ArrayXPath

|PathMeSH |Pathway mapping |Help |ChromoViz |Registration |Contact us

ArrayXPath has searched   #pathways #nodes (non-redundant) #nodes (redundant) GenMAPP 45 1391 1875 PharmGKB 9 134 180 KEGG 70 740 1788 BioCarta 346 1584 8969

ArrayXPath has identified 2565 (97.68%) out of 2626 input elements in the following pathways

Source # pathways # identified nodes # total nodes GenMAPP 45 775 803 PharmGKB 9 35 145 KEGG 69 503 1529 BioCarta 335 1098 5092

Set FDR cut off

Cluster 1 has 17 gene products

ArrayXPath has identified 5 out of 17 input elements in 5 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Complement_Activation_Classical      1/16 (16) 0.0563 0.0925 GenMAPP//Hs_S1P_Signaling      1/25 (25) 0.0868 0.0951 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      1/49 (57) 0.1644 0.1350 GenMAPP//Hs_Nucleotide_Metabolism      1/15 (15) 0.0528 0.1736 GenMapp//Hs_Cell_Cycle      1/87 (96) 0.2763 0.1816

Cluster 2 has 342 gene products

ArrayXPath has identified 156 out of 342 input elements in 35 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Nuclear_Receptors      9/37 (52) 0.0114 0.1777 GenMapp//Hs_Wnt_signaling      13/61 (61) 0.0083 0.2570 GenMAPP//Hs_Apoptosis      7/34 (34) 0.0575 0.2818 GenMapp//Hs_Cell_Cycle      14/87 (96) 0.0630 0.2818 GenMAPP//Hs_G_Protein_Signaling      13/77 (81) 0.0519 0.2818 GenMAPP//Hs_Glycogen_Metabolism      7/33 (34) 0.0499 0.2818 GenMAPP//Hs_Fatty_Acid_Synthesis      4/15 (15) 0.0634 0.2818 GenMAPP//Hs_Translation_Factors      7/49 (51) 0.2488 0.7037 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      7/49 (57) 0.2488 0.7037 GenMAPP//Hs_G13_Signaling_Pathway      5/31 (32) 0.2193 0.7037 GenMAPP//Hs_Calcium_Channels      4/26 (28) 0.2878 0.7462 GenMapp//Hs_Krebs-TCA_Cycle      5/31 (32) 0.2193 0.7582 GenMAPP//Hs_Blood_Clotting_Cascade      3/19 (22) 0.3212 0.7686 GenMapp//Hs_Inflammatory_Response_Pathway      4/29 (29) 0.3628 0.8061 GenMAPP//Hs_Matrix_Metalloproteinases      3/28 (30) 0.5770 0.8494 GenMapp//Hs_Proteasome_Degradation      4/35 (35) 0.5098 0.8494 GenMAPP//Hs_Ovarian_Infertility_Genes      3/29 (32) 0.6017 0.8494 GenMapp//Hs_Monoamine_GPCRs      4/33 (33) 0.4620 0.8494 GenMAPP//Hs_Electron_Transport_Chain      10/105 (105) 0.6825 0.8494 GenMAPP//Hs_Fatty_Acid_Degradation      3/26 (26) 0.5248 0.8494 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      4/42 (44) 0.6593 0.8494 GenMAPP//Hs_tRNA_Synthetases      2/21 (21) 0.6648 0.8494 GenMAPP//Hs_Eicosanoid_Synthesis      2/15 (19) 0.4780 0.8494 GenMAPP//Hs_Heme_Biosynthesis      1/9 (9) 0.6325 0.8494 GenMAPP//Hs_MAPK_Cascade      2/24 (25) 0.7361 0.8629 GenMapp//Hs_GPCRs_Class_C_Metabotropic_glutamate_pheromone      1/15 (18) 0.8122 0.8629 GenMAPP//Hs_Complement_Activation_Classical      1/16 (16) 0.8321 0.8629 GenMAPP//Hs_Cholesterol_Biosynthesis      1/14 (14) 0.7899 0.8629 GenMAPP//Hs_Nucleotide_Metabolism      1/15 (15) 0.8122 0.8713 GenMapp//Hs_Gap_Junction_Proteins_Connexins      2/15 (15) 0.4780 0.8748 GenMapp//Hs_Ribosomal_Proteins      5/83 (83) 0.9494 0.8889 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      10/238 (292) 1.0000 0.8889 GenMapp//Hs_GPCRs_Other      6/119 (171) 0.9911 0.8889 GenMAPP//Hs_S1P_Signaling      1/25 (25) 0.9391 0.8889 GenMapp//Hs_Peptide_GPCRs      1/69 (72) 0.9996 0.8889

Cluster 3 has 288 gene products

ArrayXPath has identified 117 out of 288 input elements in 37 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Eicosanoid_Synthesis      5/15 (19) 0.0041 0.1259 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      8/49 (57) 0.0313 0.3738 GenMapp//Hs_Nuclear_Receptors      6/37 (52) 0.0611 0.3738 GenMapp//Hs_Proteasome_Degradation      6/35 (35) 0.0484 0.3738 GenMAPP//Hs_Blood_Clotting_Cascade      4/19 (22) 0.0537 0.3738 GenMAPP//Hs_Cholesterol_Biosynthesis      3/14 (14) 0.0884 0.3809 GenMAPP//Hs_Apoptosis      5/34 (34) 0.1176 0.3809 GenMAPP//Hs_S1P_Signaling      4/25 (25) 0.1229 0.3809 GenMapp//Hs_Cell_Cycle      10/87 (96) 0.1298 0.3809 GenMAPP//Hs_Acetylcholine_Synthesis      2/7 (7) 0.0970 0.3809 GenMAPP//Hs_Fatty_Acid_Degradation      4/26 (26) 0.1370 0.3809 GenMAPP//Hs_G_Protein_Signaling      7/77 (81) 0.3895 0.7432 GenMAPP//Hs_Translation_Factors      5/49 (51) 0.3303 0.7432 GenMAPP//Hs_G13_Signaling_Pathway      3/31 (32) 0.4374 0.7432 GenMapp//Hs_Smal_ligand_GPCRs      2/16 (16) 0.3564 0.7432 GenMapp//Hs_Krebs-TCA_Cycle      3/31 (32) 0.4374 0.7432 GenMAPP//Hs_Ovarian_Infertility_Genes      3/29 (32) 0.3942 0.7432 GenMAPP//Hs_Complement_Activation_Classical      2/16 (16) 0.3564 0.7786 GenMAPP//Hs_Steroid_Biosynthesis      1/9 (33) 0.5179 0.7921 GenMAPP//Hs_tRNA_Synthetases      2/21 (21) 0.4944 0.7921 GenMapp//Hs_Nucleotide_GPCRs      1/10 (10) 0.5556 0.8092 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      2/42 (44) 0.8520 0.8265 GenMapp//Hs_Ribosomal_Proteins      5/83 (83) 0.7897 0.8265 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      7/238 (292) 0.9998 0.8265 GenMapp//Hs_Peptide_GPCRs      3/69 (72) 0.9167 0.8265 GenMapp//Hs_GPCRs_Other      2/119 (171) 0.9995 0.8265 GenMAPP//Hs_Electron_Transport_Chain      2/105 (105) 0.9985 0.8265 GenMAPP//Hs_Matrix_Metalloproteinases      1/28 (30) 0.8983 0.8265 GenMAPP//Hs_Glycogen_Metabolism      1/33 (34) 0.9328 0.8265 GenMAPP//Hs_MAPK_Cascade      1/24 (25) 0.8587 0.8265 GenMAPP//Hs_Calcium_Channels      1/26 (28) 0.8801 0.8265 GenMapp//Hs_Inflammatory_Response_Pathway      2/29 (29) 0.6728 0.8265 GenMapp//Hs_Wnt_signaling      2/61 (61) 0.9588 0.8265 GenMAPP//Hs_Fatty_Acid_Synthesis      1/15 (15) 0.7044 0.8265 GenMAPP//Hs_Nucleotide_Metabolism      1/15 (15) 0.7044 0.8618 GenMapp//Hs_Gap_Junction_Proteins_Connexins      1/15 (15) 0.7044 0.8618 GenMapp//Hs_Monoamine_GPCRs      1/33 (33) 0.9328 0.8646

Cluster 4 has 283 gene products

ArrayXPath has identified 106 out of 283 input elements in 37 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Apoptosis      10/34 (34) 0.0001 0.0026 GenMapp//Hs_Wnt_signaling      11/61 (61) 0.0036 0.0549 GenMAPP//Hs_Ovarian_Infertility_Genes      6/29 (32) 0.0159 0.0972 GenMAPP//Hs_tRNA_Synthetases      5/21 (21) 0.0152 0.0972 GenMapp//Hs_Inflammatory_Response_Pathway      6/29 (29) 0.0159 0.0972 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      8/49 (57) 0.0229 0.1013 GenMAPP//Hs_Heme_Biosynthesis      3/9 (9) 0.0232 0.1013 GenMAPP//Hs_MAPK_Cascade      5/24 (25) 0.0266 0.1015 GenMAPP//Hs_G13_Signaling_Pathway      5/31 (32) 0.0708 0.2402 GenMAPP//Hs_Matrix_Metalloproteinases      4/28 (30) 0.1438 0.4389 GenMapp//Hs_Smal_ligand_GPCRs      2/16 (16) 0.3302 0.6720 GenMapp//Hs_Cell_Cycle      8/87 (96) 0.3027 0.6720 GenMAPP//Hs_Fatty_Acid_Degradation      3/26 (26) 0.2965 0.6720 GenMAPP//Hs_Complement_Activation_Classical      2/16 (16) 0.3302 0.6720 GenMAPP//Hs_Nucleotide_Metabolism      2/15 (15) 0.3023 0.6720 GenMapp//Hs_Peptide_GPCRs      5/69 (72) 0.5815 0.7720 GenMAPP//Hs_Orphan_GPCRs      1/15 (16) 0.6828 0.7720 GenMAPP//Hs_S1P_Signaling      2/25 (25) 0.5584 0.7720 GenMAPP//Hs_GPCRs_Class_B_Secretin_like      2/23 (28) 0.5124 0.7720 GenMAPP//Hs_Electron_Transport_Chain      7/105 (105) 0.6658 0.7720 GenMapp//Hs_Gap_Junction_Proteins_Connexins      1/15 (15) 0.6828 0.7720 GenMAPP//Hs_Eicosanoid_Synthesis      1/15 (19) 0.6828 0.7720 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      3/42 (44) 0.6069 0.7720 GenMapp//Hs_Krebs-TCA_Cycle      2/31 (32) 0.6775 0.7720 GenMAPP//Hs_Fatty_Acid_Synthesis      1/15 (15) 0.6828 0.7720 GenMAPP//Hs_Blood_Clotting_Cascade      2/19 (22) 0.4118 0.7720 GenMAPP//Hs_Cholesterol_Biosynthesis      1/14 (14) 0.6575 0.7720 GenMAPP//Hs_Glycogen_Metabolism      2/33 (34) 0.7110 0.7752 GenMapp//Hs_Nuclear_Receptors      2/37 (52) 0.7694 0.7829 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like_2      1/18 (20) 0.7483 0.7829 GenMAPP//Hs_G_Protein_Signaling      4/77 (81) 0.8327 0.8199 GenMapp//Hs_GPCRs_Other      6/119 (171) 0.8871 0.8206 GenMAPP//Hs_Calcium_Channels      1/26 (28) 0.8645 0.8206 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      6/238 (292) 0.9999 0.8249 GenMAPP//Hs_Translation_Factors      1/49 (51) 0.9776 0.8249 GenMapp//Hs_Ribosomal_Proteins      1/83 (83) 0.9985 0.8249 GenMapp//Hs_Proteasome_Degradation      1/35 (35) 0.9328 0.8249

Cluster 5 has 231 gene products

ArrayXPath has identified 97 out of 231 input elements in 30 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Translation_Factors      12/49 (51) 0.0000 0.0010 GenMapp//Hs_Ribosomal_Proteins      15/83 (83) 0.0002 0.0023 GenMAPP//Hs_tRNA_Synthetases      4/21 (21) 0.0435 0.2941 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      7/49 (57) 0.0364 0.2941 GenMAPP//Hs_Acetylcholine_Synthesis      2/7 (7) 0.0717 0.3879 GenMapp//Hs_Cell_Cycle      9/87 (96) 0.1083 0.4885 GenMapp//Hs_Krebs-TCA_Cycle      4/31 (32) 0.1396 0.5397 GenMAPP//Hs_Catacholamine_Biosynthesis      1/4 (4) 0.2373 0.8028 GenMAPP//Hs_Matrix_Metalloproteinases      2/28 (30) 0.5572 0.8158 GenMapp//Hs_Wnt_signaling      4/61 (61) 0.5755 0.8158 GenMAPP//Hs_Electron_Transport_Chain      7/105 (105) 0.5401 0.8158 GenMAPP//Hs_G13_Signaling_Pathway      2/31 (32) 0.6138 0.8158 GenMAPP//Hs_Complement_Activation_Classical      1/16 (16) 0.6633 0.8158 GenMAPP//Hs_S1P_Signaling      2/25 (25) 0.4950 0.8158 GenMAPP//Hs_Fatty_Acid_Degradation      2/26 (26) 0.5163 0.8158 GenMAPP//Hs_Glycogen_Metabolism      3/33 (34) 0.3679 0.8158 GenMapp//Hs_Monoamine_GPCRs      2/33 (33) 0.6484 0.8158 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      4/42 (44) 0.2933 0.8158 GenMapp//Hs_Nucleotide_GPCRs      1/10 (10) 0.4928 0.8158 GenMapp//Hs_Pentose_Phosphate_Pathway      1/7 (8) 0.3779 0.8158 GenMAPP//Hs_Nucleotide_Metabolism      1/15 (15) 0.6395 0.8158 GenMapp//Hs_Nuclear_Receptors      2/37 (52) 0.7103 0.8357 GenMAPP//Hs_G_Protein_Signaling      4/77 (81) 0.7576 0.8541 GenMAPP//Hs_Fatty_Acid_Synthesis      1/15 (15) 0.6395 0.8652 GenMAPP//Hs_MAPK_Cascade      1/24 (25) 0.8056 0.8719 GenMAPP//Hs_Apoptosis      1/34 (34) 0.9026 0.8786 GenMapp//Hs_Inflammatory_Response_Pathway      1/29 (29) 0.8623 0.8786 GenMapp//Hs_Proteasome_Degradation      1/35 (35) 0.9091 0.8786 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      3/238 (292) 1.0000 0.9020 GenMapp//Hs_GPCRs_Other      1/119 (171) 0.9998 0.9020

Cluster 6 has 392 gene products

ArrayXPath has identified 156 out of 392 input elements in 41 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Glycogen_Metabolism      8/33 (34) 0.0135 0.2554 GenMapp//Hs_Inflammatory_Response_Pathway      7/29 (29) 0.0211 0.2652 GenMAPP//Hs_Blood_Clotting_Cascade      5/19 (22) 0.0350 0.2732 GenMapp//Hs_Wnt_signaling      11/61 (61) 0.0362 0.2732 GenMAPP//Hs_Matrix_Metalloproteinases      6/28 (30) 0.0546 0.3437 GenMAPP//Hs_Cholesterol_Biosynthesis      5/14 (14) 0.0091 0.3439 GenMapp//Hs_Nucleotide_GPCRs      3/10 (10) 0.0706 0.3811 GenMapp//Hs_Proteasome_Degradation      6/35 (35) 0.1319 0.6231 GenMAPP//Hs_Nuclear_Receptors      6/37 (52) 0.1605 0.6678 GenMAPP//Hs_Fatty_Acid_Synthesis      3/15 (15) 0.1857 0.6678 GenMAPP//Hs_GPCRs_Class_B_Secretin_like      4/23 (28) 0.1945 0.6678 GenMAPP//Hs_Heme_Biosynthesis      2/9 (9) 0.2271 0.7151 GenMapp//Hs_Peptide_GPCRs      8/69 (72) 0.3918 0.9051 GenMAPP//Hs_Catacholamine_Biosynthesis      1/4 (4) 0.3461 0.9051 GenMAPP//Hs_G13_Signaling_Pathway      4/31 (32) 0.3809 0.9051 GenMAPP//Hs_MAPK_Cascade      3/24 (25) 0.4408 0.9051 GenMAPP//Hs_Orphan_GPCRs      2/15 (16) 0.4552 0.9051 GenMapp//Hs_Gap_Junction_Proteins_Connexins      2/15 (15) 0.4552 0.9051 GenMAPP//Hs_Eicosanoid_Synthesis      2/15 (19) 0.4552 0.9051 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      17/238 (292) 0.9654 0.9203 GenMapp//Hs_GPCRs_Other      5/119 (171) 0.9957 0.9203 GenMapp//Hs_Monoamine_GPCRs      3/33 (33) 0.6619 0.9203 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      5/49 (57) 0.5591 0.9203 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like_2      1/18 (20) 0.8537 0.9203 GenMapp//Hs_Cell_Cycle      8/87 (96) 0.6653 0.9203 GenMAPP//Hs_S1P_Signaling      2/25 (25) 0.7349 0.9203 GenMAPP//Hs_G_Protein_Signaling      6/77 (81) 0.8070 0.9203 GenMAPP//Hs_tRNA_Synthetases      1/21 (21) 0.8940 0.9203 GenMAPP//Hs_Calcium_Channels      3/26 (28) 0.4952 0.9203 GenMAPP//Hs_Translation_Factors      2/49 (51) 0.9664 0.9203 GenMAPP//Hs_Apoptosis      2/34 (34) 0.8728 0.9203 GenMapp//Hs_Krebs-TCA_Cycle      3/31 (32) 0.6186 0.9203 GenMAPP//Hs_Electron_Transport_Chain      8/105 (105) 0.8509 0.9203 GenMAPP//Hs_Ovarian_Infertility_Genes      3/29 (32) 0.5717 0.9203 GenMAPP//Hs_Steroid_Biosynthesis      1/9 (33) 0.6162 0.9203 GenMapp//Hs_Pentose_Phosphate_Pathway      1/7 (8) 0.5249 0.9203 GenMapp//Hs_Ribosomal_Proteins      2/83 (83) 0.9988 0.9203 GenMAPP//Hs_Fatty_Acid_Degradation      2/26 (26) 0.7549 0.9203 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      2/42 (44) 0.9366 0.9203 GenMAPP//Hs_Complement_Activation_Classical      1/16 (16) 0.8186 0.9203 GenMapp//Hs_Smal_ligand_GPCRs      1/16 (16) 0.8186 0.9664

Cluster 7 has 243 gene products

ArrayXPath has identified 99 out of 243 input elements in 37 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Glycogen_Metabolism      12/33 (34) 0.0000 0.0000 GenMAPP//Hs_Translation_Factors      11/49 (51) 0.0003 0.0049 GenMAPP//Hs_Fatty_Acid_Synthesis      4/15 (15) 0.0155 0.1829 GenMAPP//Hs_G_Protein_Signaling      9/77 (81) 0.0732 0.4305 GenMAPP//Hs_Cholesterol_Biosynthesis      3/14 (14) 0.0648 0.4305 GenMAPP//Hs_Glucocorticoid_Mineralocorticoid_Metabolism      2/6 (9) 0.0578 0.4305 GenMAPP//Hs_Steroid_Biosynthesis      2/9 (33) 0.1214 0.6122 GenMAPP//Hs_S1P_Signaling      3/25 (25) 0.2409 0.7549 GenMAPP//Hs_MAPK_Cascade      3/24 (25) 0.2223 0.7549 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      5/49 (57) 0.2390 0.7549 GenMAPP//Hs_Complement_Activation_Classical      2/16 (16) 0.2994 0.7549 GenMAPP//Hs_Fatty_Acid_Degradation      3/26 (26) 0.2598 0.7549 GenMapp//Hs_Smal_ligand_GPCRs      2/16 (16) 0.2994 0.7549 GenMapp//Hs_GPCRs_Class_C_Metabotropic_glutamate_pheromone      2/15 (18) 0.2733 0.7549 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      4/42 (44) 0.3214 0.7563 GenMAPP//Hs_tRNA_Synthetases      2/21 (21) 0.4261 0.8356 GenMapp//Hs_Wnt_signaling      5/61 (61) 0.4051 0.8356 GenMapp//Hs_Pentose_Phosphate_Pathway      1/7 (8) 0.3912 0.8356 GenMapp//Hs_Nuclear_Receptors      3/37 (52) 0.4695 0.8721 GenMapp//Hs_Nucleotide_GPCRs      1/10 (10) 0.5083 0.8969 GenMAPP//Hs_Electron_Transport_Chain      4/105 (105) 0.9406 0.9535 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      6/238 (292) 0.9996 0.9535 GenMapp//Hs_Ribosomal_Proteins      4/83 (83) 0.8348 0.9535 GenMapp//Hs_GPCRs_Other      2/119 (171) 0.9984 0.9535 GenMapp//Hs_Peptide_GPCRs      2/69 (72) 0.9577 0.9535 GenMapp//Hs_Proteasome_Degradation      1/35 (35) 0.9186 0.9535 GenMapp//Hs_Cell_Cycle      4/87 (96) 0.8614 0.9535 GenMapp//Hs_Monoamine_GPCRs      1/33 (33) 0.9058 0.9535 GenMAPP//Hs_G13_Signaling_Pathway      2/31 (32) 0.6380 0.9535 GenMAPP//Hs_Apoptosis      2/34 (34) 0.6885 0.9535 GenMAPP//Hs_GPCRs_Class_B_Secretin_like      1/23 (28) 0.8061 0.9535 GenMAPP//Hs_Matrix_Metalloproteinases      1/28 (30) 0.8648 0.9535 GenMAPP//Hs_Calcium_Channels      1/26 (28) 0.8438 0.9535 GenMapp//Hs_Inflammatory_Response_Pathway      1/29 (29) 0.8742 0.9535 GenMAPP//Hs_Eicosanoid_Synthesis      1/15 (19) 0.6559 0.9535 GenMAPP//Hs_Ovarian_Infertility_Genes      1/29 (32) 0.8742 0.9953 GenMAPP//Hs_Orphan_GPCRs      1/15 (16) 0.6559 1.0064

Cluster 8 has 272 gene products

ArrayXPath has identified 116 out of 272 input elements in 37 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMapp//Hs_Cell_Cycle      17/87 (96) 0.0003 0.0079 GenMAPP//Hs_G13_Signaling_Pathway      3/31 (32) 0.4617 0.6244 GenMAPP//Hs_Ovarian_Infertility_Genes      4/29 (32) 0.2001 0.6244 GenMapp//Hs_Inflammatory_Response_Pathway      2/29 (29) 0.6928 0.6244 GenMapp//Hs_Ribosomal_Proteins      7/83 (83) 0.5095 0.6244 GenMapp//Hs_Nuclear_Receptors      3/37 (52) 0.5843 0.6244 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      5/42 (44) 0.2453 0.6244 GenMAPP//Hs_Fatty_Acid_Degradation      2/26 (26) 0.6331 0.6244 GenMAPP//Hs_G_Protein_Signaling      5/77 (81) 0.7600 0.6244 GenMAPP//Hs_MAPK_Cascade      3/24 (25) 0.3037 0.6244 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      5/49 (57) 0.3594 0.6244 GenMAPP//Hs_Electron_Transport_Chain      8/105 (105) 0.6238 0.6244 GenMapp//Hs_Proteasome_Degradation      4/35 (35) 0.3094 0.6244 GenMapp//Hs_Wnt_signaling      5/61 (61) 0.5542 0.6244 GenMAPP//Hs_GPCRs_Class_B_Secretin_like      2/23 (28) 0.5648 0.6244 GenMAPP//Hs_Glycogen_Metabolism      3/33 (34) 0.5044 0.6244 GenMAPP//Hs_Apoptosis      3/34 (34) 0.5251 0.6244 GenMAPP//Hs_S1P_Signaling      2/25 (25) 0.6113 0.6244 GenMAPP//Hs_Eicosanoid_Synthesis      2/15 (19) 0.3435 0.6244 GenMAPP//Hs_Matrix_Metalloproteinases      2/28 (30) 0.6739 0.6244 GenMAPP//Hs_tRNA_Synthetases      2/21 (21) 0.5145 0.6244 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like_2      1/18 (20) 0.7814 0.6244 GenMapp//Hs_Pentose_Phosphate_Pathway      1/7 (8) 0.4451 0.6244 GenMAPP//Hs_Heme_Biosynthesis      1/9 (9) 0.5313 0.6244 GenMAPP//Hs_Complement_Activation_Classical      1/16 (16) 0.7409 0.6244 GenMAPP//Hs_Orphan_GPCRs      1/15 (16) 0.7180 0.6244 GenMAPP//Hs_Blood_Clotting_Cascade      1/19 (22) 0.7993 0.6244 GenMAPP//Hs_Calcium_Channels      1/26 (28) 0.8896 0.6739 GenMapp//Hs_GPCRs_Other      3/119 (171) 0.9978 0.6754 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      8/238 (292) 0.9996 0.6754 GenMapp//Hs_Krebs-TCA_Cycle      1/31 (32) 0.9281 0.6754 GenMapp//Hs_Peptide_GPCRs      1/69 (72) 0.9974 0.6754 GenMAPP//Hs_Translation_Factors      5/49 (51) 0.3594 0.8168 GenMapp//Hs_Monoamine_GPCRs      3/33 (33) 0.5044 0.8407 GenMAPP//Hs_Nucleotide_Metabolism      2/15 (15) 0.3435 0.9541 GenMapp//Hs_GPCRs_Class_C_Metabotropic_glutamate_pheromone      2/15 (18) 0.3435 0.9541 GenMapp//Hs_Gap_Junction_Proteins_Connexins      2/15 (15) 0.3435 0.9541

Cluster 9 has 21 gene products

ArrayXPath has identified 11 out of 21 input elements in 2 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMapp//Hs_Cell_Cycle      9/87 (96) 0.0000 0.0000 GenMapp//Hs_Proteasome_Degradation      1/35 (35) 0.2256 0.1457

Cluster 10 has 163 gene products

ArrayXPath has identified 54 out of 163 input elements in 26 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMapp//Hs_Cell_Cycle      9/87 (96) 0.0033 0.0772 GenMAPP//Hs_G_Protein_Signaling      7/77 (81) 0.0195 0.1504 GenMapp//Hs_Inflammatory_Response_Pathway      4/29 (29) 0.0193 0.1504 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      5/49 (57) 0.0305 0.1766 GenMAPP//Hs_Calcium_Channels      3/26 (28) 0.0667 0.3088 GenMAPP//Hs_Complement_Activation_Classical      2/16 (16) 0.1141 0.4402 GenMAPP//Hs_Blood_Clotting_Cascade      2/19 (22) 0.1518 0.5021 GenMAPP//Hs_Ovarian_Infertility_Genes      2/29 (32) 0.2880 0.6233 GenMapp//Hs_Wnt_signaling      3/61 (61) 0.3894 0.6233 GenMapp//Hs_Nucleotide_GPCRs      1/10 (10) 0.3126 0.6233 GenMAPP//Hs_MAPK_Cascade      2/24 (25) 0.2188 0.6233 GenMAPP//Hs_Nucleotide_Metabolism      1/15 (15) 0.4306 0.6233 GenMAPP//Hs_Matrix_Metalloproteinases      2/28 (30) 0.2741 0.6233 GenMapp//Hs_GPCRs_Class_C_Metabotropic_glutamate_pheromone      1/15 (18) 0.4306 0.6233 GenMAPP//Hs_Fatty_Acid_Synthesis      1/15 (15) 0.4306 0.6233 GenMAPP//Hs_Eicosanoid_Synthesis      1/15 (19) 0.4306 0.6233 GenMAPP//Hs_tRNA_Synthetases      1/21 (21) 0.5463 0.7441 GenMAPP//Hs_Electron_Transport_Chain      3/105 (105) 0.7558 0.7956 GenMapp//Hs_Nuclear_Receptors      1/37 (52) 0.7536 0.7956 GenMAPP//Hs_G13_Signaling_Pathway      1/31 (32) 0.6899 0.7956 GenMapp//Hs_Peptide_GPCRs      2/69 (72) 0.7322 0.7956 GenMAPP//Hs_Apoptosis      1/34 (34) 0.7235 0.7956 GenMAPP//Hs_Translation_Factors      1/49 (51) 0.8448 0.8506 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      4/238 (292) 0.9841 0.8822 GenMapp//Hs_GPCRs_Other      1/119 (171) 0.9904 0.8822 GenMapp//Hs_Ribosomal_Proteins      1/83 (83) 0.9591 0.8822

Cluster NA has 374 gene products

ArrayXPath has identified 154 out of 374 input elements in 36 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Electron_Transport_Chain      26/105 (105) 0.0000 0.0003 GenMapp//Hs_Ribosomal_Proteins      20/83 (83) 0.0002 0.0025 GenMapp//Hs_Krebs-TCA_Cycle      8/31 (32) 0.0113 0.1110 GenMAPP//Hs_Nucleotide_Metabolism      5/15 (15) 0.0145 0.1110 GenMapp//Hs_Proteasome_Degradation      8/35 (35) 0.0234 0.1431 GenMAPP//Hs_G13_Signaling_Pathway      7/31 (32) 0.0355 0.1548 GenMAPP//Hs_MAPK_Cascade      6/24 (25) 0.0318 0.1548 GenMAPP//Hs_G_Protein_Signaling      11/77 (81) 0.1696 0.5751 GenMapp//Hs_Pentose_Phosphate_Pathway      2/7 (8) 0.1600 0.5751 GenMAPP//Hs_Fatty_Acid_Synthesis      3/15 (15) 0.1999 0.6101 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      7/49 (57) 0.2433 0.6751 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      6/42 (44) 0.2683 0.6826 GenMapp//Hs_Cell_Cycle      5/87 (96) 0.9605 0.8480 GenMapp//Hs_Wnt_signaling      7/61 (61) 0.4551 0.8480 GenMapp//Hs_GPCRs_Other      2/119 (171) 1.0000 0.8480 GenMAPP//Hs_tRNA_Synthetases      3/21 (21) 0.3772 0.8480 GenMAPP//Hs_Translation_Factors      6/49 (51) 0.4038 0.8480 GenMAPP//Hs_Cholesterol_Biosynthesis      1/14 (14) 0.7875 0.8480 GenMAPP//Hs_Steroid_Biosynthesis      1/9 (33) 0.6298 0.8480 GenMapp//Hs_Nuclear_Receptors      2/37 (52) 0.9126 0.8480 GenMAPP//Hs_S1P_Signaling      2/25 (25) 0.7533 0.8480 GenMAPP//Hs_Apoptosis      2/34 (34) 0.8856 0.8480 GenMAPP//Hs_Glycogen_Metabolism      4/33 (34) 0.4565 0.8480 GenMAPP//Hs_GPCRs_Class_B_Secretin_like      1/23 (28) 0.9222 0.8480 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      2/238 (292) 1.0000 0.8480 GenMAPP//Hs_Matrix_Metalloproteinases      1/28 (30) 0.9556 0.8480 GenMapp//Hs_Smal_ligand_GPCRs      1/16 (16) 0.8299 0.8480 GenMapp//Hs_Inflammatory_Response_Pathway      3/29 (29) 0.5968 0.8480 GenMAPP//Hs_Blood_Clotting_Cascade      2/19 (22) 0.6052 0.8480 GenMAPP//Hs_Calcium_Channels      1/26 (28) 0.9444 0.8480 GenMAPP//Hs_Acetylcholine_Synthesis      1/7 (7) 0.5381 0.8480 GenMAPP//Hs_Orphan_GPCRs      1/15 (16) 0.8099 0.8480 GenMAPP//Hs_Fatty_Acid_Degradation      1/26 (26) 0.9444 0.9009 GenMAPP//Hs_Heme_Biosynthesis      1/9 (9) 0.6298 0.9155 GenMapp//Hs_GPCRs_Class_C_Metabotropic_glutamate_pheromone      1/15 (18) 0.8099 0.9509 GenMAPP//Hs_Eicosanoid_Synthesis      1/15 (19) 0.8099 0.9509

Cluster 1 has 17 gene products but doesn't match to PharmGKB pathways

Cluster 2 has 342 gene products

ArrayXPath has identified 8 out of 342 input elements in 4 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway_PD      2/8 (9) 0.0565 0.2262 PharmGKB//hs_Antiarrhythmic_Drug_Pathways      3/57 (63) 0.6385 0.6448 PharmGKB//Hs_Statin_Pathway      1/18 (18) 0.6448 0.6448 PharmGKB//Hs_Irinotecan_pathway_liver_cell      1/13 (27) 0.5189 0.6448

Cluster 3 has 288 gene products

ArrayXPath has identified 5 out of 288 input elements in 4 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_ACE_Inhibitor_Pathway      1/9 (10) 0.2975 0.5950 PharmGKB//Hs_Statin_Pathway      1/18 (18) 0.5196 0.6928 PharmGKB//hs_Antiarrhythmic_Drug_Pathways      2/57 (63) 0.7098 0.7098 PharmGKB//Hs_Gemcitabine_Pathway      1/8 (9) 0.2685 1.0739

Cluster 4 has 283 gene products

ArrayXPath has identified 6 out of 283 input elements in 5 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway      1/8 (14) 0.3139 0.1207 PharmGKB//Hs_Irinotecan_pathway_cancer_cell      2/19 (25) 0.2018 0.1207 PharmGKB//Hs_Gemcitabine_Pathway      1/8 (9) 0.3139 0.1207 PharmGKB//Hs_Irinotecan_pathway_liver_cell      2/13 (27) 0.1045 0.1608 PharmGKB//hs_Antiarrhythmic_Drug_Pathways      1/57 (63) 0.9670 0.2975

Cluster 5 has 231 gene products

ArrayXPath has identified 1 out of 231 input elements in 1 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//hs_Antiarrhythmic_Drug_Pathways      1/57 (63) 0.4254 0.4254

Cluster 6 has 392 gene products

ArrayXPath has identified 11 out of 392 input elements in 6 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_ACE_Inhibitor_Pathway      3/9 (10) 0.0146 0.0874 PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway_PD      1/8 (9) 0.4355 0.8218 PharmGKB//Hs_Irinotecan_pathway_cancer_cell      1/19 (25) 0.7589 0.8218 PharmGKB//Hs_Irinotecan_pathway_liver_cell      1/13 (27) 0.6127 0.8218 PharmGKB//hs_Antiarrhythmic_Drug_Pathways      3/57 (63) 0.8218 0.8218 PharmGKB//Hs_Statin_Pathway      1/18 (18) 0.7387 0.8218

Cluster 7 has 243 gene products

ArrayXPath has identified 7 out of 243 input elements in 6 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway_PD      2/8 (9) 0.0565 0.2792 PharmGKB//Hs_Irinotecan_pathway_liver_cell      2/13 (27) 0.1383 0.3414 PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway_Gene_Regulation      1/5 (5) 0.2385 0.3926 PharmGKB//Hs_ACE_Inhibitor_Pathway      1/9 (10) 0.3925 0.4845 PharmGKB//Hs_Irinotecan_pathway_cancer_cell      1/19 (25) 0.6662 0.5483 PharmGKB//Hs_Statin_Pathway      1/18 (18) 0.6448 0.5483

Cluster 8 has 272 gene products

ArrayXPath has identified 4 out of 272 input elements in 4 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway_PD      2/8 (9) 0.0177 0.0470 PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway_Gene_Regulation      1/5 (5) 0.1426 0.1890 PharmGKB//Hs_ACE_Inhibitor_Pathway      1/9 (10) 0.2453 0.2166 PharmGKB//hs_Antiarrhythmic_Drug_Pathways      1/57 (63) 0.8946 0.5927

Cluster 9 has 21 gene products but doesn't match to PharmGKB pathways

Cluster 10 has 163 gene products

ArrayXPath has identified 3 out of 163 input elements in 2 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_ACE_Inhibitor_Pathway      1/9 (10) 0.1896 0.3098 PharmGKB//hs_Antiarrhythmic_Drug_Pathways      2/57 (63) 0.3881 0.3171

Cluster NA has 374 gene products

ArrayXPath has identified 4 out of 374 input elements in 3 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_Gemcitabine_Pathway      1/8 (9) 0.1698 0.2547 PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway_PD      1/8 (9) 0.1698 0.2547 PharmGKB//Hs_Statin_Pathway      1/18 (18) 0.3536 0.3536

Cluster 1 has 17 gene products

ArrayXPath has identified 3 out of 17 input elements in 4 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Alanine_and_aspartate_metabolism      2/21 (22) 0.0023 0.0050 KEGG//Hs_Glycine,_serine_and_threonine_metabolism      1/25 (26) 0.0981 0.0725 KEGG//Hs_Nitrogen_metabolism      1/21 (21) 0.0829 0.0725 KEGG//Hs_Arginine_and_proline_metabolism      1/43 (52) 0.1646 0.0913

Cluster 2 has 342 gene products

ArrayXPath has identified 79 out of 342 input elements in 50 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Sphingoglycolipid_metabolism      16/87 (95) 0.0076 0.0765 KEGG//Hs_Inositol_phosphate_metabolism      17/89 (93) 0.0038 0.0768 KEGG//Hs_Nicotinate_and_nicotinamide_metabolism      14/77 (78) 0.0143 0.0951 KEGG//Hs_Fatty_acid_biosynthesis_(path_1)      2/3 (34) 0.0277 0.1385 KEGG//Hs_Purine_metabolism      7/92 (121) 0.8425 0.3823 KEGG//Hs_Pyrimidine_metabolism      3/47 (56) 0.8701 0.3823 KEGG//Hs_Alanine_and_aspartate_metabolism      1/21 (22) 0.8940 0.3823 KEGG//Hs_Nitrogen_metabolism      3/21 (21) 0.3516 0.3823 KEGG//Hs_Androgen_and_estrogen_metabolism      3/27 (35) 0.5183 0.3823 KEGG//Hs_Propanoate_metabolism      2/23 (23) 0.6894 0.3823 KEGG//Hs_Pyruvate_metabolism      3/33 (34) 0.6601 0.3823 KEGG//Hs_Tyrosine_metabolism      3/37 (49) 0.7368 0.3823 KEGG//Hs_Valine,_leucine_and_isoleucine_degradation      2/31 (41) 0.8364 0.3823 KEGG//Hs_Fructose_and_mannose_metabolism      2/25 (26) 0.7339 0.3823 KEGG//Hs_Porphyrin_and_chlorophyll_metabolism      2/21 (22) 0.6392 0.3823 KEGG//Hs_Oxidative_phosphorylation      7/66 (66) 0.4979 0.3823 KEGG//Hs_Glutathione_metabolism      1/29 (29) 0.9558 0.3823 KEGG//Hs_Tryptophan_metabolism      4/55 (62) 0.8236 0.3823 KEGG//Hs_Arginine_and_proline_metabolism      2/43 (52) 0.9429 0.3823 KEGG//Hs_Pantothenate_and_CoA_biosynthesis      1/8 (8) 0.5714 0.3823 KEGG//Hs_Ubiquinone_biosynthesis      3/31 (32) 0.6163 0.3823 KEGG//Hs_Sulfur_metabolism      1/6 (6) 0.4698 0.3823 KEGG//Hs_Bile_acid_biosynthesis      2/26 (29) 0.7541 0.3823 KEGG//Hs_Taurine_and_hypotaurine_metabolism      1/5 (5) 0.4104 0.3823 KEGG//Hs_Aminosugars_metabolism      2/15 (17) 0.4524 0.3823 KEGG//Hs_Galactose_metabolism      2/22 (32) 0.6650 0.3823 KEGG//Hs_Glycolysis__Gluconeogenesis      3/52 (60) 0.9114 0.3823 KEGG//Hs_Fatty_acid_metabolism      6/57 (80) 0.5155 0.3823 KEGG//Hs_Carbon_fixation      2/16 (17) 0.4871 0.3823 KEGG//Hs_Citrate_cycle_(TCA_cycle)      3/18 (19) 0.2652 0.3823 KEGG//Hs_Glyoxylate_and_dicarboxylate_metabolism      2/11 (16) 0.3026 0.3823 KEGG//Hs_Reductive_carboxylate_cycle_(CO2_fixation)      2/7 (7) 0.1490 0.3823 KEGG//Hs_Aminoacyl-tRNA_biosynthesis      2/20 (21) 0.6118 0.3823 KEGG//Hs_Glycine,_serine_and_threonine_metabolism      1/25 (26) 0.9314 0.3823 KEGG//Hs_Urea_cycle_and_metabolism_of_amino_groups      1/18 (19) 0.8534 0.3823 KEGG//Hs_Pentose_phosphate_pathway      1/17 (19) 0.8367 0.3823 KEGG//Hs_Histidine_metabolism      2/27 (27) 0.7729 0.3823 KEGG//Hs_One_carbon_pool_by_folate      1/12 (20) 0.7204 0.3823 KEGG//Hs_Cysteine_metabolism      1/13 (13) 0.7488 0.3823 KEGG//Hs_Flavonoids,_stilbene_and_lignin_biosynthesis      1/7 (11) 0.5232 0.3823 KEGG//Hs_D-Glutamine_and_D-glutamate_metabolism      1/3 (3) 0.2713 0.3823 KEGG//Hs_Glutamate_metabolism      1/23 (24) 0.9147 0.3823 KEGG//Hs_Terpenoid_biosynthesis      1/4 (7) 0.3445 0.3823 KEGG//Hs_Phospholipid_degradation      1/10 (11) 0.6537 0.3823 KEGG//Hs_Prostaglandin_and_leukotriene_metabolism      1/22 (23) 0.9049 0.3823 KEGG//Hs_Pentose_and_glucuronate_interconversions      1/11 (12) 0.6888 0.3823 KEGG//Hs_Phenylalanine_metabolism      1/22 (24) 0.9049 0.4022 KEGG//Hs_Folate_biosynthesis      1/13 (22) 0.7488 0.4405 KEGG//Hs_Ascorbate_and_aldarate_metabolism      1/11 (11) 0.6888 0.4920 KEGG//Hs_Lipopolysaccharide_biosynthesis      1/5 (8) 0.4104 0.6840

