Bioinformatics for functional annotation of genome

Purpose

Using automatic annotation pipeline,

• high throughput finding noble genes, non-coding RNA, regulatory regions, repetitive sequence, sequence variation
• annotation at gene functional and protein level
• functional prediction and automatic annotation by data mining
• database building and informative integration of functional genomics and proteomics

Method

Genome analysis

• with completely assembled sequence
• sequence alignment with previously defined genome sequences
• genomic annotation
• mapping of genetic and genomic markers
• gene finding
• finding of non-coding RNAs and regulatory regions
• define repetitive sequence
• mapping of sequence variation

Database building and integration

support web service with backend database of genome draft and map

Postgenome informatics

• integration of essential technique like scaling, filtering, normalization method
• development of functional clustering and cluster visualization software and algorithm
• development of clustering software and algorithm based on sequence similarity : (ex. motif search)
• systemization for integrated management of biomedical data :  (ex. local integration of meta-data)
• genomic literature data mining
• research about gene regulatory network and software development
• research about gene ontology and communication standard