ArrayXPath

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ArrayXPath has searched   #pathways #nodes (non-redundant) #nodes (redundant) GenMAPP 45 1391 1875 PharmGKB 9 134 180 KEGG 70 740 1788 BioCarta 346 1584 8969

ArrayXPath has identified 2565 (97.68%) out of 2626 input elements in the following pathways

Source # pathways # identified nodes # total nodes GenMAPP 45 775 803 PharmGKB 9 35 145 KEGG 69 503 1529 BioCarta 335 1098 5092

Set FDR cut off

Cluster 1 has 17 gene products

ArrayXPath has identified 5 out of 17 input elements in 5 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Complement_Activation_Classical      1/16 (16) 0.0563 0.0925 GenMAPP//Hs_S1P_Signaling      1/25 (25) 0.0868 0.0951 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      1/49 (57) 0.1644 0.1350 GenMAPP//Hs_Nucleotide_Metabolism      1/15 (15) 0.0528 0.1736 GenMapp//Hs_Cell_Cycle      1/87 (96) 0.2763 0.1816

Cluster 2 has 342 gene products

ArrayXPath has identified 156 out of 342 input elements in 35 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Nuclear_Receptors      9/37 (52) 0.0114 0.1777 GenMapp//Hs_Wnt_signaling      13/61 (61) 0.0083 0.2570 GenMAPP//Hs_Apoptosis      7/34 (34) 0.0575 0.2818 GenMapp//Hs_Cell_Cycle      14/87 (96) 0.0630 0.2818 GenMAPP//Hs_G_Protein_Signaling      13/77 (81) 0.0519 0.2818 GenMAPP//Hs_Glycogen_Metabolism      7/33 (34) 0.0499 0.2818 GenMAPP//Hs_Fatty_Acid_Synthesis      4/15 (15) 0.0634 0.2818 GenMAPP//Hs_Translation_Factors      7/49 (51) 0.2488 0.7037 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      7/49 (57) 0.2488 0.7037 GenMAPP//Hs_G13_Signaling_Pathway      5/31 (32) 0.2193 0.7037 GenMAPP//Hs_Calcium_Channels      4/26 (28) 0.2878 0.7462 GenMapp//Hs_Krebs-TCA_Cycle      5/31 (32) 0.2193 0.7582 GenMAPP//Hs_Blood_Clotting_Cascade      3/19 (22) 0.3212 0.7686 GenMapp//Hs_Inflammatory_Response_Pathway      4/29 (29) 0.3628 0.8061 GenMAPP//Hs_Matrix_Metalloproteinases      3/28 (30) 0.5770 0.8494 GenMapp//Hs_Proteasome_Degradation      4/35 (35) 0.5098 0.8494 GenMAPP//Hs_Ovarian_Infertility_Genes      3/29 (32) 0.6017 0.8494 GenMapp//Hs_Monoamine_GPCRs      4/33 (33) 0.4620 0.8494 GenMAPP//Hs_Electron_Transport_Chain      10/105 (105) 0.6825 0.8494 GenMAPP//Hs_Fatty_Acid_Degradation      3/26 (26) 0.5248 0.8494 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      4/42 (44) 0.6593 0.8494 GenMAPP//Hs_tRNA_Synthetases      2/21 (21) 0.6648 0.8494 GenMAPP//Hs_Eicosanoid_Synthesis      2/15 (19) 0.4780 0.8494 GenMAPP//Hs_Heme_Biosynthesis      1/9 (9) 0.6325 0.8494 GenMAPP//Hs_MAPK_Cascade      2/24 (25) 0.7361 0.8629 GenMapp//Hs_GPCRs_Class_C_Metabotropic_glutamate_pheromone      1/15 (18) 0.8122 0.8629 GenMAPP//Hs_Complement_Activation_Classical      1/16 (16) 0.8321 0.8629 GenMAPP//Hs_Cholesterol_Biosynthesis      1/14 (14) 0.7899 0.8629 GenMAPP//Hs_Nucleotide_Metabolism      1/15 (15) 0.8122 0.8713 GenMapp//Hs_Gap_Junction_Proteins_Connexins      2/15 (15) 0.4780 0.8748 GenMapp//Hs_Ribosomal_Proteins      5/83 (83) 0.9494 0.8889 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      10/238 (292) 1.0000 0.8889 GenMapp//Hs_GPCRs_Other      6/119 (171) 0.9911 0.8889 GenMAPP//Hs_S1P_Signaling      1/25 (25) 0.9391 0.8889 GenMapp//Hs_Peptide_GPCRs      1/69 (72) 0.9996 0.8889

Cluster 3 has 288 gene products

ArrayXPath has identified 117 out of 288 input elements in 37 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Eicosanoid_Synthesis      5/15 (19) 0.0041 0.1259 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      8/49 (57) 0.0313 0.3738 GenMapp//Hs_Nuclear_Receptors      6/37 (52) 0.0611 0.3738 GenMapp//Hs_Proteasome_Degradation      6/35 (35) 0.0484 0.3738 GenMAPP//Hs_Blood_Clotting_Cascade      4/19 (22) 0.0537 0.3738 GenMAPP//Hs_Cholesterol_Biosynthesis      3/14 (14) 0.0884 0.3809 GenMAPP//Hs_Apoptosis      5/34 (34) 0.1176 0.3809 GenMAPP//Hs_S1P_Signaling      4/25 (25) 0.1229 0.3809 GenMapp//Hs_Cell_Cycle      10/87 (96) 0.1298 0.3809 GenMAPP//Hs_Acetylcholine_Synthesis      2/7 (7) 0.0970 0.3809 GenMAPP//Hs_Fatty_Acid_Degradation      4/26 (26) 0.1370 0.3809 GenMAPP//Hs_G_Protein_Signaling      7/77 (81) 0.3895 0.7432 GenMAPP//Hs_Translation_Factors      5/49 (51) 0.3303 0.7432 GenMAPP//Hs_G13_Signaling_Pathway      3/31 (32) 0.4374 0.7432 GenMapp//Hs_Smal_ligand_GPCRs      2/16 (16) 0.3564 0.7432 GenMapp//Hs_Krebs-TCA_Cycle      3/31 (32) 0.4374 0.7432 GenMAPP//Hs_Ovarian_Infertility_Genes      3/29 (32) 0.3942 0.7432 GenMAPP//Hs_Complement_Activation_Classical      2/16 (16) 0.3564 0.7786 GenMAPP//Hs_Steroid_Biosynthesis      1/9 (33) 0.5179 0.7921 GenMAPP//Hs_tRNA_Synthetases      2/21 (21) 0.4944 0.7921 GenMapp//Hs_Nucleotide_GPCRs      1/10 (10) 0.5556 0.8092 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      2/42 (44) 0.8520 0.8265 GenMapp//Hs_Ribosomal_Proteins      5/83 (83) 0.7897 0.8265 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      7/238 (292) 0.9998 0.8265 GenMapp//Hs_Peptide_GPCRs      3/69 (72) 0.9167 0.8265 GenMapp//Hs_GPCRs_Other      2/119 (171) 0.9995 0.8265 GenMAPP//Hs_Electron_Transport_Chain      2/105 (105) 0.9985 0.8265 GenMAPP//Hs_Matrix_Metalloproteinases      1/28 (30) 0.8983 0.8265 GenMAPP//Hs_Glycogen_Metabolism      1/33 (34) 0.9328 0.8265 GenMAPP//Hs_MAPK_Cascade      1/24 (25) 0.8587 0.8265 GenMAPP//Hs_Calcium_Channels      1/26 (28) 0.8801 0.8265 GenMapp//Hs_Inflammatory_Response_Pathway      2/29 (29) 0.6728 0.8265 GenMapp//Hs_Wnt_signaling      2/61 (61) 0.9588 0.8265 GenMAPP//Hs_Fatty_Acid_Synthesis      1/15 (15) 0.7044 0.8265 GenMAPP//Hs_Nucleotide_Metabolism      1/15 (15) 0.7044 0.8618 GenMapp//Hs_Gap_Junction_Proteins_Connexins      1/15 (15) 0.7044 0.8618 GenMapp//Hs_Monoamine_GPCRs      1/33 (33) 0.9328 0.8646

Cluster 4 has 283 gene products

ArrayXPath has identified 106 out of 283 input elements in 37 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Apoptosis      10/34 (34) 0.0001 0.0026 GenMapp//Hs_Wnt_signaling      11/61 (61) 0.0036 0.0549 GenMAPP//Hs_Ovarian_Infertility_Genes      6/29 (32) 0.0159 0.0972 GenMAPP//Hs_tRNA_Synthetases      5/21 (21) 0.0152 0.0972 GenMapp//Hs_Inflammatory_Response_Pathway      6/29 (29) 0.0159 0.0972 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      8/49 (57) 0.0229 0.1013 GenMAPP//Hs_Heme_Biosynthesis      3/9 (9) 0.0232 0.1013 GenMAPP//Hs_MAPK_Cascade      5/24 (25) 0.0266 0.1015 GenMAPP//Hs_G13_Signaling_Pathway      5/31 (32) 0.0708 0.2402 GenMAPP//Hs_Matrix_Metalloproteinases      4/28 (30) 0.1438 0.4389 GenMapp//Hs_Smal_ligand_GPCRs      2/16 (16) 0.3302 0.6720 GenMapp//Hs_Cell_Cycle      8/87 (96) 0.3027 0.6720 GenMAPP//Hs_Fatty_Acid_Degradation      3/26 (26) 0.2965 0.6720 GenMAPP//Hs_Complement_Activation_Classical      2/16 (16) 0.3302 0.6720 GenMAPP//Hs_Nucleotide_Metabolism      2/15 (15) 0.3023 0.6720 GenMapp//Hs_Peptide_GPCRs      5/69 (72) 0.5815 0.7720 GenMAPP//Hs_Orphan_GPCRs      1/15 (16) 0.6828 0.7720 GenMAPP//Hs_S1P_Signaling      2/25 (25) 0.5584 0.7720 GenMAPP//Hs_GPCRs_Class_B_Secretin_like      2/23 (28) 0.5124 0.7720 GenMAPP//Hs_Electron_Transport_Chain      7/105 (105) 0.6658 0.7720 GenMapp//Hs_Gap_Junction_Proteins_Connexins      1/15 (15) 0.6828 0.7720 GenMAPP//Hs_Eicosanoid_Synthesis      1/15 (19) 0.6828 0.7720 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      3/42 (44) 0.6069 0.7720 GenMapp//Hs_Krebs-TCA_Cycle      2/31 (32) 0.6775 0.7720 GenMAPP//Hs_Fatty_Acid_Synthesis      1/15 (15) 0.6828 0.7720 GenMAPP//Hs_Blood_Clotting_Cascade      2/19 (22) 0.4118 0.7720 GenMAPP//Hs_Cholesterol_Biosynthesis      1/14 (14) 0.6575 0.7720 GenMAPP//Hs_Glycogen_Metabolism      2/33 (34) 0.7110 0.7752 GenMapp//Hs_Nuclear_Receptors      2/37 (52) 0.7694 0.7829 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like_2      1/18 (20) 0.7483 0.7829 GenMAPP//Hs_G_Protein_Signaling      4/77 (81) 0.8327 0.8199 GenMapp//Hs_GPCRs_Other      6/119 (171) 0.8871 0.8206 GenMAPP//Hs_Calcium_Channels      1/26 (28) 0.8645 0.8206 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      6/238 (292) 0.9999 0.8249 GenMAPP//Hs_Translation_Factors      1/49 (51) 0.9776 0.8249 GenMapp//Hs_Ribosomal_Proteins      1/83 (83) 0.9985 0.8249 GenMapp//Hs_Proteasome_Degradation      1/35 (35) 0.9328 0.8249

Cluster 5 has 231 gene products

ArrayXPath has identified 97 out of 231 input elements in 30 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Translation_Factors      12/49 (51) 0.0000 0.0010 GenMapp//Hs_Ribosomal_Proteins      15/83 (83) 0.0002 0.0023 GenMAPP//Hs_tRNA_Synthetases      4/21 (21) 0.0435 0.2941 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      7/49 (57) 0.0364 0.2941 GenMAPP//Hs_Acetylcholine_Synthesis      2/7 (7) 0.0717 0.3879 GenMapp//Hs_Cell_Cycle      9/87 (96) 0.1083 0.4885 GenMapp//Hs_Krebs-TCA_Cycle      4/31 (32) 0.1396 0.5397 GenMAPP//Hs_Catacholamine_Biosynthesis      1/4 (4) 0.2373 0.8028 GenMAPP//Hs_Matrix_Metalloproteinases      2/28 (30) 0.5572 0.8158 GenMapp//Hs_Wnt_signaling      4/61 (61) 0.5755 0.8158 GenMAPP//Hs_Electron_Transport_Chain      7/105 (105) 0.5401 0.8158 GenMAPP//Hs_G13_Signaling_Pathway      2/31 (32) 0.6138 0.8158 GenMAPP//Hs_Complement_Activation_Classical      1/16 (16) 0.6633 0.8158 GenMAPP//Hs_S1P_Signaling      2/25 (25) 0.4950 0.8158 GenMAPP//Hs_Fatty_Acid_Degradation      2/26 (26) 0.5163 0.8158 GenMAPP//Hs_Glycogen_Metabolism      3/33 (34) 0.3679 0.8158 GenMapp//Hs_Monoamine_GPCRs      2/33 (33) 0.6484 0.8158 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      4/42 (44) 0.2933 0.8158 GenMapp//Hs_Nucleotide_GPCRs      1/10 (10) 0.4928 0.8158 GenMapp//Hs_Pentose_Phosphate_Pathway      1/7 (8) 0.3779 0.8158 GenMAPP//Hs_Nucleotide_Metabolism      1/15 (15) 0.6395 0.8158 GenMapp//Hs_Nuclear_Receptors      2/37 (52) 0.7103 0.8357 GenMAPP//Hs_G_Protein_Signaling      4/77 (81) 0.7576 0.8541 GenMAPP//Hs_Fatty_Acid_Synthesis      1/15 (15) 0.6395 0.8652 GenMAPP//Hs_MAPK_Cascade      1/24 (25) 0.8056 0.8719 GenMAPP//Hs_Apoptosis      1/34 (34) 0.9026 0.8786 GenMapp//Hs_Inflammatory_Response_Pathway      1/29 (29) 0.8623 0.8786 GenMapp//Hs_Proteasome_Degradation      1/35 (35) 0.9091 0.8786 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      3/238 (292) 1.0000 0.9020 GenMapp//Hs_GPCRs_Other      1/119 (171) 0.9998 0.9020