Cluster 3 has 288 gene products

ArrayXPath has identified 80 out of 288 input elements in 50 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Bile_acid_biosynthesis      2/26 (29) 0.7744 0.3832 KEGG//Hs_Fatty_acid_metabolism      7/57 (80) 0.3806 0.3832 KEGG//Hs_Glycolysis__Gluconeogenesis      3/52 (60) 0.9251 0.3832 KEGG//Hs_Tyrosine_metabolism      3/37 (49) 0.7623 0.3832 KEGG//Hs_Prostaglandin_and_leukotriene_metabolism      5/22 (23) 0.0684 0.3832 KEGG//Hs_Carbon_fixation      3/16 (17) 0.2269 0.3832 KEGG//Hs_Valine,_leucine_and_isoleucine_degradation      4/31 (41) 0.4064 0.3832 KEGG//Hs_Inositol_phosphate_metabolism      12/89 (93) 0.2001 0.3832 KEGG//Hs_Nicotinate_and_nicotinamide_metabolism      12/77 (78) 0.0889 0.3832 KEGG//Hs_Sphingoglycolipid_metabolism      13/87 (95) 0.1021 0.3832 KEGG//Hs_Glycine,_serine_and_threonine_metabolism      4/25 (26) 0.2571 0.3832 KEGG//Hs_Androgen_and_estrogen_metabolism      3/27 (35) 0.5467 0.3832 KEGG//Hs_Porphyrin_and_chlorophyll_metabolism      1/21 (22) 0.9038 0.3832 KEGG//Hs_Butanoate_metabolism      2/29 (31) 0.8252 0.3832 KEGG//Hs_Synthesis_and_degradation_of_ketone_bodies      1/6 (6) 0.4840 0.3832 KEGG//Hs_Purine_metabolism      6/92 (121) 0.9387 0.3832 KEGG//Hs_Pyrimidine_metabolism      3/47 (56) 0.8877 0.3832 KEGG//Hs_Glutamate_metabolism      2/23 (24) 0.7113 0.3832 KEGG//Hs_Methionine_metabolism      2/10 (10) 0.2795 0.3832 KEGG//Hs_Selenoamino_acid_metabolism      3/11 (11) 0.0969 0.3832 KEGG//Hs_Folate_biosynthesis      2/13 (22) 0.3992 0.3832 KEGG//Hs_Histidine_metabolism      2/27 (27) 0.7926 0.3832 KEGG//Hs_Alanine_and_aspartate_metabolism      4/21 (22) 0.1659 0.3832 KEGG//Hs_Arginine_and_proline_metabolism      3/43 (52) 0.8468 0.3832 KEGG//Hs_Lipopolysaccharide_biosynthesis      1/5 (8) 0.4236 0.3832 KEGG//Hs_Tryptophan_metabolism      6/55 (62) 0.5198 0.3832 KEGG//Hs_Pyruvate_metabolism      2/33 (34) 0.8771 0.3832 KEGG//Hs_Phenylalanine,_tyrosine_and_tryptophan_biosynthesis      1/8 (9) 0.5866 0.3832 KEGG//Hs_Cysteine_metabolism      3/13 (13) 0.1446 0.3832 KEGG//Hs_Nitrogen_metabolism      2/21 (21) 0.6618 0.3832 KEGG//Hs_Fructose_and_mannose_metabolism      1/25 (26) 0.9389 0.3832 KEGG//Hs_C21-Steroid_hormone_metabolism      1/10 (28) 0.6691 0.3832 KEGG//Hs_Citrate_cycle_(TCA_cycle)      2/18 (19) 0.5752 0.3832 KEGG//Hs_Reductive_carboxylate_cycle_(CO2_fixation)      2/7 (7) 0.1592 0.3832 KEGG//Hs_Flavonoids,_stilbene_and_lignin_biosynthesis      1/7 (11) 0.5381 0.3832 KEGG//Hs_Urea_cycle_and_metabolism_of_amino_groups      1/18 (19) 0.8650 0.3832 KEGG//Hs_Pentose_phosphate_pathway      1/17 (19) 0.8489 0.3832 KEGG//Hs_Galactose_metabolism      1/22 (32) 0.9141 0.3832 KEGG//Hs_Glyoxylate_and_dicarboxylate_metabolism      1/11 (16) 0.7040 0.3832 KEGG//Hs_Aminoacyl-tRNA_biosynthesis      1/20 (21) 0.8922 0.3832 KEGG//Hs_Phenylalanine_metabolism      1/22 (24) 0.9141 0.3974 KEGG//Hs_Oxidative_phosphorylation      2/66 (66) 0.9953 0.3981 KEGG//Hs_beta-Alanine_metabolism      1/20 (21) 0.8922 0.4150 KEGG//Hs_Propanoate_metabolism      2/23 (23) 0.7113 0.4446 KEGG//Hs_Pentose_and_glucuronate_interconversions      1/11 (12) 0.7040 0.4693 KEGG//Hs_Ascorbate_and_aldarate_metabolism      1/11 (11) 0.7040 0.4693 KEGG//Hs_Glutathione_metabolism      7/29 (29) 0.0237 0.4744 KEGG//Hs_Pantothenate_and_CoA_biosynthesis      1/8 (8) 0.5866 0.4889 KEGG//Hs_Riboflavin_metabolism      1/8 (8) 0.5866 0.4889 KEGG//Hs_Phospholipid_degradation      1/10 (11) 0.6691 0.4956

Cluster 4 has 283 gene products

ArrayXPath has identified 81 out of 283 input elements in 48 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Glycine,_serine_and_threonine_metabolism      8/25 (26) 0.0020 0.0929 KEGG//Hs_Sulfur_metabolism      2/6 (6) 0.1163 0.6722 KEGG//Hs_Inositol_phosphate_metabolism      14/89 (93) 0.0522 0.6722 KEGG//Hs_Aminoacyl-tRNA_biosynthesis      5/20 (21) 0.0430 0.6722 KEGG//Hs_One_carbon_pool_by_folate      3/12 (20) 0.1128 0.6722 KEGG//Hs_Methane_metabolism      3/11 (11) 0.0910 0.6722 KEGG//Hs_Glutamate_metabolism      5/23 (24) 0.0734 0.6722 KEGG//Hs_Sphingophospholipid_biosynthesis      1/1 (1) 0.1014 0.6722 KEGG//Hs_Folate_biosynthesis      3/13 (22) 0.1363 0.7005 KEGG//Hs_Glutathione_metabolism      5/29 (29) 0.1610 0.7446 KEGG//Hs_Riboflavin_metabolism      2/8 (8) 0.1903 0.8003 KEGG//Hs_Pyrimidine_metabolism      4/47 (56) 0.7234 0.9307 KEGG//Hs_Androgen_and_estrogen_metabolism      2/27 (35) 0.7796 0.9307 KEGG//Hs_Nicotinate_and_nicotinamide_metabolism      10/77 (78) 0.2421 0.9307 KEGG//Hs_Sphingoglycolipid_metabolism      10/87 (95) 0.3844 0.9307 KEGG//Hs_Fatty_acid_metabolism      4/57 (80) 0.8529 0.9307 KEGG//Hs_Bile_acid_biosynthesis      2/26 (29) 0.7610 0.9307 KEGG//Hs_Tyrosine_metabolism      3/37 (49) 0.7455 0.9307 KEGG//Hs_Pentose_phosphate_pathway      1/17 (19) 0.8408 0.9307 KEGG//Hs_Ubiquinone_biosynthesis      3/31 (32) 0.6259 0.9307 KEGG//Hs_Glyoxylate_and_dicarboxylate_metabolism      1/11 (16) 0.6939 0.9307 KEGG//Hs_Lysine_degradation      1/20 (23) 0.8855 0.9307 KEGG//Hs_Citrate_cycle_(TCA_cycle)      3/18 (19) 0.2721 0.9307 KEGG//Hs_Pyruvate_metabolism      2/33 (34) 0.8671 0.9307 KEGG//Hs_Butanoate_metabolism      3/29 (31) 0.5786 0.9307 KEGG//Hs_Arginine_and_proline_metabolism      3/43 (52) 0.8331 0.9307 KEGG//Hs_Urea_cycle_and_metabolism_of_amino_groups      1/18 (19) 0.8573 0.9307 KEGG//Hs_Tryptophan_metabolism      5/55 (62) 0.6759 0.9307 KEGG//Hs_Terpenoid_biosynthesis      1/4 (7) 0.3484 0.9307 KEGG//Hs_Phenylalanine_metabolism      2/22 (24) 0.6726 0.9307 KEGG//Hs_beta-Alanine_metabolism      1/20 (21) 0.8855 0.9307 KEGG//Hs_Taurine_and_hypotaurine_metabolism      1/5 (5) 0.4148 0.9307 KEGG//Hs_Porphyrin_and_chlorophyll_metabolism      3/21 (22) 0.3598 0.9307 KEGG//Hs_Cysteine_metabolism      2/13 (13) 0.3860 0.9307 KEGG//Hs_Fructose_and_mannose_metabolism      2/25 (26) 0.7410 0.9307 KEGG//Hs_Alkaloid_biosynthesis_I      1/6 (7) 0.4745 0.9307 KEGG//Hs_Carbon_fixation      1/16 (17) 0.8224 0.9307 KEGG//Hs_Phenylalanine,_tyrosine_and_tryptophan_biosynthesis      1/8 (9) 0.5765 0.9307 KEGG//Hs_Purine_metabolism      5/92 (121) 0.9708 0.9414 KEGG//Hs_Glycolysis__Gluconeogenesis      2/52 (60) 0.9771 0.9414 KEGG//Hs_Oxidative_phosphorylation      4/66 (66) 0.9221 0.9414 KEGG//Hs_Valine,_leucine_and_isoleucine_degradation      1/31 (41) 0.9661 0.9414 KEGG//Hs_Alanine_and_aspartate_metabolism      3/21 (22) 0.3598 0.9788 KEGG//Hs_Synthesis_and_degradation_of_ketone_bodies      1/6 (6) 0.4745 0.9976 KEGG//Hs_Pantothenate_and_CoA_biosynthesis      1/8 (8) 0.5765 1.0665 KEGG//Hs_Fatty_acid_biosynthesis_(path_2)      1/8 (10) 0.5765 1.0665 KEGG//Hs_Prostaglandin_and_leukotriene_metabolism      2/22 (23) 0.6726 1.0727 KEGG//Hs_Cyanoamino_acid_metabolism      1/4 (4) 0.3484 1.0743

Cluster 5 has 231 gene products

ArrayXPath has identified 61 out of 231 input elements in 45 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Arginine_and_proline_metabolism      7/43 (52) 0.0507 0.6876 KEGG//Hs_Propanoate_metabolism      4/23 (23) 0.1079 0.6876 KEGG//Hs_Valine,_leucine_and_isoleucine_degradation      5/31 (41) 0.0976 0.6876 KEGG//Hs_Inositol_phosphate_metabolism      9/89 (93) 0.2868 0.6876 KEGG//Hs_Glycolysis__Gluconeogenesis      6/52 (60) 0.2384 0.6876 KEGG//Hs_Lysine_degradation      3/20 (23) 0.2161 0.6876 KEGG//Hs_Pyruvate_metabolism      4/33 (34) 0.2752 0.6876 KEGG//Hs_Folate_biosynthesis      2/13 (22) 0.2847 0.6876 KEGG//Hs_Oxidative_phosphorylation      8/66 (66) 0.1543 0.6876 KEGG//Hs_D-Glutamine_and_D-glutamate_metabolism      1/3 (3) 0.2243 0.6876 KEGG//Hs_Urea_cycle_and_metabolism_of_amino_groups      3/18 (19) 0.1731 0.6876 KEGG//Hs_Aminoacyl-tRNA_biosynthesis      4/20 (21) 0.0708 0.6876 KEGG//Hs_Glyoxylate_and_dicarboxylate_metabolism      2/11 (16) 0.2221 0.6876 KEGG//Hs_Methionine_metabolism      2/10 (10) 0.1912 0.6876 KEGG//Hs_Lysine_biosynthesis      1/2 (2) 0.1557 0.6876 KEGG//Hs_Purine_metabolism      9/92 (121) 0.3229 0.7313 KEGG//Hs_Tyrosine_metabolism      3/37 (49) 0.5918 0.7390 KEGG//Hs_Sphingoglycolipid_metabolism      8/87 (95) 0.4092 0.7390 KEGG//Hs_Nicotinate_and_nicotinamide_metabolism      7/77 (78) 0.4357 0.7390 KEGG//Hs_beta-Alanine_metabolism      2/20 (21) 0.4929 0.7390 KEGG//Hs_Bile_acid_biosynthesis      2/26 (29) 0.6393 0.7390 KEGG//Hs_Butanoate_metabolism      3/29 (31) 0.4229 0.7390 KEGG//Hs_Histidine_metabolism      2/27 (27) 0.6603 0.7390 KEGG//Hs_Tryptophan_metabolism      4/55 (62) 0.6708 0.7390 KEGG//Hs_Ubiquinone_biosynthesis      3/31 (32) 0.4677 0.7390 KEGG//Hs_C21-Steroid_hormone_metabolism      1/10 (28) 0.5730 0.7390 KEGG//Hs_Prostaglandin_and_leukotriene_metabolism      2/22 (23) 0.5456 0.7390 KEGG//Hs_Pentose_phosphate_pathway      2/17 (19) 0.4074 0.7390 KEGG//Hs_Pyrimidine_metabolism      4/47 (56) 0.5409 0.7390 KEGG//Hs_Glutamate_metabolism      2/23 (24) 0.5705 0.7390 KEGG//Hs_One_carbon_pool_by_folate      1/12 (20) 0.6404 0.7390 KEGG//Hs_Glycine,_serine_and_threonine_metabolism      2/25 (26) 0.6174 0.7390 KEGG//Hs_Selenoamino_acid_metabolism      1/11 (11) 0.6081 0.7390 KEGG//Hs_Synthesis_and_degradation_of_ketone_bodies      1/6 (6) 0.3990 0.7390 KEGG//Hs_Ascorbate_and_aldarate_metabolism      2/11 (11) 0.2221 0.7542 KEGG//Hs_Methane_metabolism      1/11 (11) 0.6081 0.7745 KEGG//Hs_Aminosugars_metabolism      1/15 (17) 0.7223 0.7747 KEGG//Hs_Carbon_fixation      1/16 (17) 0.7452 0.7788 KEGG//Hs_Citrate_cycle_(TCA_cycle)      1/18 (19) 0.7857 0.8006 KEGG//Hs_Fatty_acid_metabolism      3/57 (80) 0.8616 0.8167 KEGG//Hs_Nitrogen_metabolism      1/21 (21) 0.8349 0.8167 KEGG//Hs_Galactose_metabolism      1/22 (32) 0.8487 0.8167 KEGG//Hs_Androgen_and_estrogen_metabolism      1/27 (35) 0.9023 0.8172 KEGG//Hs_Fructose_and_mannose_metabolism      1/25 (26) 0.8836 0.8172 KEGG//Hs_Phospholipid_degradation      3/10 (11) 0.0403 1.6444

Cluster 6 has 392 gene products

ArrayXPath has identified 94 out of 392 input elements in 52 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Arginine_and_proline_metabolism      11/43 (52) 0.0082 0.1162 KEGG//Hs_Alkaloid_biosynthesis_II      3/4 (4) 0.0060 0.1162 KEGG//Hs_Biotin_metabolism      2/2 (3) 0.0140 0.1487 KEGG//Hs_Synthesis_and_degradation_of_ketone_bodies      3/6 (6) 0.0249 0.1512 KEGG//Hs_Lysine_degradation      6/20 (23) 0.0232 0.1512 KEGG//Hs_Glycine,_serine_and_threonine_metabolism      7/25 (26) 0.0211 0.1512 KEGG//Hs_Ascorbate_and_aldarate_metabolism      4/11 (11) 0.0320 0.1699 KEGG//Hs_Butanoate_metabolism      9/29 (31) 0.0042 0.1799 KEGG//Hs_Valine,_leucine_and_isoleucine_degradation      7/31 (41) 0.0636 0.3003 KEGG//Hs_beta-Alanine_metabolism      5/20 (21) 0.0774 0.3021 KEGG//Hs_Histidine_metabolism      6/27 (27) 0.0895 0.3021 KEGG//Hs_Nitrogen_metabolism      5/21 (21) 0.0924 0.3021 KEGG//Hs_Aminosugars_metabolism      4/15 (17) 0.0913 0.3021 KEGG//Hs_Methionine_metabolism      3/10 (10) 0.1051 0.3190 KEGG//Hs_Pentose_and_glucuronate_interconversions      3/11 (12) 0.1325 0.3519 KEGG//Hs_Glutamate_metabolism      5/23 (24) 0.1264 0.3519 KEGG//Hs_One_carbon_pool_by_folate      3/12 (20) 0.1621 0.4052 KEGG//Hs_Tryptophan_metabolism      9/55 (62) 0.1941 0.4583 KEGG//Hs_Porphyrin_and_chlorophyll_metabolism      4/21 (22) 0.2325 0.4705 KEGG//Hs_Fatty_acid_metabolism      9/57 (80) 0.2251 0.4705 KEGG//Hs_Nucleotide_sugars_metabolism      1/2 (3) 0.2238 0.4705 KEGG//Hs_Galactose_metabolism      4/22 (32) 0.2600 0.5022 KEGG//Hs_Propanoate_metabolism      4/23 (23) 0.2881 0.5210 KEGG//Hs_Carbon_fixation      3/16 (17) 0.2942 0.5210 KEGG//Hs_D-Glutamine_and_D-glutamate_metabolism      1/3 (3) 0.3164 0.5376 KEGG//Hs_Pentose_phosphate_pathway      3/17 (19) 0.3289 0.5376 KEGG//Hs_Bile_acid_biosynthesis      4/26 (29) 0.3743 0.5681 KEGG//Hs_Urea_cycle_and_metabolism_of_amino_groups      3/18 (19) 0.3635 0.5681 KEGG//Hs_Cyanoamino_acid_metabolism      1/4 (4) 0.3980 0.5833 KEGG//Hs_Glycolysis__Gluconeogenesis      7/52 (60) 0.4253 0.6025 KEGG//Hs_Tyrosine_metabolism      5/37 (49) 0.4550 0.6239 KEGG//Hs_Cysteine_metabolism      2/13 (13) 0.4701 0.6244 KEGG//Hs_Phenylalanine_metabolism      3/22 (24) 0.4974 0.6406 KEGG//Hs_Pyruvate_metabolism      4/33 (34) 0.5672 0.7090 KEGG//Hs_Flavonoids,_stilbene_and_lignin_biosynthesis      1/7 (11) 0.5894 0.7157 KEGG//Hs_Phenylalanine,_tyrosine_and_tryptophan_biosynthesis      1/8 (9) 0.6387 0.7336 KEGG//Hs_Riboflavin_metabolism      1/8 (8) 0.6387 0.7336 KEGG//Hs_Purine_metabolism      10/92 (121) 0.6807 0.7451 KEGG//Hs_Ubiquinone_biosynthesis      3/31 (32) 0.7363 0.7451 KEGG//Hs_Glutathione_metabolism      3/29 (29) 0.6922 0.7451 KEGG//Hs_Alanine_and_aspartate_metabolism      2/21 (22) 0.7357 0.7451 KEGG//Hs_Phospholipid_degradation      1/10 (11) 0.7204 0.7451 KEGG//Hs_Methane_metabolism      1/11 (11) 0.7541 0.7453 KEGG//Hs_Androgen_and_estrogen_metabolism      2/27 (35) 0.8529 0.7712 KEGG//Hs_Sphingoglycolipid_metabolism      8/87 (95) 0.8426 0.7712 KEGG//Hs_Pyrimidine_metabolism      4/47 (56) 0.8346 0.7712 KEGG//Hs_Fructose_and_mannose_metabolism      2/25 (26) 0.8203 0.7712 KEGG//Hs_Inositol_phosphate_metabolism      6/89 (93) 0.9695 0.7924 KEGG//Hs_Nicotinate_and_nicotinamide_metabolism      5/77 (78) 0.9668 0.7924 KEGG//Hs_Aminoacyl-tRNA_biosynthesis      1/20 (21) 0.9233 0.7924 KEGG//Hs_Oxidative_phosphorylation      5/66 (66) 0.9160 0.7924 KEGG//Hs_Prostaglandin_and_leukotriene_metabolism      1/22 (23) 0.9409 0.7924

Cluster 7 has 243 gene products

ArrayXPath has identified 58 out of 243 input elements in 46 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Nicotinate_and_nicotinamide_metabolism      10/77 (78) 0.0387 0.5442 KEGG//Hs_Sphingoglycolipid_metabolism      11/87 (95) 0.0361 0.5442 KEGG//Hs_Inositol_phosphate_metabolism      12/89 (93) 0.0175 0.7397 KEGG//Hs_Arginine_and_proline_metabolism      6/43 (52) 0.0784 0.7707 KEGG//Hs_Cysteine_metabolism      2/13 (13) 0.2373 0.7707 KEGG//Hs_Propanoate_metabolism      3/23 (23) 0.2235 0.7707 KEGG//Hs_Urea_cycle_and_metabolism_of_amino_groups      3/18 (19) 0.1319 0.7707 KEGG//Hs_D-Arginine_and_D-ornithine_metabolism      1/3 (4) 0.2001 0.7707 KEGG//Hs_One_carbon_pool_by_folate      2/12 (20) 0.2099 0.7707 KEGG//Hs_Pentose_and_glucuronate_interconversions      2/11 (12) 0.1830 0.7707 KEGG//Hs_C21-Steroid_hormone_metabolism      2/10 (28) 0.1566 0.7707 KEGG//Hs_Nucleotide_sugars_metabolism      1/2 (3) 0.1382 0.7707 KEGG//Hs_Terpenoid_biosynthesis      1/4 (7) 0.2576 0.7769 KEGG//Hs_Glutamate_metabolism      3/23 (24) 0.2235 0.7863 KEGG//Hs_Aminoacyl-tRNA_biosynthesis      2/20 (21) 0.4265 0.8297 KEGG//Hs_Porphyrin_and_chlorophyll_metabolism      2/21 (22) 0.4519 0.8297 KEGG//Hs_Carbon_fixation      2/16 (17) 0.3199 0.8297 KEGG//Hs_Glycolysis__Gluconeogenesis      5/52 (60) 0.3127 0.8297 KEGG//Hs_Pyruvate_metabolism      3/33 (34) 0.4260 0.8297 KEGG//Hs_Nitrogen_metabolism      2/21 (21) 0.4519 0.8297 KEGG//Hs_Alkaloid_biosynthesis_I      1/6 (7) 0.3608 0.8297 KEGG//Hs_Pantothenate_and_CoA_biosynthesis      1/8 (8) 0.4498 0.8297 KEGG//Hs_Prostaglandin_and_leukotriene_metabolism      2/22 (23) 0.4767 0.8387 KEGG//Hs_Fructose_and_mannose_metabolism      2/25 (26) 0.5470 0.8460 KEGG//Hs_Methane_metabolism      1/11 (11) 0.5610 0.8460 KEGG//Hs_Phospholipid_degradation      1/10 (11) 0.5266 0.8460 KEGG//Hs_Purine_metabolism      6/92 (121) 0.6672 0.8531 KEGG//Hs_Glutathione_metabolism      1/29 (29) 0.8890 0.8531 KEGG//Hs_Fatty_acid_metabolism      3/57 (80) 0.7959 0.8531 KEGG//Hs_Alanine_and_aspartate_metabolism      1/21 (22) 0.7946 0.8531 KEGG//Hs_Valine,_leucine_and_isoleucine_degradation      2/31 (41) 0.6674 0.8531 KEGG//Hs_Tyrosine_metabolism      2/37 (49) 0.7612 0.8531 KEGG//Hs_beta-Alanine_metabolism      1/20 (21) 0.7783 0.8531 KEGG//Hs_Pyrimidine_metabolism      3/47 (56) 0.6722 0.8531 KEGG//Hs_Pentose_phosphate_pathway      1/17 (19) 0.7213 0.8531 KEGG//Hs_Bile_acid_biosynthesis      1/26 (29) 0.8601 0.8531 KEGG//Hs_Citrate_cycle_(TCA_cycle)      1/18 (19) 0.7418 0.8531 KEGG//Hs_Butanoate_metabolism      1/29 (31) 0.8890 0.8531 KEGG//Hs_Galactose_metabolism      1/22 (32) 0.8098 0.8531 KEGG//Hs_Androgen_and_estrogen_metabolism      1/27 (35) 0.8705 0.8531 KEGG//Hs_Glycine,_serine_and_threonine_metabolism      2/25 (26) 0.5470 0.8553 KEGG//Hs_Tryptophan_metabolism      2/55 (62) 0.9201 0.8633 KEGG//Hs_Histidine_metabolism      1/27 (27) 0.8705 0.8751 KEGG//Hs_Phenylalanine_metabolism      1/22 (24) 0.8098 0.8767 KEGG//Hs_Oxidative_phosphorylation      2/66 (66) 0.9613 0.8824 KEGG//Hs_Phenylalanine,_tyrosine_and_tryptophan_biosynthesis      1/8 (9) 0.4498 0.9044

Cluster 8 has 272 gene products

ArrayXPath has identified 75 out of 272 input elements in 49 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Galactose_metabolism      4/22 (32) 0.1574 0.3768 KEGG//Hs_Arginine_and_proline_metabolism      4/43 (52) 0.6193 0.3768 KEGG//Hs_Lipopolysaccharide_biosynthesis      1/5 (8) 0.4015 0.3768 KEGG//Hs_Nicotinate_and_nicotinamide_metabolism      8/77 (78) 0.4812 0.3768 KEGG//Hs_Fructose_and_mannose_metabolism      5/25 (26) 0.0859 0.3768 KEGG//Hs_Glycolysis__Gluconeogenesis      5/52 (60) 0.5858 0.3768 KEGG//Hs_Pentose_phosphate_pathway      4/17 (19) 0.0739 0.3768 KEGG//Hs_Purine_metabolism      11/92 (121) 0.2719 0.3768 KEGG//Hs_Oxidative_phosphorylation      6/66 (66) 0.6399 0.3768 KEGG//Hs_Ubiquinone_biosynthesis      3/31 (32) 0.5967 0.3768 KEGG//Hs_Pyrimidine_metabolism      5/47 (56) 0.4903 0.3768 KEGG//Hs_Carbon_fixation      3/16 (17) 0.1977 0.3768 KEGG//Hs_Tryptophan_metabolism      6/55 (62) 0.4503 0.3768 KEGG//Hs_Folate_biosynthesis      2/13 (22) 0.3659 0.3768 KEGG//Hs_Glyoxylate_and_dicarboxylate_metabolism      2/11 (16) 0.2910 0.3768 KEGG//Hs_One_carbon_pool_by_folate      2/12 (20) 0.3288 0.3768 KEGG//Hs_Inositol_phosphate_metabolism      9/89 (93) 0.5085 0.3768 KEGG//Hs_Sphingoglycolipid_metabolism      9/87 (95) 0.4786 0.3768 KEGG//Hs_Pyruvate_metabolism      3/33 (34) 0.6408 0.3768 KEGG//Hs_Prostaglandin_and_leukotriene_metabolism      2/22 (23) 0.6495 0.3768 KEGG//Hs_Riboflavin_metabolism      2/8 (8) 0.1782 0.3768 KEGG//Hs_Phenylalanine_metabolism      3/22 (24) 0.3632 0.3768 KEGG//Hs_Aminoacyl-tRNA_biosynthesis      2/20 (21) 0.5960 0.3768 KEGG//Hs_Pentose_and_glucuronate_interconversions      1/11 (12) 0.6783 0.3768 KEGG//Hs_Porphyrin_and_chlorophyll_metabolism      2/21 (22) 0.6235 0.3768 KEGG//Hs_D-Arginine_and_D-ornithine_metabolism      1/3 (4) 0.2647 0.3768 KEGG//Hs_Phospholipid_degradation      1/10 (11) 0.6431 0.3768 KEGG//Hs_Alkaloid_biosynthesis_I      1/6 (7) 0.4601 0.3768 KEGG//Hs_Flavonoids,_stilbene_and_lignin_biosynthesis      1/7 (11) 0.5131 0.3768 KEGG//Hs_Methane_metabolism      1/11 (11) 0.6783 0.3768 KEGG//Hs_Butanoate_metabolism      2/29 (31) 0.7939 0.3889 KEGG//Hs_Fatty_acid_metabolism      3/57 (80) 0.9326 0.3889 KEGG//Hs_Valine,_leucine_and_isoleucine_degradation      2/31 (41) 0.8243 0.3889 KEGG//Hs_Citrate_cycle_(TCA_cycle)      1/18 (19) 0.8451 0.3889 KEGG//Hs_Glutamate_metabolism      1/23 (24) 0.9086 0.3889 KEGG//Hs_Alanine_and_aspartate_metabolism      1/21 (22) 0.8870 0.3889 KEGG//Hs_Histidine_metabolism      2/27 (27) 0.7590 0.3889 KEGG//Hs_Lysine_degradation      1/20 (23) 0.8745 0.3889 KEGG//Hs_Glycine,_serine_and_threonine_metabolism      1/25 (26) 0.9260 0.3889 KEGG//Hs_Bile_acid_biosynthesis      1/26 (29) 0.9335 0.3889 KEGG//Hs_Androgen_and_estrogen_metabolism      2/27 (35) 0.7590 0.3995 KEGG//Hs_Tyrosine_metabolism      1/37 (49) 0.9795 0.3998 KEGG//Hs_beta-Alanine_metabolism      1/20 (21) 0.8745 0.4067 KEGG//Hs_Nitrogen_metabolism      2/21 (21) 0.6235 0.4157 KEGG//Hs_Reductive_carboxylate_cycle_(CO2_fixation)      1/7 (7) 0.5131 0.4275 KEGG//Hs_Pantothenate_and_CoA_biosynthesis      2/8 (8) 0.1782 0.5093 KEGG//Hs_Phenylalanine,_tyrosine_and_tryptophan_biosynthesis      2/8 (9) 0.1782 0.5093 KEGG//Hs_Synthesis_and_degradation_of_ketone_bodies      1/6 (6) 0.4601 0.5112 KEGG//Hs_Aminosugars_metabolism      4/15 (17) 0.0492 0.9843

Cluster 9 has 21 gene products

ArrayXPath has identified 4 out of 21 input elements in 5 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Inositol_phosphate_metabolism      3/89 (93) 0.0062 0.0062 KEGG//Hs_Sphingoglycolipid_metabolism      3/87 (95) 0.0058 0.0062 KEGG//Hs_Nicotinate_and_nicotinamide_metabolism      3/77 (78) 0.0040 0.0121 KEGG//Hs_Androgen_and_estrogen_metabolism      1/27 (35) 0.1384 0.0836 KEGG//Hs_Bile_acid_biosynthesis      1/26 (29) 0.1336 0.0836

Cluster 10 has 163 gene products

ArrayXPath has identified 37 out of 163 input elements in 29 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Glutathione_metabolism      5/29 (29) 0.0081 0.2253 KEGG//Hs_Methionine_metabolism      2/10 (10) 0.0732 0.6036 KEGG//Hs_Selenoamino_acid_metabolism      2/11 (11) 0.0869 0.6036 KEGG//Hs_Methane_metabolism      2/11 (11) 0.0869 0.6036 KEGG//Hs_Folate_biosynthesis      2/13 (22) 0.1164 0.6469 KEGG//Hs_Phenylalanine_metabolism      2/22 (24) 0.2680 0.8452 KEGG//Hs_Nicotinate_and_nicotinamide_metabolism      5/77 (78) 0.2738 0.8452 KEGG//Hs_Porphyrin_and_chlorophyll_metabolism      2/21 (22) 0.2505 0.8452 KEGG//Hs_Riboflavin_metabolism      1/8 (8) 0.3148 0.8746 KEGG//Hs_Inositol_phosphate_metabolism      5/89 (93) 0.3893 0.9011 KEGG//Hs_Sphingoglycolipid_metabolism      5/87 (95) 0.3697 0.9011 KEGG//Hs_Cysteine_metabolism      1/13 (13) 0.4602 0.9131 KEGG//Hs_One_carbon_pool_by_folate      1/12 (20) 0.4338 0.9131 KEGG//Hs_Glycolysis__Gluconeogenesis      2/52 (60) 0.7072 0.9162 KEGG//Hs_Histidine_metabolism      1/27 (27) 0.7257 0.9162 KEGG//Hs_Arginine_and_proline_metabolism      2/43 (52) 0.6015 0.9162 KEGG//Hs_Urea_cycle_and_metabolism_of_amino_groups      1/18 (19) 0.5755 0.9162 KEGG//Hs_Aminosugars_metabolism      1/15 (17) 0.5096 0.9162 KEGG//Hs_Aminoacyl-tRNA_biosynthesis      1/20 (21) 0.6145 0.9162 KEGG//Hs_Glycine,_serine_and_threonine_metabolism      1/25 (26) 0.6976 0.9162 KEGG//Hs_Prostaglandin_and_leukotriene_metabolism      1/22 (23) 0.6501 0.9162 KEGG//Hs_Pyruvate_metabolism      1/33 (34) 0.7956 0.9208 KEGG//Hs_Tyrosine_metabolism      1/37 (49) 0.8322 0.9208 KEGG//Hs_Purine_metabolism      3/92 (121) 0.8188 0.9208 KEGG//Hs_Oxidative_phosphorylation      1/66 (66) 0.9613 0.9208 KEGG//Hs_Fatty_acid_metabolism      1/57 (80) 0.9386 0.9208 KEGG//Hs_Tryptophan_metabolism      1/55 (62) 0.9320 0.9208 KEGG//Hs_Pyrimidine_metabolism      1/47 (56) 0.8981 0.9208 KEGG//Hs_Nitrogen_metabolism      2/21 (21) 0.2505 0.9939

Cluster NA has 374 gene products

ArrayXPath has identified 105 out of 374 input elements in 55 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Oxidative_phosphorylation      19/66 (66) 0.0004 0.0173 KEGG//Hs_D-Glutamine_and_D-glutamate_metabolism      2/3 (3) 0.0476 0.5821 KEGG//Hs_Butanoate_metabolism      8/29 (31) 0.0281 0.5821 KEGG//Hs_Methane_metabolism      4/11 (11) 0.0457 0.5821 KEGG//Hs_Citrate_cycle_(TCA_cycle)      5/18 (19) 0.0767 0.7503 KEGG//Hs_Inositol_phosphate_metabolism      14/89 (93) 0.2769 0.7808 KEGG//Hs_Phenylalanine_metabolism      4/22 (24) 0.3308 0.7808 KEGG//Hs_Nicotinate_and_nicotinamide_metabolism      11/77 (78) 0.4436 0.7808 KEGG//Hs_Sphingoglycolipid_metabolism      13/87 (95) 0.3604 0.7808 KEGG//Hs_Glutamate_metabolism      5/23 (24) 0.1772 0.7808 KEGG//Hs_Nitrogen_metabolism      4/21 (21) 0.2987 0.7808 KEGG//Hs_Pyrimidine_metabolism      7/47 (56) 0.4325 0.7808 KEGG//Hs_Aminoacyl-tRNA_biosynthesis      3/20 (21) 0.5070 0.7808 KEGG//Hs_Synthesis_and_degradation_of_ketone_bodies      2/6 (6) 0.1825 0.7808 KEGG//Hs_Valine,_leucine_and_isoleucine_degradation      6/31 (41) 0.2170 0.7808 KEGG//Hs_Fatty_acid_biosynthesis_(path_2)      2/8 (10) 0.2870 0.7808 KEGG//Hs_Lysine_degradation      4/20 (23) 0.2670 0.7808 KEGG//Hs_Ubiquinone_biosynthesis      5/31 (32) 0.3928 0.7808 KEGG//Hs_Glyoxylate_and_dicarboxylate_metabolism      3/11 (16) 0.1687 0.7808 KEGG//Hs_Reductive_carboxylate_cycle_(CO2_fixation)      2/7 (7) 0.2344 0.7808 KEGG//Hs_Pentose_and_glucuronate_interconversions      2/11 (12) 0.4394 0.7808 KEGG//Hs_Histidine_metabolism      4/27 (27) 0.4902 0.7808 KEGG//Hs_Sulfur_metabolism      1/6 (6) 0.5749 0.7808 KEGG//Hs_Pyruvate_metabolism      5/33 (34) 0.4492 0.7808 KEGG//Hs_Tyrosine_metabolism      5/37 (49) 0.5571 0.7808 KEGG//Hs_Alanine_and_aspartate_metabolism      3/21 (22) 0.5418 0.7808 KEGG//Hs_Carbon_fixation      3/16 (17) 0.3574 0.7808 KEGG//Hs_Aminosugars_metabolism      3/15 (17) 0.3185 0.7808 KEGG//Hs_Cysteine_metabolism      2/13 (13) 0.5310 0.7808 KEGG//Hs_Alkaloid_biosynthesis_I      1/6 (7) 0.5749 0.7808 KEGG//Hs_D-Arginine_and_D-ornithine_metabolism      1/3 (4) 0.3474 0.7808 KEGG//Hs_Lipopolysaccharide_biosynthesis      1/5 (8) 0.5095 0.7808 KEGG//Hs_Lysine_biosynthesis      1/2 (2) 0.2475 0.7808 KEGG//Hs_Propanoate_metabolism      3/23 (23) 0.6069 0.8019 KEGG//Hs_Folate_biosynthesis      2/13 (22) 0.5310 0.8112 KEGG//Hs_Bile_acid_biosynthesis      3/26 (29) 0.6926 0.8466 KEGG//Hs_Pentose_phosphate_pathway      2/17 (19) 0.6820 0.8466 KEGG//Hs_Phenylalanine,_tyrosine_and_tryptophan_biosynthesis      1/8 (9) 0.6809 0.8466 KEGG//Hs_Tryptophan_metabolism      6/55 (62) 0.7632 0.8471 KEGG//Hs_Arginine_and_proline_metabolism      4/43 (52) 0.8467 0.8471 KEGG//Hs_Urea_cycle_and_metabolism_of_amino_groups      2/18 (19) 0.7130 0.8471 KEGG//Hs_Selenoamino_acid_metabolism      1/11 (11) 0.7928 0.8471 KEGG//Hs_Glycine,_serine_and_threonine_metabolism      2/25 (26) 0.8664 0.8471 KEGG//Hs_beta-Alanine_metabolism      2/20 (21) 0.7675 0.8471 KEGG//Hs_Glycolysis__Gluconeogenesis      5/52 (60) 0.8453 0.8471 KEGG//Hs_Purine_metabolism      10/92 (121) 0.8094 0.8471 KEGG//Hs_One_carbon_pool_by_folate      1/12 (20) 0.8207 0.8471 KEGG//Hs_Fructose_and_mannose_metabolism      2/25 (26) 0.8664 0.8471 KEGG//Hs_Porphyrin_and_chlorophyll_metabolism      4/21 (22) 0.2987 0.8589 KEGG//Hs_Fatty_acid_metabolism      5/57 (80) 0.8982 0.8610 KEGG//Hs_Glutathione_metabolism      2/29 (29) 0.9161 0.8613 KEGG//Hs_Galactose_metabolism      1/22 (32) 0.9582 0.8675 KEGG//Hs_Prostaglandin_and_leukotriene_metabolism      1/22 (23) 0.9582 0.8675 KEGG//Hs_Androgen_and_estrogen_metabolism      1/27 (35) 0.9800 0.8711 KEGG//Hs_Nucleotide_sugars_metabolism      1/2 (3) 0.2475 1.0083

