Supplementary Table 2.
Class II: The genes that showed similar expression pattern at any sample time(s) at both dose levels,
but showed dose-dependent expression at any other sample time(s)
Functional Classification	Gene_ID	Gene_Symbol	Gene_Name	GB_Accession	Low			High
					06h	24h	72h	06h	24h	72h
Amino acid metabolism	mCG9003.2	Arg1	arginase 1, liver	BC050005	NC	-1.8	NC	NC	-1.7	2.1
	mCG13019.2	_	_	_	NC	-1.8	NC	NC	-1.9	1.6
	mCG1049304.1	_	_	_	-1.7	2.3	NC	-1.9	NC	NC
Carbohydrate metabolism	mCG123128.1	Idh1	isocitrate dehydrogenase 1 (NADP+), soluble	AK087063	NC	3.6	NC	NC	2.7	-4.5
Cell adhesion	mCG18022.3	Emid2	EMI domain containing 2	AJ416092	2.8	NC	-2.1	2.8	NC	NC
Cell cycle	mCG11117.2	Anapc5	anaphase-promoting complex subunit 5	BC046804	NC	12.3	NC	NC	9.3	-6.0
	mCG3701.2	Cul4a	cullin 4A	BC024113	NC	2.3	1.5	NC	1.8	-1.9
Cell structure and motility	mCG21072.1	Dncl2a	dynein, cytoplasmic, light chain 2A	AK002359	NC	-1.6	NC	NC	-1.6	1.6
	mCG9780.1	Capza1	capping protein (actin filament) muscle Z-line, alpha 1	BC016232	NC	1.7	1.9	NC	1.7	-3.3
	mCG118463.1	Spnb2	spectrin beta 2	AF017112	NC	3.7	NC	NC	3.0	-3.3
	mCG140870	_	_	BC043327	1.8	NC	NC	1.8	NC	-1.8
Developmental processes	mCG1463.3	Mbtd1	mbt domain containing 1	BC020018	NC	4.3	NC	NC	2.9	-4.9
	mCG8300.3	Nrf1	nuclear respiratory factor 1	AK014494	NC	3.1	NC	NC	2.8	-2.8
	mCG114540.2	Odz3	odd Oz/ten-m homolog 3 (Drosophila)	AK031268	NC	-1.6	NC	NC	-1.6	1.9
	mCG18542.2	Sox17	SRY-box containing gene 17	AK076707	-1.5	2.8	NC	NC	2.0	NC
Electron transport	mCG124890.1	Ndufa2	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2	BC006815	NC	-1.8	NC	NC	-1.8	1.8
	mCG17301.2	1500040F11Rik	RIKEN cDNA 1500040F11 gene	AK002389	NC	-2.0	NC	NC	-1.9	2.0
	mCG10028.3	_	_	BC059730	NC	-1.6	NC	NC	-1.8	1.4
Immunity and defense	mCG5142.3	Lta4h	leukotriene A4 hydrolase	AK005161	NC	1.9	NC	NC	2.0	-5.1
	mCG123914.1	Hspa9a	heat shock protein, A	BC057343	NC	3.4	NC	NC	2.5	-4.1
	mCG12225	H2-D4	histocompatibility 2, D region locus 4	X52914	NC	3.4	NC	NC	3.9	-8.1
Lipid, fatty acid and steroid metabolism	mCG4201	Cyp2d26	cytochrome P450, family 2, subfamily d, polypeptide 26	AK004915	NC	1.9	NC	NC	1.8	-2.3
	mCG131749.1	Scd1	stearoyl-Coenzyme A desaturase 1	BC007474	-2.3	2.6	2.4	NC	NC	-2.0
	mCG9087.1	Pla2g2e	phospholipase A2, group IIE	BC027524	1.8	-2.6	NC	1.7	NC	NC
	mCG10954.2	_	_	BC026417	NC	4.5	NC	NC	4.1	-3.0
Nucleoside, nucleotide and nucleic acid metabolism	mCG16382.1	Adk	adenosine kinase	BC009659	NC	2.6	NC	NC	2.3	-2.7
	mCG21716.1	Ahcyl1	S-adenosylhomocysteine hydrolase-like 1	BC018218	NC	7.9	NC	NC	6.3	-3.4
	mCG123064.1	H3f3a	H3 histone, family 3A	BC012687	2.1	-4.8	NC	NC	NC	3.0
	mCG8539.1	Ivns1abp	influenza virus NS1A binding protein	AK007291	NC	5.4	NC	NC	4.4	-4.3
	mCG12127.1	Lsm7	LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)	BC027511	NC	-2.3	NC	NC	-2.3	1.9
	mCG2296.1	Msl31	male-specific lethal-3 homolog 1 (Drosophila)	BC010226	NC	2.2	1.6	NC	2.1	-4.8
	mCG6479	Plag1	pleiomorphic adenoma gene 1	AF057366	NC	NC	1.9	-1.9	NC	1.5
