TBC 2013 Program

Program at a Glance

Wednesday, Oct. 2, 2013
Welcoming Reception for the OC members, TBC / ISCB-Asia 2013
OC Board Meeting with Welcoming Dinner

Pre-Conference Tutorial: Translational Bioinformatics, Real World Applications
- Please refer to PLoS Computational Biology: Translational Bioinformatics -
Tutorial I.

2:30PM ~ 3:50PM: Introduction to Translational Bioinformatics
Atul Butte (Stanford University)

3:50PM ~ 5:10PM: Phenome-Wide Association Study (PheWAS) and GWAS for Complex Disease
Marylyn D. Ritchie (Penn State University)

5:10PM ~ 6:30PM: Cancer Genomics and Epigenomics
Sun Kim (Seoul National University)

Tutorial II.

2:30PM ~ 3:50PM: Disease & drugs models with ENCODE (Encyclopedia of DNA Elements)
Yves A. Lussier (University of Illinois)

3:50PM ~ 5:10PM: Text-mining for Translational Bioinformatics
Larry Hunter (University of Colorado)

5:10PM ~ 6:30PM: Molecular approaches for Translational Bioinformatics
Maricel G. Kann (University of Maryland)

Thursday, Oct. 3, 2013

	Grand Ballroom A	Grand Ballroom B	Grand Ballroom C
7:00~6:00PM	Registration
8:30~9:30AM	ISCB Open Business Meeting
9:30~10:00AM	Opening TBC/ISCB-Asia 2013
10:00~10:20AM	Coffee Break
10:20~11:10AM	Keynote I: Translational Analytics: Semantic Computing at Genomic Scale Larry Hunter, University of Colorado
11:10~12:00PM	Keynote II: Translating a trillion points of data into therapies, diagnostics, and new insights into disease. Atul Butte, Stanford University
12:00~1:00PM	Lunch
Session	S1. Clinical Applications	S2. Cancer Bioinformatics	H1. Highlight Research
1:00~1:25PM	S1-1 Concordance of deregulated mechanisms unveiled in underpowered experiments: PTBP1 knockdown case study (published in BMC MG) Vincent Gardeux	S2-1 Integrative analysis reveals disease-associated genes and biomarkers for prostate cancer progression (published in BMC MG) Yin Li	H1-1 Heart Attacks: Leveraging a cardiovascular systems biology strategy to predict future outcomes Carlo Vittorio Cannistraci
1:25~1:50PM	S1-2 Predicting different phenotypes of asthma and eczema using machine learning (published in BMC MG) Mattia Prosperi	S2-2 A Coupling Approach of a Predictor and a Descriptor for Breast Cancer Prognosis (published in BMC MG) Hyunjung Shin	H1-2 Bridging cancer biology with the clinic: a novel personalized prognostic indicators for breast cancer Xinan Yang
1:50~2:15PM	S1-3 Comparison of warfarin therapy clinical outcomes following implementation of an automated mobile phone-based critical laboratory value text alert system (published in BMC MG) Yufeng Jane Tseng	S2-3 Identifying Potential Subtypes of Melanoma based on Pathway Activity Profiles Sungwon Jung	H1-3 Interpreting individuals' genomes: Practical applications from newborn screening, and findings from CAGI 2013--the Critical Assessment of Genome Interpretation Steven Brenner
2:15~2:40PM	S1-4 Automatic detection and resolution of measurement-unit conflicts in aggregated data (published in BMC MG) Soroush Samadian	S2-4 Identifying multi-biomarkers to distinguish malignant from benign colorectal tumors by a mixed integer programming Luonan Chen
2:40~3:00PM	Coffee Break
Session	S3. Proteoinformatics	S4. Multi-Omic Applications	H2. Highlight Research
3:00~3:25PM	S3-1 Integrated analysis of genome-wide DNA methylation and gene expression profiles in molecular subtypes of breast cancer Je-Keun Rhee	S4-1 Integrated Analysis of microRNA-target Interactions with Clinical Outcomes for Cancers (published in BMC MG) Je-Gun Joung	H2-1 The SADI Personal Health Lens: A Web Browser-Based System for Identifying Personally Relevant Drug Interactions Soroush Samadian
3:25~3:50PM	S3-2 Prediction of C-peptide Like Family using Multiple Predictive Models and Feature Encodings Junbeom Kim	S4-2 "N-of-1-pathways" unveils personal deregulated mechanisms from a single pair of RNA-seq samples: towards precision Vincent Gardeux	H2-2 Correlation network-guided novel key gene identification Feng He
3:50~4:15PM	S3-3 Derivative Component Analysis for Mass Spectral Serum Proteomic Profiles (published in BMC MG) Henry Han	S4-3 Knowledge Boosting: A graph-based integration with multi-omics data and genomic knowledge for cancer clinical outcome prediction Dokyoon Kim	H2-3 Imbalanced network biomarkers for traditional Chinese medicine Syndrome in gastritis patients Rui Li
4:15~4:45PM	Coffee Break
4:45~5:35PM	Keynote III: The function and evolution of structural genetic variants in human phenotypic variability. Charles Lee, Harvard Medical School
5:35~6:30PM	Keynote IV: Sharing and Connecting Knowledge, Rather Than Data. Anthony Brookes, University of Leicester
	Conference Dinner