Cluster 1 has 17 gene products

ArrayXPath has identified 14 out of 17 input elements in 51 out of 346 BioCarta pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value BioCarta//Hs_SODD/TNFR1 Signaling Pathway      1/10 (18) 0.0673 0.1152 BioCarta//Hs_Actions of Nitric Oxide in the Heart      2/30 (44) 0.0171 0.1152 BioCarta//Hs_Hypoxia and p53 in the Cardiovascular system      2/22 (37) 0.0093 0.1152 BioCarta//Hs_Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages      1/25 (42) 0.1606 0.1152 BioCarta//Hs_Influence of Ras and Rho proteins on G1 to S Transition      2/26 (33) 0.0130 0.1152 BioCarta//Hs_Phospholipase C Signaling Pathway      1/8 (12) 0.0542 0.1152 BioCarta//Hs_Phospholipids as signalling intermediaries      1/25 (42) 0.1606 0.1152 BioCarta//Hs_Regulation of BAD phosphorylation      1/22 (31) 0.1427 0.1152 BioCarta//Hs_Role of Erk5 in Neuronal Survival      1/17 (36) 0.1120 0.1152 BioCarta//Hs_Role of nicotinic acetylcholine receptors in the regulation of apoptosis      1/15 (24) 0.0994 0.1152 BioCarta//Hs_Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway      1/20 (23) 0.1305 0.1152 BioCarta//Hs_Trka Receptor Signaling Pathway      1/12 (12) 0.0803 0.1152 BioCarta//Hs_Classical Complement Pathway      1/14 (68) 0.0931 0.1152 BioCarta//Hs_Cell Cycle: G2/M Checkpoint      1/24 (27) 0.1547 0.1152 BioCarta//Hs_Cyclins and Cell Cycle Regulation      1/23 (46) 0.1487 0.1152 BioCarta//Hs_Effects of calcineurin in Keratinocyte Differentiation      1/18 (36) 0.1182 0.1152 BioCarta//Hs_Erythropoietin mediated neuroprotection through NF-kB      1/11 (17) 0.0738 0.1152 BioCarta//Hs_ATM Signaling Pathway      1/19 (32) 0.1244 0.1152 BioCarta//Hs_Proepithelin Conversion to Epithelin and Wound Repair Control      1/6 (40) 0.0409 0.1152 BioCarta//Hs_IL12 and Stat4 Dependent Signaling Pathway in Th1 Development      1/21 (27) 0.1366 0.1152 BioCarta//Hs_GATA3 participate in activating the Th2 cytokine genes expression      1/16 (25) 0.1057 0.1152 BioCarta//Hs_mTOR Signaling Pathway      1/24 (44) 0.1547 0.1163 BioCarta//Hs_Regulation of eIF4e and p70 S6 Kinase      1/24 (37) 0.1547 0.1163 BioCarta//Hs_Trefoil Factors Initiate Mucosal Healing      1/24 (95) 0.1547 0.1163 BioCarta//Hs_Transcription factor CREB and its extracellular signals      1/26 (26) 0.1665 0.1167 BioCarta//Hs_Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)      1/28 (41) 0.1782 0.1195 BioCarta//Hs_Cell Cycle: G1/S Check Point      1/28 (34) 0.1782 0.1195 BioCarta//Hs_Phosphoinositides and their downstream targets.      1/23 (23) 0.1487 0.1239 BioCarta//Hs_Caspase Cascade in Apoptosis      1/22 (27) 0.1427 0.1257 BioCarta//Hs_Inhibition of Cellular Proliferation by Gleevec      1/22 (23) 0.1427 0.1257 BioCarta//Hs_Ras Signaling Pathway      1/22 (23) 0.1427 0.1257 BioCarta//Hs_Induction of apoptosis through DR3 and DR4/5 Death Receptors      1/32 (37) 0.2012 0.1320 BioCarta//Hs_Apoptotic Signaling in Response to DNA Damage      1/21 (29) 0.1366 0.1359 BioCarta//Hs_AKT Signaling Pathway      1/21 (32) 0.1366 0.1359 BioCarta//Hs_IL-2 Receptor Beta Chain in T cell Activation      1/35 (38) 0.2180 0.1401 BioCarta//Hs_Role of Mitochondria in Apoptotic Signaling      1/20 (38) 0.1305 0.1437 BioCarta//Hs_Integrin Signaling Pathway      1/37 (45) 0.2291 0.1442 BioCarta//Hs_Complement Pathway      1/19 (33) 0.1244 0.1475 BioCarta//Hs_PTEN dependent cell cycle arrest and apoptosis      1/18 (21) 0.1182 0.1519 BioCarta//Hs_Telomeres, Telomerase, Cellular Aging, and Immortality      1/18 (31) 0.1182 0.1519 BioCarta//Hs_Human Cytomegalovirus and Map Kinase Pathways      1/16 (17) 0.1057 0.1630 BioCarta//Hs_p53 Signaling Pathway      1/16 (27) 0.1057 0.1630 BioCarta//Hs_IL-7 Signal Transduction      1/16 (29) 0.1057 0.1630 BioCarta//Hs_Corticosteroids and cardioprotection      2/17 (28) 0.0056 0.1729 BioCarta//Hs_NFAT and Hypertrophy of the heart (Transcription in the broken heart)      1/51 (82) 0.3025 0.1865 BioCarta//Hs_Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation      1/15 (29) 0.0994 0.1916 BioCarta//Hs_HIV-I Nef: negative effector of Fas and TNF      1/57 (77) 0.3319 0.2007 BioCarta//Hs_The IGF-1 Receptor and Longevity      1/14 (14) 0.0931 0.2050 BioCarta//Hs_B Cell Survival Pathway      1/14 (16) 0.0931 0.2050 BioCarta//Hs_TSP-1 Induced Apoptosis in Microvascular Endothelial Cell      1/6 (9) 0.0409 0.2103 BioCarta//Hs_IL 4 signaling pathway      1/11 (17) 0.0738 0.2277

Cluster 2 has 342 gene products

ArrayXPath has identified 204 out of 342 input elements in 251 out of 346 BioCarta pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value BioCarta//Hs_ADP-Ribosylation Factor      9/21 (57) 0.0003 0.0219 BioCarta//Hs_CTCF: First Multivalent Nuclear Factor      9/23 (26) 0.0007 0.0246 BioCarta//Hs_Apoptotic Signaling in Response to DNA Damage      7/21 (29) 0.0079 0.1483 BioCarta//Hs_Regulation of eIF2      4/9 (20) 0.0148 0.1483 BioCarta//Hs_Phospholipase C d1 in phospholipid associated cell signaling      3/5 (10) 0.0136 0.1483 BioCarta//Hs_Attenuation of GPCR Signaling      5/13 (13) 0.0128 0.1483 BioCarta//Hs_Ion Channel and Phorbal Esters Signaling Pathway      3/5 (7) 0.0136 0.1590 BioCarta//Hs_Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)      11/54 (64) 0.0464 0.1600 BioCarta//Hs_Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to fa      5/15 (28) 0.0245 0.1600 BioCarta//Hs_Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway      5/20 (23) 0.0777 0.1600 BioCarta//Hs_WNT Signaling Pathway      6/25 (42) 0.0656 0.1600 BioCarta//Hs_Role of Tob in T-cell activation      6/19 (30) 0.0183 0.1600 BioCarta//Hs_Degradation of the RAR and RXR by the proteasome      2/3 (11) 0.0386 0.1600 BioCarta//Hs_Transcription Regulation by Methyltransferase of CARM1      4/13 (34) 0.0576 0.1600 BioCarta//Hs_ATM Signaling Pathway      5/19 (32) 0.0642 0.1600 BioCarta//Hs_Regulation of eIF4e and p70 S6 Kinase      6/24 (37) 0.0551 0.1600 BioCarta//Hs_Phospholipase C-epsilon pathway      4/12 (25) 0.0438 0.1600 BioCarta//Hs_Inhibition of Matrix Metalloproteinases      3/9 (15) 0.0800 0.1600 BioCarta//Hs_Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy      5/18 (31) 0.0521 0.1600 BioCarta//Hs_Signaling Pathway from G-Protein Families      8/34 (42) 0.0398 0.1600 BioCarta//Hs_cdc25 and chk1 Regulatory Pathway in response to DNA damage      3/9 (13) 0.0800 0.1600 BioCarta//Hs_Transcription factor CREB and its extracellular signals      6/26 (26) 0.0773 0.1600 BioCarta//Hs_Activation of PKC through G protein coupled receptor      3/7 (8) 0.0398 0.1600 BioCarta//Hs_Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes      5/17 (20) 0.0415 0.1600 BioCarta//Hs_Spliceosomal Assembly      4/14 (14) 0.0734 0.1600 BioCarta//Hs_Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells      6/26 (43) 0.0773 0.1690 BioCarta//Hs_Bone Remodelling      4/14 (19) 0.0734 0.1713 BioCarta//Hs_B Cell Survival Pathway      4/14 (16) 0.0734 0.1713 BioCarta//Hs_TACI and BCMA stimulation of B cell immune responses.      4/14 (21) 0.0734 0.1713 BioCarta//Hs_Cadmium induces DNA synthesis and proliferation in macrophages      4/15 (21) 0.0912 0.1752 BioCarta//Hs_Nitric Oxide Signaling Pathway      5/21 (25) 0.0926 0.1752 BioCarta//Hs_Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages      6/25 (42) 0.0656 0.1767 BioCarta//Hs_Rab GTPases Mark Targets In The Endocytotic Machinery      4/12 (17) 0.0438 0.1804 BioCarta//Hs_Cystic fibrosis transmembrane conductance regulator and beta 2 adrenergic receptor pathway      4/12 (37) 0.0438 0.1804 BioCarta//Hs_Double Stranded RNA Induced Gene Expression      3/10 (14) 0.1047 0.1832 BioCarta//Hs_Erk1/Erk2 Mapk Signaling pathway      6/28 (33) 0.1038 0.1832 BioCarta//Hs_RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage      4/13 (17) 0.0576 0.1833 BioCarta//Hs_p53 Signaling Pathway      4/16 (27) 0.1108 0.1847 BioCarta//Hs_Role of MEF2D in T-cell Apoptosis      4/16 (45) 0.1108 0.1847 BioCarta//Hs_Cell Cycle: G1/S Check Point      6/28 (34) 0.1038 0.1863 BioCarta//Hs_ChREBP regulation by carbohydrates and cAMP      5/19 (30) 0.0642 0.1872 BioCarta//Hs_CCR3 signaling in Eosinophils      5/23 (30) 0.1264 0.1928 BioCarta//Hs_Map Kinase Inactivation of SMRT Corepressor      3/11 (14) 0.1319 0.1928 BioCarta//Hs_Y branching of actin filaments      4/17 (45) 0.1322 0.1928 BioCarta//Hs_Regulation of ck1/cdk5 by type 1 glutamate receptors      4/17 (38) 0.1322 0.1928 BioCarta//Hs_Corticosteroids and cardioprotection      4/17 (28) 0.1322 0.1928 BioCarta//Hs_Telomeres, Telomerase, Cellular Aging, and Immortality      4/18 (31) 0.1551 0.2010 BioCarta//Hs_mTOR Signaling Pathway      5/24 (44) 0.1452 0.2010 BioCarta//Hs_Effects of calcineurin in Keratinocyte Differentiation      4/18 (36) 0.1551 0.2010 BioCarta//Hs_Visceral Fat Deposits and the Metabolic Syndrome      2/6 (9) 0.1519 0.2010 BioCarta//Hs_Role of Parkin in the Ubiquitin-Proteasomal Pathway      3/12 (38) 0.1612 0.2016 BioCarta//Hs_Trka Receptor Signaling Pathway      3/12 (12) 0.1612 0.2016 BioCarta//Hs_CXCR4 Signaling Pathway      5/24 (35) 0.1452 0.2032 BioCarta//Hs_SREBP control of lipid synthesis      2/6 (24) 0.1519 0.2045 BioCarta//Hs_AKAP95 role in mitosis and chromosome dynamics      3/11 (39) 0.1319 0.2052 BioCarta//Hs_Melanocyte Development and Pigmentation Pathway      3/7 (13) 0.0398 0.2145 BioCarta//Hs_TGF beta signaling pathway      4/19 (76) 0.1793 0.2202 BioCarta//Hs_ALK in cardiac myocytes      6/34 (51) 0.2067 0.2226 BioCarta//Hs_g-Secretase mediated ErbB4 Signaling Pathway      2/7 (19) 0.1967 0.2226 BioCarta//Hs_Extrinsic Prothrombin Activation Pathway      3/13 (24) 0.1923 0.2226 BioCarta//Hs_Acute Myocardial Infarction      4/20 (23) 0.2047 0.2226 BioCarta//Hs_mCalpain and friends in Cell motility      4/22 (38) 0.2582 0.2232 BioCarta//Hs_Aspirin Blocks Signaling Pathway Involved in Platelet Activation      4/22 (32) 0.2582 0.2232 BioCarta//Hs_Regulation of BAD phosphorylation      4/22 (31) 0.2582 0.2232 BioCarta//Hs_NFAT and Hypertrophy of the heart (Transcription in the broken heart)      8/51 (82) 0.2498 0.2232 BioCarta//Hs_Inhibition of Cellular Proliferation by Gleevec      4/22 (23) 0.2582 0.2232 BioCarta//Hs_T Cell Receptor Signaling Pathway      7/43 (56) 0.2400 0.2232 BioCarta//Hs_Regulation of cell cycle progression by Plk3      2/8 (17) 0.2428 0.2232 BioCarta//Hs_Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility      4/21 (25) 0.2311 0.2232 BioCarta//Hs_CD40L Signaling Pathway      3/15 (27) 0.2582 0.2232 BioCarta//Hs_Role of Mitochondria in Apoptotic Signaling      4/20 (38) 0.2047 0.2239 BioCarta//Hs_Oxidative Stress Induced Gene Expression Via Nrf2      4/20 (24) 0.2047 0.2239 BioCarta//Hs_Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor      4/20 (24) 0.2047 0.2239 BioCarta//Hs_Cell to Cell Adhesion Signaling      3/13 (14) 0.1923 0.2282 BioCarta//Hs_Sonic Hedgehog (Shh) Pathway      3/16 (29) 0.2922 0.2324 BioCarta//Hs_How Progesterone Initiates the Oocyte Maturation      5/30 (32) 0.2774 0.2324 BioCarta//Hs_Polyadenylation of mRNA      2/9 (35) 0.2894 0.2324 BioCarta//Hs_Intrinsic Prothrombin Activation Pathway      4/23 (36) 0.2860 0.2324 BioCarta//Hs_Feeder Pathways for Glycolysis      2/9 (11) 0.2894 0.2328 BioCarta//Hs_Erythrocyte Differentiation Pathway      3/15 (21) 0.2582 0.2347 BioCarta//Hs_Endocytotic role of NDK, Phosphins and Dynamin      3/15 (48) 0.2582 0.2347 BioCarta//Hs_The information-processing pathway at the IFN-beta enhancer      3/15 (27) 0.2582 0.2347 BioCarta//Hs_Eukaryotic protein translation      3/15 (20) 0.2582 0.2347 BioCarta//Hs_PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase      3/15 (18) 0.2582 0.2347 BioCarta//Hs_Phosphoinositides and their downstream targets.      4/23 (23) 0.2860 0.2355 BioCarta//Hs_TPO Signaling Pathway      4/23 (54) 0.2860 0.2355 BioCarta//Hs_IL 6 signaling pathway      4/21 (48) 0.2311 0.2414 BioCarta//Hs_Cell Cycle: G2/M Checkpoint      4/24 (27) 0.3141 0.2423 BioCarta//Hs_Nitrogen-depedent regulation of Rtg1 and Rtg3 in TOR pathway      1/3 (8) 0.3149 0.2423 BioCarta//Hs_Phospholipase C Signaling Pathway      2/8 (12) 0.2428 0.2428 BioCarta//Hs_NFkB activation by Nontypeable Hemophilus influenzae      4/24 (43) 0.3141 0.2443 BioCarta//Hs_Induction of apoptosis through DR3 and DR4/5 Death Receptors      5/32 (37) 0.3263 0.2457 BioCarta//Hs_CDK Regulation of DNA Replication      3/17 (56) 0.3264 0.2457 BioCarta//Hs_Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia      2/22 (40) 0.7548 0.2469 BioCarta//Hs_HIV-I Nef: negative effector of Fas and TNF      7/57 (77) 0.5213 0.2469 BioCarta//Hs_Integrin Signaling Pathway      4/37 (45) 0.6552 0.2469 BioCarta//Hs_Phospholipids as signalling intermediaries      3/25 (42) 0.5831 0.2469 BioCarta//Hs_Signaling of Hepatocyte Growth Factor Receptor      5/36 (42) 0.4256 0.2469 BioCarta//Hs_Trefoil Factors Initiate Mucosal Healing      3/24 (95) 0.5542 0.2469 BioCarta//Hs_VEGF, Hypoxia, and Angiogenesis      4/28 (34) 0.4276 0.2469 BioCarta//Hs_Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling      4/33 (44) 0.5614 0.2469 BioCarta//Hs_Caspase Cascade in Apoptosis      2/22 (27) 0.7548 0.2469 BioCarta//Hs_CARM1 and Regulation of the Estrogen Receptor      3/26 (33) 0.6108 0.2469 BioCarta//Hs_Deregulation of CDK5 in Alzheimers Disease      2/10 (16) 0.3355 0.2469 BioCarta//Hs_Rho cell motility signaling pathway      4/30 (32) 0.4828 0.2469 BioCarta//Hs_MAPKinase Signaling Pathway      10/85 (88) 0.5618 0.2469 BioCarta//Hs_Keratinocyte Differentiation      5/46 (67) 0.6517 0.2469 BioCarta//Hs_Synaptic Proteins at the Synaptic Junction      3/20 (32) 0.4283 0.2469 BioCarta//Hs_Growth Hormone Signaling Pathway      4/26 (35) 0.3710 0.2469 BioCarta//Hs_IL 2 signaling pathway      3/22 (47) 0.4932 0.2469 BioCarta//Hs_IL-2 Receptor Beta Chain in T cell Activation      4/35 (38) 0.6100 0.2469 BioCarta//Hs_fMLP induced chemokine gene expression in HMC-1 cells      4/36 (58) 0.6330 0.2469 BioCarta//Hs_BCR Signaling Pathway      5/34 (54) 0.3759 0.2469 BioCarta//Hs_Links between Pyk2 and Map Kinases      3/28 (44) 0.6624 0.2469 BioCarta//Hs_PDGF Signaling Pathway      3/27 (61) 0.6372 0.2469 BioCarta//Hs_Thrombin signaling and protease-activated receptors      3/21 (31) 0.4611 0.2469 BioCarta//Hs_CBL mediated ligand-induced downregulation of EGF receptors      2/13 (51) 0.4670 0.2469 BioCarta//Hs_Bioactive Peptide Induced Signaling Pathway      4/38 (58) 0.6764 0.2469 BioCarta//Hs_NF-kB Signaling Pathway      3/23 (49) 0.5242 0.2469 BioCarta//Hs_TNFR2 Signaling Pathway      2/18 (32) 0.6478 0.2469 BioCarta//Hs_Signal transduction through IL1R      3/30 (41) 0.7088 0.2469 BioCarta//Hs_Acetylation and Deacetylation of RelA in The Nucleus      2/16 (34) 0.5819 0.2469 BioCarta//Hs_Fibrinolysis Pathway      2/11 (14) 0.3808 0.2469 BioCarta//Hs_Ras Signaling Pathway      2/22 (23) 0.7548 0.2469 BioCarta//Hs_IGF-1 Signaling Pathway      2/20 (45) 0.7053 0.2469 BioCarta//Hs_Platelet Amyloid Precursor Protein Pathway      2/14 (15) 0.5073 0.2469 BioCarta//Hs_Lissencephaly gene (LIS1) in neuronal migration and development      2/19 (48) 0.6776 0.2469 BioCarta//Hs_Role of ?arrestins in the activation and targeting of MAP kinases      2/17 (40) 0.6159 0.2469 BioCarta//Hs_Roles of ?arrestin-dependent Recruitment of Src Kinases in GPCR Signaling      2/21 (34) 0.7310 0.2469 BioCarta//Hs_beta-arrestins in GPCR Desensitization      2/15 (40) 0.5457 0.2469 BioCarta//Hs_Signal Dependent Regulation of Myogenesis by Corepressor MITR      1/9 (25) 0.6792 0.2469 BioCarta//Hs_Blockade of Neurotransmitter Relase by Botulinum Toxin      1/5 (28) 0.4679 0.2469 BioCarta//Hs_BRCA1-dependent Ub-ligase activity      1/8 (18) 0.6359 0.2469 BioCarta//Hs_The PRC2 Complex sets Long-term gene Silencing The Modification of Histone Tails      2/12 (20) 0.4247 0.2469 BioCarta//Hs_Eph Kinases and ephrins support platelet aggregation      1/10 (17) 0.7174 0.2469 BioCarta//Hs_Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation      1/11 (35) 0.7511 0.2469 BioCarta//Hs_Catabolic Pathways for Arginine , Histidine, Glutamate, Glutamine, and Proline      1/6 (6) 0.5311 0.2469 BioCarta//Hs_The reactions that feed amino groups into the urea cycle      1/7 (16) 0.5868 0.2469 BioCarta//Hs_Generation of amyloid b-peptide by PS1      1/4 (9) 0.3962 0.2469 BioCarta//Hs_Toll-Like Receptor Pathway      3/34 (45) 0.7869 0.2481 BioCarta//Hs_Nuclear Receptors in Lipid Metabolism and Toxicity      3/34 (43) 0.7869 0.2481 BioCarta//Hs_Stathmin and breast cancer resistance to antimicrotubule agents      2/23 (26) 0.7768 0.2481 BioCarta//Hs_Lectin Induced Complement Pathway      1/12 (56) 0.7808 0.2481 BioCarta//Hs_IL22 Soluble Receptor Signaling Pathway      1/12 (40) 0.7808 0.2484 BioCarta//Hs_Gamma-aminobutyric Acid Receptor Life Cycle      1/12 (73) 0.7808 0.2484 BioCarta//Hs_Ca++/ Calmodulin-dependent Protein Kinase Activation      1/12 (76) 0.7808 0.2484 BioCarta//Hs_Ghrelin: Regulation of Food Intake and Energy Homeostasis      1/11 (30) 0.7511 0.2492 BioCarta//Hs_Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle      1/11 (30) 0.7511 0.2492 BioCarta//Hs_Prion Pathway      1/11 (11) 0.7511 0.2492 BioCarta//Hs_BTG family proteins and cell cycle regulation      1/11 (13) 0.7511 0.2492 BioCarta//Hs_Erythropoietin mediated neuroprotection through NF-kB      1/11 (17) 0.7511 0.2492 BioCarta//Hs_Vitamin C in the Brain      1/11 (20) 0.7511 0.2492 BioCarta//Hs_Control of Gene Expression by Vitamin D Receptor      2/24 (32) 0.7970 0.2502 BioCarta//Hs_AKT Signaling Pathway      2/21 (32) 0.7310 0.2508 BioCarta//Hs_Rac 1 cell motility signaling pathway      2/21 (23) 0.7310 0.2508 BioCarta//Hs_Insulin Signaling Pathway      2/21 (48) 0.7310 0.2508 BioCarta//Hs_Sumoylation by RanBP2 Regulates Transcriptional Repression      1/10 (25) 0.7174 0.2511 BioCarta//Hs_Electron Transport Reaction in Mitochondria      1/10 (10) 0.7174 0.2511 BioCarta//Hs_Glycolysis Pathway      1/10 (21) 0.7174 0.2511 BioCarta//Hs_Free Radical Induced Apoptosis      1/10 (11) 0.7174 0.2511 BioCarta//Hs_Regulators of Bone Mineralization      1/10 (57) 0.7174 0.2511 BioCarta//Hs_Reversal of Insulin Resistance by Leptin      1/10 (11) 0.7174 0.2511 BioCarta//Hs_Apoptotic DNA fragmentation and tissue homeostasis      1/10 (15) 0.7174 0.2511 BioCarta//Hs_Mechanism of Protein Import into the Nucleus      1/9 (19) 0.6792 0.2516 BioCarta//Hs_Lck and Fyn tyrosine kinases in initiation of TCR Activation      1/9 (16) 0.6792 0.2516 BioCarta//Hs_Role of PPAR-gamma Coactivators in Obesity and Thermogenesis      1/9 (12) 0.6792 0.2516 BioCarta//Hs_B Lymphocyte Cell Surface Molecules      1/9 (10) 0.6792 0.2516 BioCarta//Hs_Visual Signal Transduction      1/9 (12) 0.6792 0.2516 BioCarta//Hs_Regulation of PGC-1a      2/23 (31) 0.7768 0.2517 BioCarta//Hs_ER-associated degradation (ERAD) Pathway      1/13 (20) 0.8069 0.2522 BioCarta//Hs_Influence of Ras and Rho proteins on G1 to S Transition      2/26 (33) 0.8327 0.2543 BioCarta//Hs_p38 MAPK Signaling Pathway      3/38 (40) 0.8469 0.2543 BioCarta//Hs_Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)      2/28 (41) 0.8626 0.2543 BioCarta//Hs_Chaperones modulate interferon Signaling Pathway      1/16 (34) 0.8682 0.2543 BioCarta//Hs_Human Cytomegalovirus and Map Kinase Pathways      1/16 (17) 0.8682 0.2543 BioCarta//Hs_Downregulated of MTA-3 in ER-negative Breast Tumors      1/16 (23) 0.8682 0.2543 BioCarta//Hs_Steps in the Glycosylation of Mammalian N-linked Oligosaccarides      1/16 (16) 0.8682 0.2543 BioCarta//Hs_Adhesion and Diapedesis of Lymphocytes      1/14 (47) 0.8300 0.2543 BioCarta//Hs_Adhesion and Diapedesis of Granulocytes      1/15 (49) 0.8503 0.2543 BioCarta//Hs_Role of nicotinic acetylcholine receptors in the regulation of apoptosis      1/15 (24) 0.8503 0.2544 BioCarta//Hs_IL 17 Signaling Pathway      1/15 (16) 0.8503 0.2544 BioCarta//Hs_Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation      1/15 (29) 0.8503 0.2544 BioCarta//Hs_The IGF-1 Receptor and Longevity      1/14 (14) 0.8300 0.2548 BioCarta//Hs_Stress Induction of HSP Regulation      1/14 (22) 0.8300 0.2548 BioCarta//Hs_Classical Complement Pathway      1/14 (68) 0.8300 0.2548 BioCarta//Hs_Selective expression of chemokine receptors during T-cell polarization      2/29 (55) 0.8757 0.2554 BioCarta//Hs_Actions of Nitric Oxide in the Heart      2/30 (44) 0.8876 0.2576 BioCarta//Hs_The 4-1BB-dependent immune response      1/18 (22) 0.8978 0.2576 BioCarta//Hs_Nerve growth factor pathway (NGF)      1/18 (38) 0.8978 0.2576 BioCarta//Hs_Sprouty regulation of tyrosine kinase signals      1/18 (31) 0.8978 0.2576 BioCarta//Hs_EGF Signaling Pathway      3/27 (54) 0.6372 0.2578 BioCarta//Hs_FAS signaling pathway ( CD95 )      3/30 (34) 0.7088 0.2584 BioCarta//Hs_PTEN dependent cell cycle arrest and apoptosis      2/18 (21) 0.6478 0.2591 BioCarta//Hs_EPO Signaling Pathway      2/19 (36) 0.6776 0.2592 BioCarta//Hs_Proteasome Complex      2/19 (24) 0.6776 0.2592 BioCarta//Hs_Complement Pathway      1/19 (33) 0.9101 0.2600 BioCarta//Hs_Stat3 Signaling Pathway      1/8 (13) 0.6359 0.2603 BioCarta//Hs_Internal Ribosome entry pathway      1/8 (39) 0.6359 0.2603 BioCarta//Hs_Overview of telomerase protein component gene hTert Transcriptional Regulation      1/8 (20) 0.6359 0.2603 BioCarta//Hs_Shuttle for transfer of acetyl groups from mitochondria to the cytosol      1/8 (11) 0.6359 0.2603 BioCarta//Hs_The Citric Acid Cycle      1/8 (9) 0.6359 0.2603 BioCarta//Hs_Calcium Signaling by HBx of Hepatitis B virus      1/8 (8) 0.6359 0.2603 BioCarta//Hs_RNA polymerase III transcription      1/8 (22) 0.6359 0.2603 BioCarta//Hs_The role of FYVE-finger proteins in vesicle transport      1/7 (35) 0.5868 0.2616 BioCarta//Hs_Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression      1/4 (7) 0.3962 0.2616 BioCarta//Hs_Malate-aspartate shuttle      1/4 (8) 0.3962 0.2616 BioCarta//Hs_Function of SLRP in Bone: An Integrated View      1/4 (4) 0.3962 0.2616 BioCarta//Hs_West Nile Virus      1/4 (4) 0.3962 0.2616 BioCarta//Hs_Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine      1/4 (4) 0.3962 0.2616 BioCarta//Hs_Transcriptional activation of dbpb from mRNA      1/4 (9) 0.3962 0.2616 BioCarta//Hs_Eicosanoid Metabolism      1/20 (20) 0.9208 0.2620 BioCarta//Hs_Ion Channels and Their Functional Role in Vascular Endothelium      3/20 (20) 0.4283 0.2630 BioCarta//Hs_Fc Epsilon Receptor I Signaling in Mast Cells      4/38 (49) 0.6764 0.2631 BioCarta//Hs_Biosynthesis of neurotransmitters      1/6 (6) 0.5311 0.2636 BioCarta//Hs_Low-density lipoprotein (LDL) pathway during atherogenesis      1/6 (10) 0.5311 0.2636 BioCarta//Hs_Wnt/LRP6 Signalling      1/6 (25) 0.5311 0.2636 BioCarta//Hs_Metabolism of Anandamide, an Endogenous Cannabinoid      1/6 (13) 0.5311 0.2636 BioCarta//Hs_Circadian Rhythms      1/6 (13) 0.5311 0.2636 BioCarta//Hs_TSP-1 Induced Apoptosis in Microvascular Endothelial Cell      1/6 (9) 0.5311 0.2636 BioCarta//Hs_SUMOylation as a mechanism to modulate CtBP-dependent gene responses      1/6 (11) 0.5311 0.2636 BioCarta//Hs_Regulation of Spermatogenesis by CREM      1/6 (14) 0.5311 0.2636 BioCarta//Hs_Activation of cAMP-dependent protein kinase, PKA      1/6 (10) 0.5311 0.2636 BioCarta//Hs_Ceramide Signaling Pathway      1/21 (21) 0.9303 0.2637 BioCarta//Hs_METS affect on Macrophage Differentiation      2/16 (30) 0.5819 0.2645 BioCarta//Hs_Regulation of transcriptional activity by PML      2/16 (24) 0.5819 0.2645 BioCarta//Hs_Multi-step Regulation of Transcription by Pitx2      2/16 (38) 0.5819 0.2645 BioCarta//Hs_IL-7 Signal Transduction      2/16 (29) 0.5819 0.2645 BioCarta//Hs_The Co-Stimulatory Signal During T-cell Activation      2/16 (40) 0.5819 0.2645 BioCarta//Hs_GATA3 participate in activating the Th2 cytokine genes expression      2/16 (25) 0.5819 0.2645 BioCarta//Hs_Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration      2/15 (15) 0.5457 0.2652 BioCarta//Hs_IL 3 signaling pathway      2/15 (30) 0.5457 0.2652 BioCarta//Hs_uCalpain and friends in Cell spread      2/17 (36) 0.6159 0.2661 BioCarta//Hs_Pertussis toxin-insensitive CCR5 Signaling in Macrophage      2/17 (38) 0.6159 0.2661 BioCarta//Hs_IL 4 signaling pathway      2/11 (17) 0.3808 0.2692 BioCarta//Hs_Activation of Src by Protein-tyrosine phosphatase alpha      2/11 (29) 0.3808 0.2692 BioCarta//Hs_How does salmonella hijack a cell      2/12 (32) 0.4247 0.2703 BioCarta//Hs_Tumor Suppressor Arf Inhibits Ribosomal Biogenesis      2/12 (17) 0.4247 0.2703 BioCarta//Hs_D4-GDI Signaling Pathway      2/12 (15) 0.4247 0.2703 BioCarta//Hs_TNF/Stress Related Signaling      1/25 (31) 0.9582 0.2705 BioCarta//Hs_Cytokines and Inflammatory Response      1/27 (78) 0.9677 0.2720 BioCarta//Hs_TNFR1 Signaling Pathway      1/29 (36) 0.9750 0.2730 BioCarta//Hs_Agrin in Postsynaptic Differentiation      1/39 (50) 0.9931 0.2770 BioCarta//Hs_Angiotensin-converting enzyme 2 regulates heart function      2/13 (34) 0.4670 0.2770 BioCarta//Hs_Estrogen-responsive protein Efp controls cell cycle and breast tumors growth      2/14 (59) 0.5073 0.2774 BioCarta//Hs_Presenilin action in Notch and Wnt signaling      2/14 (31) 0.5073 0.2774 BioCarta//Hs_Segmentation Clock      2/14 (20) 0.5073 0.2774 BioCarta//Hs_Protein Kinase A at the Centrosome      2/14 (28) 0.5073 0.2774 BioCarta//Hs_Repression of Pain Sensation by the Transcriptional Regulator DREAM      2/14 (21) 0.5073 0.2774 BioCarta//Hs_Role of ERBB2 in Signal Transduction and Oncology      3/21 (34) 0.4611 0.2783 BioCarta//Hs_Cyclins and Cell Cycle Regulation      3/23 (46) 0.5242 0.2801 BioCarta//Hs_Hypoxia and p53 in the Cardiovascular system      3/22 (37) 0.4932 0.2830