	mCG19537.2	Rad21	RAD21 homolog (S. pombe)	BC043032	-1.2	2.0	NC	NC	2.0	NC
	mCG19872.3	Rnf13	ring finger protein 13	BC058182	-1.5	2.0	NC	NC	1.8	NC
	mCG6936.3	Snrpe	small nuclear ribonucleoprotein E	BC008262	NC	-2.0	NC	NC	-1.8	2.4
	mCG20941.2	Tert	telomerase reverse transcriptase	AF073311	-2.8	5.0	NC	NC	2.3	NC
	mCG14717.2	1700022N24Rik	RIKEN cDNA 1700022N24 gene	BC014812	NC	3.0	NC	NC	3.6	-2.5
	mCG20880.1	_	_	BC062267	NC	-1.7	NC	NC	-1.5	1.6
	mCG19887.2	_	_	BC055889.1	NC	2.7	NC	NC	2.6	-2.8
Protein metabolism and modification	mCG3701.2	Cul4a	cullin 4A	BC024113	NC	2.3	1.5	NC	1.8	-1.9
	mCG5274.2	Enpep	glutamyl aminopeptidase	AK128975	NC	-2.1	NC	NC	-2.2	2.3
	mCG126848	Ide	insulin degrading enzyme	BC041675	NC	4.3	NC	NC	3.2	-3.4
	mCG130909.1	Mrpl23	mitochondrial ribosomal protein L23	AK086805	NC	-2.0	NC	NC	-1.9	1.7
	mCG141640	Pcsk9	proprotein convertase subtilisin/kexin type 9	BC038085	NC	5.8	NC	NC	7.7	-7.2
	mCG132460.1	Raf1	v-raf-1 leukemia viral oncogene 1	BC015273	NC	6.3	NC	NC	4.9	-7.4
	mCG121646.1	Rpl21	ribosomal protein L21	AK008457	NC	-1.7	NC	NC	-1.7	1.5
	mCG4898.2	Rpl30	ribosomal protein L30	BC002060	NC	-1.5	NC	NC	-1.5	1.9
	mCG115063.1	Rpl36a	ribosomal protein L36a	BC027515	NC	-1.6	NC	NC	-1.4	1.9
	mCG23116.2	Uba52	ubiquitin A-52 residue ribosomal protein fusion product 1	BC054413	NC	-1.6	NC	NC	-1.4	1.5
	mCG19768.2	Uchl5	ubiquitin carboxyl-terminal esterase L5	BC006891	NC	-1.7	NC	NC	-1.7	1.7
	mCG123291.1	_	_	AL732599	NC	-1.8	NC	NC	-1.6	1.4
	mCG3335.2	_	_	BC031891	NC	3.2	NC	NC	2.7	-2.3
Protein targeting and localization	mCG113371.1	_	_	AK013352	NC	3.6	NC	NC	4.4	-4.3
Signal transduction	mCG11764.2	Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2	AF109122	NC	2.7	-1.7	NC	NC	-2.9
	mCG22568.2	Pkp3	plakophilin 3	BC032045	NC	2.2	NC	-2.8	NC	2.1
	mCG3250.1	Bgn	biglycan	AK086920	NC	4.5	NC	NC	5.0	-4.9
	mCG21485.1	Klra2	killer cell lectin-like receptor, subfamily A, member 2	BC064711	-2.2	NC	-1.6	NC	1.9	-2.3
	mCG21707.2	Lepr	leptin receptor	U49106	-2.6	NC	2.5	-2.1	NC	NC
Transport	mCG4123.1	Slc37a2	solute carrier family 37 (glycerol-3-phosphate transporter), member 2	BC063326	-1.5	NC	NC	-2.2	1.8	NC
	mCG6958.1	Atp7b	ATPase, Cu++ transporting, beta polypeptide	U38477	NC	1.9	NC	NC	2.1	-2.7
	mCG125165	Atp8b1	ATPase, class I, type 8B, member 1	AY506548	-4.2	5.0	NC	NC	4.5	NC
	mCG16992.2	Slc17a1	solute carrier family 17 (sodium phosphate), member 1	BC013445	NC	NC	1.8	NC	3.5	-2.0
Biological process unclassified	mCG6620.2	Atp5h	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d	_	NC	-1.8	NC	NC	-1.8	1.6
	mCG1549.2	Atp5l	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit g	Y17223	NC	-2.0	NC	NC	-2.1	2.1
	mCG128765.1	Cggbp1	CGG triplet repeat binding protein 1	AK086053	-3.3	5.1	NC	NC	3.8	NC
	mCG16994.2	Cmah	cytidine monophospho-N-acetylneuraminic acid hydroxylase	BC055079	NC	5.4	NC	NC	4.2	-3.4
	mCG142308	Commd3	COMM domain containing 3	BC048815	NC	-1.5	NC	NC	-1.5	1.4