Cluster 6 has 392 gene products

ArrayXPath has identified 156 out of 392 input elements in 41 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Glycogen_Metabolism      8/33 (34) 0.0135 0.2554 GenMapp//Hs_Inflammatory_Response_Pathway      7/29 (29) 0.0211 0.2652 GenMAPP//Hs_Blood_Clotting_Cascade      5/19 (22) 0.0350 0.2732 GenMapp//Hs_Wnt_signaling      11/61 (61) 0.0362 0.2732 GenMAPP//Hs_Matrix_Metalloproteinases      6/28 (30) 0.0546 0.3437 GenMAPP//Hs_Cholesterol_Biosynthesis      5/14 (14) 0.0091 0.3439 GenMapp//Hs_Nucleotide_GPCRs      3/10 (10) 0.0706 0.3811 GenMapp//Hs_Proteasome_Degradation      6/35 (35) 0.1319 0.6231 GenMAPP//Hs_Nuclear_Receptors      6/37 (52) 0.1605 0.6678 GenMAPP//Hs_Fatty_Acid_Synthesis      3/15 (15) 0.1857 0.6678 GenMAPP//Hs_GPCRs_Class_B_Secretin_like      4/23 (28) 0.1945 0.6678 GenMAPP//Hs_Heme_Biosynthesis      2/9 (9) 0.2271 0.7151 GenMapp//Hs_Peptide_GPCRs      8/69 (72) 0.3918 0.9051 GenMAPP//Hs_Catacholamine_Biosynthesis      1/4 (4) 0.3461 0.9051 GenMAPP//Hs_G13_Signaling_Pathway      4/31 (32) 0.3809 0.9051 GenMAPP//Hs_MAPK_Cascade      3/24 (25) 0.4408 0.9051 GenMAPP//Hs_Orphan_GPCRs      2/15 (16) 0.4552 0.9051 GenMapp//Hs_Gap_Junction_Proteins_Connexins      2/15 (15) 0.4552 0.9051 GenMAPP//Hs_Eicosanoid_Synthesis      2/15 (19) 0.4552 0.9051 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      17/238 (292) 0.9654 0.9203 GenMapp//Hs_GPCRs_Other      5/119 (171) 0.9957 0.9203 GenMapp//Hs_Monoamine_GPCRs      3/33 (33) 0.6619 0.9203 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      5/49 (57) 0.5591 0.9203 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like_2      1/18 (20) 0.8537 0.9203 GenMapp//Hs_Cell_Cycle      8/87 (96) 0.6653 0.9203 GenMAPP//Hs_S1P_Signaling      2/25 (25) 0.7349 0.9203 GenMAPP//Hs_G_Protein_Signaling      6/77 (81) 0.8070 0.9203 GenMAPP//Hs_tRNA_Synthetases      1/21 (21) 0.8940 0.9203 GenMAPP//Hs_Calcium_Channels      3/26 (28) 0.4952 0.9203 GenMAPP//Hs_Translation_Factors      2/49 (51) 0.9664 0.9203 GenMAPP//Hs_Apoptosis      2/34 (34) 0.8728 0.9203 GenMapp//Hs_Krebs-TCA_Cycle      3/31 (32) 0.6186 0.9203 GenMAPP//Hs_Electron_Transport_Chain      8/105 (105) 0.8509 0.9203 GenMAPP//Hs_Ovarian_Infertility_Genes      3/29 (32) 0.5717 0.9203 GenMAPP//Hs_Steroid_Biosynthesis      1/9 (33) 0.6162 0.9203 GenMapp//Hs_Pentose_Phosphate_Pathway      1/7 (8) 0.5249 0.9203 GenMapp//Hs_Ribosomal_Proteins      2/83 (83) 0.9988 0.9203 GenMAPP//Hs_Fatty_Acid_Degradation      2/26 (26) 0.7549 0.9203 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      2/42 (44) 0.9366 0.9203 GenMAPP//Hs_Complement_Activation_Classical      1/16 (16) 0.8186 0.9203 GenMapp//Hs_Smal_ligand_GPCRs      1/16 (16) 0.8186 0.9664

Cluster 7 has 243 gene products

ArrayXPath has identified 99 out of 243 input elements in 37 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Glycogen_Metabolism      12/33 (34) 0.0000 0.0000 GenMAPP//Hs_Translation_Factors      11/49 (51) 0.0003 0.0049 GenMAPP//Hs_Fatty_Acid_Synthesis      4/15 (15) 0.0155 0.1829 GenMAPP//Hs_G_Protein_Signaling      9/77 (81) 0.0732 0.4305 GenMAPP//Hs_Cholesterol_Biosynthesis      3/14 (14) 0.0648 0.4305 GenMAPP//Hs_Glucocorticoid_Mineralocorticoid_Metabolism      2/6 (9) 0.0578 0.4305 GenMAPP//Hs_Steroid_Biosynthesis      2/9 (33) 0.1214 0.6122 GenMAPP//Hs_S1P_Signaling      3/25 (25) 0.2409 0.7549 GenMAPP//Hs_MAPK_Cascade      3/24 (25) 0.2223 0.7549 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      5/49 (57) 0.2390 0.7549 GenMAPP//Hs_Complement_Activation_Classical      2/16 (16) 0.2994 0.7549 GenMAPP//Hs_Fatty_Acid_Degradation      3/26 (26) 0.2598 0.7549 GenMapp//Hs_Smal_ligand_GPCRs      2/16 (16) 0.2994 0.7549 GenMapp//Hs_GPCRs_Class_C_Metabotropic_glutamate_pheromone      2/15 (18) 0.2733 0.7549 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      4/42 (44) 0.3214 0.7563 GenMAPP//Hs_tRNA_Synthetases      2/21 (21) 0.4261 0.8356 GenMapp//Hs_Wnt_signaling      5/61 (61) 0.4051 0.8356 GenMapp//Hs_Pentose_Phosphate_Pathway      1/7 (8) 0.3912 0.8356 GenMapp//Hs_Nuclear_Receptors      3/37 (52) 0.4695 0.8721 GenMapp//Hs_Nucleotide_GPCRs      1/10 (10) 0.5083 0.8969 GenMAPP//Hs_Electron_Transport_Chain      4/105 (105) 0.9406 0.9535 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      6/238 (292) 0.9996 0.9535 GenMapp//Hs_Ribosomal_Proteins      4/83 (83) 0.8348 0.9535 GenMapp//Hs_GPCRs_Other      2/119 (171) 0.9984 0.9535 GenMapp//Hs_Peptide_GPCRs      2/69 (72) 0.9577 0.9535 GenMapp//Hs_Proteasome_Degradation      1/35 (35) 0.9186 0.9535 GenMapp//Hs_Cell_Cycle      4/87 (96) 0.8614 0.9535 GenMapp//Hs_Monoamine_GPCRs      1/33 (33) 0.9058 0.9535 GenMAPP//Hs_G13_Signaling_Pathway      2/31 (32) 0.6380 0.9535 GenMAPP//Hs_Apoptosis      2/34 (34) 0.6885 0.9535 GenMAPP//Hs_GPCRs_Class_B_Secretin_like      1/23 (28) 0.8061 0.9535 GenMAPP//Hs_Matrix_Metalloproteinases      1/28 (30) 0.8648 0.9535 GenMAPP//Hs_Calcium_Channels      1/26 (28) 0.8438 0.9535 GenMapp//Hs_Inflammatory_Response_Pathway      1/29 (29) 0.8742 0.9535 GenMAPP//Hs_Eicosanoid_Synthesis      1/15 (19) 0.6559 0.9535 GenMAPP//Hs_Ovarian_Infertility_Genes      1/29 (32) 0.8742 0.9953 GenMAPP//Hs_Orphan_GPCRs      1/15 (16) 0.6559 1.0064

Cluster 8 has 272 gene products

ArrayXPath has identified 116 out of 272 input elements in 37 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMapp//Hs_Cell_Cycle      17/87 (96) 0.0003 0.0079 GenMAPP//Hs_G13_Signaling_Pathway      3/31 (32) 0.4617 0.6244 GenMAPP//Hs_Ovarian_Infertility_Genes      4/29 (32) 0.2001 0.6244 GenMapp//Hs_Inflammatory_Response_Pathway      2/29 (29) 0.6928 0.6244 GenMapp//Hs_Ribosomal_Proteins      7/83 (83) 0.5095 0.6244 GenMapp//Hs_Nuclear_Receptors      3/37 (52) 0.5843 0.6244 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      5/42 (44) 0.2453 0.6244 GenMAPP//Hs_Fatty_Acid_Degradation      2/26 (26) 0.6331 0.6244 GenMAPP//Hs_G_Protein_Signaling      5/77 (81) 0.7600 0.6244 GenMAPP//Hs_MAPK_Cascade      3/24 (25) 0.3037 0.6244 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      5/49 (57) 0.3594 0.6244 GenMAPP//Hs_Electron_Transport_Chain      8/105 (105) 0.6238 0.6244 GenMapp//Hs_Proteasome_Degradation      4/35 (35) 0.3094 0.6244 GenMapp//Hs_Wnt_signaling      5/61 (61) 0.5542 0.6244 GenMAPP//Hs_GPCRs_Class_B_Secretin_like      2/23 (28) 0.5648 0.6244 GenMAPP//Hs_Glycogen_Metabolism      3/33 (34) 0.5044 0.6244 GenMAPP//Hs_Apoptosis      3/34 (34) 0.5251 0.6244 GenMAPP//Hs_S1P_Signaling      2/25 (25) 0.6113 0.6244 GenMAPP//Hs_Eicosanoid_Synthesis      2/15 (19) 0.3435 0.6244 GenMAPP//Hs_Matrix_Metalloproteinases      2/28 (30) 0.6739 0.6244 GenMAPP//Hs_tRNA_Synthetases      2/21 (21) 0.5145 0.6244 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like_2      1/18 (20) 0.7814 0.6244 GenMapp//Hs_Pentose_Phosphate_Pathway      1/7 (8) 0.4451 0.6244 GenMAPP//Hs_Heme_Biosynthesis      1/9 (9) 0.5313 0.6244 GenMAPP//Hs_Complement_Activation_Classical      1/16 (16) 0.7409 0.6244 GenMAPP//Hs_Orphan_GPCRs      1/15 (16) 0.7180 0.6244 GenMAPP//Hs_Blood_Clotting_Cascade      1/19 (22) 0.7993 0.6244 GenMAPP//Hs_Calcium_Channels      1/26 (28) 0.8896 0.6739 GenMapp//Hs_GPCRs_Other      3/119 (171) 0.9978 0.6754 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      8/238 (292) 0.9996 0.6754 GenMapp//Hs_Krebs-TCA_Cycle      1/31 (32) 0.9281 0.6754 GenMapp//Hs_Peptide_GPCRs      1/69 (72) 0.9974 0.6754 GenMAPP//Hs_Translation_Factors      5/49 (51) 0.3594 0.8168 GenMapp//Hs_Monoamine_GPCRs      3/33 (33) 0.5044 0.8407 GenMAPP//Hs_Nucleotide_Metabolism      2/15 (15) 0.3435 0.9541 GenMapp//Hs_GPCRs_Class_C_Metabotropic_glutamate_pheromone      2/15 (18) 0.3435 0.9541 GenMapp//Hs_Gap_Junction_Proteins_Connexins      2/15 (15) 0.3435 0.9541

Cluster 9 has 21 gene products

ArrayXPath has identified 11 out of 21 input elements in 2 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMapp//Hs_Cell_Cycle      9/87 (96) 0.0000 0.0000 GenMapp//Hs_Proteasome_Degradation      1/35 (35) 0.2256 0.1457

Cluster 10 has 163 gene products

ArrayXPath has identified 54 out of 163 input elements in 26 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMapp//Hs_Cell_Cycle      9/87 (96) 0.0033 0.0772 GenMAPP//Hs_G_Protein_Signaling      7/77 (81) 0.0195 0.1504 GenMapp//Hs_Inflammatory_Response_Pathway      4/29 (29) 0.0193 0.1504 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      5/49 (57) 0.0305 0.1766 GenMAPP//Hs_Calcium_Channels      3/26 (28) 0.0667 0.3088 GenMAPP//Hs_Complement_Activation_Classical      2/16 (16) 0.1141 0.4402 GenMAPP//Hs_Blood_Clotting_Cascade      2/19 (22) 0.1518 0.5021 GenMAPP//Hs_Ovarian_Infertility_Genes      2/29 (32) 0.2880 0.6233 GenMapp//Hs_Wnt_signaling      3/61 (61) 0.3894 0.6233 GenMapp//Hs_Nucleotide_GPCRs      1/10 (10) 0.3126 0.6233 GenMAPP//Hs_MAPK_Cascade      2/24 (25) 0.2188 0.6233 GenMAPP//Hs_Nucleotide_Metabolism      1/15 (15) 0.4306 0.6233 GenMAPP//Hs_Matrix_Metalloproteinases      2/28 (30) 0.2741 0.6233 GenMapp//Hs_GPCRs_Class_C_Metabotropic_glutamate_pheromone      1/15 (18) 0.4306 0.6233 GenMAPP//Hs_Fatty_Acid_Synthesis      1/15 (15) 0.4306 0.6233 GenMAPP//Hs_Eicosanoid_Synthesis      1/15 (19) 0.4306 0.6233 GenMAPP//Hs_tRNA_Synthetases      1/21 (21) 0.5463 0.7441 GenMAPP//Hs_Electron_Transport_Chain      3/105 (105) 0.7558 0.7956 GenMapp//Hs_Nuclear_Receptors      1/37 (52) 0.7536 0.7956 GenMAPP//Hs_G13_Signaling_Pathway      1/31 (32) 0.6899 0.7956 GenMapp//Hs_Peptide_GPCRs      2/69 (72) 0.7322 0.7956 GenMAPP//Hs_Apoptosis      1/34 (34) 0.7235 0.7956 GenMAPP//Hs_Translation_Factors      1/49 (51) 0.8448 0.8506 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      4/238 (292) 0.9841 0.8822 GenMapp//Hs_GPCRs_Other      1/119 (171) 0.9904 0.8822 GenMapp//Hs_Ribosomal_Proteins      1/83 (83) 0.9591 0.8822