Cluster 3 has 288 gene products

ArrayXPath has identified 188 out of 288 input elements in 273 out of 346 BioCarta pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value BioCarta//Hs_Toll-Like Receptor Pathway      4/34 (45) 0.5214 0.1311 BioCarta//Hs_Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)      10/54 (64) 0.0632 0.1311 BioCarta//Hs_FAS signaling pathway ( CD95 )      3/30 (34) 0.6555 0.1311 BioCarta//Hs_HIV-I Nef: negative effector of Fas and TNF      8/57 (77) 0.2815 0.1311 BioCarta//Hs_Induction of apoptosis through DR3 and DR4/5 Death Receptors      5/32 (37) 0.2687 0.1311 BioCarta//Hs_Apoptotic Signaling in Response to DNA Damage      6/21 (29) 0.0211 0.1311 BioCarta//Hs_EGF Signaling Pathway      6/27 (54) 0.0664 0.1311 BioCarta//Hs_IL-10 Anti-inflammatory Signaling Pathway      2/13 (17) 0.4254 0.1311 BioCarta//Hs_MAPKinase Signaling Pathway      10/85 (88) 0.4569 0.1311 BioCarta//Hs_p38 MAPK Signaling Pathway      4/38 (40) 0.6131 0.1311 BioCarta//Hs_PDGF Signaling Pathway      7/27 (61) 0.0222 0.1311 BioCarta//Hs_TPO Signaling Pathway      6/23 (54) 0.0327 0.1311 BioCarta//Hs_Bioactive Peptide Induced Signaling Pathway      7/38 (58) 0.1135 0.1311 BioCarta//Hs_ER-associated degradation (ERAD) Pathway      1/13 (20) 0.7801 0.1311 BioCarta//Hs_Regulation of p27 Phosphorylation during Cell Cycle Progression      1/13 (20) 0.7801 0.1311 BioCarta//Hs_Selective expression of chemokine receptors during T-cell polarization      3/29 (55) 0.6320 0.1311 BioCarta//Hs_Agrin in Postsynaptic Differentiation      4/39 (50) 0.6342 0.1311 BioCarta//Hs_Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages      2/25 (42) 0.7784 0.1311 BioCarta//Hs_VEGF, Hypoxia, and Angiogenesis      6/28 (34) 0.0771 0.1311 BioCarta//Hs_Eicosanoid Metabolism      6/20 (20) 0.0166 0.1311 BioCarta//Hs_Aspirin Blocks Signaling Pathway Involved in Platelet Activation      6/22 (32) 0.0265 0.1311 BioCarta//Hs_Cytokines and Inflammatory Response      3/27 (78) 0.5819 0.1311 BioCarta//Hs_Hypoxia and p53 in the Cardiovascular system      5/22 (37) 0.0839 0.1311 BioCarta//Hs_NFAT and Hypertrophy of the heart (Transcription in the broken heart)      5/51 (82) 0.6740 0.1311 BioCarta//Hs_Regulation of BAD phosphorylation      4/22 (31) 0.2148 0.1311 BioCarta//Hs_Repression of Pain Sensation by the Transcriptional Regulator DREAM      3/14 (21) 0.1916 0.1311 BioCarta//Hs_Signaling Pathway from G-Protein Families      5/34 (42) 0.3134 0.1311 BioCarta//Hs_Stathmin and breast cancer resistance to antimicrotubule agents      4/23 (26) 0.2393 0.1311 BioCarta//Hs_Transcription factor CREB and its extracellular signals      4/26 (26) 0.3162 0.1311 BioCarta//Hs_Actions of Nitric Oxide in the Heart      6/30 (44) 0.1014 0.1311 BioCarta//Hs_IL-2 Receptor Beta Chain in T cell Activation      3/35 (38) 0.7567 0.1311 BioCarta//Hs_Deregulation of CDK5 in Alzheimers Disease      3/10 (16) 0.0870 0.1311 BioCarta//Hs_Integrin Signaling Pathway      5/37 (45) 0.3820 0.1311 BioCarta//Hs_Effects of calcineurin in Keratinocyte Differentiation      2/18 (36) 0.6034 0.1311 BioCarta//Hs_ATM Signaling Pathway      5/19 (32) 0.0484 0.1311 BioCarta//Hs_Intrinsic Prothrombin Activation Pathway      5/23 (36) 0.0981 0.1311 BioCarta//Hs_T Cell Receptor Signaling Pathway      5/43 (56) 0.5168 0.1311 BioCarta//Hs_Ahr Signal Transduction Pathway      2/4 (12) 0.0617 0.1311 BioCarta//Hs_Rho cell motility signaling pathway      4/30 (32) 0.4208 0.1311 BioCarta//Hs_Phospholipids as signalling intermediaries      4/25 (42) 0.2902 0.1311 BioCarta//Hs_Synaptic Proteins at the Synaptic Junction      3/20 (32) 0.3779 0.1311 BioCarta//Hs_fMLP induced chemokine gene expression in HMC-1 cells      3/36 (58) 0.7738 0.1311 BioCarta//Hs_Role of ?arrestins in the activation and targeting of MAP kinases      3/17 (40) 0.2833 0.1311 BioCarta//Hs_CCR3 signaling in Eosinophils      3/23 (30) 0.4698 0.1311 BioCarta//Hs_Cadmium induces DNA synthesis and proliferation in macrophages      4/15 (21) 0.0724 0.1311 BioCarta//Hs_Activation of PKC through G protein coupled receptor      2/7 (8) 0.1736 0.1311 BioCarta//Hs_Extrinsic Prothrombin Activation Pathway      3/13 (24) 0.1630 0.1311 BioCarta//Hs_Circadian Rhythms      3/6 (13) 0.0201 0.1311 BioCarta//Hs_Regulation of eIF4e and p70 S6 Kinase      3/24 (37) 0.4992 0.1311 BioCarta//Hs_IGF-1 Signaling Pathway      4/20 (45) 0.1681 0.1311 BioCarta//Hs_Signaling of Hepatocyte Growth Factor Receptor      5/36 (42) 0.3591 0.1311 BioCarta//Hs_Proteasome Complex      3/19 (24) 0.3464 0.1311 BioCarta//Hs_Map Kinase Inactivation of SMRT Corepressor      3/11 (14) 0.1103 0.1311 BioCarta//Hs_Biosynthesis of threonine and methionine      1/2 (2) 0.2072 0.1311 BioCarta//Hs_Feeder Pathways for Glycolysis      2/9 (11) 0.2583 0.1311 BioCarta//Hs_Ceramide Signaling Pathway      4/21 (21) 0.1910 0.1311 BioCarta//Hs_CXCR4 Signaling Pathway      2/24 (35) 0.7583 0.1311 BioCarta//Hs_EPO Signaling Pathway      2/19 (36) 0.6336 0.1311 BioCarta//Hs_Erk1/Erk2 Mapk Signaling pathway      5/28 (33) 0.1849 0.1311 BioCarta//Hs_Human Cytomegalovirus and Map Kinase Pathways      2/16 (17) 0.5374 0.1311 BioCarta//Hs_IL 2 signaling pathway      2/22 (47) 0.7135 0.1311 BioCarta//Hs_IL 6 signaling pathway      3/21 (48) 0.4091 0.1311 BioCarta//Hs_Keratinocyte Differentiation      4/46 (67) 0.7609 0.1311 BioCarta//Hs_Links between Pyk2 and Map Kinases      3/28 (44) 0.6075 0.1311 BioCarta//Hs_Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation      2/15 (29) 0.5018 0.1311 BioCarta//Hs_Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway      3/12 (16) 0.1358 0.1311 BioCarta//Hs_Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling      4/33 (44) 0.4969 0.1311 BioCarta//Hs_Regulation of PGC-1a      2/23 (31) 0.7367 0.1311 BioCarta//Hs_Role of MEF2D in T-cell Apoptosis      3/16 (45) 0.2521 0.1311 BioCarta//Hs_Nuclear Receptors in Lipid Metabolism and Toxicity      3/34 (43) 0.7385 0.1311 BioCarta//Hs_Small Leucine-rich Proteoglycan (SLRP) molecules      2/6 (6) 0.1333 0.1311 BioCarta//Hs_Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility      2/21 (25) 0.6886 0.1311 BioCarta//Hs_Fibrinolysis Pathway      2/11 (14) 0.3435 0.1311 BioCarta//Hs_Telomeres, Telomerase, Cellular Aging, and Immortality      3/18 (31) 0.3148 0.1311 BioCarta//Hs_Opposing roles of AIF in Apoptosis and Cell Survival      1/3 (8) 0.2942 0.1311 BioCarta//Hs_Hypoxia-Inducible Factor in the Cardiovascular System      3/15 (20) 0.2214 0.1311 BioCarta//Hs_Degradation of the RAR and RXR by the proteasome      2/3 (11) 0.0332 0.1311 BioCarta//Hs_FXR and LXR Regulation of Cholesterol Metabolism      2/8 (14) 0.2156 0.1311 BioCarta//Hs_Role of Ran in mitotic spindle regulation      1/10 (15) 0.6878 0.1311 BioCarta//Hs_Proepithelin Conversion to Epithelin and Wound Repair Control      1/6 (40) 0.5022 0.1311 BioCarta//Hs_Adhesion and Diapedesis of Lymphocytes      2/14 (47) 0.4644 0.1311 BioCarta//Hs_Monocyte and its Surface Molecules      1/11 (12) 0.7222 0.1311 BioCarta//Hs_The PRC2 Complex sets Long-term gene Silencing The Modification of Histone Tails      1/12 (20) 0.7529 0.1311 BioCarta//Hs_Trka Receptor Signaling Pathway      2/12 (12) 0.3850 0.1311 BioCarta//Hs_RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage      1/13 (17) 0.7801 0.1311 BioCarta//Hs_Regulation of cell cycle progression by Plk3      1/8 (17) 0.6057 0.1311 BioCarta//Hs_Mechanism of Protein Import into the Nucleus      1/9 (19) 0.6491 0.1311 BioCarta//Hs_Sumoylation by RanBP2 Regulates Transcriptional Repression      2/10 (25) 0.3011 0.1311 BioCarta//Hs_g-Secretase mediated ErbB4 Signaling Pathway      1/7 (19) 0.5569 0.1311 BioCarta//Hs_Oxidative Stress Induced Gene Expression Via Nrf2      2/20 (24) 0.6620 0.1311 BioCarta//Hs_Pertussis toxin-insensitive CCR5 Signaling in Macrophage      2/17 (38) 0.5713 0.1311 BioCarta//Hs_Phospholipase C d1 in phospholipid associated cell signaling      1/5 (10) 0.4407 0.1311 BioCarta//Hs_Transcriptional activation of dbpb from mRNA      1/4 (9) 0.3717 0.1311 BioCarta//Hs_IL12 and Stat4 Dependent Signaling Pathway in Th1 Development      2/21 (27) 0.6886 0.1312 BioCarta//Hs_Control of Gene Expression by Vitamin D Receptor      2/24 (32) 0.7583 0.1313 BioCarta//Hs_mTOR Signaling Pathway      2/24 (44) 0.7583 0.1313 BioCarta//Hs_Fc Epsilon Receptor I Signaling in Mast Cells      3/38 (49) 0.8050 0.1314 BioCarta//Hs_Growth Hormone Signaling Pathway      2/26 (35) 0.7969 0.1314 BioCarta//Hs_Bone Remodelling      1/14 (19) 0.8044 0.1314 BioCarta//Hs_Lectin Induced Complement Pathway      2/12 (56) 0.3850 0.1316 BioCarta//Hs_Cystic fibrosis transmembrane conductance regulator and beta 2 adrenergic receptor pathway      2/12 (37) 0.3850 0.1316 BioCarta//Hs_Rab GTPases Mark Targets In The Endocytotic Machinery      2/12 (17) 0.3850 0.1316 BioCarta//Hs_Role of Parkin in the Ubiquitin-Proteasomal Pathway      2/12 (38) 0.3850 0.1316 BioCarta//Hs_Spliceosomal Assembly      1/14 (14) 0.8044 0.1319 BioCarta//Hs_The IGF-1 Receptor and Longevity      1/14 (14) 0.8044 0.1319 BioCarta//Hs_Multi-step Regulation of Transcription by Pitx2      1/16 (38) 0.8453 0.1321 BioCarta//Hs_The Co-Stimulatory Signal During T-cell Activation      1/16 (40) 0.8453 0.1321 BioCarta//Hs_Downregulated of MTA-3 in ER-negative Breast Tumors      1/16 (23) 0.8453 0.1321 BioCarta//Hs_Steps in the Glycosylation of Mammalian N-linked Oligosaccarides      1/16 (16) 0.8453 0.1321 BioCarta//Hs_Acetylation and Deacetylation of RelA in The Nucleus      1/16 (34) 0.8453 0.1321 BioCarta//Hs_Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)      2/28 (41) 0.8301 0.1321 BioCarta//Hs_IL-7 Signal Transduction      1/16 (29) 0.8453 0.1321 BioCarta//Hs_Adhesion and Diapedesis of Granulocytes      1/15 (49) 0.8260 0.1321 BioCarta//Hs_Chaperones modulate interferon Signaling Pathway      1/16 (34) 0.8453 0.1321 BioCarta//Hs_Eukaryotic protein translation      3/15 (20) 0.2214 0.1322 BioCarta//Hs_Regulation of hematopoiesis by cytokines      3/15 (41) 0.2214 0.1322 BioCarta//Hs_Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration      3/15 (15) 0.2214 0.1322 BioCarta//Hs_PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase      3/15 (18) 0.2214 0.1322 BioCarta//Hs_Glycolysis Pathway      1/10 (21) 0.6878 0.1323 BioCarta//Hs_Apoptotic DNA fragmentation and tissue homeostasis      1/10 (15) 0.6878 0.1323 BioCarta//Hs_E2F1 Destruction Pathway      1/10 (16) 0.6878 0.1323 BioCarta//Hs_Double Stranded RNA Induced Gene Expression      1/10 (14) 0.6878 0.1323 BioCarta//Hs_Eph Kinases and ephrins support platelet aggregation      1/10 (17) 0.6878 0.1323 BioCarta//Hs_SODD/TNFR1 Signaling Pathway      1/10 (18) 0.6878 0.1323 BioCarta//Hs_CARM1 and Regulation of the Estrogen Receptor      2/26 (33) 0.7969 0.1323 BioCarta//Hs_Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells      2/26 (43) 0.7969 0.1323 BioCarta//Hs_Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway      2/20 (23) 0.6620 0.1324 BioCarta//Hs_Acute Myocardial Infarction      2/20 (23) 0.6620 0.1324 BioCarta//Hs_IFN alpha signaling pathway      1/9 (25) 0.6491 0.1325 BioCarta//Hs_Cyclin E Destruction Pathway      1/9 (14) 0.6491 0.1325 BioCarta//Hs_Regulation of eIF2      1/9 (20) 0.6491 0.1325 BioCarta//Hs_Polyadenylation of mRNA      1/9 (35) 0.6491 0.1325 BioCarta//Hs_B Lymphocyte Cell Surface Molecules      1/9 (10) 0.6491 0.1325 BioCarta//Hs_Cardiac Protection Against ROS      1/9 (9) 0.6491 0.1325 BioCarta//Hs_Visual Signal Transduction      1/9 (12) 0.6491 0.1325 BioCarta//Hs_Signal Dependent Regulation of Myogenesis by Corepressor MITR      1/9 (25) 0.6491 0.1325 BioCarta//Hs_Adhesion Molecules on Lymphocyte      1/9 (10) 0.6491 0.1325 BioCarta//Hs_cdc25 and chk1 Regulatory Pathway in response to DNA damage      1/9 (13) 0.6491 0.1325 BioCarta//Hs_WNT Signaling Pathway      2/25 (42) 0.7784 0.1325 BioCarta//Hs_D4-GDI Signaling Pathway      1/12 (15) 0.7529 0.1327 BioCarta//Hs_CTL mediated immune response against target cells      1/12 (25) 0.7529 0.1327 BioCarta//Hs_Gamma-aminobutyric Acid Receptor Life Cycle      1/12 (73) 0.7529 0.1327 BioCarta//Hs_Ca++/ Calmodulin-dependent Protein Kinase Activation      1/12 (76) 0.7529 0.1327 BioCarta//Hs_IFN gamma signaling pathway      1/6 (28) 0.5022 0.1330 BioCarta//Hs_Pelp1 Modulation of Estrogen Receptor Activity      1/6 (10) 0.5022 0.1330 BioCarta//Hs_Visceral Fat Deposits and the Metabolic Syndrome      1/6 (9) 0.5022 0.1330 BioCarta//Hs_ALK in cardiac myocytes      3/34 (51) 0.7385 0.1331 BioCarta//Hs_BCR Signaling Pathway      3/34 (54) 0.7385 0.1331 BioCarta//Hs_beta-arrestins in GPCR Desensitization      1/15 (40) 0.8260 0.1332 BioCarta//Hs_Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to fa      1/15 (28) 0.8260 0.1332 BioCarta//Hs_Cyclins and Cell Cycle Regulation      3/23 (46) 0.4698 0.1333 BioCarta//Hs_Stress Induction of HSP Regulation      2/14 (22) 0.4644 0.1336 BioCarta//Hs_B Cell Survival Pathway      2/14 (16) 0.4644 0.1336 BioCarta//Hs_Classical Complement Pathway      2/14 (68) 0.4644 0.1336 BioCarta//Hs_Protein Kinase A at the Centrosome      2/14 (28) 0.4644 0.1336 BioCarta//Hs_Estrogen-responsive protein Efp controls cell cycle and breast tumors growth      2/14 (59) 0.4644 0.1336 BioCarta//Hs_TACI and BCMA stimulation of B cell immune responses.      2/14 (21) 0.4644 0.1336 BioCarta//Hs_Platelet Amyloid Precursor Protein Pathway      2/14 (15) 0.4644 0.1336 BioCarta//Hs_CDK Regulation of DNA Replication      1/17 (56) 0.8624 0.1337 BioCarta//Hs_Role of Erk5 in Neuronal Survival      1/17 (36) 0.8624 0.1337 BioCarta//Hs_BTG family proteins and cell cycle regulation      1/11 (13) 0.7222 0.1337 BioCarta//Hs_Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle      1/11 (30) 0.7222 0.1337 BioCarta//Hs_Granzyme A mediated Apoptosis Pathway      1/11 (28) 0.7222 0.1337 BioCarta//Hs_Sprouty regulation of tyrosine kinase signals      3/18 (31) 0.3148 0.1340 BioCarta//Hs_Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy      3/18 (31) 0.3148 0.1340 BioCarta//Hs_Nerve growth factor pathway (NGF)      3/18 (38) 0.3148 0.1340 BioCarta//Hs_ADP-Ribosylation Factor      3/21 (57) 0.4091 0.1341 BioCarta//Hs_Role of ERBB2 in Signal Transduction and Oncology      3/21 (34) 0.4091 0.1341 BioCarta//Hs_Roles of ?arrestin-dependent Recruitment of Src Kinases in GPCR Signaling      3/21 (34) 0.4091 0.1341 BioCarta//Hs_Insulin Signaling Pathway      3/21 (48) 0.4091 0.1341 BioCarta//Hs_NF-kB Signaling Pathway      2/23 (49) 0.7367 0.1346 BioCarta//Hs_CTCF: First Multivalent Nuclear Factor      2/23 (26) 0.7367 0.1346 BioCarta//Hs_Ras Signaling Pathway      2/22 (23) 0.7135 0.1346 BioCarta//Hs_The 4-1BB-dependent immune response      1/18 (22) 0.8777 0.1350 BioCarta//Hs_TNFR2 Signaling Pathway      1/18 (32) 0.8777 0.1350 BioCarta//Hs_Inhibition of Huntingtons disease neurodegeneration by histone deacetylase inhibitors      1/4 (9) 0.3717 0.1351 BioCarta//Hs_Formation of Ketone Bodies from acetyl-CoA      1/4 (4) 0.3717 0.1351 BioCarta//Hs_T Cell Receptor and CD3 Complex      1/4 (19) 0.3717 0.1351 BioCarta//Hs_Generation of amyloid b-peptide by PS1      1/4 (9) 0.3717 0.1351 BioCarta//Hs_Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine      1/4 (4) 0.3717 0.1351 BioCarta//Hs_Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression      1/4 (7) 0.3717 0.1351 BioCarta//Hs_Basic Mechanisms of SUMOylation      1/4 (25) 0.3717 0.1351 BioCarta//Hs_Antigen Dependent B Cell Activation      2/10 (24) 0.3011 0.1353 BioCarta//Hs_Free Radical Induced Apoptosis      2/10 (11) 0.3011 0.1353 BioCarta//Hs_Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor recycling      1/5 (21) 0.4407 0.1356 BioCarta//Hs_Blockade of Neurotransmitter Relase by Botulinum Toxin      1/5 (28) 0.4407 0.1356 BioCarta//Hs_Cycling of Ran in nucleocytoplasmic transport      1/5 (8) 0.4407 0.1356 BioCarta//Hs_Ion Channel and Phorbal Esters Signaling Pathway      1/5 (7) 0.4407 0.1356 BioCarta//Hs_How Progesterone Initiates the Oocyte Maturation      4/30 (32) 0.4208 0.1357 BioCarta//Hs_Role of Tob in T-cell activation      1/19 (30) 0.8912 0.1361 BioCarta//Hs_Ras-Independent pathway in NK cell-mediated cytotoxicity      1/19 (19) 0.8912 0.1361 BioCarta//Hs_CD40L Signaling Pathway      2/15 (27) 0.5018 0.1365 BioCarta//Hs_IL 3 signaling pathway      2/15 (30) 0.5018 0.1365 BioCarta//Hs_HIV-1 defeats host-mediated resistance by CEM15      1/3 (5) 0.2942 0.1368 BioCarta//Hs_Nitrogen-depedent regulation of Rtg1 and Rtg3 in TOR pathway      1/3 (8) 0.2942 0.1368 BioCarta//Hs_Biosynthesis of Arginine in Bacteria      1/3 (3) 0.2942 0.1368 BioCarta//Hs_Role of MAL in Rho-Mediated Activation of SRF      3/19 (26) 0.3464 0.1372 BioCarta//Hs_Ion Channels and Their Functional Role in Vascular Endothelium      1/20 (20) 0.9033 0.1374 BioCarta//Hs_G-Protein Signaling Through Tubby Proteins      1/7 (11) 0.5569 0.1375 BioCarta//Hs_Regulation of Splicing through Sam68      1/7 (8) 0.5569 0.1375 BioCarta//Hs_The reactions that feed amino groups into the urea cycle      1/7 (16) 0.5569 0.1375 BioCarta//Hs_Melanocyte Development and Pigmentation Pathway      1/7 (13) 0.5569 0.1375 BioCarta//Hs_The role of FYVE-finger proteins in vesicle transport      1/7 (35) 0.5569 0.1375 BioCarta//Hs_TGF beta signaling pathway      2/19 (76) 0.6336 0.1377 BioCarta//Hs_Complement Pathway      2/19 (33) 0.6336 0.1377 BioCarta//Hs_ChREBP regulation by carbohydrates and cAMP      2/19 (30) 0.6336 0.1377 BioCarta//Hs_Lissencephaly gene (LIS1) in neuronal migration and development      2/19 (48) 0.6336 0.1377 BioCarta//Hs_Role of PPAR-gamma Coactivators in Obesity and Thermogenesis      2/9 (12) 0.2583 0.1378 BioCarta//Hs_HIV Induced T Cell Apoptosis      2/9 (23) 0.2583 0.1378 BioCarta//Hs_Lck and Fyn tyrosine kinases in initiation of TCR Activation      2/9 (16) 0.2583 0.1378 BioCarta//Hs_GATA3 participate in activating the Th2 cytokine genes expression      2/16 (25) 0.5374 0.1378 BioCarta//Hs_Sonic Hedgehog (Shh) Pathway      2/16 (29) 0.5374 0.1378 BioCarta//Hs_Cell Cycle: G1/S Check Point      3/28 (34) 0.6075 0.1381 BioCarta//Hs_Caspase Cascade in Apoptosis      1/22 (27) 0.9236 0.1384 BioCarta//Hs_Dendritic cells in regulating TH1 and TH2 Development      1/22 (25) 0.9236 0.1384 BioCarta//Hs_Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia      1/22 (40) 0.9236 0.1384 BioCarta//Hs_Cytokine Network      1/22 (103) 0.9236 0.1384 BioCarta//Hs_NO2-dependent IL 12 Pathway in NK cells      2/17 (20) 0.5713 0.1385 BioCarta//Hs_Cells and Molecules involved in local acute inflammatory response      2/17 (19) 0.5713 0.1385 BioCarta//Hs_Cell Cycle: G2/M Checkpoint      3/24 (27) 0.4992 0.1387 BioCarta//Hs_Activation of Src by Protein-tyrosine phosphatase alpha      2/11 (29) 0.3435 0.1388 BioCarta//Hs_Vitamin C in the Brain      2/11 (20) 0.3435 0.1388 BioCarta//Hs_AKAP95 role in mitosis and chromosome dynamics      2/11 (39) 0.3435 0.1388 BioCarta//Hs_Phospholipase C Signaling Pathway      2/8 (12) 0.2156 0.1391 BioCarta//Hs_RNA polymerase III transcription      2/8 (22) 0.2156 0.1391 BioCarta//Hs_Internal Ribosome entry pathway      2/8 (39) 0.2156 0.1391 BioCarta//Hs_Phosphoinositides and their downstream targets.      1/23 (23) 0.9321 0.1391 BioCarta//Hs_Trefoil Factors Initiate Mucosal Healing      1/24 (95) 0.9396 0.1392 BioCarta//Hs_NFkB activation by Nontypeable Hemophilus influenzae      1/24 (43) 0.9396 0.1392 BioCarta//Hs_IL 5 Signaling Pathway      1/8 (19) 0.6057 0.1392 BioCarta//Hs_Antigen Processing and Presentation      1/8 (16) 0.6057 0.1392 BioCarta//Hs_Shuttle for transfer of acetyl groups from mitochondria to the cytosol      1/8 (11) 0.6057 0.1392 BioCarta//Hs_The Citric Acid Cycle      1/8 (9) 0.6057 0.1392 BioCarta//Hs_Stat3 Signaling Pathway      1/8 (13) 0.6057 0.1392 BioCarta//Hs_TNF/Stress Related Signaling      1/25 (31) 0.9463 0.1397 BioCarta//Hs_Regulation of ck1/cdk5 by type 1 glutamate receptors      3/17 (38) 0.2833 0.1399 BioCarta//Hs_uCalpain and friends in Cell spread      3/17 (36) 0.2833 0.1399 BioCarta//Hs_Y branching of actin filaments      3/17 (45) 0.2833 0.1399 BioCarta//Hs_Influence of Ras and Rho proteins on G1 to S Transition      1/26 (33) 0.9523 0.1400 BioCarta//Hs_TNFR1 Signaling Pathway      3/29 (36) 0.6320 0.1412 BioCarta//Hs_METS affect on Macrophage Differentiation      3/16 (30) 0.2521 0.1420 BioCarta//Hs_p53 Signaling Pathway      3/16 (27) 0.2521 0.1420 BioCarta//Hs_Signal transduction through IL1R      1/30 (41) 0.9703 0.1422 BioCarta//Hs_IL22 Soluble Receptor Signaling Pathway      3/12 (40) 0.1358 0.1429 BioCarta//Hs_T Helper Cell Surface Molecules      3/12 (12) 0.1358 0.1429 BioCarta//Hs_T Cytotoxic Cell Surface Molecules      3/12 (12) 0.1358 0.1429 BioCarta//Hs_Phospholipase C-epsilon pathway      3/12 (25) 0.1358 0.1429 BioCarta//Hs_How does salmonella hijack a cell      3/12 (32) 0.1358 0.1429 BioCarta//Hs_Tumor Suppressor Arf Inhibits Ribosomal Biogenesis      3/12 (17) 0.1358 0.1429 BioCarta//Hs_Th1/Th2 Differentiation      2/18 (88) 0.6034 0.1437 BioCarta//Hs_Mechanisms of transcriptionalrepression by DNA methylation      3/14 (20) 0.1916 0.1474 BioCarta//Hs_Inhibition of Cellular Proliferation by Gleevec      4/22 (23) 0.2148 0.1481 BioCarta//Hs_mCalpain and friends in Cell motility      4/22 (38) 0.2148 0.1481 BioCarta//Hs_Role of Mitochondria in Apoptotic Signaling      4/20 (38) 0.1681 0.1494 BioCarta//Hs_Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor      4/20 (24) 0.1681 0.1494 BioCarta//Hs_Phosphatidylcholine Biosynthesis Pathway      1/2 (2) 0.2072 0.1507 BioCarta//Hs_Biosynthesis of Cysteine in mammals      1/2 (2) 0.2072 0.1507 BioCarta//Hs_Nitric Oxide Signaling Pathway      4/21 (25) 0.1910 0.1528 BioCarta//Hs_Thrombin signaling and protease-activated receptors      4/21 (31) 0.1910 0.1528 BioCarta//Hs_CBL mediated ligand-induced downregulation of EGF receptors      3/13 (51) 0.1630 0.1552 BioCarta//Hs_Transcription Regulation by Methyltransferase of CARM1      3/13 (34) 0.1630 0.1552 BioCarta//Hs_Attenuation of GPCR Signaling      3/13 (13) 0.1630 0.1552 BioCarta//Hs_TSP-1 Induced Apoptosis in Microvascular Endothelial Cell      2/6 (9) 0.1333 0.1720 BioCarta//Hs_Mechanism of Acetaminophen Activity and Toxicity      2/6 (7) 0.1333 0.1720 BioCarta//Hs_Bystander B Cell Activation      2/6 (15) 0.1333 0.1720 BioCarta//Hs_Metabolism of Anandamide, an Endogenous Cannabinoid      2/6 (13) 0.1333 0.1720 BioCarta//Hs_Beta-Oxidation of Fatty Acids      2/6 (6) 0.1333 0.1720 BioCarta//Hs_Prion Pathway      3/11 (11) 0.1103 0.1839 BioCarta//Hs_Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation      3/11 (35) 0.1103 0.1839 BioCarta//Hs_Erythropoietin mediated neuroprotection through NF-kB      3/11 (17) 0.1103 0.1839 BioCarta//Hs_Regulators of Bone Mineralization      3/10 (57) 0.0870 0.1933 BioCarta//Hs_IL 17 Signaling Pathway      4/15 (16) 0.0724 0.2069 BioCarta//Hs_Anthrax Toxin Mechanism of Action      2/2 (2) 0.0119 0.4778

Cluster 4 has 283 gene products

ArrayXPath has identified 193 out of 283 input elements in 254 out of 346 BioCarta pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value BioCarta//Hs_TSP-1 Induced Apoptosis in Microvascular Endothelial Cell      4/6 (9) 0.0020 0.0391 BioCarta//Hs_Signal transduction through IL1R      9/30 (41) 0.0042 0.0418 BioCarta//Hs_ATM Signaling Pathway      7/19 (32) 0.0032 0.0418 BioCarta//Hs_D4-GDI Signaling Pathway      5/12 (15) 0.0070 0.0425 BioCarta//Hs_HIV-I Nef: negative effector of Fas and TNF      13/57 (77) 0.0085 0.0425 BioCarta//Hs_AKT Signaling Pathway      7/21 (32) 0.0060 0.0425 BioCarta//Hs_Neutrophil and Its Surface Molecules      4/8 (12) 0.0076 0.0425 BioCarta//Hs_Adhesion Molecules on Lymphocyte      4/9 (10) 0.0125 0.0554 BioCarta//Hs_Bone Remodelling      5/14 (19) 0.0147 0.0589 BioCarta//Hs_IFN alpha signaling pathway      5/9 (25) 0.0015 0.0595 BioCarta//Hs_Double Stranded RNA Induced Gene Expression      4/10 (14) 0.0190 0.0690 BioCarta//Hs_Keratinocyte Differentiation      10/46 (67) 0.0279 0.0747 BioCarta//Hs_IL22 Soluble Receptor Signaling Pathway      4/12 (40) 0.0374 0.0747 BioCarta//Hs_IL 2 signaling pathway      6/22 (47) 0.0301 0.0747 BioCarta//Hs_Pertussis toxin-insensitive CCR5 Signaling in Macrophage      5/17 (38) 0.0344 0.0747 BioCarta//Hs_IL-2 Receptor Beta Chain in T cell Activation      8/35 (38) 0.0360 0.0747 BioCarta//Hs_Erythropoietin mediated neuroprotection through NF-kB      4/11 (17) 0.0273 0.0747 BioCarta//Hs_Biosynthesis of Arginine in Bacteria      2/3 (3) 0.0351 0.0747 BioCarta//Hs_FAS signaling pathway ( CD95 )      7/30 (34) 0.0440 0.0748 BioCarta//Hs_The 4-1BB-dependent immune response      5/18 (22) 0.0434 0.0748 BioCarta//Hs_Cell Cycle: G2/M Checkpoint      6/24 (27) 0.0449 0.0748 BioCarta//Hs_Caspase Cascade in Apoptosis      6/22 (27) 0.0301 0.0752 BioCarta//Hs_Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy      5/18 (31) 0.0434 0.0789 BioCarta//Hs_IL-10 Anti-inflammatory Signaling Pathway      4/13 (17) 0.0493 0.0790 BioCarta//Hs_Induction of apoptosis through DR3 and DR4/5 Death Receptors      7/32 (37) 0.0600 0.0815 BioCarta//Hs_Stress Induction of HSP Regulation      4/14 (22) 0.0632 0.0815 BioCarta//Hs_TNF/Stress Related Signaling      6/25 (31) 0.0537 0.0815 BioCarta//Hs_Adhesion and Diapedesis of Lymphocytes      4/14 (47) 0.0632 0.0815 BioCarta//Hs_Segmentation Clock      4/14 (20) 0.0632 0.0815 BioCarta//Hs_TACI and BCMA stimulation of B cell immune responses.      4/14 (21) 0.0632 0.0815 BioCarta//Hs_Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway      5/20 (23) 0.0653 0.0816 BioCarta//Hs_Inhibition of Matrix Metalloproteinases      3/9 (15) 0.0709 0.0834 BioCarta//Hs_Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases      3/9 (9) 0.0709 0.0834 BioCarta//Hs_Toll-Like Receptor Pathway      7/34 (45) 0.0793 0.0834 BioCarta//Hs_EGF Signaling Pathway      6/27 (54) 0.0743 0.0834 BioCarta//Hs_Adhesion and Diapedesis of Granulocytes      4/15 (49) 0.0789 0.0834 BioCarta//Hs_Ceramide Signaling Pathway      5/21 (21) 0.0782 0.0834 BioCarta//Hs_Monocyte and its Surface Molecules      4/11 (12) 0.0273 0.0839 BioCarta//Hs_fMLP induced chemokine gene expression in HMC-1 cells      7/36 (58) 0.1016 0.0869 BioCarta//Hs_Cell Cycle: G1/S Check Point      6/28 (34) 0.0861 0.0869 BioCarta//Hs_Inhibition of Cellular Proliferation by Gleevec      5/22 (23) 0.0924 0.0869 BioCarta//Hs_T Cell Receptor Signaling Pathway      8/43 (56) 0.1021 0.0869 BioCarta//Hs_TNFR1 Signaling Pathway      6/29 (36) 0.0989 0.0869 BioCarta//Hs_Downregulated of MTA-3 in ER-negative Breast Tumors      4/16 (23) 0.0963 0.0869 BioCarta//Hs_Blockade of Neurotransmitter Relase by Botulinum Toxin      2/5 (28) 0.1005 0.0869 BioCarta//Hs_Human Cytomegalovirus and Map Kinase Pathways      4/16 (17) 0.0963 0.0895 BioCarta//Hs_IL-7 Signal Transduction      4/16 (29) 0.0963 0.0895 BioCarta//Hs_NFAT and Hypertrophy of the heart (Transcription in the broken heart)      9/51 (82) 0.1114 0.0920 BioCarta//Hs_Catabolic pathway for asparagine and asparate      1/1 (1) 0.1127 0.0920 BioCarta//Hs_Corticosteroids and cardioprotection      4/17 (28) 0.1153 0.0922 BioCarta//Hs_BTG family proteins and cell cycle regulation      3/11 (13) 0.1178 0.0924 BioCarta//Hs_NFkB activation by Nontypeable Hemophilus influenzae      5/24 (43) 0.1243 0.0946 BioCarta//Hs_TNFR2 Signaling Pathway      4/18 (32) 0.1358 0.0946 BioCarta//Hs_Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages      5/25 (42) 0.1420 0.0946 BioCarta//Hs_Proepithelin Conversion to Epithelin and Wound Repair Control      2/6 (40) 0.1398 0.0946 BioCarta//Hs_Regulation of Spermatogenesis by CREM      2/6 (14) 0.1398 0.0948 BioCarta//Hs_IFN gamma signaling pathway      2/6 (28) 0.1398 0.0948 BioCarta//Hs_Proteolysis and Signaling Pathway of Notch      2/6 (20) 0.1398 0.0948 BioCarta//Hs_SUMOylation as a mechanism to modulate CtBP-dependent gene responses      2/6 (11) 0.1398 0.0948 BioCarta//Hs_Multi-Drug Resistance Factors      2/6 (14) 0.1398 0.0948 BioCarta//Hs_CTL mediated immune response against target cells      3/12 (25) 0.1447 0.0949 BioCarta//Hs_Influence of Ras and Rho proteins on G1 to S Transition      5/26 (33) 0.1606 0.0996 BioCarta//Hs_Oxidative Stress Induced Gene Expression Via Nrf2      4/20 (24) 0.1808 0.0996 BioCarta//Hs_PDGF Signaling Pathway      5/27 (61) 0.1802 0.0996 BioCarta//Hs_Ras-Independent pathway in NK cell-mediated cytotoxicity      4/19 (19) 0.1577 0.0996 BioCarta//Hs_Activation of PKC through G protein coupled receptor      2/7 (8) 0.1818 0.0996 BioCarta//Hs_The reactions that feed amino groups into the urea cycle      2/7 (16) 0.1818 0.0996 BioCarta//Hs_RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage      3/13 (17) 0.1733 0.0996 BioCarta//Hs_EPO Signaling Pathway      4/19 (36) 0.1577 0.1002 BioCarta//Hs_IGF-1 Signaling Pathway      4/20 (45) 0.1808 0.1019 BioCarta//Hs_CBL mediated ligand-induced downregulation of EGF receptors      3/13 (51) 0.1733 0.1019 BioCarta//Hs_ER-associated degradation (ERAD) Pathway      3/13 (20) 0.1733 0.1019 BioCarta//Hs_Hemoglobins Chaperone      3/13 (31) 0.1733 0.1019 BioCarta//Hs_IL12 and Stat4 Dependent Signaling Pathway in Th1 Development      4/21 (27) 0.2050 0.1025 BioCarta//Hs_Insulin Signaling Pathway      4/21 (48) 0.2050 0.1025 BioCarta//Hs_The IGF-1 Receptor and Longevity      3/14 (14) 0.2033 0.1025 BioCarta//Hs_Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility      4/21 (25) 0.2050 0.1025 BioCarta//Hs_Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)      5/28 (41) 0.2007 0.1025 BioCarta//Hs_Hop Pathway in Cardiac Development      1/2 (9) 0.2128 0.1051 BioCarta//Hs_Cadmium induces DNA synthesis and proliferation in macrophages      3/15 (21) 0.2344 0.1053 BioCarta//Hs_Endocytotic role of NDK, Phosphins and Dynamin      3/15 (48) 0.2344 0.1053 BioCarta//Hs_CD40L Signaling Pathway      3/15 (27) 0.2344 0.1053 BioCarta//Hs_Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation      3/15 (29) 0.2344 0.1053 BioCarta//Hs_Regulation of cell cycle progression by Plk3      2/8 (17) 0.2253 0.1053 BioCarta//Hs_Presenilin action in Notch and Wnt signaling      3/14 (31) 0.2033 0.1056 BioCarta//Hs_Stat3 Signaling Pathway      2/8 (13) 0.2253 0.1060 BioCarta//Hs_Antigen Processing and Presentation      2/8 (16) 0.2253 0.1060 BioCarta//Hs_BRCA1-dependent Ub-ligase activity      2/8 (18) 0.2253 0.1060 BioCarta//Hs_Links between Pyk2 and Map Kinases      5/28 (44) 0.2007 0.1070 BioCarta//Hs_Alternative Complement Pathway      2/9 (46) 0.2694 0.1099 BioCarta//Hs_Regulation of eIF2      2/9 (20) 0.2694 0.1099 BioCarta//Hs_NF-kB Signaling Pathway      4/23 (49) 0.2558 0.1099 BioCarta//Hs_Acetylation and Deacetylation of RelA in The Nucleus      3/16 (34) 0.2663 0.1099 BioCarta//Hs_cdc25 and chk1 Regulatory Pathway in response to DNA damage      2/9 (13) 0.2694 0.1099 BioCarta//Hs_Signal Dependent Regulation of Myogenesis by Corepressor MITR      2/9 (25) 0.2694 0.1099 BioCarta//Hs_CTCF: First Multivalent Nuclear Factor      4/23 (26) 0.2558 0.1112 BioCarta//Hs_TPO Signaling Pathway      4/23 (54) 0.2558 0.1112 BioCarta//Hs_Trefoil Factors Initiate Mucosal Healing      4/24 (95) 0.2820 0.1117 BioCarta//Hs_mTOR Signaling Pathway      4/24 (44) 0.2820 0.1117 BioCarta//Hs_Regulation of eIF4e and p70 S6 Kinase      4/24 (37) 0.2820 0.1117 BioCarta//Hs_Chaperones modulate interferon Signaling Pathway      3/16 (34) 0.2663 0.1133 BioCarta//Hs_Cells and Molecules involved in local acute inflammatory response      3/17 (19) 0.2986 0.1171 BioCarta//Hs_Phospholipids as signalling intermediaries      4/25 (42) 0.3087 0.1194 BioCarta//Hs_Free Radical Induced Apoptosis      2/10 (11) 0.3134 0.1194 BioCarta//Hs_SODD/TNFR1 Signaling Pathway      2/10 (18) 0.3134 0.1194 BioCarta//Hs_PTEN dependent cell cycle arrest and apoptosis      3/18 (21) 0.3312 0.1238 BioCarta//Hs_Nerve growth factor pathway (NGF)      3/18 (38) 0.3312 0.1238 BioCarta//Hs_BCR Signaling Pathway      5/34 (54) 0.3356 0.1243 BioCarta//Hs_Signaling of Hepatocyte Growth Factor Receptor      5/36 (42) 0.3828 0.1265 BioCarta//Hs_Fibrinolysis Pathway      2/11 (14) 0.3569 0.1265 BioCarta//Hs_TGF beta signaling pathway      3/19 (76) 0.3637 0.1265 BioCarta//Hs_Malate-aspartate shuttle      1/4 (8) 0.3805 0.1265 BioCarta//Hs_West Nile Virus      1/4 (4) 0.3805 0.1268 BioCarta//Hs_Transcriptional activation of dbpb from mRNA      1/4 (9) 0.3805 0.1268 BioCarta//Hs_Formation of Ketone Bodies from acetyl-CoA      1/4 (4) 0.3805 0.1268 BioCarta//Hs_Basic Mechanisms of SUMOylation      1/4 (25) 0.3805 0.1268 BioCarta//Hs_Mitochondrial Carnitine Palmitoyltransferase (CPT) System      1/4 (4) 0.3805 0.1268 BioCarta//Hs_Map Kinase Inactivation of SMRT Corepressor      2/11 (14) 0.3569 0.1275 BioCarta//Hs_Prion Pathway      2/11 (11) 0.3569 0.1275 BioCarta//Hs_IL 4 signaling pathway      2/11 (17) 0.3569 0.1275 BioCarta//Hs_Complement Pathway      3/19 (33) 0.3637 0.1276 BioCarta//Hs_Role of Mitochondria in Apoptotic Signaling      3/20 (38) 0.3960 0.1278 BioCarta//Hs_Cystic fibrosis transmembrane conductance regulator and beta 2 adrenergic receptor pathway      2/12 (37) 0.3993 0.1278 BioCarta//Hs_Tumor Suppressor Arf Inhibits Ribosomal Biogenesis      2/12 (17) 0.3993 0.1278 BioCarta//Hs_Ca++/ Calmodulin-dependent Protein Kinase Activation      2/12 (76) 0.3993 0.1278 BioCarta//Hs_Ras Signaling Pathway      3/22 (23) 0.4590 0.1321 BioCarta//Hs_Role of ERBB2 in Signal Transduction and Oncology      3/21 (34) 0.4278 0.1321 BioCarta//Hs_Cytokine Network      3/22 (103) 0.4590 0.1321 BioCarta//Hs_Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia      3/22 (40) 0.4590 0.1321 BioCarta//Hs_Rho cell motility signaling pathway      4/30 (32) 0.4431 0.1321 BioCarta//Hs_Phospholipase C d1 in phospholipid associated cell signaling      1/5 (10) 0.4505 0.1321 BioCarta//Hs_Cell to Cell Adhesion Signaling      2/13 (14) 0.4404 0.1321 BioCarta//Hs_Bioactive Peptide Induced Signaling Pathway      5/38 (58) 0.4299 0.1321 BioCarta//Hs_Regulation of BAD phosphorylation      3/22 (31) 0.4590 0.1321 BioCarta//Hs_Hypoxia and p53 in the Cardiovascular system      3/22 (37) 0.4590 0.1321 BioCarta//Hs_Fc Epsilon Receptor I Signaling in Mast Cells      5/38 (49) 0.4299 0.1333 BioCarta//Hs_MAPKinase Signaling Pathway      10/85 (88) 0.4950 0.1334 BioCarta//Hs_Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling      4/33 (44) 0.5203 0.1334 BioCarta//Hs_Mechanisms of transcriptionalrepression by DNA methylation      2/14 (20) 0.4799 0.1334 BioCarta//Hs_CXCR4 Signaling Pathway      3/24 (35) 0.5192 0.1334 BioCarta//Hs_Regulation of PGC-1a      3/23 (31) 0.4895 0.1334 BioCarta//Hs_Role of nicotinic acetylcholine receptors in the regulation of apoptosis      2/15 (24) 0.5177 0.1334 BioCarta//Hs_Bystander B Cell Activation      1/6 (15) 0.5127 0.1334 BioCarta//Hs_Hypoxia-Inducible Factor in the Cardiovascular System      2/15 (20) 0.5177 0.1345 BioCarta//Hs_The information-processing pathway at the IFN-beta enhancer      2/15 (27) 0.5177 0.1345 BioCarta//Hs_IL 3 signaling pathway      2/15 (30) 0.5177 0.1345 BioCarta//Hs_Regulation of p27 Phosphorylation during Cell Cycle Progression      2/13 (20) 0.4404 0.1345 BioCarta//Hs_Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor recycling      1/5 (21) 0.4505 0.1345 BioCarta//Hs_Apoptotic Signaling in Response to DNA Damage      3/21 (29) 0.4278 0.1347 BioCarta//Hs_GATA3 participate in activating the Th2 cytokine genes expression      2/16 (25) 0.5536 0.1350 BioCarta//Hs_METS affect on Macrophage Differentiation      2/16 (30) 0.5536 0.1350 BioCarta//Hs_Steps in the Glycosylation of Mammalian N-linked Oligosaccarides      2/16 (16) 0.5536 0.1350 BioCarta//Hs_ALK in cardiac myocytes      4/34 (51) 0.5450 0.1350 BioCarta//Hs_Multi-step Regulation of Transcription by Pitx2      2/16 (38) 0.5536 0.1350 BioCarta//Hs_Sonic Hedgehog (Shh) Pathway      2/16 (29) 0.5536 0.1350 BioCarta//Hs_p53 Signaling Pathway      2/16 (27) 0.5536 0.1350 BioCarta//Hs_Regulation of transcriptional activity by PML      2/16 (24) 0.5536 0.1350 BioCarta//Hs_Repression of Pain Sensation by the Transcriptional Regulator DREAM      2/14 (21) 0.4799 0.1352 BioCarta//Hs_Classical Complement Pathway      2/14 (68) 0.4799 0.1352 BioCarta//Hs_Cyclins and Cell Cycle Regulation      3/23 (46) 0.4895 0.1360 BioCarta//Hs_Transcription factor CREB and its extracellular signals      3/26 (26) 0.5756 0.1362 BioCarta//Hs_Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells      3/26 (43) 0.5756 0.1362 BioCarta//Hs_Growth Hormone Signaling Pathway      3/26 (35) 0.5756 0.1362 BioCarta//Hs_Reelin Signaling Pathway      1/7 (10) 0.5678 0.1362 BioCarta//Hs_Activation of cAMP-dependent protein kinase, PKA      1/6 (10) 0.5127 0.1367 BioCarta//Hs_Catabolic Pathways for Arginine , Histidine, Glutamate, Glutamine, and Proline      1/6 (6) 0.5127 0.1367 BioCarta//Hs_Biosynthesis of neurotransmitters      1/6 (6) 0.5127 0.1367 BioCarta//Hs_IL 18 Signaling Pathway      1/6 (8) 0.5127 0.1367 BioCarta//Hs_The role of FYVE-finger proteins in vesicle transport      1/7 (35) 0.5678 0.1368 BioCarta//Hs_CDK Regulation of DNA Replication      2/17 (56) 0.5876 0.1375 BioCarta//Hs_Erk1/Erk2 Mapk Signaling pathway      3/28 (33) 0.6277 0.1375 BioCarta//Hs_Phospholipase C-epsilon pathway      1/12 (25) 0.7632 0.1375 BioCarta//Hs_mCalpain and friends in Cell motility      2/22 (38) 0.7288 0.1375 BioCarta//Hs_Telomeres, Telomerase, Cellular Aging, and Immortality      2/18 (31) 0.6197 0.1375 BioCarta//Hs_Agrin in Postsynaptic Differentiation      4/39 (50) 0.6574 0.1375 BioCarta//Hs_Integrin Signaling Pathway      4/37 (45) 0.6147 0.1375 BioCarta//Hs_Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)      5/54 (64) 0.7472 0.1375 BioCarta//Hs_Lectin Induced Complement Pathway      1/12 (56) 0.7632 0.1375 BioCarta//Hs_The PRC2 Complex sets Long-term gene Silencing The Modification of Histone Tails      1/12 (20) 0.7632 0.1375 BioCarta//Hs_Nuclear Receptors in Lipid Metabolism and Toxicity      3/34 (43) 0.7567 0.1375 BioCarta//Hs_Eicosanoid Metabolism      2/20 (20) 0.6780 0.1375 BioCarta//Hs_Phosphoinositides and their downstream targets.      2/23 (23) 0.7516 0.1375 BioCarta//Hs_T Cytotoxic Cell Surface Molecules      1/12 (12) 0.7632 0.1375 BioCarta//Hs_T Helper Cell Surface Molecules      1/12 (12) 0.7632 0.1375 BioCarta//Hs_Trka Receptor Signaling Pathway      1/12 (12) 0.7632 0.1375 BioCarta//Hs_Role of MAL in Rho-Mediated Activation of SRF      2/19 (26) 0.6498 0.1375 BioCarta//Hs_Rab GTPases Mark Targets In The Endocytotic Machinery      1/12 (17) 0.7632 0.1375 BioCarta//Hs_Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway      1/12 (16) 0.7632 0.1375 BioCarta//Hs_Overview of telomerase protein component gene hTert Transcriptional Regulation      1/8 (20) 0.6167 0.1375 BioCarta//Hs_ADP-Ribosylation Factor      2/21 (57) 0.7043 0.1375 BioCarta//Hs_Ghrelin: Regulation of Food Intake and Energy Homeostasis      1/11 (30) 0.7329 0.1375 BioCarta//Hs_HIV Induced T Cell Apoptosis      1/9 (23) 0.6601 0.1375 BioCarta//Hs_Antigen Dependent B Cell Activation      1/10 (24) 0.6987 0.1375 BioCarta//Hs_Control of Gene Expression by Vitamin D Receptor      2/24 (32) 0.7728 0.1386 BioCarta//Hs_IL 6 signaling pathway      2/21 (48) 0.7043 0.1395 BioCarta//Hs_Rac 1 cell motility signaling pathway      2/21 (23) 0.7043 0.1395 BioCarta//Hs_Nitric Oxide Signaling Pathway      2/21 (25) 0.7043 0.1395 BioCarta//Hs_Extrinsic Prothrombin Activation Pathway      1/13 (24) 0.7901 0.1402 BioCarta//Hs_WNT Signaling Pathway      2/25 (42) 0.7923 0.1402 BioCarta//Hs_Cardiac Protection Against ROS      1/9 (9) 0.6601 0.1405 BioCarta//Hs_B Lymphocyte Cell Surface Molecules      1/9 (10) 0.6601 0.1405 BioCarta//Hs_Cyclin E Destruction Pathway      1/9 (14) 0.6601 0.1405 BioCarta//Hs_Lck and Fyn tyrosine kinases in initiation of TCR Activation      1/9 (16) 0.6601 0.1405 BioCarta//Hs_Visual Signal Transduction      1/9 (12) 0.6601 0.1405 BioCarta//Hs_Feeder Pathways for Glycolysis      1/9 (11) 0.6601 0.1405 BioCarta//Hs_Attenuation of GPCR Signaling      1/13 (13) 0.7901 0.1405 BioCarta//Hs_Sprouty regulation of tyrosine kinase signals      2/18 (31) 0.6197 0.1408 BioCarta//Hs_Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation      1/11 (35) 0.7329 0.1409 BioCarta//Hs_Granzyme A mediated Apoptosis Pathway      1/11 (28) 0.7329 0.1409 BioCarta//Hs_Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle      1/11 (30) 0.7329 0.1409 BioCarta//Hs_Activation of Src by Protein-tyrosine phosphatase alpha      1/11 (29) 0.7329 0.1409 BioCarta//Hs_VEGF, Hypoxia, and Angiogenesis      3/28 (34) 0.6277 0.1410 BioCarta//Hs_Regulators of Bone Mineralization      1/10 (57) 0.6987 0.1411 BioCarta//Hs_Deregulation of CDK5 in Alzheimers Disease      1/10 (16) 0.6987 0.1411 BioCarta//Hs_Reversal of Insulin Resistance by Leptin      1/10 (11) 0.6987 0.1411 BioCarta//Hs_Electron Transport Reaction in Mitochondria      1/10 (10) 0.6987 0.1411 BioCarta//Hs_E2F1 Destruction Pathway      1/10 (16) 0.6987 0.1411 BioCarta//Hs_Eph Kinases and ephrins support platelet aggregation      1/10 (17) 0.6987 0.1411 BioCarta//Hs_SARS Coronavirus Protease      1/10 (16) 0.6987 0.1411 BioCarta//Hs_Apoptotic DNA fragmentation and tissue homeostasis      1/10 (15) 0.6987 0.1411 BioCarta//Hs_Signaling Pathway from G-Protein Families      3/34 (42) 0.7567 0.1414 BioCarta//Hs_beta-arrestins in GPCR Desensitization      1/15 (40) 0.8351 0.1415 BioCarta//Hs_Eukaryotic protein translation      1/15 (20) 0.8351 0.1415 BioCarta//Hs_Cytokines and Inflammatory Response      2/27 (78) 0.8270 0.1415 BioCarta//Hs_Erythrocyte Differentiation Pathway      1/15 (21) 0.8351 0.1415 BioCarta//Hs_CARM1 and Regulation of the Estrogen Receptor      2/26 (33) 0.8104 0.1415 BioCarta//Hs_Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration      1/15 (15) 0.8351 0.1415 BioCarta//Hs_p38 MAPK Signaling Pathway      3/38 (40) 0.8209 0.1415 BioCarta//Hs_Estrogen-responsive protein Efp controls cell cycle and breast tumors growth      1/14 (59) 0.8139 0.1415 BioCarta//Hs_Platelet Amyloid Precursor Protein Pathway      1/14 (15) 0.8139 0.1416 BioCarta//Hs_B Cell Survival Pathway      1/14 (16) 0.8139 0.1416 BioCarta//Hs_The Citric Acid Cycle      1/8 (9) 0.6167 0.1418 BioCarta//Hs_Phospholipase C Signaling Pathway      1/8 (12) 0.6167 0.1418 BioCarta//Hs_CCR3 signaling in Eosinophils      2/23 (30) 0.7516 0.1418 BioCarta//Hs_Stathmin and breast cancer resistance to antimicrotubule agents      2/23 (26) 0.7516 0.1418 BioCarta//Hs_The Co-Stimulatory Signal During T-cell Activation      1/16 (40) 0.8539 0.1435 BioCarta//Hs_Role of MEF2D in T-cell Apoptosis      1/16 (45) 0.8539 0.1435 BioCarta//Hs_NO2-dependent IL 12 Pathway in NK cells      1/17 (20) 0.8705 0.1439 BioCarta//Hs_Role of ?arrestins in the activation and targeting of MAP kinases      1/17 (40) 0.8705 0.1439 BioCarta//Hs_uCalpain and friends in Cell spread      1/17 (36) 0.8705 0.1439 BioCarta//Hs_Role of Erk5 in Neuronal Survival      1/17 (36) 0.8705 0.1439 BioCarta//Hs_ChREBP regulation by carbohydrates and cAMP      2/19 (30) 0.6498 0.1444 BioCarta//Hs_Effects of calcineurin in Keratinocyte Differentiation      1/18 (36) 0.8853 0.1457 BioCarta//Hs_Role of Tob in T-cell activation      1/19 (30) 0.8983 0.1467 BioCarta//Hs_Lissencephaly gene (LIS1) in neuronal migration and development      1/19 (48) 0.8983 0.1467 BioCarta//Hs_Ion Channels and Their Functional Role in Vascular Endothelium      1/20 (20) 0.9099 0.1468 BioCarta//Hs_Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor      1/20 (24) 0.9099 0.1468 BioCarta//Hs_Acute Myocardial Infarction      1/20 (23) 0.9099 0.1468 BioCarta//Hs_Roles of ?arrestin-dependent Recruitment of Src Kinases in GPCR Signaling      1/21 (34) 0.9202 0.1472 BioCarta//Hs_Thrombin signaling and protease-activated receptors      1/21 (31) 0.9202 0.1472 BioCarta//Hs_Aspirin Blocks Signaling Pathway Involved in Platelet Activation      1/22 (32) 0.9293 0.1481 BioCarta//Hs_Intrinsic Prothrombin Activation Pathway      1/23 (36) 0.9374 0.1488 BioCarta//Hs_How Progesterone Initiates the Oocyte Maturation      1/30 (32) 0.9733 0.1533 BioCarta//Hs_Actions of Nitric Oxide in the Heart      1/30 (44) 0.9733 0.1533