	mCG17362.1	Deb1	differentially expressed in B16F10 1	BC027548	NC	-1.8	NC	NC	-1.5	1.8
	NM_008495.1	Lgals1	lectin, galactose binding, soluble 1	AK004298	NC	-1.8	NC	NC	-1.7	2.6
	mCG22337.2	Lrp11	low density lipoprotein receptor-related protein 11	BC059874	NC	2.0	NC	NC	4.2	-1.7
	mCG9656.2	Mmrp19	monocyte macrophage 19	AB028863	NC	-1.7	NC	NC	-1.9	1.8
	mCG19723.1	Mrpl17	mitochondrial ribosomal protein L17	AK007438	NC	-1.8	NC	NC	-1.5	1.7
	mCG5958.1	Mrps16	mitochondrial ribosomal protein S16	BC024656	NC	-2.1	NC	NC	-2.0	1.5
	mCG140303	Mrps28	mitochondrial ribosomal protein S28	BC028530	NC	-1.9	NC	NC	-1.8	1.5
	mCG116118.1	Mrps36	mitochondrial ribosomal protein S36	AK007512	NC	-1.9	NC	NC	-2.2	1.9
	mCG142200	Mrps6	mitochondrial ribosomal protein S6	BC027271	NC	-1.6	NC	NC	-1.7	1.5
	NM_147020.1	Olfr1061;Olfr1515	olfactory receptor 1061;olfactory receptor 1515	AY073068	-1.6	NC	NC	NC	NC	1.9
	mCG130546.1	Rpl41	ribosomal protein L41	AK012487	NC	-2.0	NC	NC	-1.7	2.2
	mCG23586.1	Rpp21	ribonuclease P 21kDa subunit (human)	AY251016	NC	-2.0	NC	NC	-1.5	1.8
	mCG116158.1	Serf1	small EDRK-rich factor 1	AF073517	NC	-3.0	NC	NC	-2.4	2.2
	mCG122050.1	Tbca	tubulin cofactor a	U05333	NC	-2.0	NC	NC	-1.8	1.9
	mCG4735.2	Tloc1	translocation protein 1	AK088093	NC	-1.7	NC	NC	-1.5	1.6
	mCG5717.1	Tomm7	translocase of outer mitochondrial membrane 7 homolog (yeast)	BC055352	NC	-2.6	NC	NC	-2.3	2.0
	mCG3895.1	BC028768	cDNA sequence BC028768	BC028768	NC	-2.0	NC	NC	-2.0	1.6
	mCG1027811.2	5830457H20	hypothetical protein 5830457H20	AK036681	-1.7	3.2	NC	NC	3.1	NC
	mCG22422.2	1110025L05Rik	RIKEN cDNA 1110025L05 gene	BC061197	NC	-2.6	NC	NC	-2.0	1.7
	mCG21188.2	1110030J09Rik	RIKEN cDNA 1110030J09 gene	BC025057	NC	-1.5	NC	NC	-1.3	1.9
	mCG19146.1	1110057H19Rik	RIKEN cDNA 1110057H19 gene	BC021512	NC	-1.8	NC	NC	-1.8	1.6
	mCG19223	1190005P17Rik	RIKEN cDNA 1190005P17 gene	BC024098	NC	-1.6	NC	NC	-1.4	1.7
	mCG13563.2	1190017O12Rik	RIKEN cDNA 1190017O12 gene	BC005668	NC	-1.9	NC	NC	-1.9	2.2
	mCG145663	1500015L24Rik	RIKEN cDNA 1500015L24 gene	AK005254	-1.7	NC	1.5	NC	2.6	NC
	mCG114279.1	1600022A19Rik	RIKEN cDNA 1600022A19 gene	BC031486	NC	3.1	NC	NC	2.7	-7.7
	mCG1045669.1	1810037I17Rik	RIKEN cDNA 1810037I17 gene	BC002135	NC	-2.2	NC	NC	-1.7	1.9
	mCG122056.1	2010009L17Rik	RIKEN cDNA 2010009L17 gene	AY500995	NC	4.5	2.4	NC	3.3	-2.0
	mCG4066.1	2010200O16Rik	RIKEN cDNA 2010200O16 gene	BC050932	-1.5	1.9	NC	NC	1.9	NC
	mCG11529.2	2510038A11Rik	RIKEN cDNA 2510038A11 gene	BC050115	NC	-2.2	NC	NC	-2.2	1.7
	mCG23299.2	5530601I19Rik	RIKEN cDNA 5530601I19 gene	AK017460	NC	1.9	NC	-1.6	2.1	NC
	NM_176932.2	6430510M02Rik	RIKEN cDNA 6430510M02 gene	AY380798	1.8	NC	NC	1.6	-2.5	NC
	mCG3895.1	BC028768	cDNA sequence BC028768	BC028768	NC	-2.0	NC	NC	-2.0	1.6
	mCG21203.3	BC052066	cDNA sequence BC052066	BC023782	NC	2.9	NC	NC	3.2	-4.1
	mCG50986.1	C730025P13Rik	RIKEN cDNA C730025P13 gene	BC022606	NC	NC	-1.7	NC	-1.9	1.5
	mCG131623.1	F630045L20Rik	RIKEN cDNA F630045L20 gene	AY236527	2.1	NC	-3.1	1.7	NC	NC
*; fold change to control mean value
NC; no change