Cluster NA has 374 gene products

ArrayXPath has identified 154 out of 374 input elements in 36 out of 45 GenMAPP pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value GenMAPP//Hs_Electron_Transport_Chain      26/105 (105) 0.0000 0.0003 GenMapp//Hs_Ribosomal_Proteins      20/83 (83) 0.0002 0.0025 GenMapp//Hs_Krebs-TCA_Cycle      8/31 (32) 0.0113 0.1110 GenMAPP//Hs_Nucleotide_Metabolism      5/15 (15) 0.0145 0.1110 GenMapp//Hs_Proteasome_Degradation      8/35 (35) 0.0234 0.1431 GenMAPP//Hs_G13_Signaling_Pathway      7/31 (32) 0.0355 0.1548 GenMAPP//Hs_MAPK_Cascade      6/24 (25) 0.0318 0.1548 GenMAPP//Hs_G_Protein_Signaling      11/77 (81) 0.1696 0.5751 GenMapp//Hs_Pentose_Phosphate_Pathway      2/7 (8) 0.1600 0.5751 GenMAPP//Hs_Fatty_Acid_Synthesis      3/15 (15) 0.1999 0.6101 GenMAPP//Hs_TGF_Beta_Signaling_Pathway      7/49 (57) 0.2433 0.6751 GenMAPP//Hs_Glycolysis_and_Gluconeogenesis      6/42 (44) 0.2683 0.6826 GenMapp//Hs_Cell_Cycle      5/87 (96) 0.9605 0.8480 GenMapp//Hs_Wnt_signaling      7/61 (61) 0.4551 0.8480 GenMapp//Hs_GPCRs_Other      2/119 (171) 1.0000 0.8480 GenMAPP//Hs_tRNA_Synthetases      3/21 (21) 0.3772 0.8480 GenMAPP//Hs_Translation_Factors      6/49 (51) 0.4038 0.8480 GenMAPP//Hs_Cholesterol_Biosynthesis      1/14 (14) 0.7875 0.8480 GenMAPP//Hs_Steroid_Biosynthesis      1/9 (33) 0.6298 0.8480 GenMapp//Hs_Nuclear_Receptors      2/37 (52) 0.9126 0.8480 GenMAPP//Hs_S1P_Signaling      2/25 (25) 0.7533 0.8480 GenMAPP//Hs_Apoptosis      2/34 (34) 0.8856 0.8480 GenMAPP//Hs_Glycogen_Metabolism      4/33 (34) 0.4565 0.8480 GenMAPP//Hs_GPCRs_Class_B_Secretin_like      1/23 (28) 0.9222 0.8480 GenMapp//Hs_GPCRs_Class_A_Rhodopsin-like      2/238 (292) 1.0000 0.8480 GenMAPP//Hs_Matrix_Metalloproteinases      1/28 (30) 0.9556 0.8480 GenMapp//Hs_Smal_ligand_GPCRs      1/16 (16) 0.8299 0.8480 GenMapp//Hs_Inflammatory_Response_Pathway      3/29 (29) 0.5968 0.8480 GenMAPP//Hs_Blood_Clotting_Cascade      2/19 (22) 0.6052 0.8480 GenMAPP//Hs_Calcium_Channels      1/26 (28) 0.9444 0.8480 GenMAPP//Hs_Acetylcholine_Synthesis      1/7 (7) 0.5381 0.8480 GenMAPP//Hs_Orphan_GPCRs      1/15 (16) 0.8099 0.8480 GenMAPP//Hs_Fatty_Acid_Degradation      1/26 (26) 0.9444 0.9009 GenMAPP//Hs_Heme_Biosynthesis      1/9 (9) 0.6298 0.9155 GenMapp//Hs_GPCRs_Class_C_Metabotropic_glutamate_pheromone      1/15 (18) 0.8099 0.9509 GenMAPP//Hs_Eicosanoid_Synthesis      1/15 (19) 0.8099 0.9509

Cluster 1 has 17 gene products but doesn't match to PharmGKB pathways

Cluster 2 has 342 gene products

ArrayXPath has identified 8 out of 342 input elements in 4 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway_PD      2/8 (9) 0.0565 0.2262 PharmGKB//hs_Antiarrhythmic_Drug_Pathways      3/57 (63) 0.6385 0.6448 PharmGKB//Hs_Statin_Pathway      1/18 (18) 0.6448 0.6448 PharmGKB//Hs_Irinotecan_pathway_liver_cell      1/13 (27) 0.5189 0.6448

Cluster 3 has 288 gene products

ArrayXPath has identified 5 out of 288 input elements in 4 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_ACE_Inhibitor_Pathway      1/9 (10) 0.2975 0.5950 PharmGKB//Hs_Statin_Pathway      1/18 (18) 0.5196 0.6928 PharmGKB//hs_Antiarrhythmic_Drug_Pathways      2/57 (63) 0.7098 0.7098 PharmGKB//Hs_Gemcitabine_Pathway      1/8 (9) 0.2685 1.0739

Cluster 4 has 283 gene products

ArrayXPath has identified 6 out of 283 input elements in 5 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway      1/8 (14) 0.3139 0.1207 PharmGKB//Hs_Irinotecan_pathway_cancer_cell      2/19 (25) 0.2018 0.1207 PharmGKB//Hs_Gemcitabine_Pathway      1/8 (9) 0.3139 0.1207 PharmGKB//Hs_Irinotecan_pathway_liver_cell      2/13 (27) 0.1045 0.1608 PharmGKB//hs_Antiarrhythmic_Drug_Pathways      1/57 (63) 0.9670 0.2975

Cluster 5 has 231 gene products

ArrayXPath has identified 1 out of 231 input elements in 1 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//hs_Antiarrhythmic_Drug_Pathways      1/57 (63) 0.4254 0.4254

Cluster 6 has 392 gene products

ArrayXPath has identified 11 out of 392 input elements in 6 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_ACE_Inhibitor_Pathway      3/9 (10) 0.0146 0.0874 PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway_PD      1/8 (9) 0.4355 0.8218 PharmGKB//Hs_Irinotecan_pathway_cancer_cell      1/19 (25) 0.7589 0.8218 PharmGKB//Hs_Irinotecan_pathway_liver_cell      1/13 (27) 0.6127 0.8218 PharmGKB//hs_Antiarrhythmic_Drug_Pathways      3/57 (63) 0.8218 0.8218 PharmGKB//Hs_Statin_Pathway      1/18 (18) 0.7387 0.8218

Cluster 7 has 243 gene products

ArrayXPath has identified 7 out of 243 input elements in 6 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway_PD      2/8 (9) 0.0565 0.2792 PharmGKB//Hs_Irinotecan_pathway_liver_cell      2/13 (27) 0.1383 0.3414 PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway_Gene_Regulation      1/5 (5) 0.2385 0.3926 PharmGKB//Hs_ACE_Inhibitor_Pathway      1/9 (10) 0.3925 0.4845 PharmGKB//Hs_Irinotecan_pathway_cancer_cell      1/19 (25) 0.6662 0.5483 PharmGKB//Hs_Statin_Pathway      1/18 (18) 0.6448 0.5483

Cluster 8 has 272 gene products

ArrayXPath has identified 4 out of 272 input elements in 4 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway_PD      2/8 (9) 0.0177 0.0470 PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway_Gene_Regulation      1/5 (5) 0.1426 0.1890 PharmGKB//Hs_ACE_Inhibitor_Pathway      1/9 (10) 0.2453 0.2166 PharmGKB//hs_Antiarrhythmic_Drug_Pathways      1/57 (63) 0.8946 0.5927

Cluster 9 has 21 gene products but doesn't match to PharmGKB pathways

Cluster 10 has 163 gene products

ArrayXPath has identified 3 out of 163 input elements in 2 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_ACE_Inhibitor_Pathway      1/9 (10) 0.1896 0.3098 PharmGKB//hs_Antiarrhythmic_Drug_Pathways      2/57 (63) 0.3881 0.3171

Cluster NA has 374 gene products

ArrayXPath has identified 4 out of 374 input elements in 3 out of 9 PharmGKB pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value PharmGKB//Hs_Gemcitabine_Pathway      1/8 (9) 0.1698 0.2547 PharmGKB//Hs_Glucocorticoid_and_Inflammatory_genes_Pathway_PD      1/8 (9) 0.1698 0.2547 PharmGKB//Hs_Statin_Pathway      1/18 (18) 0.3536 0.3536

Cluster 1 has 17 gene products

ArrayXPath has identified 3 out of 17 input elements in 4 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Alanine_and_aspartate_metabolism      2/21 (22) 0.0023 0.0050 KEGG//Hs_Glycine,_serine_and_threonine_metabolism      1/25 (26) 0.0981 0.0725 KEGG//Hs_Nitrogen_metabolism      1/21 (21) 0.0829 0.0725 KEGG//Hs_Arginine_and_proline_metabolism      1/43 (52) 0.1646 0.0913

Cluster 2 has 342 gene products

ArrayXPath has identified 79 out of 342 input elements in 50 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Sphingoglycolipid_metabolism      16/87 (95) 0.0076 0.0765 KEGG//Hs_Inositol_phosphate_metabolism      17/89 (93) 0.0038 0.0768 KEGG//Hs_Nicotinate_and_nicotinamide_metabolism      14/77 (78) 0.0143 0.0951 KEGG//Hs_Fatty_acid_biosynthesis_(path_1)      2/3 (34) 0.0277 0.1385 KEGG//Hs_Purine_metabolism      7/92 (121) 0.8425 0.3823 KEGG//Hs_Pyrimidine_metabolism      3/47 (56) 0.8701 0.3823 KEGG//Hs_Alanine_and_aspartate_metabolism      1/21 (22) 0.8940 0.3823 KEGG//Hs_Nitrogen_metabolism      3/21 (21) 0.3516 0.3823 KEGG//Hs_Androgen_and_estrogen_metabolism      3/27 (35) 0.5183 0.3823 KEGG//Hs_Propanoate_metabolism      2/23 (23) 0.6894 0.3823 KEGG//Hs_Pyruvate_metabolism      3/33 (34) 0.6601 0.3823 KEGG//Hs_Tyrosine_metabolism      3/37 (49) 0.7368 0.3823 KEGG//Hs_Valine,_leucine_and_isoleucine_degradation      2/31 (41) 0.8364 0.3823 KEGG//Hs_Fructose_and_mannose_metabolism      2/25 (26) 0.7339 0.3823 KEGG//Hs_Porphyrin_and_chlorophyll_metabolism      2/21 (22) 0.6392 0.3823 KEGG//Hs_Oxidative_phosphorylation      7/66 (66) 0.4979 0.3823 KEGG//Hs_Glutathione_metabolism      1/29 (29) 0.9558 0.3823 KEGG//Hs_Tryptophan_metabolism      4/55 (62) 0.8236 0.3823 KEGG//Hs_Arginine_and_proline_metabolism      2/43 (52) 0.9429 0.3823 KEGG//Hs_Pantothenate_and_CoA_biosynthesis      1/8 (8) 0.5714 0.3823 KEGG//Hs_Ubiquinone_biosynthesis      3/31 (32) 0.6163 0.3823 KEGG//Hs_Sulfur_metabolism      1/6 (6) 0.4698 0.3823 KEGG//Hs_Bile_acid_biosynthesis      2/26 (29) 0.7541 0.3823 KEGG//Hs_Taurine_and_hypotaurine_metabolism      1/5 (5) 0.4104 0.3823 KEGG//Hs_Aminosugars_metabolism      2/15 (17) 0.4524 0.3823 KEGG//Hs_Galactose_metabolism      2/22 (32) 0.6650 0.3823 KEGG//Hs_Glycolysis__Gluconeogenesis      3/52 (60) 0.9114 0.3823 KEGG//Hs_Fatty_acid_metabolism      6/57 (80) 0.5155 0.3823 KEGG//Hs_Carbon_fixation      2/16 (17) 0.4871 0.3823 KEGG//Hs_Citrate_cycle_(TCA_cycle)      3/18 (19) 0.2652 0.3823 KEGG//Hs_Glyoxylate_and_dicarboxylate_metabolism      2/11 (16) 0.3026 0.3823 KEGG//Hs_Reductive_carboxylate_cycle_(CO2_fixation)      2/7 (7) 0.1490 0.3823 KEGG//Hs_Aminoacyl-tRNA_biosynthesis      2/20 (21) 0.6118 0.3823 KEGG//Hs_Glycine,_serine_and_threonine_metabolism      1/25 (26) 0.9314 0.3823 KEGG//Hs_Urea_cycle_and_metabolism_of_amino_groups      1/18 (19) 0.8534 0.3823 KEGG//Hs_Pentose_phosphate_pathway      1/17 (19) 0.8367 0.3823 KEGG//Hs_Histidine_metabolism      2/27 (27) 0.7729 0.3823 KEGG//Hs_One_carbon_pool_by_folate      1/12 (20) 0.7204 0.3823 KEGG//Hs_Cysteine_metabolism      1/13 (13) 0.7488 0.3823 KEGG//Hs_Flavonoids,_stilbene_and_lignin_biosynthesis      1/7 (11) 0.5232 0.3823 KEGG//Hs_D-Glutamine_and_D-glutamate_metabolism      1/3 (3) 0.2713 0.3823 KEGG//Hs_Glutamate_metabolism      1/23 (24) 0.9147 0.3823 KEGG//Hs_Terpenoid_biosynthesis      1/4 (7) 0.3445 0.3823 KEGG//Hs_Phospholipid_degradation      1/10 (11) 0.6537 0.3823 KEGG//Hs_Prostaglandin_and_leukotriene_metabolism      1/22 (23) 0.9049 0.3823 KEGG//Hs_Pentose_and_glucuronate_interconversions      1/11 (12) 0.6888 0.3823 KEGG//Hs_Phenylalanine_metabolism      1/22 (24) 0.9049 0.4022 KEGG//Hs_Folate_biosynthesis      1/13 (22) 0.7488 0.4405 KEGG//Hs_Ascorbate_and_aldarate_metabolism      1/11 (11) 0.6888 0.4920 KEGG//Hs_Lipopolysaccharide_biosynthesis      1/5 (8) 0.4104 0.6840