Cluster 5 has 231 gene products

ArrayXPath has identified 135 out of 231 input elements in 189 out of 346 BioCarta pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value BioCarta//Hs_Anthrax Toxin Mechanism of Action      2/2 (2) 0.0058 0.0496 BioCarta//Hs_Control of Gene Expression by Vitamin D Receptor      6/24 (32) 0.0074 0.0496 BioCarta//Hs_Overview of telomerase protein component gene hTert Transcriptional Regulation      3/8 (20) 0.0182 0.0520 BioCarta//Hs_Internal Ribosome entry pathway      3/8 (39) 0.0182 0.0520 BioCarta//Hs_Mechanisms of transcriptionalrepression by DNA methylation      4/14 (20) 0.0176 0.0520 BioCarta//Hs_Dicer Pathway      2/2 (4) 0.0058 0.0576 BioCarta//Hs_Sumoylation by RanBP2 Regulates Transcriptional Repression      3/10 (25) 0.0349 0.0697 BioCarta//Hs_Glycolysis Pathway      3/10 (21) 0.0349 0.0697 BioCarta//Hs_mTOR Signaling Pathway      5/24 (44) 0.0310 0.0697 BioCarta//Hs_Spliceosomal Assembly      4/14 (14) 0.0176 0.0705 BioCarta//Hs_Erk1/Erk2 Mapk Signaling pathway      5/28 (33) 0.0562 0.0879 BioCarta//Hs_Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway      3/12 (16) 0.0571 0.0879 BioCarta//Hs_TGF beta signaling pathway      4/19 (76) 0.0508 0.0879 BioCarta//Hs_FAS signaling pathway ( CD95 )      3/30 (34) 0.4037 0.0948 BioCarta//Hs_CTCF: First Multivalent Nuclear Factor      3/23 (26) 0.2532 0.0948 BioCarta//Hs_IL-2 Receptor Beta Chain in T cell Activation      3/35 (38) 0.5065 0.0948 BioCarta//Hs_Inhibition of Cellular Proliferation by Gleevec      3/22 (23) 0.2322 0.0948 BioCarta//Hs_MAPKinase Signaling Pathway      9/85 (88) 0.1930 0.0948 BioCarta//Hs_Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy      2/18 (31) 0.4040 0.0948 BioCarta//Hs_WNT Signaling Pathway      4/25 (42) 0.1169 0.0948 BioCarta//Hs_fMLP induced chemokine gene expression in HMC-1 cells      3/36 (58) 0.5259 0.0948 BioCarta//Hs_Polyadenylation of mRNA      2/9 (35) 0.1458 0.0948 BioCarta//Hs_Fc Epsilon Receptor I Signaling in Mast Cells      4/38 (49) 0.3278 0.0948 BioCarta//Hs_Growth Hormone Signaling Pathway      2/26 (35) 0.6016 0.0948 BioCarta//Hs_Insulin Signaling Pathway      2/21 (48) 0.4840 0.0948 BioCarta//Hs_Integrin Signaling Pathway      3/37 (45) 0.5450 0.0948 BioCarta//Hs_Links between Pyk2 and Map Kinases      3/28 (44) 0.3609 0.0948 BioCarta//Hs_PDGF Signaling Pathway      2/27 (61) 0.6226 0.0948 BioCarta//Hs_Role of ?arrestins in the activation and targeting of MAP kinases      3/17 (40) 0.1341 0.0948 BioCarta//Hs_Role of MAL in Rho-Mediated Activation of SRF      2/19 (26) 0.4313 0.0948 BioCarta//Hs_Roles of ?arrestin-dependent Recruitment of Src Kinases in GPCR Signaling      3/21 (34) 0.2115 0.0948 BioCarta//Hs_Signaling of Hepatocyte Growth Factor Receptor      4/36 (42) 0.2921 0.0948 BioCarta//Hs_Bioactive Peptide Induced Signaling Pathway      3/38 (58) 0.5636 0.0948 BioCarta//Hs_Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling      4/33 (44) 0.2399 0.0948 BioCarta//Hs_Cell Cycle: G1/S Check Point      4/28 (34) 0.1593 0.0948 BioCarta//Hs_Cyclins and Cell Cycle Regulation      2/23 (46) 0.5335 0.0948 BioCarta//Hs_p53 Signaling Pathway      1/16 (27) 0.7204 0.0948 BioCarta//Hs_Regulation of p27 Phosphorylation during Cell Cycle Progression      2/13 (20) 0.2603 0.0948 BioCarta//Hs_HIV-I Nef: negative effector of Fas and TNF      5/57 (77) 0.4414 0.0948 BioCarta//Hs_Induction of apoptosis through DR3 and DR4/5 Death Receptors      2/32 (37) 0.7149 0.0948 BioCarta//Hs_TNFR1 Signaling Pathway      2/29 (36) 0.6620 0.0948 BioCarta//Hs_Chaperones modulate interferon Signaling Pathway      1/16 (34) 0.7204 0.0948 BioCarta//Hs_Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes      2/17 (20) 0.3760 0.0948 BioCarta//Hs_Hypoxia and p53 in the Cardiovascular system      2/22 (37) 0.5091 0.0948 BioCarta//Hs_ALK in cardiac myocytes      3/34 (51) 0.4866 0.0948 BioCarta//Hs_The Co-Stimulatory Signal During T-cell Activation      1/16 (40) 0.7204 0.0948 BioCarta//Hs_Antigen Processing and Presentation      2/8 (16) 0.1192 0.0948 BioCarta//Hs_Regulation of eIF4e and p70 S6 Kinase      3/24 (37) 0.2745 0.0948 BioCarta//Hs_Endocytotic role of NDK, Phosphins and Dynamin      2/15 (48) 0.3187 0.0948 BioCarta//Hs_Downregulated of MTA-3 in ER-negative Breast Tumors      1/16 (23) 0.7204 0.0948 BioCarta//Hs_Inhibition of Huntingtons disease neurodegeneration by histone deacetylase inhibitors      1/4 (9) 0.2719 0.0948 BioCarta//Hs_Multi-step Regulation of Transcription by Pitx2      2/16 (38) 0.3476 0.0948 BioCarta//Hs_Role of MEF2D in T-cell Apoptosis      3/16 (45) 0.1167 0.0948 BioCarta//Hs_The PRC2 Complex sets Long-term gene Silencing The Modification of Histone Tails      2/12 (20) 0.2311 0.0948 BioCarta//Hs_CARM1 and Regulation of the Estrogen Receptor      4/26 (33) 0.1304 0.0948 BioCarta//Hs_SARS Coronavirus Protease      2/10 (16) 0.1736 0.0948 BioCarta//Hs_Opposing roles of AIF in Apoptosis and Cell Survival      1/3 (8) 0.2117 0.0948 BioCarta//Hs_Role of Mitochondria in Apoptotic Signaling      2/20 (38) 0.4580 0.0948 BioCarta//Hs_PTEN dependent cell cycle arrest and apoptosis      3/18 (21) 0.1525 0.0948 BioCarta//Hs_Trka Receptor Signaling Pathway      1/12 (12) 0.6150 0.0948 BioCarta//Hs_Calcium Signaling by HBx of Hepatitis B virus      1/8 (8) 0.4703 0.0948 BioCarta//Hs_Cell Cycle: G2/M Checkpoint      2/24 (27) 0.5571 0.0948 BioCarta//Hs_Hypoxia-Inducible Factor in the Cardiovascular System      1/15 (20) 0.6971 0.0948 BioCarta//Hs_IL-7 Signal Transduction      1/16 (29) 0.7204 0.0948 BioCarta//Hs_Acetylation and Deacetylation of RelA in The Nucleus      1/16 (34) 0.7204 0.0948 BioCarta//Hs_Eph Kinases and ephrins support platelet aggregation      1/10 (17) 0.5484 0.0948 BioCarta//Hs_G-Protein Signaling Through Tubby Proteins      1/7 (11) 0.4264 0.0948 BioCarta//Hs_Actions of Nitric Oxide in the Heart      2/30 (44) 0.6805 0.0948 BioCarta//Hs_Stress Induction of HSP Regulation      1/14 (22) 0.6719 0.0948 BioCarta//Hs_Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle      2/11 (30) 0.2021 0.0948 BioCarta//Hs_Feeder Pathways for Glycolysis      1/9 (11) 0.5109 0.0948 BioCarta//Hs_FOSB gene expression and drug abuse      1/5 (11) 0.3275 0.0948 BioCarta//Hs_B Cell Survival Pathway      2/14 (16) 0.2896 0.0948 BioCarta//Hs_ER-associated degradation (ERAD) Pathway      1/13 (20) 0.6446 0.0948 BioCarta//Hs_Steps in the Glycosylation of Mammalian N-linked Oligosaccarides      1/16 (16) 0.7204 0.0948 BioCarta//Hs_Ghrelin: Regulation of Food Intake and Energy Homeostasis      1/11 (30) 0.5830 0.0948 BioCarta//Hs_Regulation of Spermatogenesis by CREM      1/6 (14) 0.3789 0.0948 BioCarta//Hs_Regulation of transcriptional activity by PML      1/16 (24) 0.7204 0.0948 BioCarta//Hs_Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)      3/54 (64) 0.7946 0.0950 BioCarta//Hs_p38 MAPK Signaling Pathway      2/38 (40) 0.8001 0.0950 BioCarta//Hs_NFAT and Hypertrophy of the heart (Transcription in the broken heart)      3/51 (82) 0.7609 0.0950 BioCarta//Hs_Signaling Pathway from G-Protein Families      2/34 (42) 0.7462 0.0950 BioCarta//Hs_CCR3 signaling in Eosinophils      1/23 (30) 0.8406 0.0950 BioCarta//Hs_TNFR2 Signaling Pathway      1/18 (32) 0.7618 0.0950 BioCarta//Hs_ADP-Ribosylation Factor      1/21 (57) 0.8128 0.0950 BioCarta//Hs_Regulation of PGC-1a      1/23 (31) 0.8406 0.0950 BioCarta//Hs_Role of Erk5 in Neuronal Survival      1/17 (36) 0.7419 0.0950 BioCarta//Hs_Phosphoinositides and their downstream targets.      1/23 (23) 0.8406 0.0950 BioCarta//Hs_Agrin in Postsynaptic Differentiation      2/39 (50) 0.8119 0.0950 BioCarta//Hs_Dendritic cells in regulating TH1 and TH2 Development      1/22 (25) 0.8272 0.0950 BioCarta//Hs_Ion Channels and Their Functional Role in Vascular Endothelium      1/20 (20) 0.7971 0.0950 BioCarta//Hs_Lissencephaly gene (LIS1) in neuronal migration and development      1/19 (48) 0.7802 0.0950 BioCarta//Hs_Thrombin signaling and protease-activated receptors      1/21 (31) 0.8128 0.0951 BioCarta//Hs_Rac 1 cell motility signaling pathway      1/21 (23) 0.8128 0.0951 BioCarta//Hs_Ras Signaling Pathway      1/22 (23) 0.8272 0.0951 BioCarta//Hs_Aspirin Blocks Signaling Pathway Involved in Platelet Activation      1/22 (32) 0.8272 0.0951 BioCarta//Hs_Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells      1/26 (43) 0.8748 0.0951 BioCarta//Hs_CXCR4 Signaling Pathway      1/24 (35) 0.8529 0.0951 BioCarta//Hs_T Cell Receptor Signaling Pathway      2/43 (56) 0.8532 0.0951 BioCarta//Hs_Influence of Ras and Rho proteins on G1 to S Transition      1/26 (33) 0.8748 0.0951 BioCarta//Hs_Phospholipids as signalling intermediaries      1/25 (42) 0.8643 0.0951 BioCarta//Hs_Transcription factor CREB and its extracellular signals      1/26 (26) 0.8748 0.0951 BioCarta//Hs_Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages      1/25 (42) 0.8643 0.0955 BioCarta//Hs_Map Kinase Inactivation of SMRT Corepressor      1/11 (14) 0.5830 0.0956 BioCarta//Hs_BTG family proteins and cell cycle regulation      1/11 (13) 0.5830 0.0956 BioCarta//Hs_Granzyme A mediated Apoptosis Pathway      1/11 (28) 0.5830 0.0956 BioCarta//Hs_Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation      1/11 (35) 0.5830 0.0956 BioCarta//Hs_Prion Pathway      1/11 (11) 0.5830 0.0956 BioCarta//Hs_Activation of Src by Protein-tyrosine phosphatase alpha      1/11 (29) 0.5830 0.0956 BioCarta//Hs_Oxidative Stress Induced Gene Expression Via Nrf2      1/20 (24) 0.7971 0.0960 BioCarta//Hs_Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway      1/20 (23) 0.7971 0.0960 BioCarta//Hs_VEGF, Hypoxia, and Angiogenesis      1/28 (34) 0.8934 0.0961 BioCarta//Hs_Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)      1/28 (41) 0.8934 0.0961 BioCarta//Hs_Cell to Cell Adhesion Signaling      1/13 (14) 0.6446 0.0962 BioCarta//Hs_Transcription Regulation by Methyltransferase of CARM1      1/13 (34) 0.6446 0.0962 BioCarta//Hs_Attenuation of GPCR Signaling      1/13 (13) 0.6446 0.0962 BioCarta//Hs_RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage      1/13 (17) 0.6446 0.0962 BioCarta//Hs_Ras-Independent pathway in NK cell-mediated cytotoxicity      1/19 (19) 0.7802 0.0963 BioCarta//Hs_ChREBP regulation by carbohydrates and cAMP      1/19 (30) 0.7802 0.0963 BioCarta//Hs_Role of Tob in T-cell activation      1/19 (30) 0.7802 0.0963 BioCarta//Hs_Complement Pathway      1/19 (33) 0.7802 0.0963 BioCarta//Hs_uCalpain and friends in Cell spread      1/17 (36) 0.7419 0.0964 BioCarta//Hs_EGF Signaling Pathway      2/27 (54) 0.6226 0.0965 BioCarta//Hs_D4-GDI Signaling Pathway      1/12 (15) 0.6150 0.0969 BioCarta//Hs_Lectin Induced Complement Pathway      1/12 (56) 0.6150 0.0969 BioCarta//Hs_Gamma-aminobutyric Acid Receptor Life Cycle      1/12 (73) 0.6150 0.0969 BioCarta//Hs_Rho cell motility signaling pathway      2/30 (32) 0.6805 0.0972 BioCarta//Hs_Segmentation Clock      1/14 (20) 0.6719 0.0974 BioCarta//Hs_The IGF-1 Receptor and Longevity      1/14 (14) 0.6719 0.0974 BioCarta//Hs_CD40L Signaling Pathway      1/15 (27) 0.6971 0.0975 BioCarta//Hs_beta-arrestins in GPCR Desensitization      1/15 (40) 0.6971 0.0975 BioCarta//Hs_Trefoil Factors Initiate Mucosal Healing      2/24 (95) 0.5571 0.0977 BioCarta//Hs_NFkB activation by Nontypeable Hemophilus influenzae      2/24 (43) 0.5571 0.0977 BioCarta//Hs_E2F1 Destruction Pathway      1/10 (16) 0.5484 0.0988 BioCarta//Hs_Reversal of Insulin Resistance by Leptin      1/10 (11) 0.5484 0.0988 BioCarta//Hs_Deregulation of CDK5 in Alzheimers Disease      1/10 (16) 0.5484 0.0988 BioCarta//Hs_Role of Ran in mitotic spindle regulation      1/10 (15) 0.5484 0.0988 BioCarta//Hs_Toll-Like Receptor Pathway      1/34 (45) 0.9344 0.0994 BioCarta//Hs_Nuclear Receptors in Lipid Metabolism and Toxicity      1/34 (43) 0.9344 0.0994 BioCarta//Hs_Cyclin E Destruction Pathway      1/9 (14) 0.5109 0.1002 BioCarta//Hs_Mechanism of Protein Import into the Nucleus      1/9 (19) 0.5109 0.1002 BioCarta//Hs_Role of PPAR-gamma Coactivators in Obesity and Thermogenesis      1/9 (12) 0.5109 0.1002 BioCarta//Hs_Signal Dependent Regulation of Myogenesis by Corepressor MITR      1/9 (25) 0.5109 0.1002 BioCarta//Hs_cdc25 and chk1 Regulatory Pathway in response to DNA damage      1/9 (13) 0.5109 0.1002 BioCarta//Hs_TPO Signaling Pathway      2/23 (54) 0.5335 0.1016 BioCarta//Hs_Keratinocyte Differentiation      1/46 (67) 0.9753 0.1032 BioCarta//Hs_Overview of telomerase RNA component gene hTerc Transcriptional Regulation      1/6 (15) 0.3789 0.1038 BioCarta//Hs_Catabolic Pathways for Arginine , Histidine, Glutamate, Glutamine, and Proline      1/6 (6) 0.3789 0.1038 BioCarta//Hs_Pelp1 Modulation of Estrogen Receptor Activity      1/6 (10) 0.3789 0.1038 BioCarta//Hs_Biosynthesis of neurotransmitters      1/6 (6) 0.3789 0.1038 BioCarta//Hs_Wnt/LRP6 Signalling      1/6 (25) 0.3789 0.1038 BioCarta//Hs_SREBP control of lipid synthesis      1/6 (24) 0.3789 0.1038 BioCarta//Hs_Proteasome Complex      2/19 (24) 0.4313 0.1052 BioCarta//Hs_EPO Signaling Pathway      2/19 (36) 0.4313 0.1052 BioCarta//Hs_Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia      2/22 (40) 0.5091 0.1061 BioCarta//Hs_IL 2 signaling pathway      2/22 (47) 0.5091 0.1061 BioCarta//Hs_Caspase Cascade in Apoptosis      2/22 (27) 0.5091 0.1061 BioCarta//Hs_BCR Signaling Pathway      3/34 (54) 0.4866 0.1069 BioCarta//Hs_IGF-1 Signaling Pathway      2/20 (45) 0.4580 0.1078 BioCarta//Hs_The role of FYVE-finger proteins in vesicle transport      1/7 (35) 0.4264 0.1080 BioCarta//Hs_The reactions that feed amino groups into the urea cycle      1/7 (16) 0.4264 0.1080 BioCarta//Hs_Melanocyte Development and Pigmentation Pathway      1/7 (13) 0.4264 0.1080 BioCarta//Hs_The Citric Acid Cycle      1/8 (9) 0.4703 0.1081 BioCarta//Hs_IL 6 signaling pathway      2/21 (48) 0.4840 0.1088 BioCarta//Hs_Human Cytomegalovirus and Map Kinase Pathways      2/16 (17) 0.3476 0.1103 BioCarta//Hs_METS affect on Macrophage Differentiation      2/16 (30) 0.3476 0.1103 BioCarta//Hs_Cycling of Ran in nucleocytoplasmic transport      1/5 (8) 0.3275 0.1110 BioCarta//Hs_Blockade of Neurotransmitter Relase by Botulinum Toxin      1/5 (28) 0.3275 0.1110 BioCarta//Hs_PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase      2/15 (18) 0.3187 0.1138 BioCarta//Hs_Cadmium induces DNA synthesis and proliferation in macrophages      2/15 (21) 0.3187 0.1138 BioCarta//Hs_IL 3 signaling pathway      2/15 (30) 0.3187 0.1138 BioCarta//Hs_Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation      2/15 (29) 0.3187 0.1138 BioCarta//Hs_Eukaryotic protein translation      2/15 (20) 0.3187 0.1138 BioCarta//Hs_CDK Regulation of DNA Replication      2/17 (56) 0.3760 0.1140 BioCarta//Hs_Malate-aspartate shuttle      1/4 (8) 0.2719 0.1157 BioCarta//Hs_Oxidative reactions of the pentose phosphate pathway      1/4 (4) 0.2719 0.1157 BioCarta//Hs_Generation of amyloid b-peptide by PS1      1/4 (9) 0.2719 0.1157 BioCarta//Hs_Biosynthesis of Proline in Bacteria      1/4 (4) 0.2719 0.1157 BioCarta//Hs_Tumor Suppressor Arf Inhibits Ribosomal Biogenesis      2/12 (17) 0.2311 0.1216 BioCarta//Hs_Rab GTPases Mark Targets In The Endocytotic Machinery      2/12 (17) 0.2311 0.1216 BioCarta//Hs_Telomeres, Telomerase, Cellular Aging, and Immortality      3/18 (31) 0.1525 0.1220 BioCarta//Hs_Nerve growth factor pathway (NGF)      3/18 (38) 0.1525 0.1220 BioCarta//Hs_Sprouty regulation of tyrosine kinase signals      3/18 (31) 0.1525 0.1220 BioCarta//Hs_Electron Transport Reaction in Mitochondria      2/10 (10) 0.1736 0.1240 BioCarta//Hs_Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility      3/21 (25) 0.2115 0.1244 BioCarta//Hs_Ceramide Signaling Pathway      3/21 (21) 0.2115 0.1244 BioCarta//Hs_Role of ERBB2 in Signal Transduction and Oncology      3/21 (34) 0.2115 0.1244 BioCarta//Hs_BRCA1-dependent Ub-ligase activity      2/8 (18) 0.1192 0.1324 BioCarta//Hs_RNA polymerase III transcription      2/8 (22) 0.1192 0.1324

