Supplementary Table 5.
Microarray results of 49 "differentially regulated" probes identified by SAM and 2-way ANOVA a.
Spot ID Gene GenBank UniGene ANOVA b Class c Function biological process Molecular function Cellular component GeneSymbol GripQuery Description V_6h vs NT V_24h vs NT V_72h vs NT L_6h vs NT L_24h vs NT L_72h vs NT H_6h vs NT H_24h vs NT H_72h vs NT
894280 Mphosph6 NM_026758 Mm.181836 MABx 403 cell cycle  M phase of mitotic cell cycle;regulation of cell cycle nucleus Mphosph6 NM_026758 M phase phosphoprotein 6 0.68 -0.06 -0.66 0.67 -0.28 -1.03 1.12 0.34 -0.78
527912 Abi3 BC035943 Mm.129228 MABx 101 cell migration regulation of cell migration molecular function unknown cellular component unknown Phospho1 BC035943 phosphatase, orphan 1 -0.51 -0.26 0.29 -1.00 -0.50 0.00 -2.40 -1.23 -0.18
901543 Hist1h2ao NM_178185 Mm.342416 MxBx 913 chromosome organization and biogenesis Hist1h2ao NM_178185 histone 1, H2ao -0.48 -0.48 -0.57 -1.30 -0.61 -0.33 -1.32 0.35 -0.03
704890 Micl NM_177686 Mm.90241 MAxx 101 immune response regulation of immune response protein phosphatase binding;sugar binding cell surface D230024O04 NM_177686 hypothetical protein D230024O04 -0.25 0.42 0.43 0.24 0.83 -0.22 1.71 0.97 0.68
931440 Prkab1 NM_031869 Mm.200912 MxBx 206 metabolism (carbohydrate ) carbohydrate metabolism;fatty acid biosynthesis;lipid biosynthesis;response to stress AMP-activated protein kinase activity;hydrolase activity, hydrolyzing O-glycosyl compounds nucleus Prkab1 NM_031869 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.54 0.34 -0.12 1.09 0.56 -0.37 1.22 0.59 -0.14
551010 Pafah1b3 NM_008776 Mm.597 MxBI 103 metabolism (lipid) lipid catabolism;spermatogenesis;spermatogenesis 1-alkyl-2-acetylglycerophosphocholine esterase activity;catalytic activity;hydrolase activity cytoplasm Pafah1b3 NM_008776 platelet-activating factor acetylhydrolase, isoform 1b, alpha1 subunit -0.67 -0.03 -0.29 -2.48 0.22 -0.47 -3.14 0.37 -0.24
735288 Nme4 BC027277 Mm.41787 MxBx 712 metabolism (nucleotide) CTP biosynthesis;GTP biosynthesis;UTP biosynthesis;nucleotide metabolism ATP binding;kinase activity;magnesium ion binding;nucleoside-diphosphate kinase activity;nucleotide binding;transferase activity extracellular space;mitochondrion Nme4 BC027277 expressed in non-metastatic cells 4, protein 0.43 0.26 -0.57 -1.92 -0.22 -0.41 -0.96 0.06 -1.12
494447 9230110J10 NM_183301 Mm.307932     MABx 204 metabolism (nucleotide) E2f2;9230110J10 NM_183301 E2F transcription factor 2;hypothetical protein 9230110J10 -0.42 0.38 -0.53 -1.78 -0.58 -1.50 -1.17 1.06 -0.33
551096 Cds2 NM_138651 Mm.284503 MABI 102 metabolism (phospholipid) phospholipid biosynthesis;phospholipid metabolism nucleotidyltransferase activity;phosphatidate cytidylyltransferase activity;transferase activity integral to membrane;membrane;mitochondrial inner membrane Cds2 NM_138651 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -0.66 -0.46 -0.48 -1.90 -0.15 -0.59 -0.91 0.36 -0.58
631716 Lsm8 NM_133939 Mm.275158 MABI 102 mRNA processing mRNA processing;nuclear mRNA splicing, via spliceosome RNA binding;U6 snRNA binding nucleus;ribonucleoprotein complex;small nucleolar ribonucleoprotein complex Lsm8 NM_133939 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) -0.40 -0.30 -0.53 -0.98 -0.18 -0.28 -0.94 0.31 -0.34