Cluster 3 has 288 gene products

ArrayXPath has identified 80 out of 288 input elements in 50 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Bile_acid_biosynthesis      2/26 (29) 0.7744 0.3832 KEGG//Hs_Fatty_acid_metabolism      7/57 (80) 0.3806 0.3832 KEGG//Hs_Glycolysis__Gluconeogenesis      3/52 (60) 0.9251 0.3832 KEGG//Hs_Tyrosine_metabolism      3/37 (49) 0.7623 0.3832 KEGG//Hs_Prostaglandin_and_leukotriene_metabolism      5/22 (23) 0.0684 0.3832 KEGG//Hs_Carbon_fixation      3/16 (17) 0.2269 0.3832 KEGG//Hs_Valine,_leucine_and_isoleucine_degradation      4/31 (41) 0.4064 0.3832 KEGG//Hs_Inositol_phosphate_metabolism      12/89 (93) 0.2001 0.3832 KEGG//Hs_Nicotinate_and_nicotinamide_metabolism      12/77 (78) 0.0889 0.3832 KEGG//Hs_Sphingoglycolipid_metabolism      13/87 (95) 0.1021 0.3832 KEGG//Hs_Glycine,_serine_and_threonine_metabolism      4/25 (26) 0.2571 0.3832 KEGG//Hs_Androgen_and_estrogen_metabolism      3/27 (35) 0.5467 0.3832 KEGG//Hs_Porphyrin_and_chlorophyll_metabolism      1/21 (22) 0.9038 0.3832 KEGG//Hs_Butanoate_metabolism      2/29 (31) 0.8252 0.3832 KEGG//Hs_Synthesis_and_degradation_of_ketone_bodies      1/6 (6) 0.4840 0.3832 KEGG//Hs_Purine_metabolism      6/92 (121) 0.9387 0.3832 KEGG//Hs_Pyrimidine_metabolism      3/47 (56) 0.8877 0.3832 KEGG//Hs_Glutamate_metabolism      2/23 (24) 0.7113 0.3832 KEGG//Hs_Methionine_metabolism      2/10 (10) 0.2795 0.3832 KEGG//Hs_Selenoamino_acid_metabolism      3/11 (11) 0.0969 0.3832 KEGG//Hs_Folate_biosynthesis      2/13 (22) 0.3992 0.3832 KEGG//Hs_Histidine_metabolism      2/27 (27) 0.7926 0.3832 KEGG//Hs_Alanine_and_aspartate_metabolism      4/21 (22) 0.1659 0.3832 KEGG//Hs_Arginine_and_proline_metabolism      3/43 (52) 0.8468 0.3832 KEGG//Hs_Lipopolysaccharide_biosynthesis      1/5 (8) 0.4236 0.3832 KEGG//Hs_Tryptophan_metabolism      6/55 (62) 0.5198 0.3832 KEGG//Hs_Pyruvate_metabolism      2/33 (34) 0.8771 0.3832 KEGG//Hs_Phenylalanine,_tyrosine_and_tryptophan_biosynthesis      1/8 (9) 0.5866 0.3832 KEGG//Hs_Cysteine_metabolism      3/13 (13) 0.1446 0.3832 KEGG//Hs_Nitrogen_metabolism      2/21 (21) 0.6618 0.3832 KEGG//Hs_Fructose_and_mannose_metabolism      1/25 (26) 0.9389 0.3832 KEGG//Hs_C21-Steroid_hormone_metabolism      1/10 (28) 0.6691 0.3832 KEGG//Hs_Citrate_cycle_(TCA_cycle)      2/18 (19) 0.5752 0.3832 KEGG//Hs_Reductive_carboxylate_cycle_(CO2_fixation)      2/7 (7) 0.1592 0.3832 KEGG//Hs_Flavonoids,_stilbene_and_lignin_biosynthesis      1/7 (11) 0.5381 0.3832 KEGG//Hs_Urea_cycle_and_metabolism_of_amino_groups      1/18 (19) 0.8650 0.3832 KEGG//Hs_Pentose_phosphate_pathway      1/17 (19) 0.8489 0.3832 KEGG//Hs_Galactose_metabolism      1/22 (32) 0.9141 0.3832 KEGG//Hs_Glyoxylate_and_dicarboxylate_metabolism      1/11 (16) 0.7040 0.3832 KEGG//Hs_Aminoacyl-tRNA_biosynthesis      1/20 (21) 0.8922 0.3832 KEGG//Hs_Phenylalanine_metabolism      1/22 (24) 0.9141 0.3974 KEGG//Hs_Oxidative_phosphorylation      2/66 (66) 0.9953 0.3981 KEGG//Hs_beta-Alanine_metabolism      1/20 (21) 0.8922 0.4150 KEGG//Hs_Propanoate_metabolism      2/23 (23) 0.7113 0.4446 KEGG//Hs_Pentose_and_glucuronate_interconversions      1/11 (12) 0.7040 0.4693 KEGG//Hs_Ascorbate_and_aldarate_metabolism      1/11 (11) 0.7040 0.4693 KEGG//Hs_Glutathione_metabolism      7/29 (29) 0.0237 0.4744 KEGG//Hs_Pantothenate_and_CoA_biosynthesis      1/8 (8) 0.5866 0.4889 KEGG//Hs_Riboflavin_metabolism      1/8 (8) 0.5866 0.4889 KEGG//Hs_Phospholipid_degradation      1/10 (11) 0.6691 0.4956

Cluster 4 has 283 gene products

ArrayXPath has identified 81 out of 283 input elements in 48 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Glycine,_serine_and_threonine_metabolism      8/25 (26) 0.0020 0.0929 KEGG//Hs_Sulfur_metabolism      2/6 (6) 0.1163 0.6722 KEGG//Hs_Inositol_phosphate_metabolism      14/89 (93) 0.0522 0.6722 KEGG//Hs_Aminoacyl-tRNA_biosynthesis      5/20 (21) 0.0430 0.6722 KEGG//Hs_One_carbon_pool_by_folate      3/12 (20) 0.1128 0.6722 KEGG//Hs_Methane_metabolism      3/11 (11) 0.0910 0.6722 KEGG//Hs_Glutamate_metabolism      5/23 (24) 0.0734 0.6722 KEGG//Hs_Sphingophospholipid_biosynthesis      1/1 (1) 0.1014 0.6722 KEGG//Hs_Folate_biosynthesis      3/13 (22) 0.1363 0.7005 KEGG//Hs_Glutathione_metabolism      5/29 (29) 0.1610 0.7446 KEGG//Hs_Riboflavin_metabolism      2/8 (8) 0.1903 0.8003 KEGG//Hs_Pyrimidine_metabolism      4/47 (56) 0.7234 0.9307 KEGG//Hs_Androgen_and_estrogen_metabolism      2/27 (35) 0.7796 0.9307 KEGG//Hs_Nicotinate_and_nicotinamide_metabolism      10/77 (78) 0.2421 0.9307 KEGG//Hs_Sphingoglycolipid_metabolism      10/87 (95) 0.3844 0.9307 KEGG//Hs_Fatty_acid_metabolism      4/57 (80) 0.8529 0.9307 KEGG//Hs_Bile_acid_biosynthesis      2/26 (29) 0.7610 0.9307 KEGG//Hs_Tyrosine_metabolism      3/37 (49) 0.7455 0.9307 KEGG//Hs_Pentose_phosphate_pathway      1/17 (19) 0.8408 0.9307 KEGG//Hs_Ubiquinone_biosynthesis      3/31 (32) 0.6259 0.9307 KEGG//Hs_Glyoxylate_and_dicarboxylate_metabolism      1/11 (16) 0.6939 0.9307 KEGG//Hs_Lysine_degradation      1/20 (23) 0.8855 0.9307 KEGG//Hs_Citrate_cycle_(TCA_cycle)      3/18 (19) 0.2721 0.9307 KEGG//Hs_Pyruvate_metabolism      2/33 (34) 0.8671 0.9307 KEGG//Hs_Butanoate_metabolism      3/29 (31) 0.5786 0.9307 KEGG//Hs_Arginine_and_proline_metabolism      3/43 (52) 0.8331 0.9307 KEGG//Hs_Urea_cycle_and_metabolism_of_amino_groups      1/18 (19) 0.8573 0.9307 KEGG//Hs_Tryptophan_metabolism      5/55 (62) 0.6759 0.9307 KEGG//Hs_Terpenoid_biosynthesis      1/4 (7) 0.3484 0.9307 KEGG//Hs_Phenylalanine_metabolism      2/22 (24) 0.6726 0.9307 KEGG//Hs_beta-Alanine_metabolism      1/20 (21) 0.8855 0.9307 KEGG//Hs_Taurine_and_hypotaurine_metabolism      1/5 (5) 0.4148 0.9307 KEGG//Hs_Porphyrin_and_chlorophyll_metabolism      3/21 (22) 0.3598 0.9307 KEGG//Hs_Cysteine_metabolism      2/13 (13) 0.3860 0.9307 KEGG//Hs_Fructose_and_mannose_metabolism      2/25 (26) 0.7410 0.9307 KEGG//Hs_Alkaloid_biosynthesis_I      1/6 (7) 0.4745 0.9307 KEGG//Hs_Carbon_fixation      1/16 (17) 0.8224 0.9307 KEGG//Hs_Phenylalanine,_tyrosine_and_tryptophan_biosynthesis      1/8 (9) 0.5765 0.9307 KEGG//Hs_Purine_metabolism      5/92 (121) 0.9708 0.9414 KEGG//Hs_Glycolysis__Gluconeogenesis      2/52 (60) 0.9771 0.9414 KEGG//Hs_Oxidative_phosphorylation      4/66 (66) 0.9221 0.9414 KEGG//Hs_Valine,_leucine_and_isoleucine_degradation      1/31 (41) 0.9661 0.9414 KEGG//Hs_Alanine_and_aspartate_metabolism      3/21 (22) 0.3598 0.9788 KEGG//Hs_Synthesis_and_degradation_of_ketone_bodies      1/6 (6) 0.4745 0.9976 KEGG//Hs_Pantothenate_and_CoA_biosynthesis      1/8 (8) 0.5765 1.0665 KEGG//Hs_Fatty_acid_biosynthesis_(path_2)      1/8 (10) 0.5765 1.0665 KEGG//Hs_Prostaglandin_and_leukotriene_metabolism      2/22 (23) 0.6726 1.0727 KEGG//Hs_Cyanoamino_acid_metabolism      1/4 (4) 0.3484 1.0743

Cluster 5 has 231 gene products

ArrayXPath has identified 61 out of 231 input elements in 45 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Arginine_and_proline_metabolism      7/43 (52) 0.0507 0.6876 KEGG//Hs_Propanoate_metabolism      4/23 (23) 0.1079 0.6876 KEGG//Hs_Valine,_leucine_and_isoleucine_degradation      5/31 (41) 0.0976 0.6876 KEGG//Hs_Inositol_phosphate_metabolism      9/89 (93) 0.2868 0.6876 KEGG//Hs_Glycolysis__Gluconeogenesis      6/52 (60) 0.2384 0.6876 KEGG//Hs_Lysine_degradation      3/20 (23) 0.2161 0.6876 KEGG//Hs_Pyruvate_metabolism      4/33 (34) 0.2752 0.6876 KEGG//Hs_Folate_biosynthesis      2/13 (22) 0.2847 0.6876 KEGG//Hs_Oxidative_phosphorylation      8/66 (66) 0.1543 0.6876 KEGG//Hs_D-Glutamine_and_D-glutamate_metabolism      1/3 (3) 0.2243 0.6876 KEGG//Hs_Urea_cycle_and_metabolism_of_amino_groups      3/18 (19) 0.1731 0.6876 KEGG//Hs_Aminoacyl-tRNA_biosynthesis      4/20 (21) 0.0708 0.6876 KEGG//Hs_Glyoxylate_and_dicarboxylate_metabolism      2/11 (16) 0.2221 0.6876 KEGG//Hs_Methionine_metabolism      2/10 (10) 0.1912 0.6876 KEGG//Hs_Lysine_biosynthesis      1/2 (2) 0.1557 0.6876 KEGG//Hs_Purine_metabolism      9/92 (121) 0.3229 0.7313 KEGG//Hs_Tyrosine_metabolism      3/37 (49) 0.5918 0.7390 KEGG//Hs_Sphingoglycolipid_metabolism      8/87 (95) 0.4092 0.7390 KEGG//Hs_Nicotinate_and_nicotinamide_metabolism      7/77 (78) 0.4357 0.7390 KEGG//Hs_beta-Alanine_metabolism      2/20 (21) 0.4929 0.7390 KEGG//Hs_Bile_acid_biosynthesis      2/26 (29) 0.6393 0.7390 KEGG//Hs_Butanoate_metabolism      3/29 (31) 0.4229 0.7390 KEGG//Hs_Histidine_metabolism      2/27 (27) 0.6603 0.7390 KEGG//Hs_Tryptophan_metabolism      4/55 (62) 0.6708 0.7390 KEGG//Hs_Ubiquinone_biosynthesis      3/31 (32) 0.4677 0.7390 KEGG//Hs_C21-Steroid_hormone_metabolism      1/10 (28) 0.5730 0.7390 KEGG//Hs_Prostaglandin_and_leukotriene_metabolism      2/22 (23) 0.5456 0.7390 KEGG//Hs_Pentose_phosphate_pathway      2/17 (19) 0.4074 0.7390 KEGG//Hs_Pyrimidine_metabolism      4/47 (56) 0.5409 0.7390 KEGG//Hs_Glutamate_metabolism      2/23 (24) 0.5705 0.7390 KEGG//Hs_One_carbon_pool_by_folate      1/12 (20) 0.6404 0.7390 KEGG//Hs_Glycine,_serine_and_threonine_metabolism      2/25 (26) 0.6174 0.7390 KEGG//Hs_Selenoamino_acid_metabolism      1/11 (11) 0.6081 0.7390 KEGG//Hs_Synthesis_and_degradation_of_ketone_bodies      1/6 (6) 0.3990 0.7390 KEGG//Hs_Ascorbate_and_aldarate_metabolism      2/11 (11) 0.2221 0.7542 KEGG//Hs_Methane_metabolism      1/11 (11) 0.6081 0.7745 KEGG//Hs_Aminosugars_metabolism      1/15 (17) 0.7223 0.7747 KEGG//Hs_Carbon_fixation      1/16 (17) 0.7452 0.7788 KEGG//Hs_Citrate_cycle_(TCA_cycle)      1/18 (19) 0.7857 0.8006 KEGG//Hs_Fatty_acid_metabolism      3/57 (80) 0.8616 0.8167 KEGG//Hs_Nitrogen_metabolism      1/21 (21) 0.8349 0.8167 KEGG//Hs_Galactose_metabolism      1/22 (32) 0.8487 0.8167 KEGG//Hs_Androgen_and_estrogen_metabolism      1/27 (35) 0.9023 0.8172 KEGG//Hs_Fructose_and_mannose_metabolism      1/25 (26) 0.8836 0.8172 KEGG//Hs_Phospholipid_degradation      3/10 (11) 0.0403 1.6444