Cluster 6 has 392 gene products

ArrayXPath has identified 242 out of 392 input elements in 260 out of 346 BioCarta pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value BioCarta//Hs_Formation of Ketone Bodies from acetyl-CoA      3/4 (4) 0.0096 0.9107 BioCarta//Hs_Monocyte and its Surface Molecules      5/11 (12) 0.0113 0.9107 BioCarta//Hs_Neutrophil and Its Surface Molecules      4/8 (12) 0.0162 0.9107 BioCarta//Hs_ChREBP regulation by carbohydrates and cAMP      6/19 (30) 0.0381 0.9107 BioCarta//Hs_Lck and Fyn tyrosine kinases in initiation of TCR Activation      4/9 (16) 0.0260 0.9107 BioCarta//Hs_TSP-1 Induced Apoptosis in Microvascular Endothelial Cell      3/6 (9) 0.0385 0.9107 BioCarta//Hs_Catabolic Pathways for Arginine , Histidine, Glutamate, Glutamine, and Proline      3/6 (6) 0.0385 0.9107 BioCarta//Hs_Small Leucine-rich Proteoglycan (SLRP) molecules      3/6 (6) 0.0385 0.9107 BioCarta//Hs_Hop Pathway in Cardiac Development      2/2 (9) 0.0193 0.9107 BioCarta//Hs_Adhesion Molecules on Lymphocyte      4/9 (10) 0.0260 0.9653 BioCarta//Hs_Ion Channels and Their Functional Role in Vascular Endothelium      6/20 (20) 0.0483 0.9663 BioCarta//Hs_IGF-1 Signaling Pathway      6/20 (45) 0.0483 0.9663 BioCarta//Hs_Leloir pathway of galactose metabolism      2/3 (3) 0.0525 0.9759 BioCarta//Hs_TNFR2 Signaling Pathway      2/18 (32) 0.7382 0.9817 BioCarta//Hs_Actions of Nitric Oxide in the Heart      4/30 (44) 0.6185 0.9817 BioCarta//Hs_HIV-I Nef: negative effector of Fas and TNF      6/57 (77) 0.8277 0.9817 BioCarta//Hs_Rho cell motility signaling pathway      3/30 (32) 0.8106 0.9817 BioCarta//Hs_Lissencephaly gene (LIS1) in neuronal migration and development      1/19 (48) 0.9430 0.9817 BioCarta//Hs_Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)      5/54 (64) 0.8916 0.9817 BioCarta//Hs_NFAT and Hypertrophy of the heart (Transcription in the broken heart)      8/51 (82) 0.4166 0.9817 BioCarta//Hs_TGF beta signaling pathway      4/19 (76) 0.2664 0.9817 BioCarta//Hs_The information-processing pathway at the IFN-beta enhancer      4/15 (27) 0.1443 0.9817 BioCarta//Hs_Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor      5/20 (24) 0.1336 0.9817 BioCarta//Hs_Growth Hormone Signaling Pathway      5/26 (35) 0.2901 0.9817 BioCarta//Hs_IL-2 Receptor Beta Chain in T cell Activation      5/35 (38) 0.5500 0.9817 BioCarta//Hs_Regulation of eIF4e and p70 S6 Kinase      3/24 (37) 0.6703 0.9817 BioCarta//Hs_Downregulated of MTA-3 in ER-negative Breast Tumors      3/16 (23) 0.3888 0.9817 BioCarta//Hs_Role of ERBB2 in Signal Transduction and Oncology      5/21 (34) 0.1566 0.9817 BioCarta//Hs_T Cell Receptor Signaling Pathway      8/43 (56) 0.2405 0.9817 BioCarta//Hs_METS affect on Macrophage Differentiation      5/16 (30) 0.0595 0.9817 BioCarta//Hs_Phospholipids as signalling intermediaries      2/25 (42) 0.8830 0.9817 BioCarta//Hs_Transcription factor CREB and its extracellular signals      3/26 (26) 0.7240 0.9817 BioCarta//Hs_T Helper Cell Surface Molecules      4/12 (12) 0.0729 0.9817 BioCarta//Hs_CTCF: First Multivalent Nuclear Factor      4/23 (26) 0.4009 0.9817 BioCarta//Hs_Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells      2/26 (43) 0.8962 0.9817 BioCarta//Hs_EGF Signaling Pathway      5/27 (54) 0.3192 0.9817 BioCarta//Hs_Fc Epsilon Receptor I Signaling in Mast Cells      5/38 (49) 0.6271 0.9817 BioCarta//Hs_Keratinocyte Differentiation      6/46 (67) 0.6352 0.9817 BioCarta//Hs_MAPKinase Signaling Pathway      9/85 (88) 0.8600 0.9817 BioCarta//Hs_PDGF Signaling Pathway      4/27 (61) 0.5307 0.9817 BioCarta//Hs_Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy      5/18 (31) 0.0928 0.9817 BioCarta//Hs_Signaling of Hepatocyte Growth Factor Receptor      7/36 (42) 0.2257 0.9817 BioCarta//Hs_B Cell Survival Pathway      3/14 (16) 0.3075 0.9817 BioCarta//Hs_ER-associated degradation (ERAD) Pathway      1/13 (20) 0.8586 0.9817 BioCarta//Hs_Induction of apoptosis through DR3 and DR4/5 Death Receptors      7/32 (37) 0.1456 0.9817 BioCarta//Hs_p38 MAPK Signaling Pathway      4/38 (40) 0.7976 0.9817 BioCarta//Hs_Cell Cycle: G1/S Check Point      3/28 (34) 0.7706 0.9817 BioCarta//Hs_Deregulation of CDK5 in Alzheimers Disease      3/10 (16) 0.1519 0.9817 BioCarta//Hs_Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages      3/25 (42) 0.6980 0.9817 BioCarta//Hs_Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway      4/20 (23) 0.2996 0.9817 BioCarta//Hs_Sonic Hedgehog (Shh) Pathway      2/16 (29) 0.6753 0.9817 BioCarta//Hs_ALK in cardiac myocytes      5/34 (51) 0.5226 0.9817 BioCarta//Hs_Agrin in Postsynaptic Differentiation      7/39 (50) 0.2939 0.9817 BioCarta//Hs_Ras Signaling Pathway      4/22 (23) 0.3671 0.9817 BioCarta//Hs_Role of Mitochondria in Apoptotic Signaling      1/20 (38) 0.9510 0.9817 BioCarta//Hs_Trefoil Factors Initiate Mucosal Healing      6/24 (95) 0.1046 0.9817 BioCarta//Hs_AKT Signaling Pathway      4/21 (32) 0.3333 0.9817 BioCarta//Hs_Erk1/Erk2 Mapk Signaling pathway      6/28 (33) 0.1839 0.9817 BioCarta//Hs_Integrin Signaling Pathway      6/37 (45) 0.4119 0.9817 BioCarta//Hs_Sprouty regulation of tyrosine kinase signals      4/18 (31) 0.2340 0.9817 BioCarta//Hs_Bioactive Peptide Induced Signaling Pathway      7/38 (58) 0.2706 0.9817 BioCarta//Hs_Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling      4/33 (44) 0.6953 0.9817 BioCarta//Hs_Role of Ran in mitotic spindle regulation      2/10 (15) 0.4156 0.9817 BioCarta//Hs_Biosynthesis of spermidine and spermine      1/1 (1) 0.1392 0.9817 BioCarta//Hs_Cells and Molecules involved in local acute inflammatory response      3/17 (19) 0.4287 0.9817 BioCarta//Hs_mCalpain and friends in Cell motility      2/22 (38) 0.8334 0.9817 BioCarta//Hs_uCalpain and friends in Cell spread      1/17 (36) 0.9228 0.9817 BioCarta//Hs_Aspirin Blocks Signaling Pathway Involved in Platelet Activation      3/22 (32) 0.6095 0.9817 BioCarta//Hs_Adhesion and Diapedesis of Lymphocytes      4/14 (47) 0.1181 0.9817 BioCarta//Hs_Melanocyte Development and Pigmentation Pathway      1/7 (13) 0.6505 0.9817 BioCarta//Hs_Hemoglobins Chaperone      3/13 (31) 0.2669 0.9817 BioCarta//Hs_Cytokines and Inflammatory Response      2/27 (78) 0.9081 0.9817 BioCarta//Hs_Erythrocyte Differentiation Pathway      3/15 (21) 0.3483 0.9817 BioCarta//Hs_Function of SLRP in Bone: An Integrated View      2/4 (4) 0.0955 0.9817 BioCarta//Hs_Selective expression of chemokine receptors during T-cell polarization      2/29 (55) 0.9281 0.9817 BioCarta//Hs_Signal transduction through IL1R      5/30 (41) 0.4077 0.9817 BioCarta//Hs_FAS signaling pathway ( CD95 )      2/30 (34) 0.9365 0.9817 BioCarta//Hs_Blockade of Neurotransmitter Relase by Botulinum Toxin      2/5 (28) 0.1449 0.9817 BioCarta//Hs_Feeder Pathways for Glycolysis      3/9 (11) 0.1179 0.9817 BioCarta//Hs_IL12 and Stat4 Dependent Signaling Pathway in Th1 Development      1/21 (27) 0.9579 0.9817 BioCarta//Hs_The Co-Stimulatory Signal During T-cell Activation      4/16 (40) 0.1726 0.9817 BioCarta//Hs_Regulation of ck1/cdk5 by type 1 glutamate receptors      2/17 (38) 0.7082 0.9817 BioCarta//Hs_Telomeres, Telomerase, Cellular Aging, and Immortality      3/18 (31) 0.4677 0.9817 BioCarta//Hs_Cyclins and Cell Cycle Regulation      1/23 (46) 0.9690 0.9817 BioCarta//Hs_Regulation of PGC-1a      3/23 (31) 0.6408 0.9817 BioCarta//Hs_Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)      2/28 (41) 0.9187 0.9817 BioCarta//Hs_Ghrelin: Regulation of Food Intake and Energy Homeostasis      2/11 (30) 0.4661 0.9817 BioCarta//Hs_The IGF-1 Receptor and Longevity      2/14 (14) 0.6007 0.9817 BioCarta//Hs_CXCR4 Signaling Pathway      2/24 (35) 0.8682 0.9817 BioCarta//Hs_Proteasome Complex      2/19 (24) 0.7656 0.9817 BioCarta//Hs_Metabolism of Anandamide, an Endogenous Cannabinoid      2/6 (13) 0.1981 0.9817 BioCarta//Hs_Fibrinolysis Pathway      3/11 (14) 0.1885 0.9817 BioCarta//Hs_Role of Parkin in the Ubiquitin-Proteasomal Pathway      3/12 (38) 0.2271 0.9817 BioCarta//Hs_Gamma-aminobutyric Acid Receptor Life Cycle      2/12 (73) 0.5139 0.9817 BioCarta//Hs_Role of MAL in Rho-Mediated Activation of SRF      3/19 (26) 0.5054 0.9817 BioCarta//Hs_FXR and LXR Regulation of Cholesterol Metabolism      3/8 (14) 0.0873 0.9817 BioCarta//Hs_Acute Myocardial Infarction      2/20 (23) 0.7905 0.9817 BioCarta//Hs_Effects of calcineurin in Keratinocyte Differentiation      1/18 (36) 0.9337 0.9817 BioCarta//Hs_fMLP induced chemokine gene expression in HMC-1 cells      2/36 (58) 0.9703 0.9817 BioCarta//Hs_Nitric Oxide Signaling Pathway      2/21 (25) 0.8130 0.9817 BioCarta//Hs_Role of MEF2D in T-cell Apoptosis      1/16 (45) 0.9102 0.9817 BioCarta//Hs_Dendritic cells in regulating TH1 and TH2 Development      1/22 (25) 0.9639 0.9817 BioCarta//Hs_Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression      1/4 (7) 0.4512 0.9817 BioCarta//Hs_Rac 1 cell motility signaling pathway      3/21 (23) 0.5765 0.9817 BioCarta//Hs_Dicer Pathway      1/2 (4) 0.2590 0.9817 BioCarta//Hs_CBL mediated ligand-induced downregulation of EGF receptors      2/13 (51) 0.5588 0.9817 BioCarta//Hs_Free Radical Induced Apoptosis      1/10 (11) 0.7776 0.9817 BioCarta//Hs_G-Protein Signaling Through Tubby Proteins      2/7 (11) 0.2532 0.9817 BioCarta//Hs_HIV-1 defeats host-mediated resistance by CEM15      1/3 (5) 0.3623 0.9817 BioCarta//Hs_Visual Signal Transduction      2/9 (12) 0.3629 0.9817 BioCarta//Hs_IL 5 Signaling Pathway      1/8 (19) 0.6993 0.9817 BioCarta//Hs_Polyadenylation of mRNA      1/9 (35) 0.7414 0.9817 BioCarta//Hs_IL22 Soluble Receptor Signaling Pathway      1/12 (40) 0.8355 0.9817 BioCarta//Hs_Adhesion and Diapedesis of Granulocytes      2/15 (49) 0.6395 0.9817 BioCarta//Hs_CCR3 signaling in Eosinophils      2/23 (30) 0.8517 0.9817 BioCarta//Hs_FOSB gene expression and drug abuse      1/5 (11) 0.5278 0.9817 BioCarta//Hs_TACI and BCMA stimulation of B cell immune responses.      1/14 (21) 0.8784 0.9817 BioCarta//Hs_Eukaryotic protein translation      1/15 (20) 0.8955 0.9817 BioCarta//Hs_Mechanism of Acetaminophen Activity and Toxicity      1/6 (7) 0.5937 0.9817 BioCarta//Hs_Map Kinase Inactivation of SMRT Corepressor      1/11 (14) 0.8087 0.9817 BioCarta//Hs_Hypoxia and p53 in the Cardiovascular system      1/22 (37) 0.9639 0.9828 BioCarta//Hs_Apoptotic Signaling in Response to DNA Damage      1/21 (29) 0.9579 0.9844 BioCarta//Hs_Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility      1/21 (25) 0.9579 0.9844 BioCarta//Hs_The 4-1BB-dependent immune response      1/18 (22) 0.9337 0.9868 BioCarta//Hs_Th1/Th2 Differentiation      1/18 (88) 0.9337 0.9868 BioCarta//Hs_Influence of Ras and Rho proteins on G1 to S Transition      1/26 (33) 0.9804 0.9880 BioCarta//Hs_Oxidative Stress Induced Gene Expression Via Nrf2      1/20 (24) 0.9510 0.9891 BioCarta//Hs_VEGF, Hypoxia, and Angiogenesis      1/28 (34) 0.9855 0.9893 BioCarta//Hs_TNFR1 Signaling Pathway      2/29 (36) 0.9281 0.9930 BioCarta//Hs_Toll-Like Receptor Pathway      1/34 (45) 0.9942 0.9942 BioCarta//Hs_Y branching of actin filaments      1/17 (45) 0.9228 0.9956 BioCarta//Hs_Steps in the Glycosylation of Mammalian N-linked Oligosaccarides      1/16 (16) 0.9102 0.9985 BioCarta//Hs_Chaperones modulate interferon Signaling Pathway      1/16 (34) 0.9102 0.9985 BioCarta//Hs_Links between Pyk2 and Map Kinases      2/28 (44) 0.9187 0.9994 BioCarta//Hs_Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration      1/15 (15) 0.8955 1.0036 BioCarta//Hs_beta-arrestins in GPCR Desensitization      1/15 (40) 0.8955 1.0036 BioCarta//Hs_IL 17 Signaling Pathway      1/15 (16) 0.8955 1.0036 BioCarta//Hs_PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase      1/15 (18) 0.8955 1.0036 BioCarta//Hs_TNF/Stress Related Signaling      2/25 (31) 0.8830 1.0158 BioCarta//Hs_Estrogen-responsive protein Efp controls cell cycle and breast tumors growth      1/14 (59) 0.8784 1.0196 BioCarta//Hs_Mechanisms of transcriptionalrepression by DNA methylation      1/14 (20) 0.8784 1.0196 BioCarta//Hs_Stress Induction of HSP Regulation      1/14 (22) 0.8784 1.0196 BioCarta//Hs_Platelet Amyloid Precursor Protein Pathway      1/14 (15) 0.8784 1.0196 BioCarta//Hs_Spliceosomal Assembly      1/14 (14) 0.8784 1.0196 BioCarta//Hs_Control of Gene Expression by Vitamin D Receptor      2/24 (32) 0.8682 1.0354 BioCarta//Hs_NFkB activation by Nontypeable Hemophilus influenzae      2/24 (43) 0.8682 1.0354 BioCarta//Hs_mTOR Signaling Pathway      2/24 (44) 0.8682 1.0354 BioCarta//Hs_How does salmonella hijack a cell      1/12 (32) 0.8355 1.0444 BioCarta//Hs_Cystic fibrosis transmembrane conductance regulator and beta 2 adrenergic receptor pathway      1/12 (37) 0.8355 1.0444 BioCarta//Hs_The PRC2 Complex sets Long-term gene Silencing The Modification of Histone Tails      1/12 (20) 0.8355 1.0444 BioCarta//Hs_Role of ?arrestins in the activation and targeting of MAP kinases      2/17 (40) 0.7082 1.0461 BioCarta//Hs_Pertussis toxin-insensitive CCR5 Signaling in Macrophage      2/17 (38) 0.7082 1.0461 BioCarta//Hs_Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes      2/17 (20) 0.7082 1.0461 BioCarta//Hs_NO2-dependent IL 12 Pathway in NK cells      2/17 (20) 0.7082 1.0461 BioCarta//Hs_ADP-Ribosylation Factor      2/21 (57) 0.8130 1.0464 BioCarta//Hs_Ceramide Signaling Pathway      2/21 (21) 0.8130 1.0464 BioCarta//Hs_Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases      1/9 (9) 0.7414 1.0476 BioCarta//Hs_Mechanism of Protein Import into the Nucleus      1/9 (19) 0.7414 1.0476 BioCarta//Hs_HIV Induced T Cell Apoptosis      1/9 (23) 0.7414 1.0476 BioCarta//Hs_IFN alpha signaling pathway      1/9 (25) 0.7414 1.0476 BioCarta//Hs_Alternative Complement Pathway      1/9 (46) 0.7414 1.0476 BioCarta//Hs_Transcription Regulation by Methyltransferase of CARM1      1/13 (34) 0.8586 1.0480 BioCarta//Hs_NF-kB Signaling Pathway      2/23 (49) 0.8517 1.0495 BioCarta//Hs_Phosphoinositides and their downstream targets.      2/23 (23) 0.8517 1.0495 BioCarta//Hs_g-Secretase mediated ErbB4 Signaling Pathway      1/7 (19) 0.6505 1.0570 BioCarta//Hs_Reelin Signaling Pathway      1/7 (10) 0.6505 1.0570 BioCarta//Hs_How Progesterone Initiates the Oocyte Maturation      3/30 (32) 0.8106 1.0590 BioCarta//Hs_Intrinsic Prothrombin Activation Pathway      3/23 (36) 0.6408 1.0613 BioCarta//Hs_TPO Signaling Pathway      3/23 (54) 0.6408 1.0613 BioCarta//Hs_Stathmin and breast cancer resistance to antimicrotubule agents      3/23 (26) 0.6408 1.0613 BioCarta//Hs_Calcium Signaling by HBx of Hepatitis B virus      1/8 (8) 0.6993 1.0633 BioCarta//Hs_Shuttle for transfer of acetyl groups from mitochondria to the cytosol      1/8 (11) 0.6993 1.0633 BioCarta//Hs_Overview of telomerase protein component gene hTert Transcriptional Regulation      1/8 (20) 0.6993 1.0633 BioCarta//Hs_RNA polymerase III transcription      1/8 (22) 0.6993 1.0633 BioCarta//Hs_SODD/TNFR1 Signaling Pathway      1/10 (18) 0.7776 1.0641 BioCarta//Hs_Sumoylation by RanBP2 Regulates Transcriptional Repression      1/10 (25) 0.7776 1.0641 BioCarta//Hs_SARS Coronavirus Protease      1/10 (16) 0.7776 1.0641 BioCarta//Hs_Granzyme A mediated Apoptosis Pathway      1/11 (28) 0.8087 1.0674 BioCarta//Hs_Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation      1/11 (35) 0.8087 1.0674 BioCarta//Hs_Prion Pathway      1/11 (11) 0.8087 1.0674 BioCarta//Hs_Eicosanoid Metabolism      2/20 (20) 0.7905 1.0704 BioCarta//Hs_Regulation of transcriptional activity by PML      2/16 (24) 0.6753 1.0771 BioCarta//Hs_Regulation of BAD phosphorylation      3/22 (31) 0.6095 1.0781 BioCarta//Hs_Inhibition of Cellular Proliferation by Gleevec      3/22 (23) 0.6095 1.0781 BioCarta//Hs_Caspase Cascade in Apoptosis      3/22 (27) 0.6095 1.0781 BioCarta//Hs_Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia      3/22 (40) 0.6095 1.0781 BioCarta//Hs_Cadmium induces DNA synthesis and proliferation in macrophages      2/15 (21) 0.6395 1.0867 BioCarta//Hs_Endocytotic role of NDK, Phosphins and Dynamin      2/15 (48) 0.6395 1.0867 BioCarta//Hs_WNT Signaling Pathway      3/25 (42) 0.6980 1.0933 BioCarta//Hs_Presenilin action in Notch and Wnt signaling      2/14 (31) 0.6007 1.0998 BioCarta//Hs_Segmentation Clock      2/14 (20) 0.6007 1.0998 BioCarta//Hs_Protein Kinase A at the Centrosome      2/14 (28) 0.6007 1.0998 BioCarta//Hs_Insulin Signaling Pathway      5/21 (48) 0.1566 1.1002 BioCarta//Hs_T Cytotoxic Cell Surface Molecules      4/12 (12) 0.0729 1.1146 BioCarta//Hs_Biosynthesis of neurotransmitters      1/6 (6) 0.5937 1.1186 BioCarta//Hs_Regulation of Spermatogenesis by CREM      1/6 (14) 0.5937 1.1186 BioCarta//Hs_Activation of cAMP-dependent protein kinase, PKA      1/6 (10) 0.5937 1.1186 BioCarta//Hs_SUMOylation as a mechanism to modulate CtBP-dependent gene responses      1/6 (11) 0.5937 1.1186 BioCarta//Hs_Beta-Oxidation of Fatty Acids      1/6 (6) 0.5937 1.1186 BioCarta//Hs_Visceral Fat Deposits and the Metabolic Syndrome      1/6 (9) 0.5937 1.1186 BioCarta//Hs_SREBP control of lipid synthesis      1/6 (24) 0.5937 1.1186 BioCarta//Hs_Proteolysis and Signaling Pathway of Notch      2/6 (20) 0.1981 1.1200 BioCarta//Hs_Pelp1 Modulation of Estrogen Receptor Activity      2/6 (10) 0.1981 1.1200 BioCarta//Hs_Multi-Drug Resistance Factors      2/6 (14) 0.1981 1.1200 BioCarta//Hs_Low-density lipoprotein (LDL) pathway during atherogenesis      2/6 (10) 0.1981 1.1200 BioCarta//Hs_Msp/Ron Receptor Signaling Pathway      2/6 (27) 0.1981 1.1200 BioCarta//Hs_Eph Kinases and ephrins support platelet aggregation      3/10 (17) 0.1519 1.1285 BioCarta//Hs_Cycling of Ran in nucleocytoplasmic transport      1/5 (8) 0.5278 1.1341 BioCarta//Hs_B Cell Receptor Complex      1/2 (10) 0.2590 1.1416 BioCarta//Hs_Catabolic pathways for alanine, glycine, serine, cysteine, tryptophan, and threonine      1/2 (2) 0.2590 1.1416 BioCarta//Hs_Alpha-synuclein and Parkin-mediated proteolysis in Parkinsons disease      1/2 (9) 0.2590 1.1416 BioCarta//Hs_Signaling Pathway from G-Protein Families      5/34 (42) 0.5226 1.1419 BioCarta//Hs_BCR Signaling Pathway      5/34 (54) 0.5226 1.1419 BioCarta//Hs_Extrinsic Prothrombin Activation Pathway      2/13 (24) 0.5588 1.1439 BioCarta//Hs_IL-10 Anti-inflammatory Signaling Pathway      2/13 (17) 0.5588 1.1439 BioCarta//Hs_Angiotensin-converting enzyme 2 regulates heart function      2/13 (34) 0.5588 1.1439 BioCarta//Hs_IL 2 signaling pathway      4/22 (47) 0.3671 1.1500 BioCarta//Hs_Phospholipase C-epsilon pathway      2/12 (25) 0.5139 1.1518 BioCarta//Hs_D4-GDI Signaling Pathway      2/12 (15) 0.5139 1.1518 BioCarta//Hs_Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway      2/12 (16) 0.5139 1.1518 BioCarta//Hs_Trka Receptor Signaling Pathway      2/12 (12) 0.5139 1.1518 BioCarta//Hs_CTL mediated immune response against target cells      2/12 (25) 0.5139 1.1518 BioCarta//Hs_Ca++/ Calmodulin-dependent Protein Kinase Activation      2/12 (76) 0.5139 1.1518 BioCarta//Hs_Roles of ?arrestin-dependent Recruitment of Src Kinases in GPCR Signaling      3/21 (34) 0.5765 1.1530 BioCarta//Hs_Thrombin signaling and protease-activated receptors      3/21 (31) 0.5765 1.1530 BioCarta//Hs_PTEN dependent cell cycle arrest and apoptosis      3/18 (21) 0.4677 1.1581 BioCarta//Hs_Nuclear Receptors in Lipid Metabolism and Toxicity      11/34 (43) 0.0045 1.1581 BioCarta//Hs_IL-7 Signal Transduction      3/16 (29) 0.3888 1.1620 BioCarta//Hs_Multi-step Regulation of Transcription by Pitx2      3/16 (38) 0.3888 1.1620 BioCarta//Hs_Acetylation and Deacetylation of RelA in The Nucleus      3/16 (34) 0.3888 1.1620 BioCarta//Hs_Role of PPAR-gamma Coactivators in Obesity and Thermogenesis      2/9 (12) 0.3629 1.1648 BioCarta//Hs_B Lymphocyte Cell Surface Molecules      2/9 (10) 0.3629 1.1648 BioCarta//Hs_Regulation of eIF2      2/9 (20) 0.3629 1.1648 BioCarta//Hs_Cardiac Protection Against ROS      2/9 (9) 0.3629 1.1648 BioCarta//Hs_Generation of amyloid b-peptide by PS1      1/4 (9) 0.4512 1.1731 BioCarta//Hs_Inhibition of Huntingtons disease neurodegeneration by histone deacetylase inhibitors      1/4 (9) 0.4512 1.1731 BioCarta//Hs_Biosynthesis of Proline in Bacteria      1/4 (4) 0.4512 1.1731 BioCarta//Hs_Oxidative reactions of the pentose phosphate pathway      1/4 (4) 0.4512 1.1731 BioCarta//Hs_T Cell Receptor and CD3 Complex      1/4 (19) 0.4512 1.1731 BioCarta//Hs_Reversal of Insulin Resistance by Leptin      2/10 (11) 0.4156 1.1745 BioCarta//Hs_Repression of Pain Sensation by the Transcriptional Regulator DREAM      3/14 (21) 0.3075 1.1757 BioCarta//Hs_IL 4 signaling pathway      2/11 (17) 0.4661 1.1765 BioCarta//Hs_AKAP95 role in mitosis and chromosome dynamics      2/11 (39) 0.4661 1.1765 BioCarta//Hs_Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor recycling      2/5 (21) 0.1449 1.1776 BioCarta//Hs_CARM1 and Regulation of the Estrogen Receptor      5/26 (33) 0.2901 1.1786 BioCarta//Hs_Bone Remodelling      4/14 (19) 0.1181 1.1811 BioCarta//Hs_West Nile Virus      2/4 (4) 0.0955 1.1829 BioCarta//Hs_Nerve growth factor pathway (NGF)      4/18 (38) 0.2340 1.1928 BioCarta//Hs_The reactions that feed amino groups into the urea cycle      2/7 (16) 0.2532 1.1967 BioCarta//Hs_The role of FYVE-finger proteins in vesicle transport      2/7 (35) 0.2532 1.1967 BioCarta//Hs_Rab GTPases Mark Targets In The Endocytotic Machinery      3/12 (17) 0.2271 1.2048 BioCarta//Hs_EPO Signaling Pathway      3/19 (36) 0.5054 1.2056 BioCarta//Hs_Ras-Independent pathway in NK cell-mediated cytotoxicity      3/19 (19) 0.5054 1.2056 BioCarta//Hs_Role of Tob in T-cell activation      3/19 (30) 0.5054 1.2056 BioCarta//Hs_Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation      3/15 (29) 0.3483 1.2074 BioCarta//Hs_Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to fa      3/15 (28) 0.3483 1.2074 BioCarta//Hs_IL 3 signaling pathway      3/15 (30) 0.3483 1.2074 BioCarta//Hs_IL 6 signaling pathway      4/21 (48) 0.3333 1.2205 BioCarta//Hs_Synaptic Proteins at the Synaptic Junction      5/20 (32) 0.1336 1.2405 BioCarta//Hs_Inhibition of Matrix Metalloproteinases      3/9 (15) 0.1179 1.2778

Cluster 7 has 243 gene products

ArrayXPath has identified 152 out of 243 input elements in 234 out of 346 BioCarta pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value BioCarta//Hs_Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling      11/33 (44) 0.0001 0.0012 BioCarta//Hs_Activation of cAMP-dependent protein kinase, PKA      4/6 (10) 0.0008 0.0076 BioCarta//Hs_Signaling of Hepatocyte Growth Factor Receptor      9/36 (42) 0.0030 0.0197 BioCarta//Hs_p38 MAPK Signaling Pathway      9/38 (40) 0.0044 0.0220 BioCarta//Hs_IGF-1 Signaling Pathway      6/20 (45) 0.0058 0.0231 BioCarta//Hs_Links between Pyk2 and Map Kinases      7/28 (44) 0.0087 0.0289 BioCarta//Hs_MAPKinase Signaling Pathway      13/85 (88) 0.0311 0.0319 BioCarta//Hs_Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)      6/28 (41) 0.0312 0.0319 BioCarta//Hs_Role of Erk5 in Neuronal Survival      5/17 (36) 0.0129 0.0319 BioCarta//Hs_Control of Gene Expression by Vitamin D Receptor      6/24 (32) 0.0150 0.0319 BioCarta//Hs_Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia      5/22 (40) 0.0382 0.0319 BioCarta//Hs_PDGF Signaling Pathway      6/27 (61) 0.0264 0.0319 BioCarta//Hs_Role of MAL in Rho-Mediated Activation of SRF      5/19 (26) 0.0209 0.0319 BioCarta//Hs_Sprouty regulation of tyrosine kinase signals      5/18 (31) 0.0166 0.0319 BioCarta//Hs_Rab GTPases Mark Targets In The Endocytotic Machinery      4/12 (17) 0.0164 0.0319 BioCarta//Hs_Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to fa      4/15 (28) 0.0366 0.0319 BioCarta//Hs_Role of PPAR-gamma Coactivators in Obesity and Thermogenesis      3/9 (12) 0.0379 0.0319 BioCarta//Hs_The IGF-1 Receptor and Longevity      4/14 (14) 0.0288 0.0319 BioCarta//Hs_Signal Dependent Regulation of Myogenesis by Corepressor MITR      3/9 (25) 0.0379 0.0330 BioCarta//Hs_Regulation of eIF2      3/9 (20) 0.0379 0.0330 BioCarta//Hs_Polyadenylation of mRNA      3/9 (35) 0.0379 0.0330 BioCarta//Hs_Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases      3/9 (9) 0.0379 0.0330 BioCarta//Hs_Regulation of PGC-1a      5/23 (31) 0.0455 0.0364 BioCarta//Hs_Glycolysis Pathway      3/10 (21) 0.0507 0.0390 BioCarta//Hs_EGF Signaling Pathway      6/27 (54) 0.0264 0.0406 BioCarta//Hs_Eukaryotic protein translation      4/15 (20) 0.0366 0.0407 BioCarta//Hs_Ceramide Signaling Pathway      4/21 (21) 0.1067 0.0444 BioCarta//Hs_Insulin Signaling Pathway      4/21 (48) 0.1067 0.0444 BioCarta//Hs_Integrin Signaling Pathway      6/37 (45) 0.1005 0.0444 BioCarta//Hs_Roles of ?arrestin-dependent Recruitment of Src Kinases in GPCR Signaling      4/21 (34) 0.1067 0.0444 BioCarta//Hs_T Cell Receptor Signaling Pathway      7/43 (56) 0.0777 0.0444 BioCarta//Hs_Biosynthesis of valine      1/1 (2) 0.0882 0.0444 BioCarta//Hs_The 4-1BB-dependent immune response      4/18 (22) 0.0669 0.0444 BioCarta//Hs_TNFR1 Signaling Pathway      5/29 (36) 0.1052 0.0444 BioCarta//Hs_ChREBP regulation by carbohydrates and cAMP      4/19 (30) 0.0791 0.0444 BioCarta//Hs_Phospholipase C-epsilon pathway      3/12 (25) 0.0817 0.0444 BioCarta//Hs_Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor      4/20 (24) 0.0924 0.0444 BioCarta//Hs_VEGF, Hypoxia, and Angiogenesis      5/28 (34) 0.0934 0.0444 BioCarta//Hs_Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation      3/11 (35) 0.0654 0.0444 BioCarta//Hs_ER-associated degradation (ERAD) Pathway      3/13 (20) 0.0996 0.0444 BioCarta//Hs_Regulation of Spermatogenesis by CREM      2/6 (14) 0.0914 0.0444 BioCarta//Hs_Blockade of Neurotransmitter Relase by Botulinum Toxin      2/5 (28) 0.0646 0.0444 BioCarta//Hs_Erk1/Erk2 Mapk Signaling pathway      5/28 (33) 0.0934 0.0445 BioCarta//Hs_Nerve growth factor pathway (NGF)      4/18 (38) 0.0669 0.0446 BioCarta//Hs_Fc Epsilon Receptor I Signaling in Mast Cells      6/38 (49) 0.1111 0.0451 BioCarta//Hs_Inhibition of Cellular Proliferation by Gleevec      4/22 (23) 0.1219 0.0451 BioCarta//Hs_Ras Signaling Pathway      4/22 (23) 0.1219 0.0451 BioCarta//Hs_Regulation of BAD phosphorylation      4/22 (31) 0.1219 0.0451 BioCarta//Hs_The reactions that feed amino groups into the urea cycle      2/7 (16) 0.1208 0.0451 BioCarta//Hs_The Role of Eosinophils in the Chemokine Network of Allergy      2/6 (16) 0.0914 0.0469 BioCarta//Hs_Regulation of Splicing through Sam68      2/7 (8) 0.1208 0.0474 BioCarta//Hs_Biosynthesis of isoleucine      1/1 (2) 0.0882 0.0477 BioCarta//Hs_Biosynthesis of leucine      1/1 (2) 0.0882 0.0477 BioCarta//Hs_Cystic fibrosis transmembrane conductance regulator and beta 2 adrenergic receptor pathway      3/12 (37) 0.0817 0.0481 BioCarta//Hs_Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation      3/15 (29) 0.1396 0.0498 BioCarta//Hs_Endocytotic role of NDK, Phosphins and Dynamin      3/15 (48) 0.1396 0.0498 BioCarta//Hs_RNA polymerase III transcription      2/8 (22) 0.1521 0.0507 BioCarta//Hs_Internal Ribosome entry pathway      2/8 (39) 0.1521 0.0507 BioCarta//Hs_IL 5 Signaling Pathway      2/8 (19) 0.1521 0.0507 BioCarta//Hs_Overview of telomerase protein component gene hTert Transcriptional Regulation      2/8 (20) 0.1521 0.0507 BioCarta//Hs_Regulation of eIF4e and p70 S6 Kinase      4/24 (37) 0.1548 0.0508 BioCarta//Hs_Alternative Complement Pathway      2/9 (46) 0.1847 0.0528 BioCarta//Hs_Toll-Like Receptor Pathway      5/34 (45) 0.1742 0.0528 BioCarta//Hs_Corticosteroids and cardioprotection      3/17 (28) 0.1838 0.0528 BioCarta//Hs_Mechanism of Protein Import into the Nucleus      2/9 (19) 0.1847 0.0528 BioCarta//Hs_Cardiac Protection Against ROS      2/9 (9) 0.1847 0.0528 BioCarta//Hs_Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)      7/54 (64) 0.1923 0.0534 BioCarta//Hs_Transcription factor CREB and its extracellular signals      4/26 (26) 0.1907 0.0534 BioCarta//Hs_Signaling Pathway from G-Protein Families      5/34 (42) 0.1742 0.0544 BioCarta//Hs_BCR Signaling Pathway      5/34 (54) 0.1742 0.0544 BioCarta//Hs_Role of ?arrestins in the activation and targeting of MAP kinases      3/17 (40) 0.1838 0.0549 BioCarta//Hs_Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes      3/17 (20) 0.1838 0.0549 BioCarta//Hs_SARS Coronavirus Protease      2/10 (16) 0.2182 0.0574 BioCarta//Hs_Keratinocyte Differentiation      6/46 (67) 0.2139 0.0574 BioCarta//Hs_Double Stranded RNA Induced Gene Expression      2/10 (14) 0.2182 0.0574 BioCarta//Hs_SODD/TNFR1 Signaling Pathway      2/10 (18) 0.2182 0.0574 BioCarta//Hs_EPO Signaling Pathway      3/19 (36) 0.2313 0.0601 BioCarta//Hs_HIV-1 defeats host-mediated resistance by CEM15      1/3 (5) 0.2420 0.0620 BioCarta//Hs_Agrin in Postsynaptic Differentiation      5/39 (50) 0.2563 0.0633 BioCarta//Hs_Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway      3/20 (23) 0.2558 0.0633 BioCarta//Hs_Oxidative Stress Induced Gene Expression Via Nrf2      3/20 (24) 0.2558 0.0639 BioCarta//Hs_How Progesterone Initiates the Oocyte Maturation      4/30 (32) 0.2690 0.0640 BioCarta//Hs_FAS signaling pathway ( CD95 )      4/30 (34) 0.2690 0.0640 BioCarta//Hs_Actions of Nitric Oxide in the Heart      4/30 (44) 0.2690 0.0640 BioCarta//Hs_NFAT and Hypertrophy of the heart (Transcription in the broken heart)      6/51 (82) 0.2905 0.0657 BioCarta//Hs_Hypoxia and p53 in the Cardiovascular system      3/22 (37) 0.3057 0.0657 BioCarta//Hs_Ahr Signal Transduction Pathway      1/4 (12) 0.3089 0.0657 BioCarta//Hs_Rac 1 cell motility signaling pathway      3/21 (23) 0.2806 0.0657 BioCarta//Hs_Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine      1/4 (4) 0.3089 0.0657 BioCarta//Hs_Trka Receptor Signaling Pathway      2/12 (12) 0.2863 0.0657 BioCarta//Hs_Biosynthesis of Proline in Bacteria      1/4 (4) 0.3089 0.0657 BioCarta//Hs_Oxidative reactions of the pentose phosphate pathway      1/4 (4) 0.3089 0.0657 BioCarta//Hs_Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway      2/12 (16) 0.2863 0.0658 BioCarta//Hs_Transcription Regulation by Methyltransferase of CARM1      2/13 (34) 0.3202 0.0660 BioCarta//Hs_Attenuation of GPCR Signaling      2/13 (13) 0.3202 0.0660 BioCarta//Hs_Angiotensin-converting enzyme 2 regulates heart function      2/13 (34) 0.3202 0.0660 BioCarta//Hs_TPO Signaling Pathway      3/23 (54) 0.3309 0.0668 BioCarta//Hs_CCR3 signaling in Eosinophils      3/23 (30) 0.3309 0.0668 BioCarta//Hs_fMLP induced chemokine gene expression in HMC-1 cells      4/36 (58) 0.3935 0.0670 BioCarta//Hs_Pelp1 Modulation of Estrogen Receptor Activity      1/6 (10) 0.4257 0.0670 BioCarta//Hs_Trefoil Factors Initiate Mucosal Healing      3/24 (95) 0.3560 0.0670 BioCarta//Hs_TNF/Stress Related Signaling      3/25 (31) 0.3810 0.0670 BioCarta//Hs_Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells      3/26 (43) 0.4058 0.0670 BioCarta//Hs_Sonic Hedgehog (Shh) Pathway      2/16 (29) 0.4189 0.0670 BioCarta//Hs_FOSB gene expression and drug abuse      1/5 (11) 0.3700 0.0670 BioCarta//Hs_Visceral Fat Deposits and the Metabolic Syndrome      1/6 (9) 0.4257 0.0670 BioCarta//Hs_ALK in cardiac myocytes      4/34 (51) 0.3518 0.0670 BioCarta//Hs_beta-arrestins in GPCR Desensitization      2/15 (40) 0.3867 0.0670 BioCarta//Hs_Bystander B Cell Activation      1/6 (15) 0.4257 0.0670 BioCarta//Hs_Multi-Drug Resistance Factors      1/6 (14) 0.4257 0.0670 BioCarta//Hs_Wnt/LRP6 Signalling      1/6 (25) 0.4257 0.0670 BioCarta//Hs_B Cell Survival Pathway      2/14 (16) 0.3537 0.0670 BioCarta//Hs_Catabolic Pathways for Arginine , Histidine, Glutamate, Glutamine, and Proline      1/6 (6) 0.4257 0.0670 BioCarta//Hs_SREBP control of lipid synthesis      1/6 (24) 0.4257 0.0670 BioCarta//Hs_Overview of telomerase RNA component gene hTerc Transcriptional Regulation      1/6 (15) 0.4257 0.0670 BioCarta//Hs_IL 2 signaling pathway      3/22 (47) 0.3057 0.0679 BioCarta//Hs_Bioactive Peptide Induced Signaling Pathway      4/38 (58) 0.4349 0.0680 BioCarta//Hs_Repression of Pain Sensation by the Transcriptional Regulator DREAM      2/14 (21) 0.3537 0.0680 BioCarta//Hs_Bone Remodelling      2/14 (19) 0.3537 0.0680 BioCarta//Hs_Protein Kinase A at the Centrosome      2/14 (28) 0.3537 0.0680 BioCarta//Hs_IL 3 signaling pathway      2/15 (30) 0.3867 0.0690 BioCarta//Hs_PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase      2/15 (18) 0.3867 0.0690 BioCarta//Hs_Hypoxia-Inducible Factor in the Cardiovascular System      2/15 (20) 0.3867 0.0690 BioCarta//Hs_Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration      2/15 (15) 0.3867 0.0690 BioCarta//Hs_Pertussis toxin-insensitive CCR5 Signaling in Macrophage      2/17 (38) 0.4502 0.0698 BioCarta//Hs_Growth Hormone Signaling Pathway      3/26 (35) 0.4058 0.0700 BioCarta//Hs_Influence of Ras and Rho proteins on G1 to S Transition      3/26 (33) 0.4058 0.0700 BioCarta//Hs_Human Cytomegalovirus and Map Kinase Pathways      2/16 (17) 0.4189 0.0704 BioCarta//Hs_GATA3 participate in activating the Th2 cytokine genes expression      2/16 (25) 0.4189 0.0704 BioCarta//Hs_PTEN dependent cell cycle arrest and apoptosis      2/18 (21) 0.4806 0.0712 BioCarta//Hs_TNFR2 Signaling Pathway      2/18 (32) 0.4806 0.0712 BioCarta//Hs_Telomeres, Telomerase, Cellular Aging, and Immortality      2/18 (31) 0.4806 0.0712 BioCarta//Hs_Effects of calcineurin in Keratinocyte Differentiation      2/18 (36) 0.4806 0.0712 BioCarta//Hs_Reelin Signaling Pathway      1/7 (10) 0.4766 0.0712 BioCarta//Hs_Lectin Induced Complement Pathway      1/12 (56) 0.6709 0.0721 BioCarta//Hs_HIV-I Nef: negative effector of Fas and TNF      5/57 (77) 0.5754 0.0721 BioCarta//Hs_ATM Signaling Pathway      2/19 (32) 0.5099 0.0721 BioCarta//Hs_mCalpain and friends in Cell motility      2/22 (38) 0.5912 0.0721 BioCarta//Hs_mTOR Signaling Pathway      2/24 (44) 0.6396 0.0721 BioCarta//Hs_Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages      2/25 (42) 0.6621 0.0721 BioCarta//Hs_How does salmonella hijack a cell      1/12 (32) 0.6709 0.0721 BioCarta//Hs_NF-kB Signaling Pathway      2/23 (49) 0.6160 0.0721 BioCarta//Hs_Tumor Suppressor Arf Inhibits Ribosomal Biogenesis      1/12 (17) 0.6709 0.0721 BioCarta//Hs_Ion Channels and Their Functional Role in Vascular Endothelium      2/20 (20) 0.5382 0.0721 BioCarta//Hs_D4-GDI Signaling Pathway      1/12 (15) 0.6709 0.0721 BioCarta//Hs_Ca++/ Calmodulin-dependent Protein Kinase Activation      1/12 (76) 0.6709 0.0721 BioCarta//Hs_Shuttle for transfer of acetyl groups from mitochondria to the cytosol      1/8 (11) 0.5229 0.0721 BioCarta//Hs_Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility      2/21 (25) 0.5653 0.0721 BioCarta//Hs_T Helper Cell Surface Molecules      1/12 (12) 0.6709 0.0721 BioCarta//Hs_Role of Ran in mitotic spindle regulation      1/10 (15) 0.6037 0.0721 BioCarta//Hs_Inhibition of Matrix Metalloproteinases      1/9 (15) 0.5652 0.0721 BioCarta//Hs_Gamma-aminobutyric Acid Receptor Life Cycle      1/12 (73) 0.6709 0.0721 BioCarta//Hs_Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle      1/11 (30) 0.6389 0.0721 BioCarta//Hs_Vitamin C in the Brain      1/11 (20) 0.6389 0.0726 BioCarta//Hs_Erythropoietin mediated neuroprotection through NF-kB      1/11 (17) 0.6389 0.0726 BioCarta//Hs_AKAP95 role in mitosis and chromosome dynamics      1/11 (39) 0.6389 0.0726 BioCarta//Hs_Map Kinase Inactivation of SMRT Corepressor      1/11 (14) 0.6389 0.0726 BioCarta//Hs_Ghrelin: Regulation of Food Intake and Energy Homeostasis      1/11 (30) 0.6389 0.0726 BioCarta//Hs_IL 4 signaling pathway      1/11 (17) 0.6389 0.0726 BioCarta//Hs_Granzyme A mediated Apoptosis Pathway      1/11 (28) 0.6389 0.0726 BioCarta//Hs_BTG family proteins and cell cycle regulation      1/11 (13) 0.6389 0.0726 BioCarta//Hs_The role of FYVE-finger proteins in vesicle transport      1/7 (35) 0.4766 0.0728 BioCarta//Hs_CARM1 and Regulation of the Estrogen Receptor      2/26 (33) 0.6835 0.0731 BioCarta//Hs_Platelet Amyloid Precursor Protein Pathway      1/14 (15) 0.7268 0.0733 BioCarta//Hs_Rho cell motility signaling pathway      2/30 (32) 0.7581 0.0733 BioCarta//Hs_Steps in the Glycosylation of Mammalian N-linked Oligosaccarides      1/16 (16) 0.7733 0.0733 BioCarta//Hs_Multi-step Regulation of Transcription by Pitx2      1/16 (38) 0.7733 0.0733 BioCarta//Hs_Role of MEF2D in T-cell Apoptosis      1/16 (45) 0.7733 0.0733 BioCarta//Hs_METS affect on Macrophage Differentiation      1/16 (30) 0.7733 0.0733 BioCarta//Hs_Regulation of hematopoiesis by cytokines      1/15 (41) 0.7511 0.0733 BioCarta//Hs_Chaperones modulate interferon Signaling Pathway      1/16 (34) 0.7733 0.0733 BioCarta//Hs_Regulation of transcriptional activity by PML      1/16 (24) 0.7733 0.0733 BioCarta//Hs_Acetylation and Deacetylation of RelA in The Nucleus      1/16 (34) 0.7733 0.0733 BioCarta//Hs_CBL mediated ligand-induced downregulation of EGF receptors      1/13 (51) 0.7002 0.0733 BioCarta//Hs_Downregulated of MTA-3 in ER-negative Breast Tumors      1/16 (23) 0.7733 0.0733 BioCarta//Hs_Ras-Independent pathway in NK cell-mediated cytotoxicity      2/19 (19) 0.5099 0.0734 BioCarta//Hs_TGF beta signaling pathway      2/19 (76) 0.5099 0.0734 BioCarta//Hs_Complement Pathway      2/19 (33) 0.5099 0.0734 BioCarta//Hs_Cells and Molecules involved in local acute inflammatory response      1/17 (19) 0.7935 0.0735 BioCarta//Hs_Regulation of ck1/cdk5 by type 1 glutamate receptors      1/17 (38) 0.7935 0.0735 BioCarta//Hs_NO2-dependent IL 12 Pathway in NK cells      1/17 (20) 0.7935 0.0735 BioCarta//Hs_uCalpain and friends in Cell spread      1/17 (36) 0.7935 0.0735 BioCarta//Hs_Y branching of actin filaments      1/17 (45) 0.7935 0.0735 BioCarta//Hs_Electron Transport Reaction in Mitochondria      1/10 (10) 0.6037 0.0736 BioCarta//Hs_Regulators of Bone Mineralization      1/10 (57) 0.6037 0.0736 BioCarta//Hs_E2F1 Destruction Pathway      1/10 (16) 0.6037 0.0736 BioCarta//Hs_Reversal of Insulin Resistance by Leptin      1/10 (11) 0.6037 0.0736 BioCarta//Hs_Sumoylation by RanBP2 Regulates Transcriptional Repression      1/10 (25) 0.6037 0.0736 BioCarta//Hs_Antigen Dependent B Cell Activation      1/10 (24) 0.6037 0.0736 BioCarta//Hs_Eph Kinases and ephrins support platelet aggregation      1/10 (17) 0.6037 0.0736 BioCarta//Hs_Stat3 Signaling Pathway      1/8 (13) 0.5229 0.0736 BioCarta//Hs_Calcium Signaling by HBx of Hepatitis B virus      1/8 (8) 0.5229 0.0736 BioCarta//Hs_Regulation of p27 Phosphorylation during Cell Cycle Progression      1/13 (20) 0.7002 0.0737 BioCarta//Hs_IL-10 Anti-inflammatory Signaling Pathway      1/13 (17) 0.7002 0.0737 BioCarta//Hs_Intrinsic Prothrombin Activation Pathway      2/23 (36) 0.6160 0.0738 BioCarta//Hs_Cyclins and Cell Cycle Regulation      2/23 (46) 0.6160 0.0738 BioCarta//Hs_ADP-Ribosylation Factor      2/21 (57) 0.5653 0.0739 BioCarta//Hs_IL 6 signaling pathway      2/21 (48) 0.5653 0.0739 BioCarta//Hs_Role of ERBB2 in Signal Transduction and Oncology      2/21 (34) 0.5653 0.0739 BioCarta//Hs_Nitric Oxide Signaling Pathway      2/21 (25) 0.5653 0.0739 BioCarta//Hs_Thrombin signaling and protease-activated receptors      2/21 (31) 0.5653 0.0739 BioCarta//Hs_Phospholipids as signalling intermediaries      2/25 (42) 0.6621 0.0740 BioCarta//Hs_Signal transduction through IL1R      2/30 (41) 0.7581 0.0747 BioCarta//Hs_Cadmium induces DNA synthesis and proliferation in macrophages      1/15 (21) 0.7511 0.0747 BioCarta//Hs_Adhesion and Diapedesis of Granulocytes      1/15 (49) 0.7511 0.0747 BioCarta//Hs_CD40L Signaling Pathway      1/15 (27) 0.7511 0.0747 BioCarta//Hs_Erythrocyte Differentiation Pathway      1/15 (21) 0.7511 0.0747 BioCarta//Hs_The information-processing pathway at the IFN-beta enhancer      1/15 (27) 0.7511 0.0747 BioCarta//Hs_IL 17 Signaling Pathway      1/15 (16) 0.7511 0.0747 BioCarta//Hs_Classical Complement Pathway      1/14 (68) 0.7268 0.0749 BioCarta//Hs_TACI and BCMA stimulation of B cell immune responses.      1/14 (21) 0.7268 0.0749 BioCarta//Hs_Mechanisms of transcriptionalrepression by DNA methylation      1/14 (20) 0.7268 0.0749 BioCarta//Hs_Aspirin Blocks Signaling Pathway Involved in Platelet Activation      2/22 (32) 0.5912 0.0758 BioCarta//Hs_IL-2 Receptor Beta Chain in T cell Activation      2/35 (38) 0.8298 0.0761 BioCarta//Hs_Lissencephaly gene (LIS1) in neuronal migration and development      1/19 (48) 0.8286 0.0761 BioCarta//Hs_Eicosanoid Metabolism      1/20 (20) 0.8439 0.0767 BioCarta//Hs_Acute Myocardial Infarction      1/20 (23) 0.8439 0.0767 BioCarta//Hs_Cyclin E Destruction Pathway      1/9 (14) 0.5652 0.0769 BioCarta//Hs_HIV Induced T Cell Apoptosis      1/9 (23) 0.5652 0.0769 BioCarta//Hs_Lck and Fyn tyrosine kinases in initiation of TCR Activation      1/9 (16) 0.5652 0.0769 BioCarta//Hs_IL12 and Stat4 Dependent Signaling Pathway in Th1 Development      1/21 (27) 0.8579 0.0769 BioCarta//Hs_Apoptotic Signaling in Response to DNA Damage      1/21 (29) 0.8579 0.0769 BioCarta//Hs_AKT Signaling Pathway      1/21 (32) 0.8579 0.0769 BioCarta//Hs_Stathmin and breast cancer resistance to antimicrotubule agents      1/23 (26) 0.8821 0.0781 BioCarta//Hs_CTCF: First Multivalent Nuclear Factor      1/23 (26) 0.8821 0.0781 BioCarta//Hs_Phosphoinositides and their downstream targets.      1/23 (23) 0.8821 0.0781 BioCarta//Hs_CXCR4 Signaling Pathway      1/24 (35) 0.8927 0.0783 BioCarta//Hs_NFkB activation by Nontypeable Hemophilus influenzae      1/24 (43) 0.8927 0.0783 BioCarta//Hs_WNT Signaling Pathway      1/25 (42) 0.9023 0.0788 BioCarta//Hs_Cytokines and Inflammatory Response      1/27 (78) 0.9190 0.0799 BioCarta//Hs_Cell Cycle: G1/S Check Point      1/28 (34) 0.9263 0.0802 BioCarta//Hs_Selective expression of chemokine receptors during T-cell polarization      1/29 (55) 0.9329 0.0804 BioCarta//Hs_Induction of apoptosis through DR3 and DR4/5 Death Receptors      1/32 (37) 0.9494 0.0815 BioCarta//Hs_Nuclear Receptors in Lipid Metabolism and Toxicity      1/34 (43) 0.9581 0.0819