924677 Leng5 NM_024168 Mm.379100 MxBx 1312 mRNA processing mRNA processing;tRNA processing;tRNA splicing endonuclease activity;hydrolase activity;nuclease activity;receptor activity;tRNA-intron endonuclease activity nucleus;tRNA-intron endonuclease complex Leng5 NM_024168 leukocyte receptor cluster (LRC) member 5 -0.50 -0.18 -0.16 -0.87 -0.27 -0.24 -0.51 -0.26 -0.28
812600 C730042F17Rik NM_145517 Mm.386860 MxBx 1311 protein targeting protein targeting integral to membrane C730042F17Rik NM_145517 RIKEN cDNA C730042F17 gene -0.61 -0.12 0.33 -0.82 -0.24 0.13 -1.15 0.14 -0.13
772594 P2ry12 NM_027571 Mm.386801 MABI 102 signal transduction G-protein coupled receptor protein signaling pathway;G-protein signaling, coupled to cAMP nucleotide second messenger;platelet activation;signal transduction G-protein coupled receptor activity;adenosine receptor activity, G-protein coupled;platelet ADP receptor activity;purinergic nucleotide receptor activity, G-protein coupled;receptor activity;rhodopsin-like receptor activity;signal transducer activity integral to membrane;integral to plasma membrane P2ry12 NM_027571 purinergic receptor P2Y, G-protein coupled 12 0.03 -0.35 0.42 -0.18 0.18 0.09 0.40 1.62 -0.11
822012 Ltb4r2 NM_020490 Mm.159670 MxBx 1209 signal transduction G-protein coupled receptor protein signaling pathway;signal transduction G-protein coupled receptor activity;leukotriene receptor activity;receptor activity;rhodopsin-like receptor activity;signal transducer activity integral to membrane Ltb4r2 NM_020490 leukotriene B4 receptor 2 -0.39 0.30 -0.53 -1.03 -0.29 0.15 -1.74 -0.23 -0.03
374634 Tec NM_013689 Mm.319581 MxBx 810 signal transduction intracellular signaling cascade;protein amino acid phosphorylation ATP binding;kinase activity;protein binding;protein kinase activity;protein serine/threonine kinase activity;protein-tyrosine kinase activity;transferase activity Tec NM_013689 cytoplasmic tyrosine kinase, Dscr28C related (Drosophila) -0.64 -0.11 -0.06 -2.15 -0.02 -0.08 -0.74 -0.38 -0.24
924253 Sh2d3c NM_013781 Mm.9593 MABI 101 signal transduction intracellular signaling cascade;signal transduction guanyl-nucleotide exchange factor activity;receptor activity;transmembrane receptor protein tyrosine kinase adaptor protein activity Sh2d3c NM_013781 SH2 domain containing 3C 0.01 -0.05 0.14 -0.35 -0.13 0.44 -1.23 -0.27 -0.23
928204 Hs1bp3 NM_021429 Mm.309954 MABI 102 signal transduction T cell differentiation;cell surface receptor linked signal transduction;intracellular signaling cascade protein binding cellular component unknown Hs1bp3 NM_021429 HS1 binding protein 3 -0.33 -0.09 -0.16 -1.45 -0.42 -0.34 -0.61 0.01 -0.56
774463 Wisp1 NM_018865 Mm.10222 MxBx 1210 signal transduction Wnt receptor signaling pathway;cell adhesion;regulation of cell growth insulin-like growth factor binding;protein binding extracellular region;extracellular space Wisp1 NM_018865 WNT1 inducible signaling pathway protein 1 -0.28 -0.61 0.17 -2.26 -0.48 -0.01 -1.36 0.09 0.22
642099 Plxnb3 NM_019587 Mm.380177     MxBx 1007 signal transduction Plxnb3 NM_019587 plexin B3 -0.13 -0.48 0.22 -1.13 -0.44 -0.22 -0.70 -0.48 0.09