Cluster 6 has 392 gene products

ArrayXPath has identified 94 out of 392 input elements in 52 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Arginine_and_proline_metabolism      11/43 (52) 0.0082 0.1162 KEGG//Hs_Alkaloid_biosynthesis_II      3/4 (4) 0.0060 0.1162 KEGG//Hs_Biotin_metabolism      2/2 (3) 0.0140 0.1487 KEGG//Hs_Synthesis_and_degradation_of_ketone_bodies      3/6 (6) 0.0249 0.1512 KEGG//Hs_Lysine_degradation      6/20 (23) 0.0232 0.1512 KEGG//Hs_Glycine,_serine_and_threonine_metabolism      7/25 (26) 0.0211 0.1512 KEGG//Hs_Ascorbate_and_aldarate_metabolism      4/11 (11) 0.0320 0.1699 KEGG//Hs_Butanoate_metabolism      9/29 (31) 0.0042 0.1799 KEGG//Hs_Valine,_leucine_and_isoleucine_degradation      7/31 (41) 0.0636 0.3003 KEGG//Hs_beta-Alanine_metabolism      5/20 (21) 0.0774 0.3021 KEGG//Hs_Histidine_metabolism      6/27 (27) 0.0895 0.3021 KEGG//Hs_Nitrogen_metabolism      5/21 (21) 0.0924 0.3021 KEGG//Hs_Aminosugars_metabolism      4/15 (17) 0.0913 0.3021 KEGG//Hs_Methionine_metabolism      3/10 (10) 0.1051 0.3190 KEGG//Hs_Pentose_and_glucuronate_interconversions      3/11 (12) 0.1325 0.3519 KEGG//Hs_Glutamate_metabolism      5/23 (24) 0.1264 0.3519 KEGG//Hs_One_carbon_pool_by_folate      3/12 (20) 0.1621 0.4052 KEGG//Hs_Tryptophan_metabolism      9/55 (62) 0.1941 0.4583 KEGG//Hs_Porphyrin_and_chlorophyll_metabolism      4/21 (22) 0.2325 0.4705 KEGG//Hs_Fatty_acid_metabolism      9/57 (80) 0.2251 0.4705 KEGG//Hs_Nucleotide_sugars_metabolism      1/2 (3) 0.2238 0.4705 KEGG//Hs_Galactose_metabolism      4/22 (32) 0.2600 0.5022 KEGG//Hs_Propanoate_metabolism      4/23 (23) 0.2881 0.5210 KEGG//Hs_Carbon_fixation      3/16 (17) 0.2942 0.5210 KEGG//Hs_D-Glutamine_and_D-glutamate_metabolism      1/3 (3) 0.3164 0.5376 KEGG//Hs_Pentose_phosphate_pathway      3/17 (19) 0.3289 0.5376 KEGG//Hs_Bile_acid_biosynthesis      4/26 (29) 0.3743 0.5681 KEGG//Hs_Urea_cycle_and_metabolism_of_amino_groups      3/18 (19) 0.3635 0.5681 KEGG//Hs_Cyanoamino_acid_metabolism      1/4 (4) 0.3980 0.5833 KEGG//Hs_Glycolysis__Gluconeogenesis      7/52 (60) 0.4253 0.6025 KEGG//Hs_Tyrosine_metabolism      5/37 (49) 0.4550 0.6239 KEGG//Hs_Cysteine_metabolism      2/13 (13) 0.4701 0.6244 KEGG//Hs_Phenylalanine_metabolism      3/22 (24) 0.4974 0.6406 KEGG//Hs_Pyruvate_metabolism      4/33 (34) 0.5672 0.7090 KEGG//Hs_Flavonoids,_stilbene_and_lignin_biosynthesis      1/7 (11) 0.5894 0.7157 KEGG//Hs_Phenylalanine,_tyrosine_and_tryptophan_biosynthesis      1/8 (9) 0.6387 0.7336 KEGG//Hs_Riboflavin_metabolism      1/8 (8) 0.6387 0.7336 KEGG//Hs_Purine_metabolism      10/92 (121) 0.6807 0.7451 KEGG//Hs_Ubiquinone_biosynthesis      3/31 (32) 0.7363 0.7451 KEGG//Hs_Glutathione_metabolism      3/29 (29) 0.6922 0.7451 KEGG//Hs_Alanine_and_aspartate_metabolism      2/21 (22) 0.7357 0.7451 KEGG//Hs_Phospholipid_degradation      1/10 (11) 0.7204 0.7451 KEGG//Hs_Methane_metabolism      1/11 (11) 0.7541 0.7453 KEGG//Hs_Androgen_and_estrogen_metabolism      2/27 (35) 0.8529 0.7712 KEGG//Hs_Sphingoglycolipid_metabolism      8/87 (95) 0.8426 0.7712 KEGG//Hs_Pyrimidine_metabolism      4/47 (56) 0.8346 0.7712 KEGG//Hs_Fructose_and_mannose_metabolism      2/25 (26) 0.8203 0.7712 KEGG//Hs_Inositol_phosphate_metabolism      6/89 (93) 0.9695 0.7924 KEGG//Hs_Nicotinate_and_nicotinamide_metabolism      5/77 (78) 0.9668 0.7924 KEGG//Hs_Aminoacyl-tRNA_biosynthesis      1/20 (21) 0.9233 0.7924 KEGG//Hs_Oxidative_phosphorylation      5/66 (66) 0.9160 0.7924 KEGG//Hs_Prostaglandin_and_leukotriene_metabolism      1/22 (23) 0.9409 0.7924

Cluster 7 has 243 gene products

ArrayXPath has identified 58 out of 243 input elements in 46 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Nicotinate_and_nicotinamide_metabolism      10/77 (78) 0.0387 0.5442 KEGG//Hs_Sphingoglycolipid_metabolism      11/87 (95) 0.0361 0.5442 KEGG//Hs_Inositol_phosphate_metabolism      12/89 (93) 0.0175 0.7397 KEGG//Hs_Arginine_and_proline_metabolism      6/43 (52) 0.0784 0.7707 KEGG//Hs_Cysteine_metabolism      2/13 (13) 0.2373 0.7707 KEGG//Hs_Propanoate_metabolism      3/23 (23) 0.2235 0.7707 KEGG//Hs_Urea_cycle_and_metabolism_of_amino_groups      3/18 (19) 0.1319 0.7707 KEGG//Hs_D-Arginine_and_D-ornithine_metabolism      1/3 (4) 0.2001 0.7707 KEGG//Hs_One_carbon_pool_by_folate      2/12 (20) 0.2099 0.7707 KEGG//Hs_Pentose_and_glucuronate_interconversions      2/11 (12) 0.1830 0.7707 KEGG//Hs_C21-Steroid_hormone_metabolism      2/10 (28) 0.1566 0.7707 KEGG//Hs_Nucleotide_sugars_metabolism      1/2 (3) 0.1382 0.7707 KEGG//Hs_Terpenoid_biosynthesis      1/4 (7) 0.2576 0.7769 KEGG//Hs_Glutamate_metabolism      3/23 (24) 0.2235 0.7863 KEGG//Hs_Aminoacyl-tRNA_biosynthesis      2/20 (21) 0.4265 0.8297 KEGG//Hs_Porphyrin_and_chlorophyll_metabolism      2/21 (22) 0.4519 0.8297 KEGG//Hs_Carbon_fixation      2/16 (17) 0.3199 0.8297 KEGG//Hs_Glycolysis__Gluconeogenesis      5/52 (60) 0.3127 0.8297 KEGG//Hs_Pyruvate_metabolism      3/33 (34) 0.4260 0.8297 KEGG//Hs_Nitrogen_metabolism      2/21 (21) 0.4519 0.8297 KEGG//Hs_Alkaloid_biosynthesis_I      1/6 (7) 0.3608 0.8297 KEGG//Hs_Pantothenate_and_CoA_biosynthesis      1/8 (8) 0.4498 0.8297 KEGG//Hs_Prostaglandin_and_leukotriene_metabolism      2/22 (23) 0.4767 0.8387 KEGG//Hs_Fructose_and_mannose_metabolism      2/25 (26) 0.5470 0.8460 KEGG//Hs_Methane_metabolism      1/11 (11) 0.5610 0.8460 KEGG//Hs_Phospholipid_degradation      1/10 (11) 0.5266 0.8460 KEGG//Hs_Purine_metabolism      6/92 (121) 0.6672 0.8531 KEGG//Hs_Glutathione_metabolism      1/29 (29) 0.8890 0.8531 KEGG//Hs_Fatty_acid_metabolism      3/57 (80) 0.7959 0.8531 KEGG//Hs_Alanine_and_aspartate_metabolism      1/21 (22) 0.7946 0.8531 KEGG//Hs_Valine,_leucine_and_isoleucine_degradation      2/31 (41) 0.6674 0.8531 KEGG//Hs_Tyrosine_metabolism      2/37 (49) 0.7612 0.8531 KEGG//Hs_beta-Alanine_metabolism      1/20 (21) 0.7783 0.8531 KEGG//Hs_Pyrimidine_metabolism      3/47 (56) 0.6722 0.8531 KEGG//Hs_Pentose_phosphate_pathway      1/17 (19) 0.7213 0.8531 KEGG//Hs_Bile_acid_biosynthesis      1/26 (29) 0.8601 0.8531 KEGG//Hs_Citrate_cycle_(TCA_cycle)      1/18 (19) 0.7418 0.8531 KEGG//Hs_Butanoate_metabolism      1/29 (31) 0.8890 0.8531 KEGG//Hs_Galactose_metabolism      1/22 (32) 0.8098 0.8531 KEGG//Hs_Androgen_and_estrogen_metabolism      1/27 (35) 0.8705 0.8531 KEGG//Hs_Glycine,_serine_and_threonine_metabolism      2/25 (26) 0.5470 0.8553 KEGG//Hs_Tryptophan_metabolism      2/55 (62) 0.9201 0.8633 KEGG//Hs_Histidine_metabolism      1/27 (27) 0.8705 0.8751 KEGG//Hs_Phenylalanine_metabolism      1/22 (24) 0.8098 0.8767 KEGG//Hs_Oxidative_phosphorylation      2/66 (66) 0.9613 0.8824 KEGG//Hs_Phenylalanine,_tyrosine_and_tryptophan_biosynthesis      1/8 (9) 0.4498 0.9044

Cluster 8 has 272 gene products

ArrayXPath has identified 75 out of 272 input elements in 49 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Galactose_metabolism      4/22 (32) 0.1574 0.3768 KEGG//Hs_Arginine_and_proline_metabolism      4/43 (52) 0.6193 0.3768 KEGG//Hs_Lipopolysaccharide_biosynthesis      1/5 (8) 0.4015 0.3768 KEGG//Hs_Nicotinate_and_nicotinamide_metabolism      8/77 (78) 0.4812 0.3768 KEGG//Hs_Fructose_and_mannose_metabolism      5/25 (26) 0.0859 0.3768 KEGG//Hs_Glycolysis__Gluconeogenesis      5/52 (60) 0.5858 0.3768 KEGG//Hs_Pentose_phosphate_pathway      4/17 (19) 0.0739 0.3768 KEGG//Hs_Purine_metabolism      11/92 (121) 0.2719 0.3768 KEGG//Hs_Oxidative_phosphorylation      6/66 (66) 0.6399 0.3768 KEGG//Hs_Ubiquinone_biosynthesis      3/31 (32) 0.5967 0.3768 KEGG//Hs_Pyrimidine_metabolism      5/47 (56) 0.4903 0.3768 KEGG//Hs_Carbon_fixation      3/16 (17) 0.1977 0.3768 KEGG//Hs_Tryptophan_metabolism      6/55 (62) 0.4503 0.3768 KEGG//Hs_Folate_biosynthesis      2/13 (22) 0.3659 0.3768 KEGG//Hs_Glyoxylate_and_dicarboxylate_metabolism      2/11 (16) 0.2910 0.3768 KEGG//Hs_One_carbon_pool_by_folate      2/12 (20) 0.3288 0.3768 KEGG//Hs_Inositol_phosphate_metabolism      9/89 (93) 0.5085 0.3768 KEGG//Hs_Sphingoglycolipid_metabolism      9/87 (95) 0.4786 0.3768 KEGG//Hs_Pyruvate_metabolism      3/33 (34) 0.6408 0.3768 KEGG//Hs_Prostaglandin_and_leukotriene_metabolism      2/22 (23) 0.6495 0.3768 KEGG//Hs_Riboflavin_metabolism      2/8 (8) 0.1782 0.3768 KEGG//Hs_Phenylalanine_metabolism      3/22 (24) 0.3632 0.3768 KEGG//Hs_Aminoacyl-tRNA_biosynthesis      2/20 (21) 0.5960 0.3768 KEGG//Hs_Pentose_and_glucuronate_interconversions      1/11 (12) 0.6783 0.3768 KEGG//Hs_Porphyrin_and_chlorophyll_metabolism      2/21 (22) 0.6235 0.3768 KEGG//Hs_D-Arginine_and_D-ornithine_metabolism      1/3 (4) 0.2647 0.3768 KEGG//Hs_Phospholipid_degradation      1/10 (11) 0.6431 0.3768 KEGG//Hs_Alkaloid_biosynthesis_I      1/6 (7) 0.4601 0.3768 KEGG//Hs_Flavonoids,_stilbene_and_lignin_biosynthesis      1/7 (11) 0.5131 0.3768 KEGG//Hs_Methane_metabolism      1/11 (11) 0.6783 0.3768 KEGG//Hs_Butanoate_metabolism      2/29 (31) 0.7939 0.3889 KEGG//Hs_Fatty_acid_metabolism      3/57 (80) 0.9326 0.3889 KEGG//Hs_Valine,_leucine_and_isoleucine_degradation      2/31 (41) 0.8243 0.3889 KEGG//Hs_Citrate_cycle_(TCA_cycle)      1/18 (19) 0.8451 0.3889 KEGG//Hs_Glutamate_metabolism      1/23 (24) 0.9086 0.3889 KEGG//Hs_Alanine_and_aspartate_metabolism      1/21 (22) 0.8870 0.3889 KEGG//Hs_Histidine_metabolism      2/27 (27) 0.7590 0.3889 KEGG//Hs_Lysine_degradation      1/20 (23) 0.8745 0.3889 KEGG//Hs_Glycine,_serine_and_threonine_metabolism      1/25 (26) 0.9260 0.3889 KEGG//Hs_Bile_acid_biosynthesis      1/26 (29) 0.9335 0.3889 KEGG//Hs_Androgen_and_estrogen_metabolism      2/27 (35) 0.7590 0.3995 KEGG//Hs_Tyrosine_metabolism      1/37 (49) 0.9795 0.3998 KEGG//Hs_beta-Alanine_metabolism      1/20 (21) 0.8745 0.4067 KEGG//Hs_Nitrogen_metabolism      2/21 (21) 0.6235 0.4157 KEGG//Hs_Reductive_carboxylate_cycle_(CO2_fixation)      1/7 (7) 0.5131 0.4275 KEGG//Hs_Pantothenate_and_CoA_biosynthesis      2/8 (8) 0.1782 0.5093 KEGG//Hs_Phenylalanine,_tyrosine_and_tryptophan_biosynthesis      2/8 (9) 0.1782 0.5093 KEGG//Hs_Synthesis_and_degradation_of_ketone_bodies      1/6 (6) 0.4601 0.5112 KEGG//Hs_Aminosugars_metabolism      4/15 (17) 0.0492 0.9843

