Online supplements of

Mesenchymaenchymal Stem Cells Transfer Mitochondria to the Cells with Virtually No Mitochondrial Function but Not with Pathogenic mtDNA Mutations

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Fig. S1 Patterns for differentially expressed genes in a time-dependent manner. The time-differential 2,653 genes are grouped into 16 clusters using SOM. The 16 clusters are arranged into a 4x4 rectangular grid so that neighboring cells have similar expression. The line graph in each cell represents the average expression of all genes in the corresponding cluster with mean ¡¾ standard error.

[Link to 4x4 SOM and GO enrichment result]   

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Fig. S2 Patterns for differentially expressed genes in a time-dependent manner. The time-differential 2,653 genes are clustered into 49 groups using Self-Organizing Maps technique. The 49 clusters are arranged into a 7x7 rectangular grid so that neighboring cells have similar expression. The line graph in each cell represents the average expression of all genes in the corresponding cluster with mean ¡¾ standard error.

[Link to 7x7 SOM and GO enrichment result]

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Fig. S3 Concept lattice was constructed from the 49 clusters with significant GO annotations from the MSCs gene-expression dataset. Only 12 among the 49 clusters demonstrate at least one significant GO term(s) (P < 0.001) in the biological process category. Overall, the dataset shows 56 significant annotations with 56 unique GO terms. The core–periphery substructures are marked with colors (i.e., core in red, communicating in green, peripheral in gray and independent in yellow).

 
BioLattice analysis Gene Ontology Categories
Biological Process Molecular Function Cellular Component All 3 Categories
Binarizing p-value

 threshold

0.05 Link Link Link Link
0.01 Link Link Link Link
0.005 Link Link Link Link
0.001 Link Link Link Link

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