900157 Hmgb3 NM_008253 Mm.336087 MxBx 1110 transcription DNA packaging;negative regulation of B cell differentiation;negative regulation of myeloid cell differentiation;regulation of transcription, DNA-dependent DNA binding chromatin;chromosome;nucleus Hmgb3 NM_008253 high mobility group box 3 -0.44 -0.61 -0.37 -1.37 -0.35 -0.16 -0.92 -0.38 -0.4
908786 Eaf2 NM_134111 Mm.386836 MxBx 910 transcription induction of apoptosis by intracellular signals;positive regulation of transcription protein binding;transcriptional activator activity nucleoplasm;nucleus Eaf2 NM_134111 ELL associated factor 2 -0.61 -0.06 -0.20 -1.32 -0.33 -0.04 -1.61 -0.29 -0.61
914782 Trim30 NM_009099 Mm.295578 MAxI 102 transcription protein ubiquitination;regulation of transcription, DNA-dependent;transcription DNA binding;transcription factor activity;ubiquitin-protein ligase activity;zinc ion binding cytoplasm;intracellular;nucleus;ubiquitin ligase complex Trim30 NM_009099 tripartite motif protein 30 0.12 0.21 0.13 0.19 0.09 0.66 1.31 0.50 0.35
413987 Cutl2 NM_007804 Mm.332661 MABI 202 transcription regulation of transcription, DNA-dependent;transcription DNA binding;transcription factor activity nucleus Cutl2 NM_007804 cut-like 2 (Drosophila) 0.61 0.27 0.55 2.28 0.72 0.60 2.61 1.24 0.6
570984 Abcg8 NM_026180 Mm.26581 MABI 101 transport transport ATP binding;ATPase activity;ATPase activity, coupled to transmembrane movement of substances integral to membrane;membrane Abcg8 NM_026180 ATP-binding cassette, sub-family G (WHITE), member 8 -0.29 0.24 0.01 -0.93 0.27 0.65 -1.65 0.32 -0.13
581260 M6prbp1 NM_025836 Mm.311696 MxBx 613 transport (carbohydrate) receptor activity M6prbp1 NM_025836 mannose-6-phosphate receptor binding protein 1 -0.45 -0.01 -0.50 -1.06 0.02 -0.47 -0.79 -0.02 -0.68
626244 Cdw92 AK008866 Mm.270088 MxBI 102 transport (choline) choline transport choline transporter activity integral to membrane NA AK008866 NA -0.61 -0.19 -0.21 -0.62 0.05 -0.28 -1.17 0.07 -0.11
929523 Txnrd3 NM_153162 Mm.229332 MxBx 1313 transport (electron) electron transport;glutathione metabolism;thioredoxin pathway arsenate reductase (glutaredoxin) activity;disulfide oxidoreductase activity;electron carrier activity;oxidoreductase activity;thioredoxin-disulfide reductase activity cytoplasm;microsome Txnrd3 NM_153162 thioredoxin reductase 3 -0.13 0.52 0.41 -1.42 0.28 0.65 -0.69 0.32 -0.09
495744 Cyp2c37 NM_010001 Mm.220317 MxBI 505 transport (electron) electron transport;transport monooxygenase activity;oxidoreductase activity;unspecific monooxygenase activity endoplasmic reticulum;membrane;microsome Cyp2c37 NM_010001 cytochrome P450, family 2. subfamily c, polypeptide 37 -0.56 0.31 0.12 0.85 0.74 -0.54 2.24 -0.18 -0.65
737168 Ap1g2 NM_007455 Mm.238879 MABx 102 transport (protein) endocytosis;intracellular protein transport;protein complex assembly;protein transport;transport;vesicle-mediated transport binding Golgi apparatus;Golgi trans face;clathrin coat of trans-Golgi network vesicle;coated pit Ap1g2 NM_007455 adaptor protein complex AP-1, gamma 2 subunit -0.64 0.00 -0.58 -1.04 -0.07 -0.49 -1.46 -0.90 -0.51