Cluster 9 has 21 gene products

ArrayXPath has identified 4 out of 21 input elements in 5 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Inositol_phosphate_metabolism      3/89 (93) 0.0062 0.0062 KEGG//Hs_Sphingoglycolipid_metabolism      3/87 (95) 0.0058 0.0062 KEGG//Hs_Nicotinate_and_nicotinamide_metabolism      3/77 (78) 0.0040 0.0121 KEGG//Hs_Androgen_and_estrogen_metabolism      1/27 (35) 0.1384 0.0836 KEGG//Hs_Bile_acid_biosynthesis      1/26 (29) 0.1336 0.0836

Cluster 10 has 163 gene products

ArrayXPath has identified 37 out of 163 input elements in 29 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Glutathione_metabolism      5/29 (29) 0.0081 0.2253 KEGG//Hs_Methionine_metabolism      2/10 (10) 0.0732 0.6036 KEGG//Hs_Selenoamino_acid_metabolism      2/11 (11) 0.0869 0.6036 KEGG//Hs_Methane_metabolism      2/11 (11) 0.0869 0.6036 KEGG//Hs_Folate_biosynthesis      2/13 (22) 0.1164 0.6469 KEGG//Hs_Phenylalanine_metabolism      2/22 (24) 0.2680 0.8452 KEGG//Hs_Nicotinate_and_nicotinamide_metabolism      5/77 (78) 0.2738 0.8452 KEGG//Hs_Porphyrin_and_chlorophyll_metabolism      2/21 (22) 0.2505 0.8452 KEGG//Hs_Riboflavin_metabolism      1/8 (8) 0.3148 0.8746 KEGG//Hs_Inositol_phosphate_metabolism      5/89 (93) 0.3893 0.9011 KEGG//Hs_Sphingoglycolipid_metabolism      5/87 (95) 0.3697 0.9011 KEGG//Hs_Cysteine_metabolism      1/13 (13) 0.4602 0.9131 KEGG//Hs_One_carbon_pool_by_folate      1/12 (20) 0.4338 0.9131 KEGG//Hs_Glycolysis__Gluconeogenesis      2/52 (60) 0.7072 0.9162 KEGG//Hs_Histidine_metabolism      1/27 (27) 0.7257 0.9162 KEGG//Hs_Arginine_and_proline_metabolism      2/43 (52) 0.6015 0.9162 KEGG//Hs_Urea_cycle_and_metabolism_of_amino_groups      1/18 (19) 0.5755 0.9162 KEGG//Hs_Aminosugars_metabolism      1/15 (17) 0.5096 0.9162 KEGG//Hs_Aminoacyl-tRNA_biosynthesis      1/20 (21) 0.6145 0.9162 KEGG//Hs_Glycine,_serine_and_threonine_metabolism      1/25 (26) 0.6976 0.9162 KEGG//Hs_Prostaglandin_and_leukotriene_metabolism      1/22 (23) 0.6501 0.9162 KEGG//Hs_Pyruvate_metabolism      1/33 (34) 0.7956 0.9208 KEGG//Hs_Tyrosine_metabolism      1/37 (49) 0.8322 0.9208 KEGG//Hs_Purine_metabolism      3/92 (121) 0.8188 0.9208 KEGG//Hs_Oxidative_phosphorylation      1/66 (66) 0.9613 0.9208 KEGG//Hs_Fatty_acid_metabolism      1/57 (80) 0.9386 0.9208 KEGG//Hs_Tryptophan_metabolism      1/55 (62) 0.9320 0.9208 KEGG//Hs_Pyrimidine_metabolism      1/47 (56) 0.8981 0.9208 KEGG//Hs_Nitrogen_metabolism      2/21 (21) 0.2505 0.9939

Cluster NA has 374 gene products

ArrayXPath has identified 105 out of 374 input elements in 55 out of 70 KEGG pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value KEGG//Hs_Oxidative_phosphorylation      19/66 (66) 0.0004 0.0173 KEGG//Hs_D-Glutamine_and_D-glutamate_metabolism      2/3 (3) 0.0476 0.5821 KEGG//Hs_Butanoate_metabolism      8/29 (31) 0.0281 0.5821 KEGG//Hs_Methane_metabolism      4/11 (11) 0.0457 0.5821 KEGG//Hs_Citrate_cycle_(TCA_cycle)      5/18 (19) 0.0767 0.7503 KEGG//Hs_Inositol_phosphate_metabolism      14/89 (93) 0.2769 0.7808 KEGG//Hs_Phenylalanine_metabolism      4/22 (24) 0.3308 0.7808 KEGG//Hs_Nicotinate_and_nicotinamide_metabolism      11/77 (78) 0.4436 0.7808 KEGG//Hs_Sphingoglycolipid_metabolism      13/87 (95) 0.3604 0.7808 KEGG//Hs_Glutamate_metabolism      5/23 (24) 0.1772 0.7808 KEGG//Hs_Nitrogen_metabolism      4/21 (21) 0.2987 0.7808 KEGG//Hs_Pyrimidine_metabolism      7/47 (56) 0.4325 0.7808 KEGG//Hs_Aminoacyl-tRNA_biosynthesis      3/20 (21) 0.5070 0.7808 KEGG//Hs_Synthesis_and_degradation_of_ketone_bodies      2/6 (6) 0.1825 0.7808 KEGG//Hs_Valine,_leucine_and_isoleucine_degradation      6/31 (41) 0.2170 0.7808 KEGG//Hs_Fatty_acid_biosynthesis_(path_2)      2/8 (10) 0.2870 0.7808 KEGG//Hs_Lysine_degradation      4/20 (23) 0.2670 0.7808 KEGG//Hs_Ubiquinone_biosynthesis      5/31 (32) 0.3928 0.7808 KEGG//Hs_Glyoxylate_and_dicarboxylate_metabolism      3/11 (16) 0.1687 0.7808 KEGG//Hs_Reductive_carboxylate_cycle_(CO2_fixation)      2/7 (7) 0.2344 0.7808 KEGG//Hs_Pentose_and_glucuronate_interconversions      2/11 (12) 0.4394 0.7808 KEGG//Hs_Histidine_metabolism      4/27 (27) 0.4902 0.7808 KEGG//Hs_Sulfur_metabolism      1/6 (6) 0.5749 0.7808 KEGG//Hs_Pyruvate_metabolism      5/33 (34) 0.4492 0.7808 KEGG//Hs_Tyrosine_metabolism      5/37 (49) 0.5571 0.7808 KEGG//Hs_Alanine_and_aspartate_metabolism      3/21 (22) 0.5418 0.7808 KEGG//Hs_Carbon_fixation      3/16 (17) 0.3574 0.7808 KEGG//Hs_Aminosugars_metabolism      3/15 (17) 0.3185 0.7808 KEGG//Hs_Cysteine_metabolism      2/13 (13) 0.5310 0.7808 KEGG//Hs_Alkaloid_biosynthesis_I      1/6 (7) 0.5749 0.7808 KEGG//Hs_D-Arginine_and_D-ornithine_metabolism      1/3 (4) 0.3474 0.7808 KEGG//Hs_Lipopolysaccharide_biosynthesis      1/5 (8) 0.5095 0.7808 KEGG//Hs_Lysine_biosynthesis      1/2 (2) 0.2475 0.7808 KEGG//Hs_Propanoate_metabolism      3/23 (23) 0.6069 0.8019 KEGG//Hs_Folate_biosynthesis      2/13 (22) 0.5310 0.8112 KEGG//Hs_Bile_acid_biosynthesis      3/26 (29) 0.6926 0.8466 KEGG//Hs_Pentose_phosphate_pathway      2/17 (19) 0.6820 0.8466 KEGG//Hs_Phenylalanine,_tyrosine_and_tryptophan_biosynthesis      1/8 (9) 0.6809 0.8466 KEGG//Hs_Tryptophan_metabolism      6/55 (62) 0.7632 0.8471 KEGG//Hs_Arginine_and_proline_metabolism      4/43 (52) 0.8467 0.8471 KEGG//Hs_Urea_cycle_and_metabolism_of_amino_groups      2/18 (19) 0.7130 0.8471 KEGG//Hs_Selenoamino_acid_metabolism      1/11 (11) 0.7928 0.8471 KEGG//Hs_Glycine,_serine_and_threonine_metabolism      2/25 (26) 0.8664 0.8471 KEGG//Hs_beta-Alanine_metabolism      2/20 (21) 0.7675 0.8471 KEGG//Hs_Glycolysis__Gluconeogenesis      5/52 (60) 0.8453 0.8471 KEGG//Hs_Purine_metabolism      10/92 (121) 0.8094 0.8471 KEGG//Hs_One_carbon_pool_by_folate      1/12 (20) 0.8207 0.8471 KEGG//Hs_Fructose_and_mannose_metabolism      2/25 (26) 0.8664 0.8471 KEGG//Hs_Porphyrin_and_chlorophyll_metabolism      4/21 (22) 0.2987 0.8589 KEGG//Hs_Fatty_acid_metabolism      5/57 (80) 0.8982 0.8610 KEGG//Hs_Glutathione_metabolism      2/29 (29) 0.9161 0.8613 KEGG//Hs_Galactose_metabolism      1/22 (32) 0.9582 0.8675 KEGG//Hs_Prostaglandin_and_leukotriene_metabolism      1/22 (23) 0.9582 0.8675 KEGG//Hs_Androgen_and_estrogen_metabolism      1/27 (35) 0.9800 0.8711 KEGG//Hs_Nucleotide_sugars_metabolism      1/2 (3) 0.2475 1.0083

Cluster 1 has 17 gene products

ArrayXPath has identified 14 out of 17 input elements in 51 out of 346 BioCarta pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value BioCarta//Hs_SODD/TNFR1 Signaling Pathway      1/10 (18) 0.0673 0.1152 BioCarta//Hs_Actions of Nitric Oxide in the Heart      2/30 (44) 0.0171 0.1152 BioCarta//Hs_Hypoxia and p53 in the Cardiovascular system      2/22 (37) 0.0093 0.1152 BioCarta//Hs_Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages      1/25 (42) 0.1606 0.1152 BioCarta//Hs_Influence of Ras and Rho proteins on G1 to S Transition      2/26 (33) 0.0130 0.1152 BioCarta//Hs_Phospholipase C Signaling Pathway      1/8 (12) 0.0542 0.1152 BioCarta//Hs_Phospholipids as signalling intermediaries      1/25 (42) 0.1606 0.1152 BioCarta//Hs_Regulation of BAD phosphorylation      1/22 (31) 0.1427 0.1152 BioCarta//Hs_Role of Erk5 in Neuronal Survival      1/17 (36) 0.1120 0.1152 BioCarta//Hs_Role of nicotinic acetylcholine receptors in the regulation of apoptosis      1/15 (24) 0.0994 0.1152 BioCarta//Hs_Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway      1/20 (23) 0.1305 0.1152 BioCarta//Hs_Trka Receptor Signaling Pathway      1/12 (12) 0.0803 0.1152 BioCarta//Hs_Classical Complement Pathway      1/14 (68) 0.0931 0.1152 BioCarta//Hs_Cell Cycle: G2/M Checkpoint      1/24 (27) 0.1547 0.1152 BioCarta//Hs_Cyclins and Cell Cycle Regulation      1/23 (46) 0.1487 0.1152 BioCarta//Hs_Effects of calcineurin in Keratinocyte Differentiation      1/18 (36) 0.1182 0.1152 BioCarta//Hs_Erythropoietin mediated neuroprotection through NF-kB      1/11 (17) 0.0738 0.1152 BioCarta//Hs_ATM Signaling Pathway      1/19 (32) 0.1244 0.1152 BioCarta//Hs_Proepithelin Conversion to Epithelin and Wound Repair Control      1/6 (40) 0.0409 0.1152 BioCarta//Hs_IL12 and Stat4 Dependent Signaling Pathway in Th1 Development      1/21 (27) 0.1366 0.1152 BioCarta//Hs_GATA3 participate in activating the Th2 cytokine genes expression      1/16 (25) 0.1057 0.1152 BioCarta//Hs_mTOR Signaling Pathway      1/24 (44) 0.1547 0.1163 BioCarta//Hs_Regulation of eIF4e and p70 S6 Kinase      1/24 (37) 0.1547 0.1163 BioCarta//Hs_Trefoil Factors Initiate Mucosal Healing      1/24 (95) 0.1547 0.1163 BioCarta//Hs_Transcription factor CREB and its extracellular signals      1/26 (26) 0.1665 0.1167 BioCarta//Hs_Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)      1/28 (41) 0.1782 0.1195 BioCarta//Hs_Cell Cycle: G1/S Check Point      1/28 (34) 0.1782 0.1195 BioCarta//Hs_Phosphoinositides and their downstream targets.      1/23 (23) 0.1487 0.1239 BioCarta//Hs_Caspase Cascade in Apoptosis      1/22 (27) 0.1427 0.1257 BioCarta//Hs_Inhibition of Cellular Proliferation by Gleevec      1/22 (23) 0.1427 0.1257 BioCarta//Hs_Ras Signaling Pathway      1/22 (23) 0.1427 0.1257 BioCarta//Hs_Induction of apoptosis through DR3 and DR4/5 Death Receptors      1/32 (37) 0.2012 0.1320 BioCarta//Hs_Apoptotic Signaling in Response to DNA Damage      1/21 (29) 0.1366 0.1359 BioCarta//Hs_AKT Signaling Pathway      1/21 (32) 0.1366 0.1359 BioCarta//Hs_IL-2 Receptor Beta Chain in T cell Activation      1/35 (38) 0.2180 0.1401 BioCarta//Hs_Role of Mitochondria in Apoptotic Signaling      1/20 (38) 0.1305 0.1437 BioCarta//Hs_Integrin Signaling Pathway      1/37 (45) 0.2291 0.1442 BioCarta//Hs_Complement Pathway      1/19 (33) 0.1244 0.1475 BioCarta//Hs_PTEN dependent cell cycle arrest and apoptosis      1/18 (21) 0.1182 0.1519 BioCarta//Hs_Telomeres, Telomerase, Cellular Aging, and Immortality      1/18 (31) 0.1182 0.1519 BioCarta//Hs_Human Cytomegalovirus and Map Kinase Pathways      1/16 (17) 0.1057 0.1630 BioCarta//Hs_p53 Signaling Pathway      1/16 (27) 0.1057 0.1630 BioCarta//Hs_IL-7 Signal Transduction      1/16 (29) 0.1057 0.1630 BioCarta//Hs_Corticosteroids and cardioprotection      2/17 (28) 0.0056 0.1729 BioCarta//Hs_NFAT and Hypertrophy of the heart (Transcription in the broken heart)      1/51 (82) 0.3025 0.1865 BioCarta//Hs_Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation      1/15 (29) 0.0994 0.1916 BioCarta//Hs_HIV-I Nef: negative effector of Fas and TNF      1/57 (77) 0.3319 0.2007 BioCarta//Hs_The IGF-1 Receptor and Longevity      1/14 (14) 0.0931 0.2050 BioCarta//Hs_B Cell Survival Pathway      1/14 (16) 0.0931 0.2050 BioCarta//Hs_TSP-1 Induced Apoptosis in Microvascular Endothelial Cell      1/6 (9) 0.0409 0.2103 BioCarta//Hs_IL 4 signaling pathway      1/11 (17) 0.0738 0.2277