Cluster 8 has 272 gene products

ArrayXPath has identified 160 out of 272 input elements in 232 out of 346 BioCarta pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value BioCarta//Hs_CDK Regulation of DNA Replication      6/17 (56) 0.0033 0.1651 BioCarta//Hs_Ras Signaling Pathway      5/22 (23) 0.0494 0.1821 BioCarta//Hs_RNA polymerase III transcription      3/8 (22) 0.0324 0.1821 BioCarta//Hs_Induction of apoptosis through DR3 and DR4/5 Death Receptors      5/32 (37) 0.1781 0.1821 BioCarta//Hs_Influence of Ras and Rho proteins on G1 to S Transition      6/26 (33) 0.0301 0.1821 BioCarta//Hs_Keratinocyte Differentiation      7/46 (67) 0.1363 0.1821 BioCarta//Hs_MAPKinase Signaling Pathway      11/85 (88) 0.1712 0.1821 BioCarta//Hs_NF-kB Signaling Pathway      3/23 (49) 0.3722 0.1821 BioCarta//Hs_Signal transduction through IL1R      6/30 (41) 0.0567 0.1821 BioCarta//Hs_TACI and BCMA stimulation of B cell immune responses.      4/14 (21) 0.0361 0.1821 BioCarta//Hs_TNF/Stress Related Signaling      5/25 (31) 0.0794 0.1821 BioCarta//Hs_Phosphoinositides and their downstream targets.      6/23 (23) 0.0167 0.1821 BioCarta//Hs_fMLP induced chemokine gene expression in HMC-1 cells      6/36 (58) 0.1168 0.1821 BioCarta//Hs_Growth Hormone Signaling Pathway      4/26 (35) 0.2258 0.1821 BioCarta//Hs_IL-2 Receptor Beta Chain in T cell Activation      4/35 (38) 0.4248 0.1821 BioCarta//Hs_Links between Pyk2 and Map Kinases      6/28 (44) 0.0421 0.1821 BioCarta//Hs_METS affect on Macrophage Differentiation      4/16 (30) 0.0566 0.1821 BioCarta//Hs_p38 MAPK Signaling Pathway      6/38 (40) 0.1420 0.1821 BioCarta//Hs_PDGF Signaling Pathway      4/27 (61) 0.2471 0.1821 BioCarta//Hs_Regulation of transcriptional activity by PML      2/16 (24) 0.4551 0.1821 BioCarta//Hs_Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy      4/18 (31) 0.0822 0.1821 BioCarta//Hs_Role of MAL in Rho-Mediated Activation of SRF      3/19 (26) 0.2644 0.1821 BioCarta//Hs_Signaling of Hepatocyte Growth Factor Receptor      4/36 (42) 0.4468 0.1821 BioCarta//Hs_Signaling Pathway from G-Protein Families      5/34 (42) 0.2124 0.1821 BioCarta//Hs_T Cell Receptor Signaling Pathway      6/43 (56) 0.2146 0.1821 BioCarta//Hs_Transcription factor CREB and its extracellular signals      5/26 (26) 0.0911 0.1821 BioCarta//Hs_CCR3 signaling in Eosinophils      4/23 (30) 0.1656 0.1821 BioCarta//Hs_BCR Signaling Pathway      6/34 (54) 0.0941 0.1821 BioCarta//Hs_Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling      5/33 (44) 0.1950 0.1821 BioCarta//Hs_Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)      5/28 (41) 0.1171 0.1821 BioCarta//Hs_Cell Cycle: G1/S Check Point      4/28 (34) 0.2687 0.1821 BioCarta//Hs_Cyclin E Destruction Pathway      2/9 (14) 0.2059 0.1821 BioCarta//Hs_E2F1 Destruction Pathway      3/10 (16) 0.0604 0.1821 BioCarta//Hs_p53 Signaling Pathway      2/16 (27) 0.4551 0.1821 BioCarta//Hs_Glycolysis Pathway      2/10 (21) 0.2423 0.1821 BioCarta//Hs_Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)      6/54 (64) 0.4025 0.1821 BioCarta//Hs_CARM1 and Regulation of the Estrogen Receptor      3/26 (33) 0.4515 0.1821 BioCarta//Hs_Control of Gene Expression by Vitamin D Receptor      3/24 (32) 0.3990 0.1821 BioCarta//Hs_Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration      3/15 (15) 0.1623 0.1821 BioCarta//Hs_Human Cytomegalovirus and Map Kinase Pathways      2/16 (17) 0.4551 0.1821 BioCarta//Hs_Oxidative Stress Induced Gene Expression Via Nrf2      3/20 (24) 0.2912 0.1821 BioCarta//Hs_ER-associated degradation (ERAD) Pathway      3/13 (20) 0.1169 0.1821 BioCarta//Hs_Cell to Cell Adhesion Signaling      2/13 (14) 0.3516 0.1821 BioCarta//Hs_Multi-step Regulation of Transcription by Pitx2      2/16 (38) 0.4551 0.1821 BioCarta//Hs_WNT Signaling Pathway      3/25 (42) 0.4254 0.1821 BioCarta//Hs_ALK in cardiac myocytes      4/34 (51) 0.4026 0.1821 BioCarta//Hs_FAS signaling pathway ( CD95 )      4/30 (34) 0.3129 0.1821 BioCarta//Hs_TNFR1 Signaling Pathway      4/29 (36) 0.2907 0.1821 BioCarta//Hs_Overview of telomerase RNA component gene hTerc Transcriptional Regulation      2/6 (15) 0.1032 0.1821 BioCarta//Hs_g-Secretase mediated ErbB4 Signaling Pathway      2/7 (19) 0.1358 0.1821 BioCarta//Hs_Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases      3/9 (9) 0.0453 0.1821 BioCarta//Hs_IL12 and Stat4 Dependent Signaling Pathway in Th1 Development      4/21 (27) 0.1292 0.1821 BioCarta//Hs_Effects of calcineurin in Keratinocyte Differentiation      3/18 (36) 0.2379 0.1821 BioCarta//Hs_Role of MEF2D in T-cell Apoptosis      2/16 (45) 0.4551 0.1821 BioCarta//Hs_Steps in the Glycosylation of Mammalian N-linked Oligosaccarides      3/16 (16) 0.1867 0.1821 BioCarta//Hs_Biosynthesis of neurotransmitters      1/6 (6) 0.4492 0.1821 BioCarta//Hs_Apoptotic Signaling in Response to DNA Damage      3/21 (29) 0.3182 0.1821 BioCarta//Hs_Ion Channel and Phorbal Esters Signaling Pathway      2/5 (7) 0.0733 0.1821 BioCarta//Hs_Pertussis toxin-insensitive CCR5 Signaling in Macrophage      3/17 (38) 0.2120 0.1821 BioCarta//Hs_Phospholipase C d1 in phospholipid associated cell signaling      1/5 (10) 0.3915 0.1821 BioCarta//Hs_Phospholipase C Signaling Pathway      2/8 (12) 0.1703 0.1821 BioCarta//Hs_PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase      2/15 (18) 0.4216 0.1821 BioCarta//Hs_D4-GDI Signaling Pathway      2/12 (15) 0.3155 0.1821 BioCarta//Hs_Caspase Cascade in Apoptosis      3/22 (27) 0.3453 0.1821 BioCarta//Hs_Bone Remodelling      2/14 (19) 0.3870 0.1821 BioCarta//Hs_Generation of amyloid b-peptide by PS1      1/4 (9) 0.3279 0.1821 BioCarta//Hs_Biosynthesis of Cysteine from serine in bacteria and plants      1/1 (1) 0.0945 0.1821 BioCarta//Hs_HIV-I Nef: negative effector of Fas and TNF      5/57 (77) 0.6392 0.1843 BioCarta//Hs_Integrin Signaling Pathway      3/37 (45) 0.6951 0.1843 BioCarta//Hs_NFAT and Hypertrophy of the heart (Transcription in the broken heart)      5/51 (82) 0.5365 0.1843 BioCarta//Hs_Bioactive Peptide Induced Signaling Pathway      4/38 (58) 0.4901 0.1843 BioCarta//Hs_Phospholipids as signalling intermediaries      2/25 (42) 0.7004 0.1843 BioCarta//Hs_Y branching of actin filaments      2/17 (45) 0.4876 0.1843 BioCarta//Hs_Agrin in Postsynaptic Differentiation      4/39 (50) 0.5112 0.1843 BioCarta//Hs_Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages      2/25 (42) 0.7004 0.1843 BioCarta//Hs_Th1/Th2 Differentiation      2/18 (88) 0.5188 0.1843 BioCarta//Hs_Ion Channels and Their Functional Role in Vascular Endothelium      2/20 (20) 0.5773 0.1843 BioCarta//Hs_Antigen Processing and Presentation      1/8 (16) 0.5487 0.1843 BioCarta//Hs_Thrombin signaling and protease-activated receptors      2/21 (31) 0.6046 0.1843 BioCarta//Hs_Lissencephaly gene (LIS1) in neuronal migration and development      2/19 (48) 0.5487 0.1843 BioCarta//Hs_Reelin Signaling Pathway      1/7 (10) 0.5014 0.1843 BioCarta//Hs_Hypoxia and p53 in the Cardiovascular system      2/22 (37) 0.6305 0.1843 BioCarta//Hs_CTCF: First Multivalent Nuclear Factor      2/23 (26) 0.6551 0.1843 BioCarta//Hs_Eph Kinases and ephrins support platelet aggregation      1/10 (17) 0.6303 0.1843 BioCarta//Hs_Cystic fibrosis transmembrane conductance regulator and beta 2 adrenergic receptor pathway      1/12 (37) 0.6973 0.1843 BioCarta//Hs_Regulation of eIF2      1/9 (20) 0.5915 0.1843 BioCarta//Hs_Fibrinolysis Pathway      1/11 (14) 0.6655 0.1843 BioCarta//Hs_Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway      1/12 (16) 0.6973 0.1855 BioCarta//Hs_Ca++/ Calmodulin-dependent Protein Kinase Activation      1/12 (76) 0.6973 0.1855 BioCarta//Hs_CTL mediated immune response against target cells      1/12 (25) 0.6973 0.1855 BioCarta//Hs_T Cytotoxic Cell Surface Molecules      1/12 (12) 0.6973 0.1855 BioCarta//Hs_T Helper Cell Surface Molecules      1/12 (12) 0.6973 0.1855 BioCarta//Hs_Rab GTPases Mark Targets In The Endocytotic Machinery      1/12 (17) 0.6973 0.1855 BioCarta//Hs_Role of Parkin in the Ubiquitin-Proteasomal Pathway      1/12 (38) 0.6973 0.1855 BioCarta//Hs_Prion Pathway      1/11 (11) 0.6655 0.1859 BioCarta//Hs_Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle      1/11 (30) 0.6655 0.1859 BioCarta//Hs_Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation      1/11 (35) 0.6655 0.1859 BioCarta//Hs_BTG family proteins and cell cycle regulation      1/11 (13) 0.6655 0.1859 BioCarta//Hs_Vitamin C in the Brain      1/11 (20) 0.6655 0.1859 BioCarta//Hs_Monocyte and its Surface Molecules      1/11 (12) 0.6655 0.1859 BioCarta//Hs_Activation of Src by Protein-tyrosine phosphatase alpha      1/11 (29) 0.6655 0.1859 BioCarta//Hs_Inhibition of Huntingtons disease neurodegeneration by histone deacetylase inhibitors      1/4 (9) 0.3279 0.1863 BioCarta//Hs_Malate-aspartate shuttle      1/4 (8) 0.3279 0.1863 BioCarta//Hs_West Nile Virus      1/4 (4) 0.3279 0.1863 BioCarta//Hs_Function of SLRP in Bone: An Integrated View      1/4 (4) 0.3279 0.1863 BioCarta//Hs_Protein Kinase A at the Centrosome      1/14 (28) 0.7522 0.1871 BioCarta//Hs_The IGF-1 Receptor and Longevity      1/14 (14) 0.7522 0.1871 BioCarta//Hs_Adhesion and Diapedesis of Lymphocytes      1/14 (47) 0.7522 0.1871 BioCarta//Hs_Mechanisms of transcriptionalrepression by DNA methylation      1/14 (20) 0.7522 0.1871 BioCarta//Hs_Segmentation Clock      1/14 (20) 0.7522 0.1871 BioCarta//Hs_Stress Induction of HSP Regulation      1/14 (22) 0.7522 0.1871 BioCarta//Hs_B Cell Survival Pathway      1/14 (16) 0.7522 0.1871 BioCarta//Hs_Classical Complement Pathway      1/14 (68) 0.7522 0.1871 BioCarta//Hs_Extrinsic Prothrombin Activation Pathway      1/13 (24) 0.7261 0.1871 BioCarta//Hs_Erk1/Erk2 Mapk Signaling pathway      2/28 (33) 0.7590 0.1879 BioCarta//Hs_Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells      3/26 (43) 0.4515 0.1881 BioCarta//Hs_Attenuation of GPCR Signaling      1/13 (13) 0.7261 0.1881 BioCarta//Hs_Hemoglobins Chaperone      1/13 (31) 0.7261 0.1881 BioCarta//Hs_Selective expression of chemokine receptors during T-cell polarization      2/29 (55) 0.7762 0.1884 BioCarta//Hs_Erythrocyte Differentiation Pathway      1/15 (21) 0.7758 0.1884 BioCarta//Hs_IL 3 signaling pathway      1/15 (30) 0.7758 0.1892 BioCarta//Hs_Adhesion and Diapedesis of Granulocytes      1/15 (49) 0.7758 0.1892 BioCarta//Hs_Rho cell motility signaling pathway      2/30 (32) 0.7924 0.1898 BioCarta//Hs_Acetylation and Deacetylation of RelA in The Nucleus      1/16 (34) 0.7972 0.1898 BioCarta//Hs_GATA3 participate in activating the Th2 cytokine genes expression      1/16 (25) 0.7972 0.1898 BioCarta//Hs_Sonic Hedgehog (Shh) Pathway      1/16 (29) 0.7972 0.1898 BioCarta//Hs_Cadmium induces DNA synthesis and proliferation in macrophages      2/15 (21) 0.4216 0.1899 BioCarta//Hs_Role of nicotinic acetylcholine receptors in the regulation of apoptosis      2/15 (24) 0.4216 0.1899 BioCarta//Hs_The information-processing pathway at the IFN-beta enhancer      2/15 (27) 0.4216 0.1899 BioCarta//Hs_Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to fa      2/15 (28) 0.4216 0.1899 BioCarta//Hs_Hypoxia-Inducible Factor in the Cardiovascular System      2/15 (20) 0.4216 0.1899 BioCarta//Hs_IL 2 signaling pathway      2/22 (47) 0.6305 0.1899 BioCarta//Hs_Inhibition of Cellular Proliferation by Gleevec      2/22 (23) 0.6305 0.1899 BioCarta//Hs_Aspirin Blocks Signaling Pathway Involved in Platelet Activation      2/22 (32) 0.6305 0.1899 BioCarta//Hs_Regulation of BAD phosphorylation      2/22 (31) 0.6305 0.1899 BioCarta//Hs_EGF Signaling Pathway      4/27 (54) 0.2471 0.1900 BioCarta//Hs_Beta-Oxidation of Fatty Acids      1/6 (6) 0.4492 0.1903 BioCarta//Hs_SUMOylation as a mechanism to modulate CtBP-dependent gene responses      1/6 (11) 0.4492 0.1903 BioCarta//Hs_Wnt/LRP6 Signalling      1/6 (25) 0.4492 0.1903 BioCarta//Hs_Overview of telomerase protein component gene hTert Transcriptional Regulation      1/8 (20) 0.5487 0.1905 BioCarta//Hs_The Citric Acid Cycle      1/8 (9) 0.5487 0.1905 BioCarta//Hs_Neutrophil and Its Surface Molecules      1/8 (12) 0.5487 0.1905 BioCarta//Hs_uCalpain and friends in Cell spread      1/17 (36) 0.8165 0.1908 BioCarta//Hs_Cells and Molecules involved in local acute inflammatory response      1/17 (19) 0.8165 0.1908 BioCarta//Hs_NO2-dependent IL 12 Pathway in NK cells      1/17 (20) 0.8165 0.1908 BioCarta//Hs_Corticosteroids and cardioprotection      1/17 (28) 0.8165 0.1908 BioCarta//Hs_RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage      2/13 (17) 0.3516 0.1911 BioCarta//Hs_Transcription Regulation by Methyltransferase of CARM1      2/13 (34) 0.3516 0.1911 BioCarta//Hs_The role of FYVE-finger proteins in vesicle transport      1/7 (35) 0.5014 0.1914 BioCarta//Hs_Regulation of Splicing through Sam68      1/7 (8) 0.5014 0.1914 BioCarta//Hs_Activation of PKC through G protein coupled receptor      1/7 (8) 0.5014 0.1914 BioCarta//Hs_Regulation of PGC-1a      2/23 (31) 0.6551 0.1915 BioCarta//Hs_Cyclins and Cell Cycle Regulation      2/23 (46) 0.6551 0.1915 BioCarta//Hs_Intrinsic Prothrombin Activation Pathway      2/23 (36) 0.6551 0.1915 BioCarta//Hs_Toll-Like Receptor Pathway      4/34 (45) 0.4026 0.1917 BioCarta//Hs_AKT Signaling Pathway      3/21 (32) 0.3182 0.1917 BioCarta//Hs_Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility      3/21 (25) 0.3182 0.1917 BioCarta//Hs_Insulin Signaling Pathway      3/21 (48) 0.3182 0.1917 BioCarta//Hs_Rac 1 cell motility signaling pathway      3/21 (23) 0.3182 0.1917 BioCarta//Hs_Ceramide Signaling Pathway      3/21 (21) 0.3182 0.1917 BioCarta//Hs_The 4-1BB-dependent immune response      2/18 (22) 0.5188 0.1921 BioCarta//Hs_Sprouty regulation of tyrosine kinase signals      2/18 (31) 0.5188 0.1921 BioCarta//Hs_Apoptotic DNA fragmentation and tissue homeostasis      2/10 (15) 0.2423 0.1923 BioCarta//Hs_Role of Erk5 in Neuronal Survival      3/17 (36) 0.2120 0.1927 BioCarta//Hs_Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes      3/17 (20) 0.2120 0.1927 BioCarta//Hs_Polyadenylation of mRNA      1/9 (35) 0.5915 0.1933 BioCarta//Hs_Signal Dependent Regulation of Myogenesis by Corepressor MITR      1/9 (25) 0.5915 0.1933 BioCarta//Hs_Adhesion Molecules on Lymphocyte      1/9 (10) 0.5915 0.1933 BioCarta//Hs_Visual Signal Transduction      1/9 (12) 0.5915 0.1933 BioCarta//Hs_Mechanism of Protein Import into the Nucleus      1/9 (19) 0.5915 0.1933 BioCarta//Hs_Regulation of cell cycle progression by Plk3      2/8 (17) 0.1703 0.1935 BioCarta//Hs_Calcium Signaling by HBx of Hepatitis B virus      2/8 (8) 0.1703 0.1935 BioCarta//Hs_Shuttle for transfer of acetyl groups from mitochondria to the cytosol      2/8 (11) 0.1703 0.1935 BioCarta//Hs_BRCA1-dependent Ub-ligase activity      2/8 (18) 0.1703 0.1935 BioCarta//Hs_Nuclear Receptors in Lipid Metabolism and Toxicity      2/34 (43) 0.8472 0.1949 BioCarta//Hs_Role of Tob in T-cell activation      1/19 (30) 0.8499 0.1949 BioCarta//Hs_TGF beta signaling pathway      1/19 (76) 0.8499 0.1949 BioCarta//Hs_Complement Pathway      1/19 (33) 0.8499 0.1949 BioCarta//Hs_Nitric Oxide Signaling Pathway      2/21 (25) 0.6046 0.1950 BioCarta//Hs_TNFR2 Signaling Pathway      3/18 (32) 0.2379 0.1950 BioCarta//Hs_Nerve growth factor pathway (NGF)      3/18 (38) 0.2379 0.1950 BioCarta//Hs_NFkB activation by Nontypeable Hemophilus influenzae      3/24 (43) 0.3990 0.1956 BioCarta//Hs_Cell Cycle: G2/M Checkpoint      3/24 (27) 0.3990 0.1956 BioCarta//Hs_CXCR4 Signaling Pathway      3/24 (35) 0.3990 0.1956 BioCarta//Hs_Trefoil Factors Initiate Mucosal Healing      3/24 (95) 0.3990 0.1956 BioCarta//Hs_Reversal of Insulin Resistance by Leptin      1/10 (11) 0.6303 0.1958 BioCarta//Hs_Free Radical Induced Apoptosis      1/10 (11) 0.6303 0.1958 BioCarta//Hs_Electron Transport Reaction in Mitochondria      1/10 (10) 0.6303 0.1958 BioCarta//Hs_Sumoylation by RanBP2 Regulates Transcriptional Repression      1/10 (25) 0.6303 0.1958 BioCarta//Hs_Deregulation of CDK5 in Alzheimers Disease      1/10 (16) 0.6303 0.1958 BioCarta//Hs_IL 6 signaling pathway      1/21 (48) 0.8772 0.1958 BioCarta//Hs_Role of ERBB2 in Signal Transduction and Oncology      1/21 (34) 0.8772 0.1958 BioCarta//Hs_Roles of ?arrestin-dependent Recruitment of Src Kinases in GPCR Signaling      1/21 (34) 0.8772 0.1958 BioCarta//Hs_ADP-Ribosylation Factor      1/21 (57) 0.8772 0.1958 BioCarta//Hs_Acute Myocardial Infarction      1/20 (23) 0.8643 0.1958 BioCarta//Hs_ATM Signaling Pathway      2/19 (32) 0.5487 0.1960 BioCarta//Hs_Ras-Independent pathway in NK cell-mediated cytotoxicity      2/19 (19) 0.5487 0.1960 BioCarta//Hs_Proteasome Complex      2/19 (24) 0.5487 0.1960 BioCarta//Hs_Synaptic Proteins at the Synaptic Junction      2/20 (32) 0.5773 0.1964 BioCarta//Hs_IGF-1 Signaling Pathway      2/20 (45) 0.5773 0.1964 BioCarta//Hs_Role of Mitochondria in Apoptotic Signaling      1/20 (38) 0.8643 0.1964 BioCarta//Hs_Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia      1/22 (40) 0.8890 0.1967 BioCarta//Hs_mCalpain and friends in Cell motility      1/22 (38) 0.8890 0.1967 BioCarta//Hs_EPO Signaling Pathway      3/19 (36) 0.2644 0.1973 BioCarta//Hs_cdc25 and chk1 Regulatory Pathway in response to DNA damage      2/9 (13) 0.2059 0.1980 BioCarta//Hs_Inhibition of Matrix Metalloproteinases      2/9 (15) 0.2059 0.1980 BioCarta//Hs_B Lymphocyte Cell Surface Molecules      2/9 (10) 0.2059 0.1980 BioCarta//Hs_Stathmin and breast cancer resistance to antimicrotubule agents      1/23 (26) 0.8996 0.1982 BioCarta//Hs_mTOR Signaling Pathway      1/24 (44) 0.9093 0.1985 BioCarta//Hs_Regulation of eIF4e and p70 S6 Kinase      1/24 (37) 0.9093 0.1985 BioCarta//Hs_Repression of Pain Sensation by the Transcriptional Regulator DREAM      2/14 (21) 0.3870 0.2016 BioCarta//Hs_Presenilin action in Notch and Wnt signaling      2/14 (31) 0.3870 0.2016 BioCarta//Hs_Cytokines and Inflammatory Response      1/27 (78) 0.9330 0.2028 BioCarta//Hs_How Progesterone Initiates the Oocyte Maturation      1/30 (32) 0.9505 0.2048 BioCarta//Hs_Actions of Nitric Oxide in the Heart      1/30 (44) 0.9505 0.2048 BioCarta//Hs_Trka Receptor Signaling Pathway      2/12 (12) 0.3155 0.2049 BioCarta//Hs_Tumor Suppressor Arf Inhibits Ribosomal Biogenesis      2/12 (17) 0.3155 0.2049 BioCarta//Hs_How does salmonella hijack a cell      2/12 (32) 0.3155 0.2049 BioCarta//Hs_Gamma-aminobutyric Acid Receptor Life Cycle      2/12 (73) 0.3155 0.2049 BioCarta//Hs_Eicosanoid Metabolism      3/20 (20) 0.2912 0.2051 BioCarta//Hs_Fc Epsilon Receptor I Signaling in Mast Cells      6/38 (49) 0.1420 0.2089 BioCarta//Hs_TPO Signaling Pathway      4/23 (54) 0.1656 0.2123 BioCarta//Hs_VEGF, Hypoxia, and Angiogenesis      5/28 (34) 0.1171 0.2169 BioCarta//Hs_Melanocyte Development and Pigmentation Pathway      2/7 (13) 0.1358 0.2190 BioCarta//Hs_G-Protein Signaling Through Tubby Proteins      2/7 (11) 0.1358 0.2190 BioCarta//Hs_CD40L Signaling Pathway      3/15 (27) 0.1623 0.2193 BioCarta//Hs_Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation      3/15 (29) 0.1623 0.2193 BioCarta//Hs_Regulation of p27 Phosphorylation during Cell Cycle Progression      3/13 (20) 0.1169 0.2339 BioCarta//Hs_CBL mediated ligand-induced downregulation of EGF receptors      3/13 (51) 0.1169 0.2339 BioCarta//Hs_Mechanism of Acetaminophen Activity and Toxicity      2/6 (7) 0.1032 0.2457 BioCarta//Hs_TSP-1 Induced Apoptosis in Microvascular Endothelial Cell      2/6 (9) 0.1032 0.2457 BioCarta//Hs_Double Stranded RNA Induced Gene Expression      3/10 (14) 0.0604 0.2516

Cluster 9 has 21 gene products

ArrayXPath has identified 11 out of 21 input elements in 21 out of 346 BioCarta pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value BioCarta//Hs_cdc25 and chk1 Regulatory Pathway in response to DNA damage      3/9 (13) 0.0000 0.0001 BioCarta//Hs_Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle      3/11 (30) 0.0000 0.0001 BioCarta//Hs_Activation of Src by Protein-tyrosine phosphatase alpha      3/11 (29) 0.0000 0.0001 BioCarta//Hs_Cell Cycle: G2/M Checkpoint      4/24 (27) 0.0000 0.0001 BioCarta//Hs_RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage      3/13 (17) 0.0000 0.0001 BioCarta//Hs_Role of Ran in mitotic spindle regulation      2/10 (15) 0.0016 0.0030 BioCarta//Hs_Stathmin and breast cancer resistance to antimicrotubule agents      2/23 (26) 0.0084 0.0140 BioCarta//Hs_How Progesterone Initiates the Oocyte Maturation      2/30 (32) 0.0141 0.0206 BioCarta//Hs_Regulation of Splicing through Sam68      1/7 (8) 0.0433 0.0561 BioCarta//Hs_Regulation of cell cycle progression by Plk3      1/8 (17) 0.0494 0.0575 BioCarta//Hs_Mechanism of Protein Import into the Nucleus      1/9 (19) 0.0554 0.0587 BioCarta//Hs_Apoptotic DNA fragmentation and tissue homeostasis      1/10 (15) 0.0614 0.0596 BioCarta//Hs_AKAP95 role in mitosis and chromosome dynamics      1/11 (39) 0.0673 0.0603 BioCarta//Hs_Estrogen-responsive protein Efp controls cell cycle and breast tumors growth      1/14 (59) 0.0850 0.0618 BioCarta//Hs_Protein Kinase A at the Centrosome      1/14 (28) 0.0850 0.0618 BioCarta//Hs_B Cell Survival Pathway      1/14 (16) 0.0850 0.0618 BioCarta//Hs_Sonic Hedgehog (Shh) Pathway      1/16 (29) 0.0966 0.0662 BioCarta//Hs_Cyclins and Cell Cycle Regulation      1/23 (46) 0.1361 0.0881 BioCarta//Hs_Cell Cycle: G1/S Check Point      1/28 (34) 0.1634 0.1001 BioCarta//Hs_Keratinocyte Differentiation      1/46 (67) 0.2553 0.1487 BioCarta//Hs_MAPKinase Signaling Pathway      1/85 (88) 0.4240 0.2351