924107 Rab34 AF327929 Mm.275864 MxBx 908 transport (protein) endocytosis;protein transport;small GTPase mediated signal transduction;transport GTP binding;GTPase activity;guanyl nucleotide binding Golgi apparatus;early endosome;ruffle NA AF327929 NA -0.66 -0.34 -0.44 -1.06 -0.37 -0.75 -1.00 -0.82 -0.58
587635 Pop4 NM_025390 Mm.22284 MxBI 102 tRNA processing tRNA processing hydrolase activity;ribonuclease P activity;ribonuclease activity nucleus Pop4 NM_025390 processing of precursor 4, ribonuclease P/MRP family, (S. cerevisiae) -0.60 0.39 -0.44 -1.57 0.10 -0.04 -0.22 0.01 0.18
928053 0610010O12Rik AK002512 Mm.272527 MxBx 909 nucleus NA AK002512 NA -0.47 -0.02 -0.28 -1.25 0.09 -0.65 -1.45 -0.13 9E-03
596059 Angel1 NM_144524 Mm.63979 MxBx 813 extracellular space 1110030H02Rik NM_144524 RIKEN cDNA 1110030H02 gene -0.44 -0.11 -0.62 -1.57 -0.24 -0.71 -1.30 -0.35 -0.56
378072 2010208K18Rik NM_028095 Mm.28631 MxBI 105 methyltransferase activity;transferase activity 2010208K18Rik NM_028095 RIKEN cDNA 2010208K18 gene -0.47 -0.31 -0.62 -1.13 0.01 -0.32 0.01 -0.04 -0.64
806549 6330583M11Rik NM_024465 Mm.112632 MxBI 102 catalytic activity 6330583M11Rik NM_024465 RIKEN cDNA 6330583M11 gene -0.55 -0.15 -0.17 -0.98 -0.10 0.04 -0.59 -0.01 -0.13
530097 A530050D06Rik BC023353 Mm.77133 MxBx 910 NA BC023353 NA -0.61 -0.20 -0.23 -1.30 -0.16 -0.40 -1.41 -0.08 -0.31
491149 Acrv1 AK030129 Mm.4776 MAxx 101 acrosome;extracellular space Acrv1 AK030129 acrosomal vesicle protein 1 -0.01 0.38 0.38 0.06 0.49 0.43 1.79 1.05 1.03
580857 AU040829 NM_175003 Mm.134338 MABI 101 AU040829 NM_175003 expressed sequence AU040829 -0.29 0.10 -0.20 -2.19 -0.12 -0.50 -1.58 -0.41 -0.03
854101 B230308G19Rik NM_173427 Mm.60400 MABI 102 B230308G19Rik NM_173427 RIKEN cDNA B230308G19 gene -0.32 -0.37 -0.55 -2.26 -0.73 -1.04 -0.65 -0.60 -1.45
482840 BC027342 NM_146251 Mm.29046 MxBx 1113 BC027342 NM_146251 cDNA sequence BC027342 -0.64 0.14 0.01 -1.24 -0.05 0.23 -1.35 0.12 -0.1
440174 BC061259 NM_198424 Mm.36852 MABx 104 BC061259 NM_198424 cDNA sequence BC061259 -0.40 -0.38 -0.05 -1.29 -0.40 -0.36 -0.51 -0.26 -0.13
309451 Igtp NM_018738 Mm.33902 MxBx 605 GTPase activity cytosol Igtp NM_018738 interferon gamma induced GTPase 0.44 0.32 0.23 1.03 0.12 0.43 1.87 -0.01 0.48
420519 LOC209387 NM_199146 Mm.277377 MxBx 301 LOC209387 NM_199146 tripartite motif protein 30-like 0.20 -0.41 -0.25 0.53 0.61 0.10 1.69 -0.12 0.51
888038 LOC433243 AK077243 Mm.383335 MAxx 101 NA AK077243 NA 0.63 0.43 0.62 0.65 0.27 0.56 2.41 0.89 0.85
651122 Tusc3 NM_030254 Mm.272722 MxBx 911 extracellular space;integral to membrane;mitochondrion Tusc3 NM_030254 tumor suppressor candidate 3 -0.67 -0.19 -0.41 -1.75 0.07 -0.49 -1.05 -0.07 -0.19
710465 Wdfy1 NM_027057 Mm.379166 MxBI 105 Wdfy1 NM_027057 WD repeat and FYVE domain containing 1 0.11 0.00 -0.55 -0.82 -0.74 -0.27 -1.35 0.73 -0.62
509871 MxBI 102 NA NA NA -0.66 -0.48 -0.58 -2.29 -0.24 0.19 -1.13 0.14 -0.4
532042 MxBx 1013 NA NA NA -0.63 -0.40 -0.35 -1.93 0.02 -0.57 -1.82 0.75 -0.71
742311 MxBx 1007 NA NA NA 0.36 0.09 0.60 -0.72 0.01 1.26 -1.59 -0.17 0.58
a Each value represents the fold change (in log2 value) versus the non-treated control.
b Eight ANOVA groups where A, B, I, x stands for dose, time, interaction, and blank, respectively.
c ANOVA cluster numbers classified to have approximately 25 genes per class.