Cluster 2 has 342 gene products

ArrayXPath has identified 204 out of 342 input elements in 251 out of 346 BioCarta pathways.

Clusters GenMAPP 1 2 3 4 5 6 7 8 9 10 NA PharmGKB 1 2 3 4 5 6 7 8 9 10 NA KEGG 1 2 3 4 5 6 7 8 9 10 NA BioCarta 1 2 3 4 5 6 7 8 9 10 NA

Pathway Identified node p-value q-value BioCarta//Hs_ADP-Ribosylation Factor      9/21 (57) 0.0003 0.0219 BioCarta//Hs_CTCF: First Multivalent Nuclear Factor      9/23 (26) 0.0007 0.0246 BioCarta//Hs_Apoptotic Signaling in Response to DNA Damage      7/21 (29) 0.0079 0.1483 BioCarta//Hs_Regulation of eIF2      4/9 (20) 0.0148 0.1483 BioCarta//Hs_Phospholipase C d1 in phospholipid associated cell signaling      3/5 (10) 0.0136 0.1483 BioCarta//Hs_Attenuation of GPCR Signaling      5/13 (13) 0.0128 0.1483 BioCarta//Hs_Ion Channel and Phorbal Esters Signaling Pathway      3/5 (7) 0.0136 0.1590 BioCarta//Hs_Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)      11/54 (64) 0.0464 0.1600 BioCarta//Hs_Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to fa      5/15 (28) 0.0245 0.1600 BioCarta//Hs_Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway      5/20 (23) 0.0777 0.1600 BioCarta//Hs_WNT Signaling Pathway      6/25 (42) 0.0656 0.1600 BioCarta//Hs_Role of Tob in T-cell activation      6/19 (30) 0.0183 0.1600 BioCarta//Hs_Degradation of the RAR and RXR by the proteasome      2/3 (11) 0.0386 0.1600 BioCarta//Hs_Transcription Regulation by Methyltransferase of CARM1      4/13 (34) 0.0576 0.1600 BioCarta//Hs_ATM Signaling Pathway      5/19 (32) 0.0642 0.1600 BioCarta//Hs_Regulation of eIF4e and p70 S6 Kinase      6/24 (37) 0.0551 0.1600 BioCarta//Hs_Phospholipase C-epsilon pathway      4/12 (25) 0.0438 0.1600 BioCarta//Hs_Inhibition of Matrix Metalloproteinases      3/9 (15) 0.0800 0.1600 BioCarta//Hs_Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy      5/18 (31) 0.0521 0.1600 BioCarta//Hs_Signaling Pathway from G-Protein Families      8/34 (42) 0.0398 0.1600 BioCarta//Hs_cdc25 and chk1 Regulatory Pathway in response to DNA damage      3/9 (13) 0.0800 0.1600 BioCarta//Hs_Transcription factor CREB and its extracellular signals      6/26 (26) 0.0773 0.1600 BioCarta//Hs_Activation of PKC through G protein coupled receptor      3/7 (8) 0.0398 0.1600 BioCarta//Hs_Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes      5/17 (20) 0.0415 0.1600 BioCarta//Hs_Spliceosomal Assembly      4/14 (14) 0.0734 0.1600 BioCarta//Hs_Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells      6/26 (43) 0.0773 0.1690 BioCarta//Hs_Bone Remodelling      4/14 (19) 0.0734 0.1713 BioCarta//Hs_B Cell Survival Pathway      4/14 (16) 0.0734 0.1713 BioCarta//Hs_TACI and BCMA stimulation of B cell immune responses.      4/14 (21) 0.0734 0.1713 BioCarta//Hs_Cadmium induces DNA synthesis and proliferation in macrophages      4/15 (21) 0.0912 0.1752 BioCarta//Hs_Nitric Oxide Signaling Pathway      5/21 (25) 0.0926 0.1752 BioCarta//Hs_Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages      6/25 (42) 0.0656 0.1767 BioCarta//Hs_Rab GTPases Mark Targets In The Endocytotic Machinery      4/12 (17) 0.0438 0.1804 BioCarta//Hs_Cystic fibrosis transmembrane conductance regulator and beta 2 adrenergic receptor pathway      4/12 (37) 0.0438 0.1804 BioCarta//Hs_Double Stranded RNA Induced Gene Expression      3/10 (14) 0.1047 0.1832 BioCarta//Hs_Erk1/Erk2 Mapk Signaling pathway      6/28 (33) 0.1038 0.1832 BioCarta//Hs_RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage      4/13 (17) 0.0576 0.1833 BioCarta//Hs_p53 Signaling Pathway      4/16 (27) 0.1108 0.1847 BioCarta//Hs_Role of MEF2D in T-cell Apoptosis      4/16 (45) 0.1108 0.1847 BioCarta//Hs_Cell Cycle: G1/S Check Point      6/28 (34) 0.1038 0.1863 BioCarta//Hs_ChREBP regulation by carbohydrates and cAMP      5/19 (30) 0.0642 0.1872 BioCarta//Hs_CCR3 signaling in Eosinophils      5/23 (30) 0.1264 0.1928 BioCarta//Hs_Map Kinase Inactivation of SMRT Corepressor      3/11 (14) 0.1319 0.1928 BioCarta//Hs_Y branching of actin filaments      4/17 (45) 0.1322 0.1928 BioCarta//Hs_Regulation of ck1/cdk5 by type 1 glutamate receptors      4/17 (38) 0.1322 0.1928 BioCarta//Hs_Corticosteroids and cardioprotection      4/17 (28) 0.1322 0.1928 BioCarta//Hs_Telomeres, Telomerase, Cellular Aging, and Immortality      4/18 (31) 0.1551 0.2010 BioCarta//Hs_mTOR Signaling Pathway      5/24 (44) 0.1452 0.2010 BioCarta//Hs_Effects of calcineurin in Keratinocyte Differentiation      4/18 (36) 0.1551 0.2010 BioCarta//Hs_Visceral Fat Deposits and the Metabolic Syndrome      2/6 (9) 0.1519 0.2010 BioCarta//Hs_Role of Parkin in the Ubiquitin-Proteasomal Pathway      3/12 (38) 0.1612 0.2016 BioCarta//Hs_Trka Receptor Signaling Pathway      3/12 (12) 0.1612 0.2016 BioCarta//Hs_CXCR4 Signaling Pathway      5/24 (35) 0.1452 0.2032 BioCarta//Hs_SREBP control of lipid synthesis      2/6 (24) 0.1519 0.2045 BioCarta//Hs_AKAP95 role in mitosis and chromosome dynamics      3/11 (39) 0.1319 0.2052 BioCarta//Hs_Melanocyte Development and Pigmentation Pathway      3/7 (13) 0.0398 0.2145 BioCarta//Hs_TGF beta signaling pathway      4/19 (76) 0.1793 0.2202 BioCarta//Hs_ALK in cardiac myocytes      6/34 (51) 0.2067 0.2226 BioCarta//Hs_g-Secretase mediated ErbB4 Signaling Pathway      2/7 (19) 0.1967 0.2226 BioCarta//Hs_Extrinsic Prothrombin Activation Pathway      3/13 (24) 0.1923 0.2226 BioCarta//Hs_Acute Myocardial Infarction      4/20 (23) 0.2047 0.2226 BioCarta//Hs_mCalpain and friends in Cell motility      4/22 (38) 0.2582 0.2232 BioCarta//Hs_Aspirin Blocks Signaling Pathway Involved in Platelet Activation      4/22 (32) 0.2582 0.2232 BioCarta//Hs_Regulation of BAD phosphorylation      4/22 (31) 0.2582 0.2232 BioCarta//Hs_NFAT and Hypertrophy of the heart (Transcription in the broken heart)      8/51 (82) 0.2498 0.2232 BioCarta//Hs_Inhibition of Cellular Proliferation by Gleevec      4/22 (23) 0.2582 0.2232 BioCarta//Hs_T Cell Receptor Signaling Pathway      7/43 (56) 0.2400 0.2232 BioCarta//Hs_Regulation of cell cycle progression by Plk3      2/8 (17) 0.2428 0.2232 BioCarta//Hs_Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility      4/21 (25) 0.2311 0.2232 BioCarta//Hs_CD40L Signaling Pathway      3/15 (27) 0.2582 0.2232 BioCarta//Hs_Role of Mitochondria in Apoptotic Signaling      4/20 (38) 0.2047 0.2239 BioCarta//Hs_Oxidative Stress Induced Gene Expression Via Nrf2      4/20 (24) 0.2047 0.2239 BioCarta//Hs_Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor      4/20 (24) 0.2047 0.2239 BioCarta//Hs_Cell to Cell Adhesion Signaling      3/13 (14) 0.1923 0.2282 BioCarta//Hs_Sonic Hedgehog (Shh) Pathway      3/16 (29) 0.2922 0.2324 BioCarta//Hs_How Progesterone Initiates the Oocyte Maturation      5/30 (32) 0.2774 0.2324 BioCarta//Hs_Polyadenylation of mRNA      2/9 (35) 0.2894 0.2324 BioCarta//Hs_Intrinsic Prothrombin Activation Pathway      4/23 (36) 0.2860 0.2324 BioCarta//Hs_Feeder Pathways for Glycolysis      2/9 (11) 0.2894 0.2328 BioCarta//Hs_Erythrocyte Differentiation Pathway      3/15 (21) 0.2582 0.2347 BioCarta//Hs_Endocytotic role of NDK, Phosphins and Dynamin      3/15 (48) 0.2582 0.2347 BioCarta//Hs_The information-processing pathway at the IFN-beta enhancer      3/15 (27) 0.2582 0.2347 BioCarta//Hs_Eukaryotic protein translation      3/15 (20) 0.2582 0.2347 BioCarta//Hs_PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase      3/15 (18) 0.2582 0.2347 BioCarta//Hs_Phosphoinositides and their downstream targets.      4/23 (23) 0.2860 0.2355 BioCarta//Hs_TPO Signaling Pathway      4/23 (54) 0.2860 0.2355 BioCarta//Hs_IL 6 signaling pathway      4/21 (48) 0.2311 0.2414 BioCarta//Hs_Cell Cycle: G2/M Checkpoint      4/24 (27) 0.3141 0.2423 BioCarta//Hs_Nitrogen-depedent regulation of Rtg1 and Rtg3 in TOR pathway      1/3 (8) 0.3149 0.2423 BioCarta//Hs_Phospholipase C Signaling Pathway      2/8 (12) 0.2428 0.2428 BioCarta//Hs_NFkB activation by Nontypeable Hemophilus influenzae      4/24 (43) 0.3141 0.2443 BioCarta//Hs_Induction of apoptosis through DR3 and DR4/5 Death Receptors      5/32 (37) 0.3263 0.2457 BioCarta//Hs_CDK Regulation of DNA Replication      3/17 (56) 0.3264 0.2457 BioCarta//Hs_Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia      2/22 (40) 0.7548 0.2469 BioCarta//Hs_HIV-I Nef: negative effector of Fas and TNF      7/57 (77) 0.5213 0.2469 BioCarta//Hs_Integrin Signaling Pathway      4/37 (45) 0.6552 0.2469 BioCarta//Hs_Phospholipids as signalling intermediaries      3/25 (42) 0.5831 0.2469 BioCarta//Hs_Signaling of Hepatocyte Growth Factor Receptor      5/36 (42) 0.4256 0.2469 BioCarta//Hs_Trefoil Factors Initiate Mucosal Healing      3/24 (95) 0.5542 0.2469 BioCarta//Hs_VEGF, Hypoxia, and Angiogenesis      4/28 (34) 0.4276 0.2469 BioCarta//Hs_Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling      4/33 (44) 0.5614 0.2469 BioCarta//Hs_Caspase Cascade in Apoptosis      2/22 (27) 0.7548 0.2469 BioCarta//Hs_CARM1 and Regulation of the Estrogen Receptor      3/26 (33) 0.6108 0.2469 BioCarta//Hs_Deregulation of CDK5 in Alzheimers Disease      2/10 (16) 0.3355 0.2469 BioCarta//Hs_Rho cell motility signaling pathway      4/30 (32) 0.4828 0.2469 BioCarta//Hs_MAPKinase Signaling Pathway      10/85 (88) 0.5618 0.2469 BioCarta//Hs_Keratinocyte Differentiation      5/46 (67) 0.6517 0.2469 BioCarta//Hs_Synaptic Proteins at the Synaptic Junction      3/20 (32) 0.4283 0.2469 BioCarta//Hs_Growth Hormone Signaling Pathway      4/26 (35) 0.3710 0.2469 BioCarta//Hs_IL 2 signaling pathway      3/22 (47) 0.4932 0.2469 BioCarta//Hs_IL-2 Receptor Beta Chain in T cell Activation      4/35 (38) 0.6100 0.2469 BioCarta//Hs_fMLP induced chemokine gene expression in HMC-1 cells      4/36 (58) 0.6330 0.2469 BioCarta//Hs_BCR Signaling