Cluster 10 has 163 gene products

ArrayXPath has identified 116 out of 163 input elements in 217 out of 346 BioCarta pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value BioCarta//Hs_mCalpain and friends in Cell motility      7/22 (38) 0.0004 0.0384 BioCarta//Hs_Acute Myocardial Infarction      7/20 (23) 0.0002 0.0391 BioCarta//Hs_Platelet Amyloid Precursor Protein Pathway      5/14 (15) 0.0017 0.1011 BioCarta//Hs_Integrin Signaling Pathway      8/37 (45) 0.0027 0.1147 BioCarta//Hs_Eph Kinases and ephrins support platelet aggregation      4/10 (17) 0.0032 0.1147 BioCarta//Hs_Intrinsic Prothrombin Activation Pathway      5/23 (36) 0.0173 0.3613 BioCarta//Hs_Regulators of Bone Mineralization      3/10 (57) 0.0265 0.3613 BioCarta//Hs_Neuroregulin receptor degredation protein-1 Controls ErbB3 receptor recycling      2/5 (21) 0.0407 0.3613 BioCarta//Hs_Agrin in Postsynaptic Differentiation      6/39 (50) 0.0463 0.3613 BioCarta//Hs_Signaling of Hepatocyte Growth Factor Receptor      6/36 (42) 0.0326 0.3613 BioCarta//Hs_VEGF, Hypoxia, and Angiogenesis      5/28 (34) 0.0383 0.3613 BioCarta//Hs_Aspirin Blocks Signaling Pathway Involved in Platelet Activation      5/22 (32) 0.0143 0.3613 BioCarta//Hs_uCalpain and friends in Cell spread      4/17 (36) 0.0249 0.3613 BioCarta//Hs_Actions of Nitric Oxide in the Heart      5/30 (44) 0.0498 0.3613 BioCarta//Hs_Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor      4/20 (24) 0.0433 0.3613 BioCarta//Hs_Fibrinolysis Pathway      3/11 (14) 0.0346 0.3613 BioCarta//Hs_IFN gamma signaling pathway      2/6 (28) 0.0584 0.3613 BioCarta//Hs_TSP-1 Induced Apoptosis in Microvascular Endothelial Cell      2/6 (9) 0.0584 0.3613 BioCarta//Hs_Circadian Rhythms      2/6 (13) 0.0584 0.3613 BioCarta//Hs_ChREBP regulation by carbohydrates and cAMP      4/19 (30) 0.0365 0.3613 BioCarta//Hs_Attenuation of GPCR Signaling      3/13 (13) 0.0543 0.3613 BioCarta//Hs_Activation of cAMP-dependent protein kinase, PKA      2/6 (10) 0.0584 0.3613 BioCarta//Hs_Transcriptional activation of dbpb from mRNA      2/4 (9) 0.0256 0.3613 BioCarta//Hs_Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia      5/22 (40) 0.0143 0.3658 BioCarta//Hs_Cell Cycle: G1/S Check Point      5/28 (34) 0.0383 0.3822 BioCarta//Hs_Angiotensin-converting enzyme 2 regulates heart function      3/13 (34) 0.0543 0.3897 BioCarta//Hs_Cell to Cell Adhesion Signaling      3/13 (14) 0.0543 0.3897 BioCarta//Hs_Repression of Pain Sensation by the Transcriptional Regulator DREAM      3/14 (21) 0.0657 0.3933 BioCarta//Hs_ATM Signaling Pathway      4/19 (32) 0.0365 0.4094 BioCarta//Hs_CXCR4 Signaling Pathway      4/24 (35) 0.0769 0.4263 BioCarta//Hs_Signaling Pathway from G-Protein Families      5/34 (42) 0.0784 0.4263 BioCarta//Hs_The information-processing pathway at the IFN-beta enhancer      3/15 (27) 0.0782 0.4263 BioCarta//Hs_Vitamin C in the Brain      3/11 (20) 0.0346 0.4437 BioCarta//Hs_METS affect on Macrophage Differentiation      3/16 (30) 0.0916 0.4697 BioCarta//Hs_p53 Signaling Pathway      3/16 (27) 0.0916 0.4697 BioCarta//Hs_Antigen Processing and Presentation      2/8 (16) 0.0996 0.4967 BioCarta//Hs_Biosynthesis of threonine and methionine      1/2 (2) 0.1326 0.5180 BioCarta//Hs_Erk1/Erk2 Mapk Signaling pathway      4/28 (33) 0.1205 0.5180 BioCarta//Hs_NFAT and Hypertrophy of the heart (Transcription in the broken heart)      6/51 (82) 0.1319 0.5180 BioCarta//Hs_Selective expression of chemokine receptors during T-cell polarization      4/29 (55) 0.1328 0.5180 BioCarta//Hs_Th1/Th2 Differentiation      3/18 (88) 0.1210 0.5180 BioCarta//Hs_Adhesion Molecules on Lymphocyte      2/9 (10) 0.1225 0.5180 BioCarta//Hs_TGF beta signaling pathway      3/19 (76) 0.1368 0.5225 BioCarta//Hs_Alternative Complement Pathway      2/9 (46) 0.1225 0.5236 BioCarta//Hs_Inhibition of Matrix Metalloproteinases      2/9 (15) 0.1225 0.5236 BioCarta//Hs_Biosynthesis of Cysteine in mammals      1/2 (2) 0.1326 0.5289 BioCarta//Hs_How Progesterone Initiates the Oocyte Maturation      4/30 (32) 0.1455 0.5367 BioCarta//Hs_Reversal of Insulin Resistance by Leptin      2/10 (11) 0.1465 0.5367 BioCarta//Hs_Nerve growth factor pathway (NGF)      3/18 (38) 0.1210 0.5568 BioCarta//Hs_The PRC2 Complex sets Long-term gene Silencing The Modification of Histone Tails      2/12 (20) 0.1969 0.5610 BioCarta//Hs_Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway      2/12 (16) 0.1969 0.5610 BioCarta//Hs_Trka Receptor Signaling Pathway      2/12 (12) 0.1969 0.5610 BioCarta//Hs_Thrombin signaling and protease-activated receptors      3/21 (31) 0.1705 0.5610 BioCarta//Hs_Tumor Suppressor Arf Inhibits Ribosomal Biogenesis      2/12 (17) 0.1969 0.5610 BioCarta//Hs_Monocyte and its Surface Molecules      2/11 (12) 0.1714 0.5610 BioCarta//Hs_HIV-1 defeats host-mediated resistance by CEM15      1/3 (5) 0.1922 0.5610 BioCarta//Hs_Hypoxia and p53 in the Cardiovascular system      3/22 (37) 0.1881 0.5610 BioCarta//Hs_Cystic fibrosis transmembrane conductance regulator and beta 2 adrenergic receptor pathway      2/12 (37) 0.1969 0.5610 BioCarta//Hs_Phospholipase C-epsilon pathway      2/12 (25) 0.1969 0.5610 BioCarta//Hs_Cyclins and Cell Cycle Regulation      3/23 (46) 0.2062 0.5693 BioCarta//Hs_Keratinocyte Differentiation      5/46 (67) 0.2040 0.5693 BioCarta//Hs_Map Kinase Inactivation of SMRT Corepressor      2/11 (14) 0.1714 0.5697 BioCarta//Hs_IL 4 signaling pathway      2/11 (17) 0.1714 0.5697 BioCarta//Hs_BTG family proteins and cell cycle regulation      2/11 (13) 0.1714 0.5697 BioCarta//Hs_fMLP induced chemokine gene expression in HMC-1 cells      4/36 (58) 0.2306 0.5881 BioCarta//Hs_B Cell Survival Pathway      2/14 (16) 0.2490 0.5881 BioCarta//Hs_Adhesion and Diapedesis of Lymphocytes      2/14 (47) 0.2490 0.5881 BioCarta//Hs_Protein Kinase A at the Centrosome      2/14 (28) 0.2490 0.5881 BioCarta//Hs_Transcription Regulation by Methyltransferase of CARM1      2/13 (34) 0.2228 0.5881 BioCarta//Hs_Inhibition of Huntingtons disease neurodegeneration by histone deacetylase inhibitors      1/4 (9) 0.2478 0.5881 BioCarta//Hs_Influence of Ras and Rho proteins on G1 to S Transition      3/26 (33) 0.2624 0.5962 BioCarta//Hs_Transcription factor CREB and its extracellular signals      3/26 (26) 0.2624 0.5962 BioCarta//Hs_Bioactive Peptide Induced Signaling Pathway      4/38 (58) 0.2613 0.5962 BioCarta//Hs_Extrinsic Prothrombin Activation Pathway      2/13 (24) 0.2228 0.5969 BioCarta//Hs_Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to fa      2/15 (28) 0.2753 0.6026 BioCarta//Hs_Hypoxia-Inducible Factor in the Cardiovascular System      2/15 (20) 0.2753 0.6026 BioCarta//Hs_IL 17 Signaling Pathway      2/15 (16) 0.2753 0.6026 BioCarta//Hs_IL 2 signaling pathway      3/22 (47) 0.1881 0.6028 BioCarta//Hs_EGF Signaling Pathway      3/27 (54) 0.2816 0.6081 BioCarta//Hs_Regulation of transcriptional activity by PML      2/16 (24) 0.3015 0.6081 BioCarta//Hs_IL-7 Signal Transduction      2/16 (29) 0.3015 0.6081 BioCarta//Hs_Chaperones modulate interferon Signaling Pathway      2/16 (34) 0.3015 0.6081 BioCarta//Hs_Downregulated of MTA-3 in ER-negative Breast Tumors      2/16 (23) 0.3015 0.6081 BioCarta//Hs_GATA3 participate in activating the Th2 cytokine genes expression      2/16 (25) 0.3015 0.6081 BioCarta//Hs_Sonic Hedgehog (Shh) Pathway      2/16 (29) 0.3015 0.6081 BioCarta//Hs_Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine      1/4 (4) 0.2478 0.6092 BioCarta//Hs_Biosynthesis of Proline in Bacteria      1/4 (4) 0.2478 0.6092 BioCarta//Hs_Generation of amyloid b-peptide by PS1      1/4 (9) 0.2478 0.6092 BioCarta//Hs_Ahr Signal Transduction Pathway      1/4 (12) 0.2478 0.6092 BioCarta//Hs_Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy      2/18 (31) 0.3535 0.6100 BioCarta//Hs_Sprouty regulation of tyrosine kinase signals      2/18 (31) 0.3535 0.6100 BioCarta//Hs_T Cell Receptor Signaling Pathway      4/43 (56) 0.3410 0.6100 BioCarta//Hs_Signal transduction through IL1R      3/30 (41) 0.3398 0.6100 BioCarta//Hs_Effects of calcineurin in Keratinocyte Differentiation      2/18 (36) 0.3535 0.6100 BioCarta//Hs_Regulation of ck1/cdk5 by type 1 glutamate receptors      2/17 (38) 0.3276 0.6100 BioCarta//Hs_Proepithelin Conversion to Epithelin and Wound Repair Control      1/6 (40) 0.3478 0.6100 BioCarta//Hs_Wnt/LRP6 Signalling      1/6 (25) 0.3478 0.6180 BioCarta//Hs_Msp/Ron Receptor Signaling Pathway      1/6 (27) 0.3478 0.6180 BioCarta//Hs_Catabolic Pathways for Arginine , Histidine, Glutamate, Glutamine, and Proline      1/6 (6) 0.3478 0.6180 BioCarta//Hs_Proteolysis and Signaling Pathway of Notch      1/6 (20) 0.3478 0.6180 BioCarta//Hs_Regulation of Spermatogenesis by CREM      1/6 (14) 0.3478 0.6180 BioCarta//Hs_Multi-Drug Resistance Factors      1/6 (14) 0.3478 0.6180 BioCarta//Hs_Internal Ribosome entry pathway      1/8 (39) 0.4346 0.6190 BioCarta//Hs_Calcium Signaling by HBx of Hepatitis B virus      1/8 (8) 0.4346 0.6190 BioCarta//Hs_Regulation of cell cycle progression by Plk3      1/8 (17) 0.4346 0.6190 BioCarta//Hs_Ras-Independent pathway in NK cell-mediated cytotoxicity      2/19 (19) 0.3789 0.6190 BioCarta//Hs_Nitric Oxide Signaling Pathway      2/21 (25) 0.4286 0.6190 BioCarta//Hs_G-Protein Signaling Through Tubby Proteins      1/7 (11) 0.3927 0.6190 BioCarta//Hs_Toll-Like Receptor Pathway      3/34 (45) 0.4168 0.6190 BioCarta//Hs_Neutrophil and Its Surface Molecules      1/8 (12) 0.4346 0.6190 BioCarta//Hs_Oxidative Stress Induced Gene Expression Via Nrf2      2/20 (24) 0.4040 0.6190 BioCarta//Hs_RNA polymerase III transcription      1/8 (22) 0.4346 0.6190 BioCarta//Hs_The role of FYVE-finger proteins in vesicle transport      1/7 (35) 0.3927 0.6238 BioCarta//Hs_Regulation of Splicing through Sam68      1/7 (8) 0.3927 0.6238 BioCarta//Hs_Reelin Signaling Pathway      1/7 (10) 0.3927 0.6238 BioCarta//Hs_g-Secretase mediated ErbB4 Signaling Pathway      1/7 (19) 0.3927 0.6238 BioCarta//Hs_Complement Pathway      2/19 (33) 0.3789 0.6298 BioCarta//Hs_EPO Signaling Pathway      2/19 (36) 0.3789 0.6298 BioCarta//Hs_Role of MAL in Rho-Mediated Activation of SRF      2/19 (26) 0.3789 0.6298 BioCarta//Hs_IGF-1 Signaling Pathway      2/20 (45) 0.4040 0.6306 BioCarta//Hs_CCR3 signaling in Eosinophils      2/23 (30) 0.4761 0.6330 BioCarta//Hs_Regulation of BAD phosphorylation      2/22 (31) 0.4526 0.6330 BioCarta//Hs_Stathmin and breast cancer resistance to antimicrotubule agents      2/23 (26) 0.4761 0.6330 BioCarta//Hs_Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases      1/9 (9) 0.4736 0.6330 BioCarta//Hs_Inhibition of Cellular Proliferation by Gleevec      2/22 (23) 0.4526 0.6347 BioCarta//Hs_Insulin Signaling Pathway      2/21 (48) 0.4286 0.6358 BioCarta//Hs_Roles of ?arrestin-dependent Recruitment of Src Kinases in GPCR Signaling      2/21 (34) 0.4286 0.6358 BioCarta//Hs_ADP-Ribosylation Factor      2/21 (57) 0.4286 0.6358 BioCarta//Hs_Cyclin E Destruction Pathway      1/9 (14) 0.4736 0.6391 BioCarta//Hs_Lck and Fyn tyrosine kinases in initiation of TCR Activation      1/9 (16) 0.4736 0.6391 BioCarta//Hs_Cardiac Protection Against ROS      1/9 (9) 0.4736 0.6391 BioCarta//Hs_Polyadenylation of mRNA      1/9 (35) 0.4736 0.6391 BioCarta//Hs_Cells and Molecules involved in local acute inflammatory response      2/17 (19) 0.3276 0.6392 BioCarta//Hs_Pertussis toxin-insensitive CCR5 Signaling in Macrophage      2/17 (38) 0.3276 0.6392 BioCarta//Hs_BCR Signaling Pathway      3/34 (54) 0.4168 0.6393 BioCarta//Hs_Fc Epsilon Receptor I Signaling in Mast Cells      3/38 (49) 0.4908 0.6421 BioCarta//Hs_Trefoil Factors Initiate Mucosal Healing      2/24 (95) 0.4990 0.6421 BioCarta//Hs_Activation of Src by Protein-tyrosine phosphatase alpha      1/11 (29) 0.5438 0.6421 BioCarta//Hs_Ghrelin: Regulation of Food Intake and Energy Homeostasis      1/11 (30) 0.5438 0.6421 BioCarta//Hs_Sumoylation by RanBP2 Regulates Transcriptional Repression      1/10 (25) 0.5099 0.6421 BioCarta//Hs_Prion Pathway      1/11 (11) 0.5438 0.6421 BioCarta//Hs_Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)      4/54 (64) 0.5148 0.6421 BioCarta//Hs_Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells      2/26 (43) 0.5428 0.6421 BioCarta//Hs_Phospholipids as signalling intermediaries      2/25 (42) 0.5212 0.6421 BioCarta//Hs_Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation      1/11 (35) 0.5438 0.6421 BioCarta//Hs_AKAP95 role in mitosis and chromosome dynamics      1/11 (39) 0.5438 0.6421 BioCarta//Hs_Erythropoietin mediated neuroprotection through NF-kB      1/11 (17) 0.5438 0.6421 BioCarta//Hs_NFkB activation by Nontypeable Hemophilus influenzae      2/24 (43) 0.4990 0.6490 BioCarta//Hs_Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages      2/25 (42) 0.5212 0.6496 BioCarta//Hs_WNT Signaling Pathway      2/25 (42) 0.5212 0.6496 BioCarta//Hs_E2F1 Destruction Pathway      1/10 (16) 0.5099 0.6537 BioCarta//Hs_HIV-I Nef: negative effector of Fas and TNF      4/57 (77) 0.5589 0.6557 BioCarta//Hs_PDGF Signaling Pathway      2/27 (61) 0.5637 0.6570 BioCarta//Hs_Lectin Induced Complement Pathway      1/12 (56) 0.5753 0.6577 BioCarta//Hs_CTL mediated immune response against target cells      1/12 (25) 0.5753 0.6577 BioCarta//Hs_Role of Parkin in the Ubiquitin-Proteasomal Pathway      1/12 (38) 0.5753 0.6577 BioCarta//Hs_Links between Pyk2 and Map Kinases      2/28 (44) 0.5839 0.6633 BioCarta//Hs_Regulation of p27 Phosphorylation during Cell Cycle Progression      1/13 (20) 0.6047 0.6667 BioCarta//Hs_Eukaryotic protein translation      1/15 (20) 0.6575 0.6667 BioCarta//Hs_IL 3 signaling pathway      1/15 (30) 0.6575 0.6667 BioCarta//Hs_Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation      1/15 (29) 0.6575 0.6667 BioCarta//Hs_Cadmium induces DNA synthesis and proliferation in macrophages      1/15 (21) 0.6575 0.6667 BioCarta//Hs_Endocytotic role of NDK, Phosphins and Dynamin      1/15 (48) 0.6575 0.6667 BioCarta//Hs_Role of nicotinic acetylcholine receptors in the regulation of apoptosis      1/15 (24) 0.6575 0.6667 BioCarta//Hs_PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase      1/15 (18) 0.6575 0.6667 BioCarta//Hs_beta-arrestins in GPCR Desensitization      1/15 (40) 0.6575 0.6667 BioCarta//Hs_FAS signaling pathway ( CD95 )      2/30 (34) 0.6222 0.6667 BioCarta//Hs_TNFR1 Signaling Pathway      2/29 (36) 0.6034 0.6667 BioCarta//Hs_Bone Remodelling      1/14 (19) 0.6320 0.6667 BioCarta//Hs_CARM1 and Regulation of the Estrogen Receptor      2/26 (33) 0.5428 0.6673 BioCarta//Hs_CBL mediated ligand-induced downregulation of EGF receptors      1/13 (51) 0.6047 0.6699 BioCarta//Hs_ER-associated degradation (ERAD) Pathway      1/13 (20) 0.6047 0.6699 BioCarta//Hs_Classical Complement Pathway      1/14 (68) 0.6320 0.6712 BioCarta//Hs_Estrogen-responsive protein Efp controls cell cycle and breast tumors growth      1/14 (59) 0.6320 0.6712 BioCarta//Hs_The IGF-1 Receptor and Longevity      1/14 (14) 0.6320 0.6712 BioCarta//Hs_Presenilin action in Notch and Wnt signaling      1/14 (31) 0.6320 0.6712 BioCarta//Hs_TACI and BCMA stimulation of B cell immune responses.      1/14 (21) 0.6320 0.6712 BioCarta//Hs_Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling      2/33 (44) 0.6746 0.6802 BioCarta//Hs_IL-2 Receptor Beta Chain in T cell Activation      2/35 (38) 0.7062 0.6851 BioCarta//Hs_Nuclear Receptors in Lipid Metabolism and Toxicity      2/34 (43) 0.6907 0.6851 BioCarta//Hs_CDK Regulation of DNA Replication      1/17 (56) 0.7034 0.6851 BioCarta//Hs_Role of Erk5 in Neuronal Survival      1/17 (36) 0.7034 0.6861 BioCarta//Hs_Y branching of actin filaments      1/17 (45) 0.7034 0.6861 BioCarta//Hs_Corticosteroids and cardioprotection      1/17 (28) 0.7034 0.6861 BioCarta//Hs_Role of ?arrestins in the activation and targeting of MAP kinases      1/17 (40) 0.7034 0.6861 BioCarta//Hs_IL 6 signaling pathway      1/21 (48) 0.7776 0.6875 BioCarta//Hs_p38 MAPK Signaling Pathway      2/38 (40) 0.7488 0.6875 BioCarta//Hs_Role of ERBB2 in Signal Transduction and Oncology      1/21 (34) 0.7776 0.6875 BioCarta//Hs_Rac 1 cell motility signaling pathway      1/21 (23) 0.7776 0.6875 BioCarta//Hs_Apoptotic Signaling in Response to DNA Damage      1/21 (29) 0.7776 0.6875 BioCarta//Hs_Proteasome Complex      1/19 (24) 0.7431 0.6875 BioCarta//Hs_Ceramide Signaling Pathway      1/21 (21) 0.7776 0.6875 BioCarta//Hs_IL12 and Stat4 Dependent Signaling Pathway in Th1 Development      1/21 (27) 0.7776 0.6875 BioCarta//Hs_The 4-1BB-dependent immune response      1/18 (22) 0.7239 0.6875 BioCarta//Hs_Eicosanoid Metabolism      1/20 (20) 0.7609 0.6875 BioCarta//Hs_Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility      1/21 (25) 0.7776 0.6875 BioCarta//Hs_Telomeres, Telomerase, Cellular Aging, and Immortality      1/18 (31) 0.7239 0.6911 BioCarta//Hs_PTEN dependent cell cycle arrest and apoptosis      1/18 (21) 0.7239 0.6911 BioCarta//Hs_Ras Signaling Pathway      1/22 (23) 0.7930 0.6934 BioCarta//Hs_TPO Signaling Pathway      1/23 (54) 0.8074 0.6934 BioCarta//Hs_Phosphoinositides and their downstream targets.      1/23 (23) 0.8074 0.6934 BioCarta//Hs_CTCF: First Multivalent Nuclear Factor      1/23 (26) 0.8074 0.6934 BioCarta//Hs_NF-kB Signaling Pathway      1/23 (49) 0.8074 0.6934 BioCarta//Hs_Caspase Cascade in Apoptosis      1/22 (27) 0.7930 0.6943 BioCarta//Hs_mTOR Signaling Pathway      1/24 (44) 0.8209 0.6950 BioCarta//Hs_Control of Gene Expression by Vitamin D Receptor      1/24 (32) 0.8209 0.6950 BioCarta//Hs_Cell Cycle: G2/M Checkpoint      1/24 (27) 0.8209 0.6950 BioCarta//Hs_Role of Mitochondria in Apoptotic Signaling      1/20 (38) 0.7609 0.6968 BioCarta//Hs_Synaptic Proteins at the Synaptic Junction      1/20 (32) 0.7609 0.6968 BioCarta//Hs_Ion Channels and Their Functional Role in Vascular Endothelium      1/20 (20) 0.7609 0.6968 BioCarta//Hs_Role of Tob in T-cell activation      1/19 (30) 0.7431 0.6983 BioCarta//Hs_Lissencephaly gene (LIS1) in neuronal migration and development      1/19 (48) 0.7431 0.6983 BioCarta//Hs_TNF/Stress Related Signaling      1/25 (31) 0.8333 0.7022 BioCarta//Hs_Growth Hormone Signaling Pathway      1/26 (35) 0.8450 0.7087 BioCarta//Hs_MAPKinase Signaling Pathway      4/85 (88) 0.8504 0.7099 BioCarta//Hs_Induction of apoptosis through DR3 and DR4/5 Death Receptors      1/32 (37) 0.8996 0.7475 BioCarta//Hs_ALK in cardiac myocytes      1/34 (51) 0.9132 0.7553

Cluster NA has 374 gene products

ArrayXPath has identified 220 out of 374 input elements in 235 out of 346 BioCarta pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value BioCarta//Hs_Proteasome Complex      9/19 (24) 0.0002 0.0062 BioCarta//Hs_Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration      8/15 (15) 0.0002 0.0101 BioCarta//Hs_Rac 1 cell motility signaling pathway      8/21 (23) 0.0027 0.0269 BioCarta//Hs_How does salmonella hijack a cell      6/12 (32) 0.0018 0.0269 BioCarta//Hs_Rho cell motility signaling pathway      10/30 (32) 0.0026 0.0269 BioCarta//Hs_Rab GTPases Mark Targets In The Endocytotic Machinery      6/12 (17) 0.0018 0.0274 BioCarta//Hs_MAPKinase Signaling Pathway      19/85 (88) 0.0074 0.0558 BioCarta//Hs_Antisense Pathway      3/4 (13) 0.0073 0.0558 BioCarta//Hs_Shuttle for transfer of acetyl groups from mitochondria to the cytosol      4/8 (11) 0.0115 0.0769 BioCarta//Hs_Y branching of actin filaments      6/17 (45) 0.0141 0.0849 BioCarta//Hs_Fc Epsilon Receptor I Signaling in Mast Cells      10/38 (49) 0.0161 0.0879 BioCarta//Hs_IGF-1 Signaling Pathway      6/20 (45) 0.0320 0.1371 BioCarta//Hs_WNT Signaling Pathway      7/25 (42) 0.0304 0.1371 BioCarta//Hs_Overview of telomerase RNA component gene hTerc Transcriptional Regulation      3/6 (15) 0.0299 0.1371 BioCarta//Hs_Insulin Signaling Pathway      6/21 (48) 0.0402 0.1419 BioCarta//Hs_ADP-Ribosylation Factor      6/21 (57) 0.0402 0.1419 BioCarta//Hs_AKAP95 role in mitosis and chromosome dynamics      4/11 (39) 0.0400 0.1419 BioCarta//Hs_Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia      6/22 (40) 0.0497 0.1490 BioCarta//Hs_PDGF Signaling Pathway      7/27 (61) 0.0451 0.1490 BioCarta//Hs_Ras Signaling Pathway      6/22 (23) 0.0497 0.1490 BioCarta//Hs_Role of MAL in Rho-Mediated Activation of SRF      5/19 (26) 0.0813 0.1525 BioCarta//Hs_mTOR Signaling Pathway      6/24 (44) 0.0723 0.1525 BioCarta//Hs_Regulation of p27 Phosphorylation during Cell Cycle Progression      4/13 (20) 0.0708 0.1525 BioCarta//Hs_Nerve growth factor pathway (NGF)      5/18 (38) 0.0665 0.1525 BioCarta//Hs_Signaling of Hepatocyte Growth Factor Receptor      8/36 (42) 0.0749 0.1525 BioCarta//Hs_Signaling Pathway from G-Protein Families      8/34 (42) 0.0560 0.1525 BioCarta//Hs_TGF beta signaling pathway      5/19 (76) 0.0813 0.1525 BioCarta//Hs_Generation of amyloid b-peptide by PS1      2/4 (9) 0.0804 0.1525 BioCarta//Hs_The Citric Acid Cycle      3/8 (9) 0.0690 0.1525 BioCarta//Hs_BCR Signaling Pathway      8/34 (54) 0.0560 0.1527 BioCarta//Hs_Mechanism of Protein Import into the Nucleus      3/9 (19) 0.0941 0.1544 BioCarta//Hs_Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway      5/20 (23) 0.0978 0.1544 BioCarta//Hs_Synaptic Proteins at the Synaptic Junction      5/20 (32) 0.0978 0.1544 BioCarta//Hs_Protein Kinase A at the Centrosome      4/14 (28) 0.0897 0.1544 BioCarta//Hs_p38 MAPK Signaling Pathway      8/38 (40) 0.0972 0.1544 BioCarta//Hs_NFAT and Hypertrophy of the heart (Transcription in the broken heart)      10/51 (82) 0.1005 0.1547 BioCarta//Hs_EGF Signaling Pathway      6/27 (54) 0.1157 0.1572 BioCarta//Hs_Reversal of Insulin Resistance by Leptin      3/10 (11) 0.1224 0.1572 BioCarta//Hs_FOSB gene expression and drug abuse      2/5 (11) 0.1231 0.1572 BioCarta//Hs_Nitric Oxide Signaling Pathway      5/21 (25) 0.1157 0.1572 BioCarta//Hs_Endocytotic role of NDK, Phosphins and Dynamin      4/15 (48) 0.1107 0.1572 BioCarta//Hs_Eph Kinases and ephrins support platelet aggregation      3/10 (17) 0.1224 0.1596 BioCarta//Hs_Basic Mechanisms of SUMOylation      2/4 (25) 0.0804 0.1609 BioCarta//Hs_IL 6 signaling pathway      5/21 (48) 0.1157 0.1615 BioCarta//Hs_Thrombin signaling and protease-activated receptors      5/21 (31) 0.1157 0.1615 BioCarta//Hs_Bioactive Peptide Induced Signaling Pathway      8/38 (58) 0.0972 0.1619 BioCarta//Hs_ER-associated degradation (ERAD) Pathway      4/13 (20) 0.0708 0.1634 BioCarta//Hs_fMLP induced chemokine gene expression in HMC-1 cells      7/36 (58) 0.1606 0.1720 BioCarta//Hs_Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway      3/12 (16) 0.1863 0.1720 BioCarta//Hs_T Cell Receptor Signaling Pathway      8/43 (56) 0.1673 0.1720 BioCarta//Hs_Control of Gene Expression by Vitamin D Receptor      5/24 (32) 0.1780 0.1720 BioCarta//Hs_How Progesterone Initiates the Oocyte Maturation      6/30 (32) 0.1695 0.1720 BioCarta//Hs_SUMOylation as a mechanism to modulate CtBP-dependent gene responses      2/6 (11) 0.1697 0.1720 BioCarta//Hs_uCalpain and friends in Cell spread      4/17 (36) 0.1584 0.1720 BioCarta//Hs_Regulation of PGC-1a      5/23 (31) 0.1560 0.1720 BioCarta//Hs_Ca++/ Calmodulin-dependent Protein Kinase Activation      3/12 (76) 0.1863 0.1720 BioCarta//Hs_Effects of calcineurin in Keratinocyte Differentiation      4/18 (36) 0.1847 0.1720 BioCarta//Hs_Granzyme A mediated Apoptosis Pathway      3/11 (28) 0.1533 0.1720 BioCarta//Hs_Beta-Oxidation of Fatty Acids      2/6 (6) 0.1697 0.1726 BioCarta//Hs_NFkB activation by Nontypeable Hemophilus influenzae      5/24 (43) 0.1780 0.1750 BioCarta//Hs_PTEN dependent cell cycle arrest and apoptosis      4/18 (21) 0.1847 0.1759 BioCarta//Hs_Phosphoinositides and their downstream targets.      5/23 (23) 0.1560 0.1765 BioCarta//Hs_TPO Signaling Pathway      5/23 (54) 0.1560 0.1765 BioCarta//Hs_CCR3 signaling in Eosinophils      5/23 (30) 0.1560 0.1765 BioCarta//Hs_Phospholipids as signalling intermediaries      5/25 (42) 0.2011 0.1800 BioCarta//Hs_Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages      5/25 (42) 0.2011 0.1800 BioCarta//Hs_EPO Signaling Pathway      4/19 (36) 0.2123 0.1873 BioCarta//Hs_Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation      3/11 (35) 0.1533 0.1877 BioCarta//Hs_Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling      6/33 (44) 0.2318 0.1898 BioCarta//Hs_The role of FYVE-finger proteins in vesicle transport      2/7 (35) 0.2186 0.1898 BioCarta//Hs_Transcription factor CREB and its extracellular signals      5/26 (26) 0.2251 0.1898 BioCarta//Hs_Anthrax Toxin Mechanism of Action      1/2 (2) 0.2372 0.1898 BioCarta//Hs_Dicer Pathway      1/2 (4) 0.2372 0.1898 BioCarta//Hs_Catabolic pathways for alanine, glycine, serine, cysteine, tryptophan, and threonine      1/2 (2) 0.2372 0.1898 BioCarta//Hs_Influence of Ras and Rho proteins on G1 to S Transition      5/26 (33) 0.2251 0.1902 BioCarta//Hs_Spliceosomal Assembly      3/14 (14) 0.2567 0.2001 BioCarta//Hs_B Cell Survival Pathway      3/14 (16) 0.2567 0.2001 BioCarta//Hs_Role of ERBB2 in Signal Transduction and Oncology      4/21 (34) 0.2703 0.2053 BioCarta//Hs_Overview of telomerase protein component gene hTert Transcriptional Regulation      2/8 (20) 0.2685 0.2053 BioCarta//Hs_Erk1/Erk2 Mapk Signaling pathway      5/28 (33) 0.2755 0.2066 BioCarta//Hs_Integrin Signaling Pathway      6/37 (45) 0.3235 0.2111 BioCarta//Hs_PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase      3/15 (18) 0.2932 0.2111 BioCarta//Hs_mCalpain and friends in Cell motility      4/22 (38) 0.3004 0.2111 BioCarta//Hs_Stathmin and breast cancer resistance to antimicrotubule agents      4/23 (26) 0.3308 0.2111 BioCarta//Hs_Multi-step Regulation of Transcription by Pitx2      3/16 (38) 0.3301 0.2111 BioCarta//Hs_Role of PPAR-gamma Coactivators in Obesity and Thermogenesis      2/9 (12) 0.3184 0.2111 BioCarta//Hs_Role of Ran in mitotic spindle regulation      2/10 (15) 0.3674 0.2119 BioCarta//Hs_E2F1 Destruction Pathway      2/10 (16) 0.3674 0.2119 BioCarta//Hs_Sumoylation by RanBP2 Regulates Transcriptional Repression      2/10 (25) 0.3674 0.2119 BioCarta//Hs_Deregulation of CDK5 in Alzheimers Disease      2/10 (16) 0.3674 0.2119 BioCarta//Hs_Regulation of ck1/cdk5 by type 1 glutamate receptors      3/17 (38) 0.3668 0.2119 BioCarta//Hs_Trefoil Factors Initiate Mucosal Healing      4/24 (95) 0.3613 0.2119 BioCarta//Hs_SARS Coronavirus Protease      2/10 (16) 0.3674 0.2119 BioCarta//Hs_IL 2 signaling pathway      4/22 (47) 0.3004 0.2120 BioCarta//Hs_Inhibition of Cellular Proliferation by Gleevec      4/22 (23) 0.3004 0.2120 BioCarta//Hs_IL-7 Signal Transduction      3/16 (29) 0.3301 0.2129 BioCarta//Hs_Regulation of transcriptional activity by PML      3/16 (24) 0.3301 0.2129 BioCarta//Hs_Role of MEF2D in T-cell Apoptosis      3/16 (45) 0.3301 0.2129 BioCarta//Hs_Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)      8/54 (64) 0.3739 0.2137 BioCarta//Hs_Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation      3/15 (29) 0.2932 0.2146 BioCarta//Hs_Cycling of Ran in nucleocytoplasmic transport      1/5 (8) 0.4922 0.2164 BioCarta//Hs_IL 17 Signaling Pathway      2/15 (16) 0.5843 0.2164 BioCarta//Hs_IL 3 signaling pathway      2/15 (30) 0.5843 0.2164 BioCarta//Hs_Cadmium induces DNA synthesis and proliferation in macrophages      2/15 (21) 0.5843 0.2164 BioCarta//Hs_Aspirin Blocks Signaling Pathway Involved in Platelet Activation      3/22 (32) 0.5408 0.2164 BioCarta//Hs_FAS signaling pathway ( CD95 )      4/30 (34) 0.5384 0.2164 BioCarta//Hs_HIV-I Nef: negative effector of Fas and TNF      8/57 (77) 0.4355 0.2164 BioCarta//Hs_Agrin in Postsynaptic Differentiation      5/39 (50) 0.5615 0.2164 BioCarta//Hs_The information-processing pathway at the IFN-beta enhancer      2/15 (27) 0.5843 0.2164 BioCarta//Hs_CD40L Signaling Pathway      2/15 (27) 0.5843 0.2164 BioCarta//Hs_Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells      4/26 (43) 0.4222 0.2164 BioCarta//Hs_Presenilin action in Notch and Wnt signaling      2/14 (31) 0.5455 0.2164 BioCarta//Hs_Ras-Independent pathway in NK cell-mediated cytotoxicity      3/19 (19) 0.4391 0.2164 BioCarta//Hs_Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)      4/28 (41) 0.4816 0.2164 BioCarta//Hs_Role of nicotinic acetylcholine receptors in the regulation of apoptosis      2/15 (24) 0.5843 0.2164 BioCarta//Hs_NF-kB Signaling Pathway      3/23 (49) 0.5723 0.2164 BioCarta//Hs_Extrinsic Prothrombin Activation Pathway      2/13 (24) 0.5042 0.2164 BioCarta//Hs_Acute Myocardial Infarction      3/20 (23) 0.4741 0.2164 BioCarta//Hs_Apoptotic Signaling in Response to DNA Damage      3/21 (29) 0.5080 0.2164 BioCarta//Hs_IL22 Soluble Receptor Signaling Pathway      2/12 (40) 0.4606 0.2164 BioCarta//Hs_Prion Pathway      2/11 (11) 0.4149 0.2164 BioCarta//Hs_Inhibition of Huntingtons disease neurodegeneration by histone deacetylase inhibitors      1/4 (9) 0.4183 0.2164 BioCarta//Hs_Pelp1 Modulation of Estrogen Receptor Activity      1/6 (10) 0.5566 0.2164 BioCarta//Hs_Cyclin E Destruction Pathway      2/9 (14) 0.3184 0.2171 BioCarta//Hs_Regulation of eIF2      2/9 (20) 0.3184 0.2171 BioCarta//Hs_Catabolic Pathways for Arginine , Histidine, Glutamate, Glutamine, and Proline      1/6 (6) 0.5566 0.2183 BioCarta//Hs_SREBP control of lipid synthesis      1/6 (24) 0.5566 0.2183 BioCarta//Hs_Bystander B Cell Activation      1/6 (15) 0.5566 0.2183 BioCarta//Hs_Proteolysis and Signaling Pathway of Notch      1/6 (20) 0.5566 0.2183 BioCarta//Hs_Circadian Rhythms      1/6 (13) 0.5566 0.2183 BioCarta//Hs_Small Leucine-rich Proteoglycan (SLRP) molecules      1/6 (6) 0.5566 0.2183 BioCarta//Hs_Metabolism of Anandamide, an Endogenous Cannabinoid      1/6 (13) 0.5566 0.2183 BioCarta//Hs_IFN gamma signaling pathway      1/6 (28) 0.5566 0.2183 BioCarta//Hs_Sonic Hedgehog (Shh) Pathway      2/16 (29) 0.6206 0.2190 BioCarta//Hs_Regulation of eIF4e and p70 S6 Kinase      3/24 (37) 0.6025 0.2190 BioCarta//Hs_Reelin Signaling Pathway      1/7 (10) 0.6130 0.2190 BioCarta//Hs_GATA3 participate in activating the Th2 cytokine genes expression      2/16 (25) 0.6206 0.2190 BioCarta//Hs_The Co-Stimulatory Signal During T-cell Activation      2/16 (40) 0.6206 0.2190 BioCarta//Hs_Human Cytomegalovirus and Map Kinase Pathways      2/16 (17) 0.6206 0.2190 BioCarta//Hs_CTCF: First Multivalent Nuclear Factor      3/23 (26) 0.5723 0.2201 BioCarta//Hs_Growth Hormone Signaling Pathway      4/26 (35) 0.4222 0.2203 BioCarta//Hs_Roles of ?arrestin-dependent Recruitment of Src Kinases in GPCR Signaling      3/21 (34) 0.5080 0.2209 BioCarta//Hs_AKT Signaling Pathway      3/21 (32) 0.5080 0.2209 BioCarta//Hs_The PRC2 Complex sets Long-term gene Silencing The Modification of Histone Tails      2/12 (20) 0.4606 0.2211 BioCarta//Hs_Role of Parkin in the Ubiquitin-Proteasomal Pathway      2/12 (38) 0.4606 0.2211 BioCarta//Hs_Cystic fibrosis transmembrane conductance regulator and beta 2 adrenergic receptor pathway      2/12 (37) 0.4606 0.2211 BioCarta//Hs_Gamma-aminobutyric Acid Receptor Life Cycle      2/12 (73) 0.4606 0.2211 BioCarta//Hs_Tumor Suppressor Arf Inhibits Ribosomal Biogenesis      2/12 (17) 0.4606 0.2211 BioCarta//Hs_ChREBP regulation by carbohydrates and cAMP      3/19 (30) 0.4391 0.2214 BioCarta//Hs_Lissencephaly gene (LIS1) in neuronal migration and development      3/19 (48) 0.4391 0.2214 BioCarta//Hs_TNF/Stress Related Signaling      3/25 (31) 0.6312 0.2215 BioCarta//Hs_The reactions that feed amino groups into the urea cycle      1/7 (16) 0.6130 0.2216 BioCarta//Hs_Melanocyte Development and Pigmentation Pathway      1/7 (13) 0.6130 0.2216 BioCarta//Hs_Regulation of cell cycle progression by Plk3      1/8 (17) 0.6622 0.2220 BioCarta//Hs_CARM1 and Regulation of the Estrogen Receptor      3/26 (33) 0.6584 0.2220 BioCarta//Hs_Toll-Like Receptor Pathway      4/34 (45) 0.6418 0.2220 BioCarta//Hs_Corticosteroids and cardioprotection      2/17 (28) 0.6544 0.2220 BioCarta//Hs_Phospholipase C Signaling Pathway      1/8 (12) 0.6622 0.2220 BioCarta//Hs_FXR and LXR Regulation of Cholesterol Metabolism      1/8 (14) 0.6622 0.2220 BioCarta//Hs_Biosynthesis of Proline in Bacteria      1/4 (4) 0.4183 0.2221 BioCarta//Hs_Formation of Ketone Bodies from acetyl-CoA      1/4 (4) 0.4183 0.2221 BioCarta//Hs_Malate-aspartate shuttle      1/4 (8) 0.4183 0.2221 BioCarta//Hs_Oxidative reactions of the pentose phosphate pathway      1/4 (4) 0.4183 0.2221 BioCarta//Hs_West Nile Virus      1/4 (4) 0.4183 0.2221 BioCarta//Hs_Role of ?arrestins in the activation and targeting of MAP kinases      3/17 (40) 0.3668 0.2223 BioCarta//Hs_Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes      3/17 (20) 0.3668 0.2223 BioCarta//Hs_ALK in cardiac myocytes      4/34 (51) 0.6418 0.2226 BioCarta//Hs_Links between Pyk2 and Map Kinases      4/28 (44) 0.4816 0.2240 BioCarta//Hs_VEGF, Hypoxia, and Angiogenesis      4/28 (34) 0.4816 0.2240 BioCarta//Hs_Hemoglobins Chaperone      2/13 (31) 0.5042 0.2241 BioCarta//Hs_CBL mediated ligand-induced downregulation of EGF receptors      2/13 (51) 0.5042 0.2241 BioCarta//Hs_IL-10 Anti-inflammatory Signaling Pathway      2/13 (17) 0.5042 0.2241 BioCarta//Hs_Transcription Regulation by Methyltransferase of CARM1      2/13 (34) 0.5042 0.2241 BioCarta//Hs_Role of Erk5 in Neuronal Survival      2/17 (36) 0.6544 0.2244 BioCarta//Hs_CXCR4 Signaling Pathway      4/24 (35) 0.3613 0.2258 BioCarta//Hs_Platelet Amyloid Precursor Protein Pathway      2/14 (15) 0.5455 0.2273 BioCarta//Hs_Stress Induction of HSP Regulation      2/14 (22) 0.5455 0.2273 BioCarta//Hs_The IGF-1 Receptor and Longevity      2/14 (14) 0.5455 0.2273 BioCarta//Hs_Keratinocyte Differentiation      5/46 (67) 0.7117 0.2284 BioCarta//Hs_Sprouty regulation of tyrosine kinase signals      2/18 (31) 0.6858 0.2284 BioCarta//Hs_Cell Cycle: G1/S Check Point      3/28 (34) 0.7085 0.2284 BioCarta//Hs_IFN alpha signaling pathway      1/9 (25) 0.7051 0.2284 BioCarta//Hs_Polyadenylation of mRNA      1/9 (35) 0.7051 0.2287 BioCarta//Hs_B Lymphocyte Cell Surface Molecules      1/9 (10) 0.7051 0.2287 BioCarta//Hs_Cardiac Protection Against ROS      1/9 (9) 0.7051 0.2287 BioCarta//Hs_Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases      1/9 (9) 0.7051 0.2287 BioCarta//Hs_TNFR1 Signaling Pathway      3/29 (36) 0.7314 0.2297 BioCarta//Hs_Antigen Dependent B Cell Activation      1/10 (24) 0.7427 0.2297 BioCarta//Hs_Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor      2/20 (24) 0.7416 0.2297 BioCarta//Hs_Free Radical Induced Apoptosis      1/10 (11) 0.7427 0.2297 BioCarta//Hs_Electron Transport Reaction in Mitochondria      1/10 (10) 0.7427 0.2297 BioCarta//Hs_Apoptotic DNA fragmentation and tissue homeostasis      1/10 (15) 0.7427 0.2297 BioCarta//Hs_Signal transduction through IL1R      3/30 (41) 0.7529 0.2316 BioCarta//Hs_Fibrinolysis Pathway      2/11 (14) 0.4149 0.2327 BioCarta//Hs_Ceramide Signaling Pathway      2/21 (21) 0.7662 0.2338 BioCarta//Hs_Map Kinase Inactivation of SMRT Corepressor      1/11 (14) 0.7755 0.2338 BioCarta//Hs_Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle      1/11 (30) 0.7755 0.2338 BioCarta//Hs_Vitamin C in the Brain      1/11 (20) 0.7755 0.2338 BioCarta//Hs_Oxidative Stress Induced Gene Expression Via Nrf2      2/20 (24) 0.7416 0.2342 BioCarta//Hs_Regulation of BAD phosphorylation      2/22 (31) 0.7887 0.2366 BioCarta//Hs_Cyclins and Cell Cycle Regulation      2/23 (46) 0.8094 0.2369 BioCarta//Hs_Trka Receptor Signaling Pathway      1/12 (12) 0.8041 0.2369 BioCarta//Hs_Intrinsic Prothrombin Activation Pathway      2/23 (36) 0.8094 0.2369 BioCarta//Hs_T Cytotoxic Cell Surface Molecules      1/12 (12) 0.8041 0.2377 BioCarta//Hs_Phospholipase C-epsilon pathway      1/12 (25) 0.8041 0.2377 BioCarta//Hs_Cell Cycle: G2/M Checkpoint      2/24 (27) 0.8282 0.2392 BioCarta//Hs_Attenuation of GPCR Signaling      1/13 (13) 0.8291 0.2392 BioCarta//Hs_Cell to Cell Adhesion Signaling      1/13 (14) 0.8291 0.2392 BioCarta//Hs_Regulation of hematopoiesis by cytokines      1/15 (41) 0.8699 0.2394 BioCarta//Hs_IL-2 Receptor Beta Chain in T cell Activation      3/35 (38) 0.8402 0.2394 BioCarta//Hs_Eukaryotic protein translation      1/15 (20) 0.8699 0.2394 BioCarta//Hs_Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to fa      1/15 (28) 0.8699 0.2394 BioCarta//Hs_Hypoxia-Inducible Factor in the Cardiovascular System      1/15 (20) 0.8699 0.2394 BioCarta//Hs_beta-arrestins in GPCR Desensitization      1/15 (40) 0.8699 0.2394 BioCarta//Hs_Adhesion and Diapedesis of Lymphocytes      1/14 (47) 0.8509 0.2394 BioCarta//Hs_Estrogen-responsive protein Efp controls cell cycle and breast tumors growth      1/14 (59) 0.8509 0.2397 BioCarta//Hs_Repression of Pain Sensation by the Transcriptional Regulator DREAM      1/14 (21) 0.8509 0.2397 BioCarta//Hs_Segmentation Clock      1/14 (20) 0.8509 0.2397 BioCarta//Hs_Steps in the Glycosylation of Mammalian N-linked Oligosaccarides      1/16 (16) 0.8865 0.2407 BioCarta//Hs_Downregulated of MTA-3 in ER-negative Breast Tumors      1/16 (23) 0.8865 0.2407 BioCarta//Hs_Acetylation and Deacetylation of RelA in The Nucleus      1/16 (34) 0.8865 0.2407 BioCarta//Hs_Th1/Th2 Differentiation      1/18 (88) 0.9137 0.2415 BioCarta//Hs_Actions of Nitric Oxide in the Heart      2/30 (44) 0.9099 0.2415 BioCarta//Hs_Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy      1/18 (31) 0.9137 0.2415 BioCarta//Hs_CDK Regulation of DNA Replication      1/17 (56) 0.9011 0.2415 BioCarta//Hs_TNFR2 Signaling Pathway      1/18 (32) 0.9137 0.2415 BioCarta//Hs_Pertussis toxin-insensitive CCR5 Signaling in Macrophage      1/17 (38) 0.9011 0.2424 BioCarta//Hs_Role of Tob in T-cell activation      1/19 (30) 0.9248 0.2426 BioCarta//Hs_Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility      1/21 (25) 0.9428 0.2426 BioCarta//Hs_Dendritic cells in regulating TH1 and TH2 Development      1/22 (25) 0.9501 0.2426 BioCarta//Hs_Nuclear Receptors in Lipid Metabolism and Toxicity      2/34 (43) 0.9424 0.2426 BioCarta//Hs_Induction of apoptosis through DR3 and DR4/5 Death Receptors      2/32 (37) 0.9278 0.2426 BioCarta//Hs_Role of Mitochondria in Apoptotic Signaling      1/20 (38) 0.9344 0.2426 BioCarta//Hs_Caspase Cascade in Apoptosis      1/22 (27) 0.9501 0.2426 BioCarta//Hs_Hypoxia and p53 in the Cardiovascular system      1/22 (37) 0.9501 0.2426

Last Updated (14, February, 2005)  powered by SNUBI