_metabolism      2/33 (34) 0.8771 0.3832 KEGG//Hs_Phenylalanine,_tyrosine_and_tryptophan_biosynthesis      1/8 (9) 0.5866 0.3832 KEGG//Hs_Cysteine_metabolism      3/13 (13) 0.1446 0.3832 KEGG//Hs_Nitrogen_metabolism      2/21 (21) 0.6618 0.3832 KEGG//Hs_Fructose_and_mannose_metabolism      1/25 (26) 0.9389 0.3832 KEGG//Hs_C21-Steroid_hormone_metabolism      1/10 (28) 0.6691 0.3832 KEGG//Hs_Citrate_cycle_(TCA_cycle)      2/18 (19) 0.5752 0.3832 KEGG//Hs_Reductive_carboxylate_cycle_(CO2_fixation)      2/7 (7) 0.1592 0.3832 KEGG//Hs_Flavonoids,_stilbene_and_lignin_biosynthesis      1/7 (11) 0.5381 0.3832 KEGG//Hs_Urea_cycle_and_metabolism_of_amino_groups      1/18 (19) 0.8650 0.3832 KEGG//Hs_Pentose_phosphate_pathway      1/17 (19) 0.8489 0.3832 KEGG//Hs_Galactose_metabolism      1/22 (32) 0.9141 0.3832 KEGG//Hs_Glyoxylate_and_dicarboxylate_metabolism      1/11 (16) 0.7040 0.3832 KEGG//Hs_Aminoacyl-tRNA_biosynthesis      1/20 (21) 0.8922 0.3832 KEGG//Hs_Phenylalanine_metabolism      1/22 (24) 0.9141 0.3974 KEGG//Hs_Oxidative_phosphorylation      2/66 (66) 0.9953 0.3981 KEGG//Hs_beta-Alanine_metabolism      1/20 (21) 0.8922 0.4150 KEGG//Hs_Propanoate_metabolism      2/23 (23) 0.7113 0.4446 KEGG//Hs_Pentose_and_glucuronate_interconversions      1/11 (12) 0.7040 0.4693 KEGG//Hs_Ascorbate_and_aldarate_metabolism      1/11 (11) 0.7040 0.4693 KEGG//Hs_Glutathione_metabolism      7/29 (29) 0.0237 0.4744 KEGG//Hs_Pantothenate_and_CoA_biosynthesis      1/8 (8) 0.5866 0.4889 KEGG//Hs_Riboflavin_metabolism      1/8 (8) 0.5866 0.4889 KEGG//Hs_Phospholipid_degradation      1/10 (11) 0.6691 0.4956

Cluster 4 has 283 gene products

ArrayXPath has identified 81 out of 283 input elements in 48 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Glycine,_serine_and_threonine_metabolism      8/25 (26) 0.0020 0.0929 KEGG//Hs_Sulfur_metabolism      2/6 (6) 0.1163 0.6722 KEGG//Hs_Inositol_phosphate_metabolism      14/89 (93) 0.0522 0.6722 KEGG//Hs_Aminoacyl-tRNA_biosynthesis      5/20 (21) 0.0430 0.6722 KEGG//Hs_One_carbon_pool_by_folate      3/12 (20) 0.1128 0.6722 KEGG//Hs_Methane_metabolism      3/11 (11)