Pathway      5/34 (54) 0.3759 0.2469 BioCarta//Hs_Links between Pyk2 and Map Kinases      3/28 (44) 0.6624 0.2469 BioCarta//Hs_PDGF Signaling Pathway      3/27 (61) 0.6372 0.2469 BioCarta//Hs_Thrombin signaling and protease-activated receptors      3/21 (31) 0.4611 0.2469 BioCarta//Hs_CBL mediated ligand-induced downregulation of EGF receptors      2/13 (51) 0.4670 0.2469 BioCarta//Hs_Bioactive Peptide Induced Signaling Pathway      4/38 (58) 0.6764 0.2469 BioCarta//Hs_NF-kB Signaling Pathway      3/23 (49) 0.5242 0.2469 BioCarta//Hs_TNFR2 Signaling Pathway      2/18 (32) 0.6478 0.2469 BioCarta//Hs_Signal transduction through IL1R      3/30 (41) 0.7088 0.2469 BioCarta//Hs_Acetylation and Deacetylation of RelA in The Nucleus      2/16 (34) 0.5819 0.2469 BioCarta//Hs_Fibrinolysis Pathway      2/11 (14) 0.3808 0.2469 BioCarta//Hs_Ras Signaling Pathway      2/22 (23) 0.7548 0.2469 BioCarta//Hs_IGF-1 Signaling Pathway      2/20 (45) 0.7053 0.2469 BioCarta//Hs_Platelet Amyloid Precursor Protein Pathway      2/14 (15) 0.5073 0.2469 BioCarta//Hs_Lissencephaly gene (LIS1) in neuronal migration and development      2/19 (48) 0.6776 0.2469 BioCarta//Hs_Role of ?arrestins in the activation and targeting of MAP kinases      2/17 (40) 0.6159 0.2469 BioCarta//Hs_Roles of ?arrestin-dependent Recruitment of Src Kinases in GPCR Signaling      2/21 (34) 0.7310 0.2469 BioCarta//Hs_beta-arrestins in GPCR Desensitization      2/15 (40) 0.5457 0.2469 BioCarta//Hs_Signal Dependent Regulation of Myogenesis by Corepressor MITR      1/9 (25) 0.6792 0.2469 BioCarta//Hs_Blockade of Neurotransmitter Relase by Botulinum Toxin      1/5 (28) 0.4679 0.2469 BioCarta//Hs_BRCA1-dependent Ub-ligase activity      1/8 (18) 0.6359 0.2469 BioCarta//Hs_The PRC2 Complex sets Long-term gene Silencing The Modification of Histone Tails      2/12 (20) 0.4247 0.2469 BioCarta//Hs_Eph Kinases and ephrins support platelet aggregation      1/10 (17) 0.7174 0.2469 BioCarta//Hs_Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation      1/11 (35) 0.7511 0.2469 BioCarta//Hs_Catabolic Pathways for Arginine , Histidine, Glutamate, Glutamine, and Proline      1/6 (6) 0.5311 0.2469 BioCarta//Hs_The reactions that feed amino groups into the urea cycle      1/7 (16) 0.5868 0.2469 BioCarta//Hs_Generation of amyloid b-peptide by PS1      1/4 (9) 0.3962 0.2469 BioCarta//Hs_Toll-Like Receptor Pathway      3/34 (45) 0.7869 0.2481 BioCarta//Hs_Nuclear Receptors in Lipid Metabolism and Toxicity      3/34 (43) 0.7869 0.2481 BioCarta//Hs_Stathmin and breast cancer resistance to antimicrotubule agents      2/23 (26) 0.7768 0.2481 BioCarta//Hs_Lectin Induced Complement Pathway      1/12 (56) 0.7808 0.2481 BioCarta//Hs_IL22 Soluble Receptor Signaling Pathway      1/12 (40) 0.7808 0.2484 BioCarta//Hs_Gamma-aminobutyric Acid Receptor Life Cycle      1/12 (73) 0.7808 0.2484 BioCarta//Hs_Ca++/ Calmodulin-dependent Protein Kinase Activation      1/12 (76) 0.7808 0.2484 BioCarta//Hs_Ghrelin: Regulation of Food Intake and Energy Homeostasis      1/11 (30) 0.7511 0.2492 BioCarta//Hs_Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle      1/11 (30) 0.7511 0.2492 BioCarta//Hs_Prion Pathway      1/11 (11) 0.7511 0.2492 BioCarta//Hs_BTG family proteins and cell cycle regulation      1/11 (13) 0.7511 0.2492 BioCarta//Hs_Erythropoietin mediated neuroprotection through NF-kB      1/11 (17) 0.7511 0.2492 BioCarta//Hs_Vitamin C in the Brain      1/11 (20) 0.7511 0.2492 BioCarta//Hs_Control of Gene Expression by Vitamin D Receptor      2/24 (32) 0.7970 0.2502 BioCarta//Hs_AKT Signaling Pathway      2/21 (32) 0.7310 0.2508 BioCarta//Hs_Rac 1 cell motility signaling pathway      2/21 (23) 0.7310 0.2508 BioCarta//Hs_Insulin Signaling Pathway      2/21 (48) 0.7310 0.2508 BioCarta//Hs_Sumoylation by RanBP2 Regulates Transcriptional Repression      1/10 (25) 0.7174 0.2511 BioCarta//Hs_Electron Transport Reaction in Mitochondria      1/10 (10) 0.7174 0.2511 BioCarta//Hs_Glycolysis Pathway      1/10 (21) 0.7174 0.2511 BioCarta//Hs_Free Radical Induced Apoptosis      1/10 (11) 0.7174 0.2511 BioCarta//Hs_Regulators of Bone Mineralization      1/10 (57) 0.7174 0.2511 BioCarta//Hs_Reversal of Insulin Resistance by Leptin      1/10 (11) 0.7174 0.2511 BioCarta//Hs_Apoptotic DNA fragmentation and tissue homeostasis      1/10 (15) 0.7174 0.2511 BioCarta//Hs_Mechanism of Protein Import into the Nucleus      1/9 (19) 0.6792 0.2516 BioCarta//Hs_Lck and Fyn tyrosine kinases in initiation of TCR Activation      1/9 (16) 0.6792 0.2516 BioCarta//Hs_Role of PPAR-gamma Coactivators in Obesity and Thermogenesis      1/9 (12) 0.6792 0.2516 BioCarta//Hs_B Lymphocyte Cell Surface Molecules      1/9 (10) 0.6792 0.2516 BioCarta//Hs_Visual Signal Transduction      1/9 (12) 0.6792 0.2516 BioCarta//Hs_Regulation of PGC-1a      2/23 (31) 0.7768 0.2517 BioCarta//Hs_ER-associated degradation (ERAD) Pathway      1/13 (20) 0.8069 0.2522 BioCarta//Hs_Influence of Ras and Rho proteins on G1 to S Transition      2/26 (33) 0.8327 0.2543 BioCarta//Hs_p38 MAPK Signaling Pathway      3/38 (40) 0.8469 0.2543 BioCarta//Hs_Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)      2/28 (41) 0.8626 0.2543 BioCarta//Hs_Chaperones modulate interferon Signaling Pathway      1/16 (34) 0.8682 0.2543 BioCarta//Hs_Human Cytomegalovirus and Map Kinase Pathways      1/16 (17) 0.8682 0.2543 BioCarta//Hs_Downregulated of MTA-3 in ER-negative Breast Tumors      1/16 (23) 0.8682 0.2543 BioCarta//Hs_Steps in the Glycosylation of Mammalian N-linked Oligosaccarides      1/16 (16) 0.8682 0.2543 BioCarta//Hs_Adhesion and Diapedesis of Lymphocytes      1/14 (47) 0.8300 0.2543 BioCarta//Hs_Adhesion and Diapedesis of Granulocytes      1/15 (49) 0.8503 0.2543 BioCarta//Hs_Role of nicotinic acetylcholine receptors in the regulation of apoptosis      1/15 (24) 0.8503 0.2544 BioCarta//Hs_IL 17 Signaling Pathway      1/15 (16) 0.8503 0.2544 BioCarta//Hs_Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation      1/15 (29) 0.8503 0.2544 BioCarta//Hs_The IGF-1 Receptor and Longevity      1/14 (14) 0.8300 0.2548 BioCarta//Hs_Stress Induction of HSP Regulation      1/14 (22) 0.8300 0.2548 BioCarta//Hs_Classical Complement Pathway      1/14 (68) 0.8300 0.2548 BioCarta//Hs_Selective expression of chemokine receptors during T-cell polarization      2/29 (55) 0.8757 0.2554 BioCarta//Hs_Actions of Nitric Oxide in the Heart      2/30 (44) 0.8876 0.2576 BioCarta//Hs_The 4-1BB-dependent immune response      1/18 (22) 0.8978 0.2576 BioCarta//Hs_Nerve growth factor pathway (NGF)      1/18 (38) 0.8978 0.2576 BioCarta//Hs_Sprouty regulation of tyrosine kinase signals      1/18 (31) 0.8978 0.2576 BioCarta//Hs_EGF Signaling Pathway      3/27 (54) 0.6372 0.2578 BioCarta//Hs_FAS signaling pathway ( CD95 )      3/30 (34) 0.7088 0.2584 BioCarta//Hs_PTEN dependent cell cycle arrest and apoptosis      2/18 (21) 0.6478 0.2591 BioCarta//Hs_EPO Signaling Pathway      2/19 (36) 0.6776 0.2592 BioCarta//Hs_Proteasome Complex      2/19 (24) 0.6776 0.2592 BioCarta//Hs_Complement Pathway      1/19 (33) 0.9101 0.2600 BioCarta//Hs_Stat3 Signaling Pathway      1/8 (13) 0.6359 0.2603 BioCarta//Hs_Internal Ribosome entry pathway      1/8 (39) 0.6359 0.2603 BioCarta//Hs_Overview of telomerase protein component gene hTert Transcriptional Regulation      1/8 (20) 0.6359 0.2603 BioCarta//Hs_Shuttle for transfer of acetyl groups from mitochondria to the cytosol      1/8 (11) 0.6359 0.2603 BioCarta//Hs_The Citric Acid Cycle      1/8 (9) 0.6359 0.2603 BioCarta//Hs_Calcium Signaling by HBx of Hepatitis B virus      1/8 (8) 0.6359 0.2603 BioCarta//Hs_RNA polymerase III transcription      1/8 (22) 0.6359 0.2603 BioCarta//Hs_The role of FYVE-finger proteins in vesicle transport      1/7 (35) 0.5868 0.2616 BioCarta//Hs_Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression      1/4 (7) 0.3962 0.2616 BioCarta//Hs_Malate-aspartate shuttle      1/4 (8) 0.3962 0.2616 BioCarta//Hs_Function of SLRP in Bone: An Integrated View      1/4 (4) 0.3962 0.2616 BioCarta//Hs_West Nile Virus      1/4 (4) 0.3962 0.2616 BioCarta//Hs_Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine      1/4 (4) 0.3962 0.2616 BioCarta//Hs_Transcriptional activation of dbpb from mRNA      1/4 (9) 0.3962 0.2616 BioCarta//Hs_Eicosanoid Metabolism      1/20 (20) 0.9208 0.2620 BioCarta//Hs_Ion Channels and Their Functional Role in Vascular Endothelium      3/20 (20) 0.4283 0.2630 BioCarta//Hs_Fc Epsilon Receptor I Signaling in Mast Cells      4/38 (49) 0.6764 0.2631 BioCarta//Hs_Biosynthesis of neurotransmitters      1/6 (6) 0.5311 0.2636 BioCarta//Hs_Low-density lipoprotein (LDL) pathway during atherogenesis      1/6 (10) 0.5311 0.2636 BioCarta//Hs_Wnt/LRP6 Signalling      1/6 (25) 0.5311 0.2636 BioCarta//Hs_Metabolism of Anandamide, an Endogenous Cannabinoid      1/6 (13) 0.5311 0.2636 BioCarta//Hs_Circadian Rhythms      1/6 (13) 0.5311 0.2636 BioCarta//Hs_TSP-1 Induced Apoptosis in Microvascular Endothelial Cell      1/6 (9) 0.5311 0.2636 BioCarta//Hs_SUMOylation as a mechanism to modulate CtBP-dependent gene responses      1/6 (11) 0.5311 0.2636 BioCarta//Hs_Regulation of Spermatogenesis by CREM      1/6 (14) 0.5311 0.2636 BioCarta//Hs_Activation of cAMP-dependent protein kinase, PKA      1/6 (10) 0.5311 0.2636 BioCarta//Hs_Ceramide Signaling Pathway      1/21 (21) 0.9303 0.2637 BioCarta//Hs_METS affect on Macrophage Differentiation      2/16 (30) 0.5819 0.2645 BioCarta//Hs_Regulation of transcriptional activity by PML      2/16 (24) 0.5819 0.2645 BioCarta//Hs_Multi-step Regulation of Transcription by Pitx2      2/16 (38) 0.5819 0.2645 BioCarta//Hs_IL-7 Signal Transduction      2/16 (29) 0.5819 0.2645 BioCarta//Hs_The Co-Stimulatory Signal During