Friday, Oct. 4, 2013

	Grand Ballroom A	Grand Ballroom B	Grand Ballroom C
Session	S5. Linking Phenotypes	H3. Highlight Research	ISCB Scientific Session
8:30~8:55AM	S5-1 The Multiscale Backbone of the Human Phenotype Network based on Biological PathwaysNetwork (published in BioData Mining) Christian Darabos	H3-1 Computational Studies of Ubiqutin and Ubiquitin-like Conjugation Gao Tianshun	I-1 Balanced Nucleo-cytosolic Partitioning Defines a Spatial Network for Coordination of Circadian Physiology in Plants Daehee Hwang
8:55~9:20AM	S5-2 Integrative approach for modeling the association of multi-layered genomic data with gene expression traits Kyung-Ah Sohn	H3-2 Mechanisms of PDGFRα promiscuity and PDGFRβ specificity in association with PDGFB Janneth González	I-2 NGS sequence analysis for regulation and epigenomics Tim Bailey
9:20~9:45AM	S5-3 ATHENA: Identifying interactions between different levels of genomic data associated with cancer clinical outcomes using grammatical evolution neural network (published in BioData Mining) Dokyoon Kim	H3-3 displayHTS: a R package for visualizing high-throughput screening data results Xiaohua Zhang	I-3 Revisiting statistical significance for finding combinatorial effects Jun Sese
9:45~10:10AM	S5-4 Topological Analysis of Statistical Epistasis Networks Reveals Pathways Associated with Alzheimer's Disease Qinxin Pan	H3-4 Methylerythritol phosphate pathway to isoprenoids: Kinetic modeling and in silico enzyme inhibitions in P. falciparum Indira Ghosh	I-4 An integrative characterization of recurrent molecular aberrations in glioblastoma genomes Chen-Hsiang Yeang
10:10~10:40AM	Coffee Break
10:40~11:30AM	Keynote V: Personalome: clinically actionable 'Omics. Yves Lussier, University of Illinois at Chicago
11:30~12:20PM	Keynote VI: Translational bioinformatics for identification of prostate cancer biomarkers. Bairong Shen, Soochow University
12:20~1:20PM	Lunch
Session	S6. Post-GWAS	S7. Biomedical Big Data	H4. Highlight Research
1:20~1:45PM	S6-1 Practical issues for screening and variable selection method in a Genome-Wide Association Analysis Yong-gang Kim	S7-1 Health Monitoring System based on Lifelog Analysis Yongjin Kwon	H4-1 A protein domain-centric approach for the comparative analysis of human and yeast phenotypically relevant mutations Maricel Kann
1:45~2:10PM	S6-2 IGENT: Efficient Entropy based Algorithm for Detecting Genome-wide Gene-Gene Interaction Analysis (published in BMC MG) Min-Seok Kwon	S7-2 Differentially Private Distributed Logistic Regression using Public and Private Biomedical Datasets (published in BMC MG) Xiaoqian Jiang	H4-2 Yin and Yang of reciprocally scale-free biological networks between lethal genes and disease genes Ju Han Kim
2:10~2:35PM	S6-3 Identification of novel therapeutics for complex diseases from genome-wide association data (published in BMC MG) Mani P. Grover	S7-3 Effectively processing medical term queries on the UMLS Metathesaurus by Layered Dynamic Programming (published in BMC MG) Yang Xiang	H4-3 Comparative analysis using K-mer and K-flank patterns provides evidence for CpG island sequence evolution in mammalian genomes Heejoon Chae
2:35~ 2:50PM	Coffee Break
Session	S8. New Technologies	H5. Highlight Research	H6. Highlight Research
2:50~3:15PM	S8-1 GAMUT: GPU Accelerated MicroRNA analysis to Uncover Target genes through CUDA-miRanda (published in BMC MG) Xiaoqian Jiang	H5-1 Arpeggio: harmonic compression of ChIP-seq data reveals protein-chromatin interaction signatures Kelly Stanton	H6-1 Statistical epistasis networks reduce the computational complexity of searching three-locus genetic models Jason H. Moore
3:15~3:40PM	S8-2 A Novel Multi-scale Visualization Software for Data-driven Biomedical Data Exploration Gang Su	H5-2 TrAp: a tree approach for fingerprinting subclonal tumor composition Yuval Kluger	H6-2 PhenDisco (Phenotype Discoverer): a New Information Retrieval System for the database of Genotypes and Phenotypes Hyeoneui Kim
3:40~4:05PM	S8-3 In Silico Cancer Cell versus Stroma cellularity index computed from species-specific human and mouse transcriptome of xenograft models: towards accurate stroma targeting therapy assessment (published in BMC MG) Xinan Yang	H5-3 Variants Affecting Exon Skipping Contribute to Complex Traits Younghee Lee	H6-3 Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network Sarah Pendergrass
4:05~ 4:20PM	Coffee Break
4:20~5:10PM	Keynote VII: Distal enhancers and their role in mediating genotype-phenotype associations. Sridhar Hannenhalli, University of Maryland
5:10~6:00PM	Keynote VIII: Co-methylation. Terry Speed, UC Berkeley
6:00~6:30PM	Special Remark on Translational Bioinformatics Paper Publications and TBC 2011 ~ 2013, by the Chief Editor of JAMIA Lucila Ohno-Machado, UC San Diego
	Closing Ceremony with Traditional TBC Lottery

Floor Plan